Is the pathology of corticobasal syndrome predictable in life?
Identifieur interne : 002243 ( Main/Exploration ); précédent : 002242; suivant : 002244Is the pathology of corticobasal syndrome predictable in life?
Auteurs : Bhaskara P. Shelley [Royaume-Uni] ; John R. Hodges [Royaume-Uni, Australie] ; Christopher M. Kipps [Royaume-Uni] ; John H. Xuereb [Royaume-Uni] ; Thomas H. Bak [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-08-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Alzheimer Disease (complications), Alzheimer Disease (diagnosis), Alzheimer Disease (pathology), Alzheimer disease, Alzheimer's disease, Anatomic pathology, Aphasia, Aphasia (etiology), Aphasia (pathology), Apraxias (etiology), Apraxias (pathology), Autopsy, Behavior, Brain (pathology), Cognition Disorders (etiology), Cognition Disorders (pathology), Degeneration, Diagnosis, Differential, Disease Progression, Female, Follow-Up Studies, Humans, Male, Memory Disorders (etiology), Memory Disorders (pathology), Middle Aged, Nervous system diseases, Neuropsychological Tests, Predictive Value of Tests, Syndrome, Tauopathies (complications), Tauopathies (diagnosis), Tauopathies (pathology), behavior, corticobasal degeneration, corticobasal syndrome, nonfluent aphasia, pathology, utilization behavior.
- MESH :
- complications : Alzheimer Disease, Tauopathies.
- diagnosis : Alzheimer Disease, Tauopathies.
- etiology : Aphasia, Apraxias, Cognition Disorders, Memory Disorders.
- pathology : Alzheimer Disease, Aphasia, Apraxias, Brain, Cognition Disorders, Memory Disorders, Tauopathies.
- Aged, Autopsy, Diagnosis, Differential, Disease Progression, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Predictive Value of Tests, Syndrome.
Abstract
Corticobasal syndrome (CBS) has been associated with a heterogeneous spectrum of pathologies with an increasing number of reports of Alzheimer's type pathology. There is, however, no means of predicting pathology of CBS in vivo at present. We compared the clinical features of patients presenting with CBS who have either pathologic changes of classic corticobasal degeneration (CBD) or Alzheimer's disease (AD) at post‐mortem to identify predictors of the specific pathological processes in life. Twelve patients with CBS were followed prospectively; six had AD and six had classic CBD neuropathology. After review of the presenting clinical features, we identified nine potential predictor variables, compared their frequency in the two groups, and performed a discriminant function analysis. Initial episodic memory complaints and poor performance on the combined orientation‐memory subtest of the Addenbrooke's Cognitive Examination (ACE) reliably predicted AD pathology while varying combinations of early frontal‐lobe type behavioral symptoms, nonfluent language disturbance, orobuccal apraxia, and utilization behavior predicted CBD pathology ante‐mortem. CBS is frequently associated with Alzheimer's disease pathology. Early episodic memory impairment versus early behavioral symptomatology appears to best predict AD or CBD pathology in life. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22558
Affiliations:
- Australie, Royaume-Uni
- Angleterre, Angleterre de l'Est, Écosse
- Cambridge, Édimbourg
- Université d'Édimbourg, Université de Cambridge
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Le document en format XML
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There is, however, no means of predicting pathology of CBS in vivo at present. We compared the clinical features of patients presenting with CBS who have either pathologic changes of classic corticobasal degeneration (CBD) or Alzheimer's disease (AD) at post‐mortem to identify predictors of the specific pathological processes in life. Twelve patients with CBS were followed prospectively; six had AD and six had classic CBD neuropathology. After review of the presenting clinical features, we identified nine potential predictor variables, compared their frequency in the two groups, and performed a discriminant function analysis. Initial episodic memory complaints and poor performance on the combined orientation‐memory subtest of the Addenbrooke's Cognitive Examination (ACE) reliably predicted AD pathology while varying combinations of early frontal‐lobe type behavioral symptoms, nonfluent language disturbance, orobuccal apraxia, and utilization behavior predicted CBD pathology ante‐mortem. CBS is frequently associated with Alzheimer's disease pathology. Early episodic memory impairment versus early behavioral symptomatology appears to best predict AD or CBD pathology in life. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Australie</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Écosse</li></region><settlement><li>Cambridge</li><li>Édimbourg</li></settlement><orgName><li>Université d'Édimbourg</li><li>Université de Cambridge</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Shelley, Bhaskara P" sort="Shelley, Bhaskara P" uniqKey="Shelley B" first="Bhaskara P." last="Shelley">Bhaskara P. Shelley</name></region><name sortKey="Bak, Thomas H" sort="Bak, Thomas H" uniqKey="Bak T" first="Thomas H." last="Bak">Thomas H. Bak</name><name sortKey="Hodges, John R" sort="Hodges, John R" uniqKey="Hodges J" first="John R." last="Hodges">John R. Hodges</name><name sortKey="Kipps, Christopher M" sort="Kipps, Christopher M" uniqKey="Kipps C" first="Christopher M." last="Kipps">Christopher M. Kipps</name><name sortKey="Xuereb, John H" sort="Xuereb, John H" uniqKey="Xuereb J" first="John H." last="Xuereb">John H. Xuereb</name></country><country name="Australie"><noRegion><name sortKey="Hodges, John R" sort="Hodges, John R" uniqKey="Hodges J" first="John R." last="Hodges">John R. Hodges</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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