MovDisordV3, PubMed, Corpus, bibRecord, 000A99

Enteric alpha-synuclein expression is increased in Parkinson's disease but not Alzheimer's disease.

Identifieur interne : 000A99 ( PubMed/Corpus ); précédent : 000A98; suivant : 000B00

Enteric alpha-synuclein expression is increased in Parkinson's disease but not Alzheimer's disease.

Auteurs : Andrea Gold ; Zorbey T. Turkalp ; David G. Munoz

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.

RBID : pubmed:23362176

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Alzheimer Disease (metabolism), Alzheimer Disease (pathology), Autopsy, Brain (pathology), Enteric Nervous System (metabolism), Enteric Nervous System (pathology), Female, Humans, Immunohistochemistry, Lewy Bodies (pathology), Male, Middle Aged, Myenteric Plexus (pathology), Parkinson Disease (metabolism), Parkinson Disease (pathology), Submucous Plexus (pathology), Young Adult, alpha-Synuclein (biosynthesis).
MESH :
- chemical , biosynthesis : alpha-Synuclein.
- metabolism : Alzheimer Disease, Enteric Nervous System, Parkinson Disease.
- pathology : Alzheimer Disease, Brain, Enteric Nervous System, Lewy Bodies, Myenteric Plexus, Parkinson Disease, Submucous Plexus.
- Adult, Aged, Aged, 80 and over, Autopsy, Female, Humans, Immunohistochemistry, Male, Middle Aged, Young Adult.

Abstract

Alpha-synuclein (α-Syn) is immunohistochemically detectable in enteric neurons in some subjects. We determined its age distribution in the general autopsy population and in an age-matched subset investigated differences with Parkinson's (PD) and Alzheimer's diseases (AD).

DOI: 10.1002/mds.25298
PubMed: 23362176

Links to Exploration step

pubmed:23362176

Le document en format XML

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<author><name sortKey="Gold, Andrea" sort="Gold, Andrea" uniqKey="Gold A" first="Andrea" last="Gold">Andrea Gold</name>
<affiliation><nlm:affiliation>Laboratory Medicine, St. Michael's Hospital, University of Toronto & Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Turkalp, Zorbey T" sort="Turkalp, Zorbey T" uniqKey="Turkalp Z" first="Zorbey T" last="Turkalp">Zorbey T. Turkalp</name>
</author>
<author><name sortKey="Munoz, David G" sort="Munoz, David G" uniqKey="Munoz D" first="David G" last="Munoz">David G. Munoz</name>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Enteric alpha-synuclein expression is increased in Parkinson's disease but not Alzheimer's disease.</title>
<author><name sortKey="Gold, Andrea" sort="Gold, Andrea" uniqKey="Gold A" first="Andrea" last="Gold">Andrea Gold</name>
<affiliation><nlm:affiliation>Laboratory Medicine, St. Michael's Hospital, University of Toronto & Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Turkalp, Zorbey T" sort="Turkalp, Zorbey T" uniqKey="Turkalp Z" first="Zorbey T" last="Turkalp">Zorbey T. Turkalp</name>
</author>
<author><name sortKey="Munoz, David G" sort="Munoz, David G" uniqKey="Munoz D" first="David G" last="Munoz">David G. Munoz</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2013" type="published">2013</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Alzheimer Disease (metabolism)</term>
<term>Alzheimer Disease (pathology)</term>
<term>Autopsy</term>
<term>Brain (pathology)</term>
<term>Enteric Nervous System (metabolism)</term>
<term>Enteric Nervous System (pathology)</term>
<term>Female</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Lewy Bodies (pathology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Myenteric Plexus (pathology)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson Disease (pathology)</term>
<term>Submucous Plexus (pathology)</term>
<term>Young Adult</term>
<term>alpha-Synuclein (biosynthesis)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>alpha-Synuclein</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Alzheimer Disease</term>
<term>Enteric Nervous System</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Alzheimer Disease</term>
<term>Brain</term>
<term>Enteric Nervous System</term>
<term>Lewy Bodies</term>
<term>Myenteric Plexus</term>
<term>Parkinson Disease</term>
<term>Submucous Plexus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Autopsy</term>
<term>Female</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Young Adult</term>
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<front><div type="abstract" xml:lang="en">Alpha-synuclein (α-Syn) is immunohistochemically detectable in enteric neurons in some subjects. We determined its age distribution in the general autopsy population and in an age-matched subset investigated differences with Parkinson's (PD) and Alzheimer's diseases (AD).</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">23362176</PMID>
<DateCreated><Year>2013</Year>
<Month>02</Month>
<Day>25</Day>
</DateCreated>
<DateCompleted><Year>2013</Year>
<Month>08</Month>
<Day>06</Day>
</DateCompleted>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>28</Volume>
<Issue>2</Issue>
<PubDate><Year>2013</Year>
<Month>Feb</Month>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>Enteric alpha-synuclein expression is increased in Parkinson's disease but not Alzheimer's disease.</ArticleTitle>
<Pagination><MedlinePgn>237-40</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.25298</ELocationID>
<Abstract><AbstractText Label="BACKGROUND AND OBJECTIVE" NlmCategory="OBJECTIVE">Alpha-synuclein (α-Syn) is immunohistochemically detectable in enteric neurons in some subjects. We determined its age distribution in the general autopsy population and in an age-matched subset investigated differences with Parkinson's (PD) and Alzheimer's diseases (AD).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Archival autopsy samples of colon from 95 cases (77 general population, 10 PD, and 8 AD) were immunostained with monoclonal antibody KM51. α-Syn detectability was semiquantitatively graded 1 to 3.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">α-Syn was detectable in 52% of the general population, and its level of expression did not change between ages 40 and 91. All PD subjects were α-Syn positive, with higher prevalence (P = 0.001) and grade (P = 0.003) than age-matched controls. AD subjects were no more likely to be α-Syn positive or have a higher grade than controls.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Either PD develops selectively in the enterically α-Syn-positive population subset or PD induces this expression. Absence of increased α-Syn expression in AD points to differences in pathogenesis.</AbstractText>
<CopyrightInformation>© 2013 Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gold</LastName>
<ForeName>Andrea</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Laboratory Medicine, St. Michael's Hospital, University of Toronto & Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Turkalp</LastName>
<ForeName>Zorbey T</ForeName>
<Initials>ZT</Initials>
</Author>
<Author ValidYN="Y"><LastName>Munoz</LastName>
<ForeName>David G</ForeName>
<Initials>DG</Initials>
</Author>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2013</Year>
<Month>01</Month>
<Day>29</Day>
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</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Mov Disord</MedlineTA>
<NlmUniqueID>8610688</NlmUniqueID>
<ISSNLinking>0885-3185</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D051844">alpha-Synuclein</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D000544">Alzheimer Disease</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D001344">Autopsy</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D001921">Brain</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D017615">Enteric Nervous System</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D007150">Immunohistochemistry</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D016631">Lewy Bodies</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D009197">Myenteric Plexus</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D013368">Submucous Plexus</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D055815">Young Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D051844">alpha-Synuclein</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000096">biosynthesis</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
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<PubMedPubDate PubStatus="revised"><Year>2012</Year>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Enteric alpha-synuclein expression is increased in Parkinson's disease but not Alzheimer's disease.

Enteric alpha-synuclein expression is increased in Parkinson's disease but not Alzheimer's disease.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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