MovDisordV3, PubMed, Corpus, bibRecord, 001571

Grasping premanifest Huntington's disease - shaping new endpoints for new trials.

Identifieur interne : 001571 ( PubMed/Corpus ); précédent : 001570; suivant : 001572

Grasping premanifest Huntington's disease - shaping new endpoints for new trials.

Auteurs : Ralf Reilmann ; Stefan Bohlen ; Thomas Klopstock ; Andreas Bender ; Adolf Weindl ; Philipp Saemann ; Dorothee P. Auer ; Erich B. Ringelstein ; Herwig W. Lange

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.

RBID : pubmed:20818671

English descriptors

KwdEn :
- Adult, Analysis of Variance, Clinical Trials as Topic, Disease Progression, Female, Follow-Up Studies, Hand Strength (physiology), Humans, Huntington Disease (diagnosis), Huntington Disease (physiopathology), Male, Middle Aged.
MESH :
- diagnosis : Huntington Disease.
- physiology : Hand Strength.
- physiopathology : Huntington Disease.
- Adult, Analysis of Variance, Clinical Trials as Topic, Disease Progression, Female, Follow-Up Studies, Humans, Male, Middle Aged.

Abstract

Future clinical trials in subjects with premanifest Huntington's disease (preHD) may depend on the availability of biomarkers. It was previously shown in symptomatic HD that, the grip force variability coefficient-of-variation (GFV-C) in a grasping paradigm was correlated to the Unified-Huntington's-Disease-Rating-Scale-Total-Motor-Score (UHDRS-TMS) and increased in a 3 year follow-up study. To further elucidate its potential as a biomarker, we investigated whether GFV-C is able to detect a motor phenotype in preHD and is correlated to the genotype assessed by a disease-burden-score. The ability of preHD (n = 15) and symptomatic HD subjects (n = 20) to maintain stable grip forces, while holding an object (250 g and 500 g), was measured and compared with the controls (n = 19). GFV-C was increased in preHD at 500 g, in symptomatic subjects at both weights and was correlated to the disease-burden-score and UHDRS-TMS. GFV-C may be a useful objective and quantitative marker of motor dysfunction across genetically diagnosed premanifest and symptomatic HD subjects.

DOI: 10.1002/mds.23300
PubMed: 20818671

Links to Exploration step

pubmed:20818671

Le document en format XML

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<author><name sortKey="Reilmann, Ralf" sort="Reilmann, Ralf" uniqKey="Reilmann R" first="Ralf" last="Reilmann">Ralf Reilmann</name>
<affiliation><nlm:affiliation>Department of Neurology, University Clinic Muenster (UKM), Westfaelische Wilhelms University of Muenster, Muenster, Germany. r.reilmann@uni-muenster.de</nlm:affiliation>
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<author><name sortKey="Bohlen, Stefan" sort="Bohlen, Stefan" uniqKey="Bohlen S" first="Stefan" last="Bohlen">Stefan Bohlen</name>
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<author><name sortKey="Klopstock, Thomas" sort="Klopstock, Thomas" uniqKey="Klopstock T" first="Thomas" last="Klopstock">Thomas Klopstock</name>
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<author><name sortKey="Bender, Andreas" sort="Bender, Andreas" uniqKey="Bender A" first="Andreas" last="Bender">Andreas Bender</name>
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<author><name sortKey="Weindl, Adolf" sort="Weindl, Adolf" uniqKey="Weindl A" first="Adolf" last="Weindl">Adolf Weindl</name>
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<author><name sortKey="Saemann, Philipp" sort="Saemann, Philipp" uniqKey="Saemann P" first="Philipp" last="Saemann">Philipp Saemann</name>
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<author><name sortKey="Auer, Dorothee P" sort="Auer, Dorothee P" uniqKey="Auer D" first="Dorothee P" last="Auer">Dorothee P. Auer</name>
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<author><name sortKey="Ringelstein, Erich B" sort="Ringelstein, Erich B" uniqKey="Ringelstein E" first="Erich B" last="Ringelstein">Erich B. Ringelstein</name>
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<author><name sortKey="Lange, Herwig W" sort="Lange, Herwig W" uniqKey="Lange H" first="Herwig W" last="Lange">Herwig W. Lange</name>
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<author><name sortKey="Bohlen, Stefan" sort="Bohlen, Stefan" uniqKey="Bohlen S" first="Stefan" last="Bohlen">Stefan Bohlen</name>
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<author><name sortKey="Klopstock, Thomas" sort="Klopstock, Thomas" uniqKey="Klopstock T" first="Thomas" last="Klopstock">Thomas Klopstock</name>
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<author><name sortKey="Bender, Andreas" sort="Bender, Andreas" uniqKey="Bender A" first="Andreas" last="Bender">Andreas Bender</name>
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<author><name sortKey="Weindl, Adolf" sort="Weindl, Adolf" uniqKey="Weindl A" first="Adolf" last="Weindl">Adolf Weindl</name>
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<author><name sortKey="Saemann, Philipp" sort="Saemann, Philipp" uniqKey="Saemann P" first="Philipp" last="Saemann">Philipp Saemann</name>
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<author><name sortKey="Ringelstein, Erich B" sort="Ringelstein, Erich B" uniqKey="Ringelstein E" first="Erich B" last="Ringelstein">Erich B. Ringelstein</name>
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<author><name sortKey="Lange, Herwig W" sort="Lange, Herwig W" uniqKey="Lange H" first="Herwig W" last="Lange">Herwig W. Lange</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Female</term>
<term>Follow-Up Studies</term>
<term>Hand Strength (physiology)</term>
<term>Humans</term>
<term>Huntington Disease (diagnosis)</term>
<term>Huntington Disease (physiopathology)</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Huntington Disease</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hand Strength</term>
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<term>Analysis of Variance</term>
<term>Clinical Trials as Topic</term>
<term>Disease Progression</term>
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<front><div type="abstract" xml:lang="en">Future clinical trials in subjects with premanifest Huntington's disease (preHD) may depend on the availability of biomarkers. It was previously shown in symptomatic HD that, the grip force variability coefficient-of-variation (GFV-C) in a grasping paradigm was correlated to the Unified-Huntington's-Disease-Rating-Scale-Total-Motor-Score (UHDRS-TMS) and increased in a 3 year follow-up study. To further elucidate its potential as a biomarker, we investigated whether GFV-C is able to detect a motor phenotype in preHD and is correlated to the genotype assessed by a disease-burden-score. The ability of preHD (n = 15) and symptomatic HD subjects (n = 20) to maintain stable grip forces, while holding an object (250 g and 500 g), was measured and compared with the controls (n = 19). GFV-C was increased in preHD at 500 g, in symptomatic subjects at both weights and was correlated to the disease-burden-score and UHDRS-TMS. GFV-C may be a useful objective and quantitative marker of motor dysfunction across genetically diagnosed premanifest and symptomatic HD subjects.</div>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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<Abstract><AbstractText>Future clinical trials in subjects with premanifest Huntington's disease (preHD) may depend on the availability of biomarkers. It was previously shown in symptomatic HD that, the grip force variability coefficient-of-variation (GFV-C) in a grasping paradigm was correlated to the Unified-Huntington's-Disease-Rating-Scale-Total-Motor-Score (UHDRS-TMS) and increased in a 3 year follow-up study. To further elucidate its potential as a biomarker, we investigated whether GFV-C is able to detect a motor phenotype in preHD and is correlated to the genotype assessed by a disease-burden-score. The ability of preHD (n = 15) and symptomatic HD subjects (n = 20) to maintain stable grip forces, while holding an object (250 g and 500 g), was measured and compared with the controls (n = 19). GFV-C was increased in preHD at 500 g, in symptomatic subjects at both weights and was correlated to the disease-burden-score and UHDRS-TMS. GFV-C may be a useful objective and quantitative marker of motor dysfunction across genetically diagnosed premanifest and symptomatic HD subjects.</AbstractText>
<CopyrightInformation>© 2010 Movement Disorder Society.</CopyrightInformation>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Grasping premanifest Huntington's disease - shaping new endpoints for new trials.

Grasping premanifest Huntington's disease - shaping new endpoints for new trials.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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