Enteric alpha-synuclein expression is increased in Parkinson's disease but not Alzheimer's disease.
Identifieur interne : 000998 ( Main/Merge ); précédent : 000997; suivant : 000999Enteric alpha-synuclein expression is increased in Parkinson's disease but not Alzheimer's disease.
Auteurs : Andrea Gold [Canada] ; Zorbey T. Turkalp ; David G. MunozSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Alzheimer Disease (metabolism), Alzheimer Disease (pathology), Autopsy, Brain (pathology), Enteric Nervous System (metabolism), Enteric Nervous System (pathology), Female, Humans, Immunohistochemistry, Lewy Bodies (pathology), Male, Middle Aged, Myenteric Plexus (pathology), Parkinson Disease (metabolism), Parkinson Disease (pathology), Submucous Plexus (pathology), Young Adult, alpha-Synuclein (biosynthesis).
- MESH :
- chemical , biosynthesis : alpha-Synuclein.
- metabolism : Alzheimer Disease, Enteric Nervous System, Parkinson Disease.
- pathology : Alzheimer Disease, Brain, Enteric Nervous System, Lewy Bodies, Myenteric Plexus, Parkinson Disease, Submucous Plexus.
- Adult, Aged, Aged, 80 and over, Autopsy, Female, Humans, Immunohistochemistry, Male, Middle Aged, Young Adult.
Abstract
Alpha-synuclein (α-Syn) is immunohistochemically detectable in enteric neurons in some subjects. We determined its age distribution in the general autopsy population and in an age-matched subset investigated differences with Parkinson's (PD) and Alzheimer's diseases (AD).
DOI: 10.1002/mds.25298
PubMed: 23362176
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pubmed:23362176Le document en format XML
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