Grasping premanifest Huntington's disease – shaping new endpoints for new trials
Identifieur interne : 002100 ( Main/Merge ); précédent : 002099; suivant : 002101Grasping premanifest Huntington's disease – shaping new endpoints for new trials
Auteurs : Ralf Reilmann [Allemagne] ; Stefan Bohlen [Allemagne] ; Thomas Klopstock [Allemagne] ; Andreas Bender [Allemagne] ; Adolf Weindl [Allemagne] ; Philipp Saemann [Allemagne] ; Dorothee P. Auer [Allemagne] ; Erich B. Ringelstein [Allemagne] ; Herwig W. Lange [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-12-15.
English descriptors
- KwdEn :
- Adult, Analysis of Variance, Clinical Trials as Topic, Disease Progression, Female, Follow-Up Studies, Hand Strength (physiology), Humans, Huntington Disease (diagnosis), Huntington Disease (physiopathology), Male, Middle Aged, biomarker, clinical physiology, grip force, huntington's disease, motor control.
- MESH :
- diagnosis : Huntington Disease.
- physiology : Hand Strength.
- physiopathology : Huntington Disease.
- Adult, Analysis of Variance, Clinical Trials as Topic, Disease Progression, Female, Follow-Up Studies, Humans, Male, Middle Aged.
Abstract
Future clinical trials in subjects with premanifest Huntington's disease (preHD) may depend on the availability of biomarkers. It was previously shown in symptomatic HD that, the grip force variability coefficient‐of‐variation (GFV‐C) in a grasping paradigm was correlated to the Unified‐Huntington's‐Disease‐Rating‐Scale‐Total‐Motor‐Score (UHDRS‐TMS) and increased in a 3 year follow‐up study. To further elucidate its potential as a biomarker, we investigated whether GFV‐C is able to detect a motor phenotype in preHD and is correlated to the genotype assessed by a disease‐burden‐score. The ability of preHD (n = 15) and symptomatic HD subjects (n = 20) to maintain stable grip forces, while holding an object (250 g and 500 g), was measured and compared with the controls (n = 19). GFV‐C was increased in preHD at 500 g, in symptomatic subjects at both weights and was correlated to the disease‐burden‐score and UHDRS‐TMS. GFV‐C may be a useful objective and quantitative marker of motor dysfunction across genetically diagnosed premanifest and symptomatic HD subjects. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.23300
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000A86
- to stream Istex, to step Curation: 000A86
- to stream Istex, to step Checkpoint: 000943
- to stream PubMed, to step Corpus: 001571
- to stream PubMed, to step Curation: 001571
- to stream PubMed, to step Checkpoint: 001860
- to stream Ncbi, to step Merge: 002E46
- to stream Ncbi, to step Curation: 002E46
- to stream Ncbi, to step Checkpoint: 002E46
Links to Exploration step
ISTEX:B3EDF76AC2B045373765C575999D5ED9853E60BELe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Grasping premanifest Huntington's disease – shaping new endpoints for new trials</title>
<author><name sortKey="Reilmann, Ralf" sort="Reilmann, Ralf" uniqKey="Reilmann R" first="Ralf" last="Reilmann">Ralf Reilmann</name>
</author>
<author><name sortKey="Bohlen, Stefan" sort="Bohlen, Stefan" uniqKey="Bohlen S" first="Stefan" last="Bohlen">Stefan Bohlen</name>
</author>
<author><name sortKey="Klopstock, Thomas" sort="Klopstock, Thomas" uniqKey="Klopstock T" first="Thomas" last="Klopstock">Thomas Klopstock</name>
</author>
<author><name sortKey="Bender, Andreas" sort="Bender, Andreas" uniqKey="Bender A" first="Andreas" last="Bender">Andreas Bender</name>
</author>
<author><name sortKey="Weindl, Adolf" sort="Weindl, Adolf" uniqKey="Weindl A" first="Adolf" last="Weindl">Adolf Weindl</name>
</author>
<author><name sortKey="Saemann, Philipp" sort="Saemann, Philipp" uniqKey="Saemann P" first="Philipp" last="Saemann">Philipp Saemann</name>
</author>
<author><name sortKey="Auer, Dorothee P" sort="Auer, Dorothee P" uniqKey="Auer D" first="Dorothee P." last="Auer">Dorothee P. Auer</name>
</author>
<author><name sortKey="Ringelstein, Erich B" sort="Ringelstein, Erich B" uniqKey="Ringelstein E" first="Erich B." last="Ringelstein">Erich B. Ringelstein</name>
</author>
<author><name sortKey="Lange, Herwig W" sort="Lange, Herwig W" uniqKey="Lange H" first="Herwig W." last="Lange">Herwig W. Lange</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:B3EDF76AC2B045373765C575999D5ED9853E60BE</idno>
<date when="2010" year="2010">2010</date>
<idno type="doi">10.1002/mds.23300</idno>
<idno type="url">https://api.istex.fr/document/B3EDF76AC2B045373765C575999D5ED9853E60BE/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000A86</idno>
<idno type="wicri:Area/Istex/Curation">000A86</idno>
<idno type="wicri:Area/Istex/Checkpoint">000943</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Reilmann R:grasping:premanifest:huntington</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:20818671</idno>
<idno type="wicri:Area/PubMed/Corpus">001571</idno>
<idno type="wicri:Area/PubMed/Curation">001571</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001860</idno>
<idno type="wicri:Area/Ncbi/Merge">002E46</idno>
<idno type="wicri:Area/Ncbi/Curation">002E46</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002E46</idno>
<idno type="wicri:Area/Main/Merge">002100</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Grasping premanifest Huntington's disease – shaping new endpoints for new trials</title>
<author><name sortKey="Reilmann, Ralf" sort="Reilmann, Ralf" uniqKey="Reilmann R" first="Ralf" last="Reilmann">Ralf Reilmann</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Clinic Muenster (UKM), Westfaelische Wilhelms University of Muenster, Muenster</wicri:regionArea>
<wicri:noRegion>Muenster</wicri:noRegion>
<wicri:noRegion>Muenster</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bohlen, Stefan" sort="Bohlen, Stefan" uniqKey="Bohlen S" first="Stefan" last="Bohlen">Stefan Bohlen</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Clinic Muenster (UKM), Westfaelische Wilhelms University of Muenster, Muenster</wicri:regionArea>
<wicri:noRegion>Muenster</wicri:noRegion>
<wicri:noRegion>Muenster</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Klopstock, Thomas" sort="Klopstock, Thomas" uniqKey="Klopstock T" first="Thomas" last="Klopstock">Thomas Klopstock</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Friedrich‐Baur‐Institute, Ludwig‐Maximilians‐University, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bender, Andreas" sort="Bender, Andreas" uniqKey="Bender A" first="Andreas" last="Bender">Andreas Bender</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Friedrich‐Baur‐Institute, Ludwig‐Maximilians‐University, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weindl, Adolf" sort="Weindl, Adolf" uniqKey="Weindl A" first="Adolf" last="Weindl">Adolf Weindl</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Technical University Munich</wicri:regionArea>
<wicri:noRegion>Technical University Munich</wicri:noRegion>
<wicri:noRegion>Technical University Munich</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Saemann, Philipp" sort="Saemann, Philipp" uniqKey="Saemann P" first="Philipp" last="Saemann">Philipp Saemann</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Radiology, Max Planck Institute of Psychiatry, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Auer, Dorothee P" sort="Auer, Dorothee P" uniqKey="Auer D" first="Dorothee P." last="Auer">Dorothee P. Auer</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Radiology, Max Planck Institute of Psychiatry, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ringelstein, Erich B" sort="Ringelstein, Erich B" uniqKey="Ringelstein E" first="Erich B." last="Ringelstein">Erich B. Ringelstein</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Clinic Muenster (UKM), Westfaelische Wilhelms University of Muenster, Muenster</wicri:regionArea>
<wicri:noRegion>Muenster</wicri:noRegion>
<wicri:noRegion>Muenster</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lange, Herwig W" sort="Lange, Herwig W" uniqKey="Lange H" first="Herwig W." last="Lange">Herwig W. Lange</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Clinic Muenster (UKM), Westfaelische Wilhelms University of Muenster, Muenster</wicri:regionArea>
<wicri:noRegion>Muenster</wicri:noRegion>
<wicri:noRegion>Muenster</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2010-12-15">2010-12-15</date>
<biblScope unit="vol">25</biblScope>
<biblScope unit="issue">16</biblScope>
<biblScope unit="page" from="2858">2858</biblScope>
<biblScope unit="page" to="2862">2862</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">B3EDF76AC2B045373765C575999D5ED9853E60BE</idno>
<idno type="DOI">10.1002/mds.23300</idno>
<idno type="ArticleID">MDS23300</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Analysis of Variance</term>
<term>Clinical Trials as Topic</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Hand Strength (physiology)</term>
<term>Humans</term>
<term>Huntington Disease (diagnosis)</term>
<term>Huntington Disease (physiopathology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>biomarker</term>
<term>clinical physiology</term>
<term>grip force</term>
<term>huntington's disease</term>
<term>motor control</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Huntington Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hand Strength</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Huntington Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Analysis of Variance</term>
<term>Clinical Trials as Topic</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Future clinical trials in subjects with premanifest Huntington's disease (preHD) may depend on the availability of biomarkers. It was previously shown in symptomatic HD that, the grip force variability coefficient‐of‐variation (GFV‐C) in a grasping paradigm was correlated to the Unified‐Huntington's‐Disease‐Rating‐Scale‐Total‐Motor‐Score (UHDRS‐TMS) and increased in a 3 year follow‐up study. To further elucidate its potential as a biomarker, we investigated whether GFV‐C is able to detect a motor phenotype in preHD and is correlated to the genotype assessed by a disease‐burden‐score. The ability of preHD (n = 15) and symptomatic HD subjects (n = 20) to maintain stable grip forces, while holding an object (250 g and 500 g), was measured and compared with the controls (n = 19). GFV‐C was increased in preHD at 500 g, in symptomatic subjects at both weights and was correlated to the disease‐burden‐score and UHDRS‐TMS. GFV‐C may be a useful objective and quantitative marker of motor dysfunction across genetically diagnosed premanifest and symptomatic HD subjects. © 2010 Movement Disorder Society</div>
</front>
</TEI>
<double doi="10.1002/mds.23300"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Grasping premanifest Huntington's disease – shaping new endpoints for new trials</title>
<author><name sortKey="Reilmann, Ralf" sort="Reilmann, Ralf" uniqKey="Reilmann R" first="Ralf" last="Reilmann">Ralf Reilmann</name>
</author>
<author><name sortKey="Bohlen, Stefan" sort="Bohlen, Stefan" uniqKey="Bohlen S" first="Stefan" last="Bohlen">Stefan Bohlen</name>
</author>
<author><name sortKey="Klopstock, Thomas" sort="Klopstock, Thomas" uniqKey="Klopstock T" first="Thomas" last="Klopstock">Thomas Klopstock</name>
</author>
<author><name sortKey="Bender, Andreas" sort="Bender, Andreas" uniqKey="Bender A" first="Andreas" last="Bender">Andreas Bender</name>
</author>
<author><name sortKey="Weindl, Adolf" sort="Weindl, Adolf" uniqKey="Weindl A" first="Adolf" last="Weindl">Adolf Weindl</name>
</author>
<author><name sortKey="Saemann, Philipp" sort="Saemann, Philipp" uniqKey="Saemann P" first="Philipp" last="Saemann">Philipp Saemann</name>
</author>
<author><name sortKey="Auer, Dorothee P" sort="Auer, Dorothee P" uniqKey="Auer D" first="Dorothee P." last="Auer">Dorothee P. Auer</name>
</author>
<author><name sortKey="Ringelstein, Erich B" sort="Ringelstein, Erich B" uniqKey="Ringelstein E" first="Erich B." last="Ringelstein">Erich B. Ringelstein</name>
</author>
<author><name sortKey="Lange, Herwig W" sort="Lange, Herwig W" uniqKey="Lange H" first="Herwig W." last="Lange">Herwig W. Lange</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:B3EDF76AC2B045373765C575999D5ED9853E60BE</idno>
<date when="2010" year="2010">2010</date>
<idno type="doi">10.1002/mds.23300</idno>
<idno type="url">https://api.istex.fr/document/B3EDF76AC2B045373765C575999D5ED9853E60BE/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000A86</idno>
<idno type="wicri:Area/Istex/Curation">000A86</idno>
<idno type="wicri:Area/Istex/Checkpoint">000943</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Reilmann R:grasping:premanifest:huntington</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Grasping premanifest Huntington's disease – shaping new endpoints for new trials</title>
<author><name sortKey="Reilmann, Ralf" sort="Reilmann, Ralf" uniqKey="Reilmann R" first="Ralf" last="Reilmann">Ralf Reilmann</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Clinic Muenster (UKM), Westfaelische Wilhelms University of Muenster, Muenster</wicri:regionArea>
<wicri:noRegion>Muenster</wicri:noRegion>
<wicri:noRegion>Muenster</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bohlen, Stefan" sort="Bohlen, Stefan" uniqKey="Bohlen S" first="Stefan" last="Bohlen">Stefan Bohlen</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Clinic Muenster (UKM), Westfaelische Wilhelms University of Muenster, Muenster</wicri:regionArea>
<wicri:noRegion>Muenster</wicri:noRegion>
<wicri:noRegion>Muenster</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Klopstock, Thomas" sort="Klopstock, Thomas" uniqKey="Klopstock T" first="Thomas" last="Klopstock">Thomas Klopstock</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Friedrich‐Baur‐Institute, Ludwig‐Maximilians‐University, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bender, Andreas" sort="Bender, Andreas" uniqKey="Bender A" first="Andreas" last="Bender">Andreas Bender</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Friedrich‐Baur‐Institute, Ludwig‐Maximilians‐University, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weindl, Adolf" sort="Weindl, Adolf" uniqKey="Weindl A" first="Adolf" last="Weindl">Adolf Weindl</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Technical University Munich</wicri:regionArea>
<wicri:noRegion>Technical University Munich</wicri:noRegion>
<wicri:noRegion>Technical University Munich</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Saemann, Philipp" sort="Saemann, Philipp" uniqKey="Saemann P" first="Philipp" last="Saemann">Philipp Saemann</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Radiology, Max Planck Institute of Psychiatry, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Auer, Dorothee P" sort="Auer, Dorothee P" uniqKey="Auer D" first="Dorothee P." last="Auer">Dorothee P. Auer</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Radiology, Max Planck Institute of Psychiatry, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ringelstein, Erich B" sort="Ringelstein, Erich B" uniqKey="Ringelstein E" first="Erich B." last="Ringelstein">Erich B. Ringelstein</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Clinic Muenster (UKM), Westfaelische Wilhelms University of Muenster, Muenster</wicri:regionArea>
<wicri:noRegion>Muenster</wicri:noRegion>
<wicri:noRegion>Muenster</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lange, Herwig W" sort="Lange, Herwig W" uniqKey="Lange H" first="Herwig W." last="Lange">Herwig W. Lange</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Clinic Muenster (UKM), Westfaelische Wilhelms University of Muenster, Muenster</wicri:regionArea>
<wicri:noRegion>Muenster</wicri:noRegion>
<wicri:noRegion>Muenster</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2010-12-15">2010-12-15</date>
<biblScope unit="vol">25</biblScope>
<biblScope unit="issue">16</biblScope>
<biblScope unit="page" from="2858">2858</biblScope>
<biblScope unit="page" to="2862">2862</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">B3EDF76AC2B045373765C575999D5ED9853E60BE</idno>
<idno type="DOI">10.1002/mds.23300</idno>
<idno type="ArticleID">MDS23300</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>biomarker</term>
<term>clinical physiology</term>
<term>grip force</term>
<term>huntington's disease</term>
<term>motor control</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Future clinical trials in subjects with premanifest Huntington's disease (preHD) may depend on the availability of biomarkers. It was previously shown in symptomatic HD that, the grip force variability coefficient‐of‐variation (GFV‐C) in a grasping paradigm was correlated to the Unified‐Huntington's‐Disease‐Rating‐Scale‐Total‐Motor‐Score (UHDRS‐TMS) and increased in a 3 year follow‐up study. To further elucidate its potential as a biomarker, we investigated whether GFV‐C is able to detect a motor phenotype in preHD and is correlated to the genotype assessed by a disease‐burden‐score. The ability of preHD (n = 15) and symptomatic HD subjects (n = 20) to maintain stable grip forces, while holding an object (250 g and 500 g), was measured and compared with the controls (n = 19). GFV‐C was increased in preHD at 500 g, in symptomatic subjects at both weights and was correlated to the disease‐burden‐score and UHDRS‐TMS. GFV‐C may be a useful objective and quantitative marker of motor dysfunction across genetically diagnosed premanifest and symptomatic HD subjects. © 2010 Movement Disorder Society</div>
</front>
</TEI>
</ISTEX>
<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Grasping premanifest Huntington's disease - shaping new endpoints for new trials.</title>
<author><name sortKey="Reilmann, Ralf" sort="Reilmann, Ralf" uniqKey="Reilmann R" first="Ralf" last="Reilmann">Ralf Reilmann</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Clinic Muenster (UKM), Westfaelische Wilhelms University of Muenster, Muenster, Germany. r.reilmann@uni-muenster.de</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Clinic Muenster (UKM), Westfaelische Wilhelms University of Muenster, Muenster</wicri:regionArea>
<wicri:noRegion>Muenster</wicri:noRegion>
<wicri:noRegion>Muenster</wicri:noRegion>
<wicri:noRegion>Muenster</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bohlen, Stefan" sort="Bohlen, Stefan" uniqKey="Bohlen S" first="Stefan" last="Bohlen">Stefan Bohlen</name>
</author>
<author><name sortKey="Klopstock, Thomas" sort="Klopstock, Thomas" uniqKey="Klopstock T" first="Thomas" last="Klopstock">Thomas Klopstock</name>
</author>
<author><name sortKey="Bender, Andreas" sort="Bender, Andreas" uniqKey="Bender A" first="Andreas" last="Bender">Andreas Bender</name>
</author>
<author><name sortKey="Weindl, Adolf" sort="Weindl, Adolf" uniqKey="Weindl A" first="Adolf" last="Weindl">Adolf Weindl</name>
</author>
<author><name sortKey="Saemann, Philipp" sort="Saemann, Philipp" uniqKey="Saemann P" first="Philipp" last="Saemann">Philipp Saemann</name>
</author>
<author><name sortKey="Auer, Dorothee P" sort="Auer, Dorothee P" uniqKey="Auer D" first="Dorothee P" last="Auer">Dorothee P. Auer</name>
</author>
<author><name sortKey="Ringelstein, Erich B" sort="Ringelstein, Erich B" uniqKey="Ringelstein E" first="Erich B" last="Ringelstein">Erich B. Ringelstein</name>
</author>
<author><name sortKey="Lange, Herwig W" sort="Lange, Herwig W" uniqKey="Lange H" first="Herwig W" last="Lange">Herwig W. Lange</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2010">2010</date>
<idno type="doi">10.1002/mds.23300</idno>
<idno type="RBID">pubmed:20818671</idno>
<idno type="pmid">20818671</idno>
<idno type="wicri:Area/PubMed/Corpus">001571</idno>
<idno type="wicri:Area/PubMed/Curation">001571</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001860</idno>
<idno type="wicri:Area/Ncbi/Merge">002E46</idno>
<idno type="wicri:Area/Ncbi/Curation">002E46</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002E46</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Grasping premanifest Huntington's disease - shaping new endpoints for new trials.</title>
<author><name sortKey="Reilmann, Ralf" sort="Reilmann, Ralf" uniqKey="Reilmann R" first="Ralf" last="Reilmann">Ralf Reilmann</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Clinic Muenster (UKM), Westfaelische Wilhelms University of Muenster, Muenster, Germany. r.reilmann@uni-muenster.de</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Clinic Muenster (UKM), Westfaelische Wilhelms University of Muenster, Muenster</wicri:regionArea>
<wicri:noRegion>Muenster</wicri:noRegion>
<wicri:noRegion>Muenster</wicri:noRegion>
<wicri:noRegion>Muenster</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bohlen, Stefan" sort="Bohlen, Stefan" uniqKey="Bohlen S" first="Stefan" last="Bohlen">Stefan Bohlen</name>
</author>
<author><name sortKey="Klopstock, Thomas" sort="Klopstock, Thomas" uniqKey="Klopstock T" first="Thomas" last="Klopstock">Thomas Klopstock</name>
</author>
<author><name sortKey="Bender, Andreas" sort="Bender, Andreas" uniqKey="Bender A" first="Andreas" last="Bender">Andreas Bender</name>
</author>
<author><name sortKey="Weindl, Adolf" sort="Weindl, Adolf" uniqKey="Weindl A" first="Adolf" last="Weindl">Adolf Weindl</name>
</author>
<author><name sortKey="Saemann, Philipp" sort="Saemann, Philipp" uniqKey="Saemann P" first="Philipp" last="Saemann">Philipp Saemann</name>
</author>
<author><name sortKey="Auer, Dorothee P" sort="Auer, Dorothee P" uniqKey="Auer D" first="Dorothee P" last="Auer">Dorothee P. Auer</name>
</author>
<author><name sortKey="Ringelstein, Erich B" sort="Ringelstein, Erich B" uniqKey="Ringelstein E" first="Erich B" last="Ringelstein">Erich B. Ringelstein</name>
</author>
<author><name sortKey="Lange, Herwig W" sort="Lange, Herwig W" uniqKey="Lange H" first="Herwig W" last="Lange">Herwig W. Lange</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2010" type="published">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Analysis of Variance</term>
<term>Clinical Trials as Topic</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Hand Strength (physiology)</term>
<term>Humans</term>
<term>Huntington Disease (diagnosis)</term>
<term>Huntington Disease (physiopathology)</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Huntington Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hand Strength</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Huntington Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Analysis of Variance</term>
<term>Clinical Trials as Topic</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Future clinical trials in subjects with premanifest Huntington's disease (preHD) may depend on the availability of biomarkers. It was previously shown in symptomatic HD that, the grip force variability coefficient-of-variation (GFV-C) in a grasping paradigm was correlated to the Unified-Huntington's-Disease-Rating-Scale-Total-Motor-Score (UHDRS-TMS) and increased in a 3 year follow-up study. To further elucidate its potential as a biomarker, we investigated whether GFV-C is able to detect a motor phenotype in preHD and is correlated to the genotype assessed by a disease-burden-score. The ability of preHD (n = 15) and symptomatic HD subjects (n = 20) to maintain stable grip forces, while holding an object (250 g and 500 g), was measured and compared with the controls (n = 19). GFV-C was increased in preHD at 500 g, in symptomatic subjects at both weights and was correlated to the disease-burden-score and UHDRS-TMS. GFV-C may be a useful objective and quantitative marker of motor dysfunction across genetically diagnosed premanifest and symptomatic HD subjects.</div>
</front>
</TEI>
</PubMed>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002100 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 002100 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Merge |type= RBID |clé= ISTEX:B3EDF76AC2B045373765C575999D5ED9853E60BE |texte= Grasping premanifest Huntington's disease – shaping new endpoints for new trials }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |