MovDisordV3, PascalFrancis, Corpus, bibRecord, 000845

Voluptuary Habits and Clinical Subtypes of Parkinson's Disease: The FRAGAMP Case-Control Study

Identifieur interne : 000845 ( PascalFrancis/Corpus ); précédent : 000844; suivant : 000846

Voluptuary Habits and Clinical Subtypes of Parkinson's Disease: The FRAGAMP Case-Control Study

Auteurs : Alessandra Nicoletti ; Pierfrancesco Pugliese ; Giuseppe Nicoletti ; Gennarina Arabia ; Grazia Annesi ; Michele De Mari ; Paolo Lamberti ; Lucia Grasso ; Roberto Marconi ; Antonio Epifanio ; Letterio Morgante ; Autilia Cozzolino ; Paolo Barone ; Giusi Torchia ; Aldo Quattrone ; Mario Zappia

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:10-0491588

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Tabagisme, Pathologie du système nerveux, Soustype, Etude cas témoin, Epidémiologie, Alcool.

English descriptors

KwdEn :
- Alcohol, Case control study, Epidemiology, Nervous system diseases, Parkinson disease, Subtype, Tobacco smoking.

Abstract

We evaluated the possible association between smoking, coffee drinking, and alcohol consumption and Parkinson's disease (PD). The FRAGAMP study is a large Italian multicenter case-control study carried out to evaluate the possible role of environmental and genetic factors in PD. Adjusted ORs were estimated using unconditional logistic regression. Smoking, coffee, and alcohol consumption were also considered as surrogate markers of lifestyle and analysis was carried out considering the presence of at least one, two, or three factors. This latter analysis was separately performed considering Tremor-Dominant (TD) and Akinetic-Rigid (AR) patients. Four hundred ninety-two PD patients (292 men and 200 women) and 459 controls (160 men and 299 women) were enrolled in the study. Multivariate analysis showed a significant negative association between PD and cigarette smoking (OR 0.51; 95%CI 0.36-0.72), coffee drinking (OR 0.61; 95%CI 0.43-0.87) and wine consumption (OR 0.62; 95%CI 0.44-0.86); a significant trend dose-effect (P < 0.05) has been found for all the factors studied. We have also found a trend dose-effect for the presence of at least one, two or three factors with a greater risk reduction (83%) for the presence of three factors. However, a different strength of association between TD and AR was found with a greater risk reduction for the AR patients. We found a significant inverse association between PD smoking, coffee, and alcohol consumption. When analysis was carried out considering the association of these factors as possible surrogate markers of a peculiar lifestyle the association was stronger for the AR phenotype.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`03`	`1`		`@1 NICOLETTI (Giuseppe)`
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A11	`05`	`1`		`@1 ANNESI (Grazia)`
A11	`06`	`1`		`@1 DE MARI (Michele)`
A11	`07`	`1`		`@1 LAMBERTI (Paolo)`
A11	`08`	`1`		`@1 GRASSO (Lucia)`
A11	`09`	`1`		`@1 MARCONI (Roberto)`
A11	`10`	`1`		`@1 EPIFANIO (Antonio)`
A11	`11`	`1`		`@1 MORGANTE (Letterio)`
A11	`12`	`1`		`@1 COZZOLINO (Autilia)`
A11	`13`	`1`		`@1 BARONE (Paolo)`
A11	`14`	`1`		`@1 TORCHIA (Giusi)`
A11	`15`	`1`		`@1 QUATTRONE (Aldo)`
A11	`16`	`1`		`@1 ZAPPIA (Mario)`
A14	`01`			`@1 Dipartimento di Neuroscienze, Università di Catania @2 Catania @3 ITA @Z 1 aut. @Z 16 aut.`
A14	`02`			`@1 Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza @3 ITA @Z 2 aut. @Z 3 aut. @Z 5 aut. @Z 14 aut. @Z 15 aut.`
A14	`03`			`@1 Clinical Neurologica, Universitd "Magna Græcia" di Catanzaro @2 Catanzaro @3 ITA @Z 4 aut. @Z 15 aut.`
A14	`04`			`@1 Clinica Neurologica, Università di Bari @2 Bari @3 ITA @Z 6 aut. @Z 7 aut.`
A14	`05`			`@1 Divisione di Neurologia, Ospedale Misericordia @2 Grosseto @3 ITA @Z 8 aut. @Z 9 aut.`
A14	`06`			`@1 Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina @2 Messina @3 ITA @Z 10 aut. @Z 11 aut.`
A14	`07`			`@1 Dipartimento di Scienze Neurologiche, Universitd Federico II @2 Napoli @3 ITA @Z 12 aut. @Z 13 aut.`
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A44				`@0 0000 @1 © 2010 INIST-CNRS. All rights reserved.`
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C01	`01`		`ENG`	@0 We evaluated the possible association between smoking, coffee drinking, and alcohol consumption and Parkinson's disease (PD). The FRAGAMP study is a large Italian multicenter case-control study carried out to evaluate the possible role of environmental and genetic factors in PD. Adjusted ORs were estimated using unconditional logistic regression. Smoking, coffee, and alcohol consumption were also considered as surrogate markers of lifestyle and analysis was carried out considering the presence of at least one, two, or three factors. This latter analysis was separately performed considering Tremor-Dominant (TD) and Akinetic-Rigid (AR) patients. Four hundred ninety-two PD patients (292 men and 200 women) and 459 controls (160 men and 299 women) were enrolled in the study. Multivariate analysis showed a significant negative association between PD and cigarette smoking (OR 0.51; 95%CI 0.36-0.72), coffee drinking (OR 0.61; 95%CI 0.43-0.87) and wine consumption (OR 0.62; 95%CI 0.44-0.86); a significant trend dose-effect (P < 0.05) has been found for all the factors studied. We have also found a trend dose-effect for the presence of at least one, two or three factors with a greater risk reduction (83%) for the presence of three factors. However, a different strength of association between TD and AR was found with a greater risk reduction for the AR patients. We found a significant inverse association between PD smoking, coffee, and alcohol consumption. When analysis was carried out considering the association of these factors as possible surrogate markers of a peculiar lifestyle the association was stronger for the AR phenotype.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 01`
C03	`01`	`X`	`ENG`	`@0 Parkinson disease @2 NM @5 01`
C03	`01`	`X`	`SPA`	`@0 Parkinson enfermedad @2 NM @5 01`
C03	`02`	`X`	`FRE`	`@0 Tabagisme @5 02`
C03	`02`	`X`	`ENG`	`@0 Tobacco smoking @5 02`
C03	`02`	`X`	`SPA`	`@0 Tabaquismo @5 02`
C03	`03`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 03`
C03	`03`	`X`	`ENG`	`@0 Nervous system diseases @5 03`
C03	`03`	`X`	`SPA`	`@0 Sistema nervioso patología @5 03`
C03	`04`	`X`	`FRE`	`@0 Soustype @5 09`
C03	`04`	`X`	`ENG`	`@0 Subtype @5 09`
C03	`04`	`X`	`SPA`	`@0 Subtipo @5 09`
C03	`05`	`X`	`FRE`	`@0 Etude cas témoin @5 10`
C03	`05`	`X`	`ENG`	`@0 Case control study @5 10`
C03	`05`	`X`	`SPA`	`@0 Estudio caso control @5 10`
C03	`06`	`X`	`FRE`	`@0 Epidémiologie @5 11`
C03	`06`	`X`	`ENG`	`@0 Epidemiology @5 11`
C03	`06`	`X`	`SPA`	`@0 Epidemiología @5 11`
C03	`07`	`X`	`FRE`	`@0 Alcool @5 12`
C03	`07`	`X`	`ENG`	`@0 Alcohol @5 12`
C03	`07`	`X`	`SPA`	`@0 Alcohol @5 12`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 38`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`04`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 40`
C07	`04`	`X`	`ENG`	`@0 Central nervous system disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 40`
N21				`@1 326`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 10-0491588 INIST
ET :	Voluptuary Habits and Clinical Subtypes of Parkinson's Disease: The FRAGAMP Case-Control Study
AU :	NICOLETTI (Alessandra); PUGLIESE (Pierfrancesco); NICOLETTI (Giuseppe); ARABIA (Gennarina); ANNESI (Grazia); DE MARI (Michele); LAMBERTI (Paolo); GRASSO (Lucia); MARCONI (Roberto); EPIFANIO (Antonio); MORGANTE (Letterio); COZZOLINO (Autilia); BARONE (Paolo); TORCHIA (Giusi); QUATTRONE (Aldo); ZAPPIA (Mario)
AF :	Dipartimento di Neuroscienze, Università di Catania/Catania/Italie (1 aut., 16 aut.); Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza/Italie (2 aut., 3 aut., 5 aut., 14 aut., 15 aut.); Clinical Neurologica, Universitd "Magna Græcia" di Catanzaro/Catanzaro/Italie (4 aut., 15 aut.); Clinica Neurologica, Università di Bari/Bari/Italie (6 aut., 7 aut.); Divisione di Neurologia, Ospedale Misericordia/Grosseto/Italie (8 aut., 9 aut.); Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina/Messina/Italie (10 aut., 11 aut.); Dipartimento di Scienze Neurologiche, Universitd Federico II/Napoli/Italie (12 aut., 13 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 14; Pp. 2387-2394; Bibl. 35 ref.
LA :	Anglais
EA :	We evaluated the possible association between smoking, coffee drinking, and alcohol consumption and Parkinson's disease (PD). The FRAGAMP study is a large Italian multicenter case-control study carried out to evaluate the possible role of environmental and genetic factors in PD. Adjusted ORs were estimated using unconditional logistic regression. Smoking, coffee, and alcohol consumption were also considered as surrogate markers of lifestyle and analysis was carried out considering the presence of at least one, two, or three factors. This latter analysis was separately performed considering Tremor-Dominant (TD) and Akinetic-Rigid (AR) patients. Four hundred ninety-two PD patients (292 men and 200 women) and 459 controls (160 men and 299 women) were enrolled in the study. Multivariate analysis showed a significant negative association between PD and cigarette smoking (OR 0.51; 95%CI 0.36-0.72), coffee drinking (OR 0.61; 95%CI 0.43-0.87) and wine consumption (OR 0.62; 95%CI 0.44-0.86); a significant trend dose-effect (P < 0.05) has been found for all the factors studied. We have also found a trend dose-effect for the presence of at least one, two or three factors with a greater risk reduction (83%) for the presence of three factors. However, a different strength of association between TD and AR was found with a greater risk reduction for the AR patients. We found a significant inverse association between PD smoking, coffee, and alcohol consumption. When analysis was carried out considering the association of these factors as possible surrogate markers of a peculiar lifestyle the association was stronger for the AR phenotype.
CC :	002B17; 002B17G
FD :	Maladie de Parkinson; Tabagisme; Pathologie du système nerveux; Soustype; Etude cas témoin; Epidémiologie; Alcool
FG :	Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central
ED :	Parkinson disease; Tobacco smoking; Nervous system diseases; Subtype; Case control study; Epidemiology; Alcohol
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Parkinson enfermedad; Tabaquismo; Sistema nervioso patología; Subtipo; Estudio caso control; Epidemiología; Alcohol
LO :	INIST-20953.354000192780100180
ID :	10-0491588

Links to Exploration step

Pascal:10-0491588

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Voluptuary Habits and Clinical Subtypes of Parkinson's Disease: The FRAGAMP Case-Control Study</title>
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<author><name sortKey="Pugliese, Pierfrancesco" sort="Pugliese, Pierfrancesco" uniqKey="Pugliese P" first="Pierfrancesco" last="Pugliese">Pierfrancesco Pugliese</name>
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<author><name sortKey="Nicoletti, Giuseppe" sort="Nicoletti, Giuseppe" uniqKey="Nicoletti G" first="Giuseppe" last="Nicoletti">Giuseppe Nicoletti</name>
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<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
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<s3>ITA</s3>
<sZ>6 aut.</sZ>
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<affiliation><inist:fA14 i1="05"><s1>Divisione di Neurologia, Ospedale Misericordia</s1>
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<s3>ITA</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
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<affiliation><inist:fA14 i1="05"><s1>Divisione di Neurologia, Ospedale Misericordia</s1>
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<s3>ITA</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
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<affiliation><inist:fA14 i1="06"><s1>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina</s1>
<s2>Messina</s2>
<s3>ITA</s3>
<sZ>10 aut.</sZ>
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<affiliation><inist:fA14 i1="06"><s1>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina</s1>
<s2>Messina</s2>
<s3>ITA</s3>
<sZ>10 aut.</sZ>
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<author><name sortKey="Cozzolino, Autilia" sort="Cozzolino, Autilia" uniqKey="Cozzolino A" first="Autilia" last="Cozzolino">Autilia Cozzolino</name>
<affiliation><inist:fA14 i1="07"><s1>Dipartimento di Scienze Neurologiche, Universitd Federico II</s1>
<s2>Napoli</s2>
<s3>ITA</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
</affiliation>
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<author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name>
<affiliation><inist:fA14 i1="07"><s1>Dipartimento di Scienze Neurologiche, Universitd Federico II</s1>
<s2>Napoli</s2>
<s3>ITA</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
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<affiliation><inist:fA14 i1="02"><s1>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza</s1>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>14 aut.</sZ>
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<author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name>
<affiliation><inist:fA14 i1="02"><s1>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza</s1>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
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</affiliation>
<affiliation><inist:fA14 i1="03"><s1>Clinical Neurologica, Universitd "Magna Græcia" di Catanzaro</s1>
<s2>Catanzaro</s2>
<s3>ITA</s3>
<sZ>4 aut.</sZ>
<sZ>15 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Zappia, Mario" sort="Zappia, Mario" uniqKey="Zappia M" first="Mario" last="Zappia">Mario Zappia</name>
<affiliation><inist:fA14 i1="01"><s1>Dipartimento di Neuroscienze, Università di Catania</s1>
<s2>Catania</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>16 aut.</sZ>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2010">2010</date>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alcohol</term>
<term>Case control study</term>
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<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Subtype</term>
<term>Tobacco smoking</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Tabagisme</term>
<term>Pathologie du   système nerveux</term>
<term>Soustype</term>
<term>Etude cas témoin</term>
<term>Epidémiologie</term>
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<front><div type="abstract" xml:lang="en">We evaluated the possible association between smoking, coffee drinking, and alcohol consumption and Parkinson's disease (PD). The FRAGAMP study is a large Italian multicenter case-control study carried out to evaluate the possible role of environmental and genetic factors in PD. Adjusted ORs were estimated using unconditional logistic regression. Smoking, coffee, and alcohol consumption were also considered as surrogate markers of lifestyle and analysis was carried out considering the presence of at least one, two, or three factors. This latter analysis was separately performed considering Tremor-Dominant (TD) and Akinetic-Rigid (AR) patients. Four hundred ninety-two PD patients (292 men and 200 women) and 459 controls (160 men and 299 women) were enrolled in the study. Multivariate analysis showed a significant negative association between PD and cigarette smoking (OR 0.51; 95%CI 0.36-0.72), coffee drinking (OR 0.61; 95%CI 0.43-0.87) and wine consumption (OR 0.62; 95%CI 0.44-0.86); a significant trend dose-effect (P < 0.05) has been found for all the factors studied. We have also found a trend dose-effect for the presence of at least one, two or three factors with a greater risk reduction (83%) for the presence of three factors. However, a different strength of association between TD and AR was found with a greater risk reduction for the AR patients. We found a significant inverse association between PD smoking, coffee, and alcohol consumption. When analysis was carried out considering the association of these factors as possible surrogate markers of a peculiar lifestyle the association was stronger for the AR phenotype.</div>
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<fA14 i1="02"><s1>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza</s1>
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<fA14 i1="03"><s1>Clinical Neurologica, Universitd "Magna Græcia" di Catanzaro</s1>
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<sZ>4 aut.</sZ>
<sZ>15 aut.</sZ>
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<fA14 i1="04"><s1>Clinica Neurologica, Università di Bari</s1>
<s2>Bari</s2>
<s3>ITA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Divisione di Neurologia, Ospedale Misericordia</s1>
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<s3>ITA</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
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<fA14 i1="06"><s1>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina</s1>
<s2>Messina</s2>
<s3>ITA</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
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<fA14 i1="07"><s1>Dipartimento di Scienze Neurologiche, Universitd Federico II</s1>
<s2>Napoli</s2>
<s3>ITA</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
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<fA20><s1>2387-2394</s1>
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<fC01 i1="01" l="ENG"><s0>We evaluated the possible association between smoking, coffee drinking, and alcohol consumption and Parkinson's disease (PD). The FRAGAMP study is a large Italian multicenter case-control study carried out to evaluate the possible role of environmental and genetic factors in PD. Adjusted ORs were estimated using unconditional logistic regression. Smoking, coffee, and alcohol consumption were also considered as surrogate markers of lifestyle and analysis was carried out considering the presence of at least one, two, or three factors. This latter analysis was separately performed considering Tremor-Dominant (TD) and Akinetic-Rigid (AR) patients. Four hundred ninety-two PD patients (292 men and 200 women) and 459 controls (160 men and 299 women) were enrolled in the study. Multivariate analysis showed a significant negative association between PD and cigarette smoking (OR 0.51; 95%CI 0.36-0.72), coffee drinking (OR 0.61; 95%CI 0.43-0.87) and wine consumption (OR 0.62; 95%CI 0.44-0.86); a significant trend dose-effect (P < 0.05) has been found for all the factors studied. We have also found a trend dose-effect for the presence of at least one, two or three factors with a greater risk reduction (83%) for the presence of three factors. However, a different strength of association between TD and AR was found with a greater risk reduction for the AR patients. We found a significant inverse association between PD smoking, coffee, and alcohol consumption. When analysis was carried out considering the association of these factors as possible surrogate markers of a peculiar lifestyle the association was stronger for the AR phenotype.</s0>
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<server><NO>PASCAL 10-0491588 INIST</NO>
<ET>Voluptuary Habits and Clinical Subtypes of Parkinson's Disease: The FRAGAMP Case-Control Study</ET>
<AU>NICOLETTI (Alessandra); PUGLIESE (Pierfrancesco); NICOLETTI (Giuseppe); ARABIA (Gennarina); ANNESI (Grazia); DE MARI (Michele); LAMBERTI (Paolo); GRASSO (Lucia); MARCONI (Roberto); EPIFANIO (Antonio); MORGANTE (Letterio); COZZOLINO (Autilia); BARONE (Paolo); TORCHIA (Giusi); QUATTRONE (Aldo); ZAPPIA (Mario)</AU>
<AF>Dipartimento di Neuroscienze, Università di Catania/Catania/Italie (1 aut., 16 aut.); Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza/Italie (2 aut., 3 aut., 5 aut., 14 aut., 15 aut.); Clinical Neurologica, Universitd "Magna Græcia" di Catanzaro/Catanzaro/Italie (4 aut., 15 aut.); Clinica Neurologica, Università di Bari/Bari/Italie (6 aut., 7 aut.); Divisione di Neurologia, Ospedale Misericordia/Grosseto/Italie (8 aut., 9 aut.); Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina/Messina/Italie (10 aut., 11 aut.); Dipartimento di Scienze Neurologiche, Universitd Federico II/Napoli/Italie (12 aut., 13 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 14; Pp. 2387-2394; Bibl. 35 ref.</SO>
<LA>Anglais</LA>
<EA>We evaluated the possible association between smoking, coffee drinking, and alcohol consumption and Parkinson's disease (PD). The FRAGAMP study is a large Italian multicenter case-control study carried out to evaluate the possible role of environmental and genetic factors in PD. Adjusted ORs were estimated using unconditional logistic regression. Smoking, coffee, and alcohol consumption were also considered as surrogate markers of lifestyle and analysis was carried out considering the presence of at least one, two, or three factors. This latter analysis was separately performed considering Tremor-Dominant (TD) and Akinetic-Rigid (AR) patients. Four hundred ninety-two PD patients (292 men and 200 women) and 459 controls (160 men and 299 women) were enrolled in the study. Multivariate analysis showed a significant negative association between PD and cigarette smoking (OR 0.51; 95%CI 0.36-0.72), coffee drinking (OR 0.61; 95%CI 0.43-0.87) and wine consumption (OR 0.62; 95%CI 0.44-0.86); a significant trend dose-effect (P < 0.05) has been found for all the factors studied. We have also found a trend dose-effect for the presence of at least one, two or three factors with a greater risk reduction (83%) for the presence of three factors. However, a different strength of association between TD and AR was found with a greater risk reduction for the AR patients. We found a significant inverse association between PD smoking, coffee, and alcohol consumption. When analysis was carried out considering the association of these factors as possible surrogate markers of a peculiar lifestyle the association was stronger for the AR phenotype.</EA>
<CC>002B17; 002B17G</CC>
<FD>Maladie de Parkinson; Tabagisme; Pathologie du   système nerveux; Soustype; Etude cas témoin; Epidémiologie; Alcool</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central</FG>
<ED>Parkinson disease; Tobacco smoking; Nervous system diseases; Subtype; Case control study; Epidemiology; Alcohol</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Voluptuary Habits and Clinical Subtypes of Parkinson's Disease: The FRAGAMP Case-Control Study

Voluptuary Habits and Clinical Subtypes of Parkinson's Disease: The FRAGAMP Case-Control Study

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