Enlarged hyperechogenic substantia nigra as a risk marker for Parkinson's disease.
Identifieur interne : 000999 ( Main/Merge ); précédent : 000998; suivant : 000A00Enlarged hyperechogenic substantia nigra as a risk marker for Parkinson's disease.
Auteurs : Daniela Berg [Allemagne] ; Stefanie Behnke ; Klaus Seppi ; Jana Godau ; Stefanie Lerche ; Philipp Mahlknecht ; Inga Liepelt-Scarfone ; Christoph Pausch ; Niko Schneider ; Alexandra Gaenslen ; Kathrin Brockmann ; Karin Srulijes ; Heiko Huber ; Isabel Wurster ; Heike Stockner ; Stefan Kiechl ; Johann Willeit ; Arno Gasperi ; Klaus Fassbender ; Thomas Gasser ; Werner Poewe [Autriche]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Biological Markers, Cohort Studies, Data Interpretation, Statistical, Disease Progression, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Middle Aged, Parkinson Disease (ultrasonography), Prospective Studies, Risk Assessment, Substantia Nigra (ultrasonography), Ultrasonography, Doppler, Color, Ultrasonography, Doppler, Transcranial.
- MESH :
- chemical : Biological Markers.
- ultrasonography : Parkinson Disease, Substantia Nigra.
- Aged, Aged, 80 and over, Cohort Studies, Data Interpretation, Statistical, Disease Progression, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Middle Aged, Prospective Studies, Risk Assessment, Ultrasonography, Doppler, Color, Ultrasonography, Doppler, Transcranial.
Abstract
SN hyperechogenicity (SN+), determined by transcranial sonography, has been proposed as a risk factor for Parkinson's disease (PD). Recently, we reported a 17.4-fold increased risk for PD in individuals with SN+ older than 50 years within 3 years.
DOI: 10.1002/mds.25192
PubMed: 23115051
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<author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name>
<affiliation wicri:level="3"><nlm:affiliation>Center of Neurology, Department of Neurodegeneration and Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany. daniela.berg@uni-tuebingen.de</nlm:affiliation>
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<author><name sortKey="Lerche, Stefanie" sort="Lerche, Stefanie" uniqKey="Lerche S" first="Stefanie" last="Lerche">Stefanie Lerche</name>
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<author><name sortKey="Mahlknecht, Philipp" sort="Mahlknecht, Philipp" uniqKey="Mahlknecht P" first="Philipp" last="Mahlknecht">Philipp Mahlknecht</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Aged, 80 and over</term>
<term>Biological Markers</term>
<term>Cohort Studies</term>
<term>Data Interpretation, Statistical</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (ultrasonography)</term>
<term>Prospective Studies</term>
<term>Risk Assessment</term>
<term>Substantia Nigra (ultrasonography)</term>
<term>Ultrasonography, Doppler, Color</term>
<term>Ultrasonography, Doppler, Transcranial</term>
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<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Biological Markers</term>
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<keywords scheme="MESH" qualifier="ultrasonography" xml:lang="en"><term>Parkinson Disease</term>
<term>Substantia Nigra</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Cohort Studies</term>
<term>Data Interpretation, Statistical</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prospective Studies</term>
<term>Risk Assessment</term>
<term>Ultrasonography, Doppler, Color</term>
<term>Ultrasonography, Doppler, Transcranial</term>
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<front><div type="abstract" xml:lang="en">SN hyperechogenicity (SN+), determined by transcranial sonography, has been proposed as a risk factor for Parkinson's disease (PD). Recently, we reported a 17.4-fold increased risk for PD in individuals with SN+ older than 50 years within 3 years.</div>
</front>
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