Voluptuary Habits and Clinical Subtypes of Parkinson's Disease: The FRAGAMP Case-Control Study
Identifieur interne : 002474 ( PascalFrancis/Curation ); précédent : 002473; suivant : 002475Voluptuary Habits and Clinical Subtypes of Parkinson's Disease: The FRAGAMP Case-Control Study
Auteurs : Alessandra Nicoletti [Italie] ; Pierfrancesco Pugliese [Italie] ; Giuseppe Nicoletti [Italie] ; Gennarina Arabia [Italie] ; Grazia Annesi [Italie] ; Michele De Mari [Italie] ; Paolo Lamberti [Italie] ; Lucia Grasso [Italie] ; Roberto Marconi [Italie] ; Antonio Epifanio [Italie] ; Letterio Morgante [Italie] ; Autilia Cozzolino [Italie] ; Paolo Barone [Italie] ; Giusi Torchia [Italie] ; Aldo Quattrone [Italie] ; Mario Zappia [Italie]Source :
- Movement disorders [ 0885-3185 ] ; 2010.
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Abstract
We evaluated the possible association between smoking, coffee drinking, and alcohol consumption and Parkinson's disease (PD). The FRAGAMP study is a large Italian multicenter case-control study carried out to evaluate the possible role of environmental and genetic factors in PD. Adjusted ORs were estimated using unconditional logistic regression. Smoking, coffee, and alcohol consumption were also considered as surrogate markers of lifestyle and analysis was carried out considering the presence of at least one, two, or three factors. This latter analysis was separately performed considering Tremor-Dominant (TD) and Akinetic-Rigid (AR) patients. Four hundred ninety-two PD patients (292 men and 200 women) and 459 controls (160 men and 299 women) were enrolled in the study. Multivariate analysis showed a significant negative association between PD and cigarette smoking (OR 0.51; 95%CI 0.36-0.72), coffee drinking (OR 0.61; 95%CI 0.43-0.87) and wine consumption (OR 0.62; 95%CI 0.44-0.86); a significant trend dose-effect (P < 0.05) has been found for all the factors studied. We have also found a trend dose-effect for the presence of at least one, two or three factors with a greater risk reduction (83%) for the presence of three factors. However, a different strength of association between TD and AR was found with a greater risk reduction for the AR patients. We found a significant inverse association between PD smoking, coffee, and alcohol consumption. When analysis was carried out considering the association of these factors as possible surrogate markers of a peculiar lifestyle the association was stronger for the AR phenotype.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Voluptuary Habits and Clinical Subtypes of Parkinson's Disease: The FRAGAMP Case-Control Study</title><author><name sortKey="Nicoletti, Alessandra" sort="Nicoletti, Alessandra" uniqKey="Nicoletti A" first="Alessandra" last="Nicoletti">Alessandra Nicoletti</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Dipartimento di Neuroscienze, Università di Catania</s1><s2>Catania</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Pugliese, Pierfrancesco" sort="Pugliese, Pierfrancesco" uniqKey="Pugliese P" first="Pierfrancesco" last="Pugliese">Pierfrancesco Pugliese</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza</s1><s3>ITA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>14 aut.</sZ><sZ>15 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aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Grasso, Lucia" sort="Grasso, Lucia" uniqKey="Grasso L" first="Lucia" last="Grasso">Lucia Grasso</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Divisione di Neurologia, Ospedale Misericordia</s1><s2>Grosseto</s2><s3>ITA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Marconi, Roberto" sort="Marconi, Roberto" uniqKey="Marconi R" first="Roberto" last="Marconi">Roberto Marconi</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Divisione di Neurologia, Ospedale Misericordia</s1><s2>Grosseto</s2><s3>ITA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Epifanio, Antonio" sort="Epifanio, Antonio" uniqKey="Epifanio A" first="Antonio" last="Epifanio">Antonio Epifanio</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina</s1><s2>Messina</s2><s3>ITA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Morgante, Letterio" sort="Morgante, Letterio" uniqKey="Morgante L" first="Letterio" last="Morgante">Letterio Morgante</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina</s1><s2>Messina</s2><s3>ITA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Cozzolino, Autilia" sort="Cozzolino, Autilia" uniqKey="Cozzolino A" first="Autilia" last="Cozzolino">Autilia Cozzolino</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Dipartimento di Scienze Neurologiche, Universitd Federico II</s1><s2>Napoli</s2><s3>ITA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Dipartimento di Scienze Neurologiche, Universitd Federico II</s1><s2>Napoli</s2><s3>ITA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Torchia, Giusi" sort="Torchia, Giusi" uniqKey="Torchia G" first="Giusi" last="Torchia">Giusi Torchia</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza</s1><s3>ITA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza</s1><s3>ITA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Italie</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Clinical Neurologica, Universitd "Magna Græcia" di Catanzaro</s1><s2>Catanzaro</s2><s3>ITA</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Zappia, Mario" sort="Zappia, Mario" uniqKey="Zappia M" first="Mario" last="Zappia">Mario Zappia</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Dipartimento di Neuroscienze, Università di Catania</s1><s2>Catania</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">10-0491588</idno><date when="2010">2010</date><idno type="stanalyst">PASCAL 10-0491588 INIST</idno><idno type="RBID">Pascal:10-0491588</idno><idno type="wicri:Area/PascalFrancis/Corpus">000845</idno><idno type="wicri:Area/PascalFrancis/Curation">002474</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Voluptuary Habits and Clinical Subtypes of Parkinson's Disease: The FRAGAMP Case-Control Study</title><author><name sortKey="Nicoletti, Alessandra" sort="Nicoletti, Alessandra" uniqKey="Nicoletti A" first="Alessandra" last="Nicoletti">Alessandra Nicoletti</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Dipartimento di Neuroscienze, Università di Catania</s1><s2>Catania</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Pugliese, Pierfrancesco" sort="Pugliese, Pierfrancesco" uniqKey="Pugliese P" first="Pierfrancesco" last="Pugliese">Pierfrancesco Pugliese</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza</s1><s3>ITA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Nicoletti, Giuseppe" sort="Nicoletti, Giuseppe" uniqKey="Nicoletti G" first="Giuseppe" last="Nicoletti">Giuseppe Nicoletti</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza</s1><s3>ITA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Arabia, Gennarina" sort="Arabia, Gennarina" uniqKey="Arabia G" first="Gennarina" last="Arabia">Gennarina Arabia</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Clinical Neurologica, Universitd "Magna Græcia" di Catanzaro</s1><s2>Catanzaro</s2><s3>ITA</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza</s1><s3>ITA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="De Mari, Michele" sort="De Mari, Michele" uniqKey="De Mari M" first="Michele" last="De Mari">Michele De Mari</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Clinica Neurologica, Università di Bari</s1><s2>Bari</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Lamberti, Paolo" sort="Lamberti, Paolo" uniqKey="Lamberti P" first="Paolo" last="Lamberti">Paolo Lamberti</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Clinica Neurologica, Università di Bari</s1><s2>Bari</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Grasso, Lucia" sort="Grasso, Lucia" uniqKey="Grasso L" first="Lucia" last="Grasso">Lucia Grasso</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Divisione di Neurologia, Ospedale Misericordia</s1><s2>Grosseto</s2><s3>ITA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Marconi, Roberto" sort="Marconi, Roberto" uniqKey="Marconi R" first="Roberto" last="Marconi">Roberto Marconi</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Divisione di Neurologia, Ospedale Misericordia</s1><s2>Grosseto</s2><s3>ITA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Epifanio, Antonio" sort="Epifanio, Antonio" uniqKey="Epifanio A" first="Antonio" last="Epifanio">Antonio Epifanio</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina</s1><s2>Messina</s2><s3>ITA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Morgante, Letterio" sort="Morgante, Letterio" uniqKey="Morgante L" first="Letterio" last="Morgante">Letterio Morgante</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina</s1><s2>Messina</s2><s3>ITA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Cozzolino, Autilia" sort="Cozzolino, Autilia" uniqKey="Cozzolino A" first="Autilia" last="Cozzolino">Autilia Cozzolino</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Dipartimento di Scienze Neurologiche, Universitd Federico II</s1><s2>Napoli</s2><s3>ITA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Dipartimento di Scienze Neurologiche, Universitd Federico II</s1><s2>Napoli</s2><s3>ITA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Torchia, Giusi" sort="Torchia, Giusi" uniqKey="Torchia G" first="Giusi" last="Torchia">Giusi Torchia</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza</s1><s3>ITA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza</s1><s3>ITA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Italie</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Clinical Neurologica, Universitd "Magna Græcia" di Catanzaro</s1><s2>Catanzaro</s2><s3>ITA</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author><author><name sortKey="Zappia, Mario" sort="Zappia, Mario" uniqKey="Zappia M" first="Mario" last="Zappia">Mario Zappia</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Dipartimento di Neuroscienze, Università di Catania</s1><s2>Catania</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Italie</country></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alcohol</term><term>Case control study</term><term>Epidemiology</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Subtype</term><term>Tobacco smoking</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Tabagisme</term><term>Pathologie du système nerveux</term><term>Soustype</term><term>Etude cas témoin</term><term>Epidémiologie</term><term>Alcool</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Tabagisme</term><term>Alcool</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We evaluated the possible association between smoking, coffee drinking, and alcohol consumption and Parkinson's disease (PD). The FRAGAMP study is a large Italian multicenter case-control study carried out to evaluate the possible role of environmental and genetic factors in PD. Adjusted ORs were estimated using unconditional logistic regression. Smoking, coffee, and alcohol consumption were also considered as surrogate markers of lifestyle and analysis was carried out considering the presence of at least one, two, or three factors. This latter analysis was separately performed considering Tremor-Dominant (TD) and Akinetic-Rigid (AR) patients. Four hundred ninety-two PD patients (292 men and 200 women) and 459 controls (160 men and 299 women) were enrolled in the study. Multivariate analysis showed a significant negative association between PD and cigarette smoking (OR 0.51; 95%CI 0.36-0.72), coffee drinking (OR 0.61; 95%CI 0.43-0.87) and wine consumption (OR 0.62; 95%CI 0.44-0.86); a significant trend dose-effect (P < 0.05) has been found for all the factors studied. We have also found a trend dose-effect for the presence of at least one, two or three factors with a greater risk reduction (83%) for the presence of three factors. However, a different strength of association between TD and AR was found with a greater risk reduction for the AR patients. We found a significant inverse association between PD smoking, coffee, and alcohol consumption. When analysis was carried out considering the association of these factors as possible surrogate markers of a peculiar lifestyle the association was stronger for the AR phenotype.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>25</s2></fA05><fA06><s2>14</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Voluptuary Habits and Clinical Subtypes of Parkinson's Disease: The FRAGAMP Case-Control Study</s1></fA08><fA11 i1="01" i2="1"><s1>NICOLETTI (Alessandra)</s1></fA11><fA11 i1="02" i2="1"><s1>PUGLIESE (Pierfrancesco)</s1></fA11><fA11 i1="03" i2="1"><s1>NICOLETTI (Giuseppe)</s1></fA11><fA11 i1="04" i2="1"><s1>ARABIA (Gennarina)</s1></fA11><fA11 i1="05" i2="1"><s1>ANNESI (Grazia)</s1></fA11><fA11 i1="06" i2="1"><s1>DE MARI (Michele)</s1></fA11><fA11 i1="07" i2="1"><s1>LAMBERTI (Paolo)</s1></fA11><fA11 i1="08" i2="1"><s1>GRASSO (Lucia)</s1></fA11><fA11 i1="09" i2="1"><s1>MARCONI (Roberto)</s1></fA11><fA11 i1="10" i2="1"><s1>EPIFANIO (Antonio)</s1></fA11><fA11 i1="11" i2="1"><s1>MORGANTE (Letterio)</s1></fA11><fA11 i1="12" i2="1"><s1>COZZOLINO (Autilia)</s1></fA11><fA11 i1="13" i2="1"><s1>BARONE (Paolo)</s1></fA11><fA11 i1="14" i2="1"><s1>TORCHIA (Giusi)</s1></fA11><fA11 i1="15" i2="1"><s1>QUATTRONE (Aldo)</s1></fA11><fA11 i1="16" i2="1"><s1>ZAPPIA (Mario)</s1></fA11><fA14 i1="01"><s1>Dipartimento di Neuroscienze, Università di Catania</s1><s2>Catania</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>16 aut.</sZ></fA14><fA14 i1="02"><s1>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza</s1><s3>ITA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></fA14><fA14 i1="03"><s1>Clinical Neurologica, Universitd "Magna Græcia" di Catanzaro</s1><s2>Catanzaro</s2><s3>ITA</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ></fA14><fA14 i1="04"><s1>Clinica Neurologica, Università di Bari</s1><s2>Bari</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="05"><s1>Divisione di Neurologia, Ospedale Misericordia</s1><s2>Grosseto</s2><s3>ITA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ></fA14><fA14 i1="06"><s1>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina</s1><s2>Messina</s2><s3>ITA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></fA14><fA14 i1="07"><s1>Dipartimento di Scienze Neurologiche, Universitd Federico II</s1><s2>Napoli</s2><s3>ITA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ></fA14><fA20><s1>2387-2394</s1></fA20><fA21><s1>2010</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000192780100180</s5></fA43><fA44><s0>0000</s0><s1>© 2010 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>35 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>10-0491588</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>We evaluated the possible association between smoking, coffee drinking, and alcohol consumption and Parkinson's disease (PD). The FRAGAMP study is a large Italian multicenter case-control study carried out to evaluate the possible role of environmental and genetic factors in PD. Adjusted ORs were estimated using unconditional logistic regression. Smoking, coffee, and alcohol consumption were also considered as surrogate markers of lifestyle and analysis was carried out considering the presence of at least one, two, or three factors. This latter analysis was separately performed considering Tremor-Dominant (TD) and Akinetic-Rigid (AR) patients. Four hundred ninety-two PD patients (292 men and 200 women) and 459 controls (160 men and 299 women) were enrolled in the study. Multivariate analysis showed a significant negative association between PD and cigarette smoking (OR 0.51; 95%CI 0.36-0.72), coffee drinking (OR 0.61; 95%CI 0.43-0.87) and wine consumption (OR 0.62; 95%CI 0.44-0.86); a significant trend dose-effect (P < 0.05) has been found for all the factors studied. We have also found a trend dose-effect for the presence of at least one, two or three factors with a greater risk reduction (83%) for the presence of three factors. However, a different strength of association between TD and AR was found with a greater risk reduction for the AR patients. We found a significant inverse association between PD smoking, coffee, and alcohol consumption. When analysis was carried out considering the association of these factors as possible surrogate markers of a peculiar lifestyle the association was stronger for the AR phenotype.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Tabagisme</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Tobacco smoking</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Tabaquismo</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Soustype</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Subtype</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Subtipo</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Etude cas témoin</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Case control study</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Estudio caso control</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Epidémiologie</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Epidemiology</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Epidemiología</s0><s5>11</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Alcool</s0><s5>12</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Alcohol</s0><s5>12</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Alcohol</s0><s5>12</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>40</s5></fC07><fN21><s1>326</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist></record>Pour manipuler ce document sous Unix (Dilib)
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