Grasping premanifest Huntington's disease – shaping new endpoints for new trials
Identifieur interne : 000A86 ( Istex/Corpus ); précédent : 000A85; suivant : 000A87Grasping premanifest Huntington's disease – shaping new endpoints for new trials
Auteurs : Ralf Reilmann ; Stefan Bohlen ; Thomas Klopstock ; Andreas Bender ; Adolf Weindl ; Philipp Saemann ; Dorothee P. Auer ; Erich B. Ringelstein ; Herwig W. LangeSource :
- Movement Disorders [ 0885-3185 ] ; 2010-12-15.
English descriptors
Abstract
Future clinical trials in subjects with premanifest Huntington's disease (preHD) may depend on the availability of biomarkers. It was previously shown in symptomatic HD that, the grip force variability coefficient‐of‐variation (GFV‐C) in a grasping paradigm was correlated to the Unified‐Huntington's‐Disease‐Rating‐Scale‐Total‐Motor‐Score (UHDRS‐TMS) and increased in a 3 year follow‐up study. To further elucidate its potential as a biomarker, we investigated whether GFV‐C is able to detect a motor phenotype in preHD and is correlated to the genotype assessed by a disease‐burden‐score. The ability of preHD (n = 15) and symptomatic HD subjects (n = 20) to maintain stable grip forces, while holding an object (250 g and 500 g), was measured and compared with the controls (n = 19). GFV‐C was increased in preHD at 500 g, in symptomatic subjects at both weights and was correlated to the disease‐burden‐score and UHDRS‐TMS. GFV‐C may be a useful objective and quantitative marker of motor dysfunction across genetically diagnosed premanifest and symptomatic HD subjects. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.23300
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It was previously shown in symptomatic HD that, the grip force variability coefficient‐of‐variation (GFV‐C) in a grasping paradigm was correlated to the Unified‐Huntington's‐Disease‐Rating‐Scale‐Total‐Motor‐Score (UHDRS‐TMS) and increased in a 3 year follow‐up study. To further elucidate its potential as a biomarker, we investigated whether GFV‐C is able to detect a motor phenotype in preHD and is correlated to the genotype assessed by a disease‐burden‐score. The ability of preHD (n = 15) and symptomatic HD subjects (n = 20) to maintain stable grip forces, while holding an object (250 g and 500 g), was measured and compared with the controls (n = 19). GFV‐C was increased in preHD at 500 g, in symptomatic subjects at both weights and was correlated to the disease‐burden‐score and UHDRS‐TMS. GFV‐C may be a useful objective and quantitative marker of motor dysfunction across genetically diagnosed premanifest and symptomatic HD subjects. © 2010 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Ralf Reilmann MD</name><affiliations><json:string>Department of Neurology, University Clinic Muenster (UKM), Westfaelische Wilhelms University of Muenster, Muenster, Germany</json:string></affiliations></json:item><json:item><name>Stefan Bohlen MD</name><affiliations><json:string>Department of Neurology, University Clinic Muenster (UKM), Westfaelische Wilhelms University of Muenster, Muenster, Germany</json:string></affiliations></json:item><json:item><name>Thomas Klopstock MD</name><affiliations><json:string>Department of Neurology, Friedrich‐Baur‐Institute, Ludwig‐Maximilians‐University, Munich, Germany</json:string></affiliations></json:item><json:item><name>Andreas Bender MD</name><affiliations><json:string>Department of Neurology, Friedrich‐Baur‐Institute, Ludwig‐Maximilians‐University, Munich, Germany</json:string></affiliations></json:item><json:item><name>Adolf Weindl MD</name><affiliations><json:string>Department of Neurology, Technical University Munich, Germany</json:string></affiliations></json:item><json:item><name>Philipp Saemann MD</name><affiliations><json:string>Department of Radiology, Max Planck Institute of Psychiatry, Munich, Germany</json:string></affiliations></json:item><json:item><name>Dorothee P. Auer MD</name><affiliations><json:string>Department of Radiology, Max Planck Institute of Psychiatry, Munich, Germany</json:string></affiliations></json:item><json:item><name>Erich B. Ringelstein MD</name><affiliations><json:string>Department of Neurology, University Clinic Muenster (UKM), Westfaelische Wilhelms University of Muenster, Muenster, Germany</json:string></affiliations></json:item><json:item><name>Herwig W. Lange MD</name><affiliations><json:string>Department of Neurology, University Clinic Muenster (UKM), Westfaelische Wilhelms University of Muenster, Muenster, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>huntington's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>motor control</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>grip force</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>clinical physiology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>biomarker</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Future clinical trials in subjects with premanifest Huntington's disease (preHD) may depend on the availability of biomarkers. It was previously shown in symptomatic HD that, the grip force variability coefficient‐of‐variation (GFV‐C) in a grasping paradigm was correlated to the Unified‐Huntington's‐Disease‐Rating‐Scale‐Total‐Motor‐Score (UHDRS‐TMS) and increased in a 3 year follow‐up study. To further elucidate its potential as a biomarker, we investigated whether GFV‐C is able to detect a motor phenotype in preHD and is correlated to the genotype assessed by a disease‐burden‐score. The ability of preHD (n = 15) and symptomatic HD subjects (n = 20) to maintain stable grip forces, while holding an object (250 g and 500 g), was measured and compared with the controls (n = 19). GFV‐C was increased in preHD at 500 g, in symptomatic subjects at both weights and was correlated to the disease‐burden‐score and UHDRS‐TMS. GFV‐C may be a useful objective and quantitative marker of motor dysfunction across genetically diagnosed premanifest and symptomatic HD subjects. © 2010 Movement Disorder Society</abstract><qualityIndicators><score>6.98</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1107</abstractCharCount><pdfWordCount>19371</pdfWordCount><pdfCharCount>127329</pdfCharCount><pdfPageCount>34</pdfPageCount><abstractWordCount>165</abstractWordCount></qualityIndicators><title>Grasping premanifest Huntington's disease – shaping new endpoints for new trials</title><genre><json:string>Serial article</json:string></genre><host><volume>25</volume><pages><total>5</total><last>2862</last><first>2858</first></pages><issn><json:string>0885-3185</json:string></issn><issue>16</issue><subject><json:item><value>Brief Report</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2010</publicationDate><copyrightDate>2010</copyrightDate><doi><json:string>10.1002/mds.23300</json:string></doi><id>B3EDF76AC2B045373765C575999D5ED9853E60BE</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/B3EDF76AC2B045373765C575999D5ED9853E60BE/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/B3EDF76AC2B045373765C575999D5ED9853E60BE/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/B3EDF76AC2B045373765C575999D5ED9853E60BE/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Grasping premanifest Huntington's disease – shaping new endpoints for new trials</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2010</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: Nothing to report.</note><note>“Innovative Medical Research” of the University of Münster Medical School - No. # RE 12 02 25;</note><note>Department of Radiology, Max Planck Institute of Psychiatry, Munich</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Grasping premanifest Huntington's disease – shaping new endpoints for new trials</title><author><persName><forename type="first">Ralf</forename><surname>Reilmann</surname><roleName type="degree">MD</roleName></persName><note type="correspondence"><p>Correspondence: Department of Neurology, University Clinic Muenster (UKM), University of Muenster, Albert Schweitzer Strasse 33, Muenster 48129</p></note><affiliation>Department of Neurology, University Clinic Muenster (UKM), Westfaelische Wilhelms University of Muenster, Muenster, Germany</affiliation></author><author><persName><forename type="first">Stefan</forename><surname>Bohlen</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, University Clinic Muenster (UKM), Westfaelische Wilhelms University of Muenster, Muenster, Germany</affiliation></author><author><persName><forename type="first">Thomas</forename><surname>Klopstock</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Friedrich‐Baur‐Institute, Ludwig‐Maximilians‐University, Munich, Germany</affiliation></author><author><persName><forename type="first">Andreas</forename><surname>Bender</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Friedrich‐Baur‐Institute, Ludwig‐Maximilians‐University, Munich, Germany</affiliation></author><author><persName><forename type="first">Adolf</forename><surname>Weindl</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Technical University Munich, Germany</affiliation></author><author><persName><forename type="first">Philipp</forename><surname>Saemann</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Radiology, Max Planck Institute of Psychiatry, Munich, Germany</affiliation></author><author><persName><forename type="first">Dorothee P.</forename><surname>Auer</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Radiology, Max Planck Institute of Psychiatry, Munich, Germany</affiliation></author><author><persName><forename type="first">Erich B.</forename><surname>Ringelstein</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, University Clinic Muenster (UKM), Westfaelische Wilhelms University of Muenster, Muenster, Germany</affiliation></author><author><persName><forename type="first">Herwig W.</forename><surname>Lange</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, University Clinic Muenster (UKM), Westfaelische Wilhelms University of Muenster, Muenster, Germany</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. 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It was previously shown in symptomatic HD that, the grip force variability coefficient‐of‐variation (GFV‐C) in a grasping paradigm was correlated to the Unified‐Huntington's‐Disease‐Rating‐Scale‐Total‐Motor‐Score (UHDRS‐TMS) and increased in a 3 year follow‐up study. To further elucidate its potential as a biomarker, we investigated whether GFV‐C is able to detect a motor phenotype in preHD and is correlated to the genotype assessed by a disease‐burden‐score. The ability of preHD (n = 15) and symptomatic HD subjects (n = 20) to maintain stable grip forces, while holding an object (250 g and 500 g), was measured and compared with the controls (n = 19). GFV‐C was increased in preHD at 500 g, in symptomatic subjects at both weights and was correlated to the disease‐burden‐score and UHDRS‐TMS. GFV‐C may be a useful objective and quantitative marker of motor dysfunction across genetically diagnosed premanifest and symptomatic HD subjects. © 2010 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>huntington's disease</term></item><item><term>motor control</term></item><item><term>grip force</term></item><item><term>clinical physiology</term></item><item><term>biomarker</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-07-01">Received</change><change when="2010-05-17">Registration</change><change when="2010-12-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/B3EDF76AC2B045373765C575999D5ED9853E60BE/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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affiliationRef="#af1"><personName><givenNames>Stefan</givenNames><familyName>Bohlen</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Thomas</givenNames><familyName>Klopstock</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Andreas</givenNames><familyName>Bender</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Adolf</givenNames><familyName>Weindl</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Philipp</givenNames><familyName>Saemann</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Dorothee P.</givenNames><familyName>Auer</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Erich B.</givenNames><familyName>Ringelstein</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Herwig W.</givenNames><familyName>Lange</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurology, University Clinic Muenster (UKM), Westfaelische Wilhelms University of Muenster, Muenster, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurology, Friedrich‐Baur‐Institute, Ludwig‐Maximilians‐University, Munich, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurology, Technical University Munich, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="DE" type="organization"><unparsedAffiliation>Department of Radiology, Max Planck Institute of Psychiatry, Munich, Germany</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">huntington's disease</keyword><keyword xml:id="kwd2">motor control</keyword><keyword xml:id="kwd3">grip force</keyword><keyword xml:id="kwd4">clinical physiology</keyword><keyword xml:id="kwd5">biomarker</keyword></keywordGroup><fundingInfo><fundingAgency>“Innovative Medical Research” of the University of Münster Medical School</fundingAgency><fundingNumber># RE 12 02 25</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Department of Radiology, Max Planck Institute of Psychiatry, Munich</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Future clinical trials in subjects with premanifest Huntington's disease (preHD) may depend on the availability of biomarkers. It was previously shown in symptomatic HD that, the grip force variability coefficient‐of‐variation (GFV‐C) in a grasping paradigm was correlated to the Unified‐Huntington's‐Disease‐Rating‐Scale‐Total‐Motor‐Score (UHDRS‐TMS) and increased in a 3 year follow‐up study. To further elucidate its potential as a biomarker, we investigated whether GFV‐C is able to detect a motor phenotype in preHD and is correlated to the genotype assessed by a disease‐burden‐score. The ability of preHD (n = 15) and symptomatic HD subjects (n = 20) to maintain stable grip forces, while holding an object (250 g and 500 g), was measured and compared with the controls (n = 19). GFV‐C was increased in preHD at 500 g, in symptomatic subjects at both weights and was correlated to the disease‐burden‐score and UHDRS‐TMS. GFV‐C may be a useful objective and quantitative marker of motor dysfunction across genetically diagnosed premanifest and symptomatic HD subjects. © 2010 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn4"><p>Potential conflict of interest: Nothing to report.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Grasping premanifest Huntington's disease – shaping new endpoints for new trials</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Motor Assessment in Premanifest HD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Grasping premanifest Huntington's disease – shaping new endpoints for new trials</title></titleInfo><name type="personal"><namePart type="given">Ralf</namePart><namePart type="family">Reilmann</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University Clinic Muenster (UKM), Westfaelische Wilhelms University of Muenster, Muenster, Germany</affiliation><description>Correspondence: Department of Neurology, University Clinic Muenster (UKM), University of Muenster, Albert Schweitzer Strasse 33, Muenster 48129</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stefan</namePart><namePart type="family">Bohlen</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University Clinic Muenster (UKM), Westfaelische Wilhelms University of Muenster, Muenster, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thomas</namePart><namePart type="family">Klopstock</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Friedrich‐Baur‐Institute, Ludwig‐Maximilians‐University, Munich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andreas</namePart><namePart type="family">Bender</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Friedrich‐Baur‐Institute, Ludwig‐Maximilians‐University, Munich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Adolf</namePart><namePart type="family">Weindl</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Technical University Munich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Philipp</namePart><namePart type="family">Saemann</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Radiology, Max Planck Institute of Psychiatry, Munich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dorothee P.</namePart><namePart type="family">Auer</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Radiology, Max Planck Institute of Psychiatry, Munich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Erich B.</namePart><namePart type="family">Ringelstein</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University Clinic Muenster (UKM), Westfaelische Wilhelms University of Muenster, Muenster, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Herwig W.</namePart><namePart type="family">Lange</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University Clinic Muenster (UKM), Westfaelische Wilhelms University of Muenster, Muenster, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-12-15</dateIssued><dateCaptured encoding="w3cdtf">2009-07-01</dateCaptured><dateValid encoding="w3cdtf">2010-05-17</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">1</extent><extent unit="references">17</extent><extent unit="words">3757</extent></physicalDescription><abstract lang="en">Future clinical trials in subjects with premanifest Huntington's disease (preHD) may depend on the availability of biomarkers. It was previously shown in symptomatic HD that, the grip force variability coefficient‐of‐variation (GFV‐C) in a grasping paradigm was correlated to the Unified‐Huntington's‐Disease‐Rating‐Scale‐Total‐Motor‐Score (UHDRS‐TMS) and increased in a 3 year follow‐up study. To further elucidate its potential as a biomarker, we investigated whether GFV‐C is able to detect a motor phenotype in preHD and is correlated to the genotype assessed by a disease‐burden‐score. The ability of preHD (n = 15) and symptomatic HD subjects (n = 20) to maintain stable grip forces, while holding an object (250 g and 500 g), was measured and compared with the controls (n = 19). GFV‐C was increased in preHD at 500 g, in symptomatic subjects at both weights and was correlated to the disease‐burden‐score and UHDRS‐TMS. GFV‐C may be a useful objective and quantitative marker of motor dysfunction across genetically diagnosed premanifest and symptomatic HD subjects. © 2010 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><note type="funding">“Innovative Medical Research” of the University of Münster Medical School - No. # RE 12 02 25; </note><note type="funding">Department of Radiology, Max Planck Institute of Psychiatry, Munich</note><subject lang="en"><genre>Keywords</genre><topic>huntington's disease</topic><topic>motor control</topic><topic>grip force</topic><topic>clinical physiology</topic><topic>biomarker</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>16</number></detail><extent unit="pages"><start>2858</start><end>2862</end><total>5</total></extent></part></relatedItem><identifier type="istex">B3EDF76AC2B045373765C575999D5ED9853E60BE</identifier><identifier type="DOI">10.1002/mds.23300</identifier><identifier type="ArticleID">MDS23300</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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