Is the pathology of corticobasal syndrome predictable in life?
Identifieur interne : 002726 ( Ncbi/Merge ); précédent : 002725; suivant : 002727Is the pathology of corticobasal syndrome predictable in life?
Auteurs : Bhaskara P. Shelley [Royaume-Uni] ; John R. Hodges ; Christopher M. Kipps ; John H. Xuereb ; Thomas H. BakSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- Aged, Alzheimer Disease (complications), Alzheimer Disease (diagnosis), Alzheimer Disease (pathology), Aphasia (etiology), Aphasia (pathology), Apraxias (etiology), Apraxias (pathology), Autopsy, Brain (pathology), Cognition Disorders (etiology), Cognition Disorders (pathology), Diagnosis, Differential, Disease Progression, Female, Follow-Up Studies, Humans, Male, Memory Disorders (etiology), Memory Disorders (pathology), Middle Aged, Neuropsychological Tests, Predictive Value of Tests, Syndrome, Tauopathies (complications), Tauopathies (diagnosis), Tauopathies (pathology).
- MESH :
- complications : Alzheimer Disease, Tauopathies.
- diagnosis : Alzheimer Disease, Tauopathies.
- etiology : Aphasia, Apraxias, Cognition Disorders, Memory Disorders.
- pathology : Alzheimer Disease, Aphasia, Apraxias, Brain, Cognition Disorders, Memory Disorders, Tauopathies.
- Aged, Autopsy, Diagnosis, Differential, Disease Progression, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Predictive Value of Tests, Syndrome.
Abstract
Corticobasal syndrome (CBS) has been associated with a heterogeneous spectrum of pathologies with an increasing number of reports of Alzheimer's type pathology. There is, however, no means of predicting pathology of CBS in vivo at present. We compared the clinical features of patients presenting with CBS who have either pathologic changes of classic corticobasal degeneration (CBD) or Alzheimer's disease (AD) at post-mortem to identify predictors of the specific pathological processes in life. Twelve patients with CBS were followed prospectively; six had AD and six had classic CBD neuropathology. After review of the presenting clinical features, we identified nine potential predictor variables, compared their frequency in the two groups, and performed a discriminant function analysis. Initial episodic memory complaints and poor performance on the combined orientation-memory subtest of the Addenbrooke's Cognitive Examination (ACE) reliably predicted AD pathology while varying combinations of early frontal-lobe type behavioral symptoms, nonfluent language disturbance, orobuccal apraxia, and utilization behavior predicted CBD pathology ante-mortem. CBS is frequently associated with Alzheimer's disease pathology. Early episodic memory impairment versus early behavioral symptomatology appears to best predict AD or CBD pathology in life.
DOI: 10.1002/mds.22558
PubMed: 19533751
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Hodges</name></author><author><name sortKey="Kipps, Christopher M" sort="Kipps, Christopher M" uniqKey="Kipps C" first="Christopher M" last="Kipps">Christopher M. Kipps</name></author><author><name sortKey="Xuereb, John H" sort="Xuereb, John H" uniqKey="Xuereb J" first="John H" last="Xuereb">John H. Xuereb</name></author><author><name sortKey="Bak, Thomas H" sort="Bak, Thomas H" uniqKey="Bak T" first="Thomas H" last="Bak">Thomas H. Bak</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1002/mds.22558</idno><idno type="RBID">pubmed:19533751</idno><idno type="pmid">19533751</idno><idno type="wicri:Area/PubMed/Corpus">001C51</idno><idno type="wicri:Area/PubMed/Curation">001C51</idno><idno type="wicri:Area/PubMed/Checkpoint">001D50</idno><idno type="wicri:Area/Ncbi/Merge">002726</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Is the pathology of corticobasal syndrome predictable in life?</title><author><name sortKey="Shelley, Bhaskara P" sort="Shelley, Bhaskara P" uniqKey="Shelley B" first="Bhaskara P" last="Shelley">Bhaskara P. Shelley</name><affiliation wicri:level="4"><nlm:affiliation>Department of Clinical Neurosciences, University of Cambridge, Addenbrooke's Hospital, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neurosciences, University of Cambridge, Addenbrooke's Hospital</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Hodges, John R" sort="Hodges, John R" uniqKey="Hodges J" first="John R" last="Hodges">John R. Hodges</name></author><author><name sortKey="Kipps, Christopher M" sort="Kipps, Christopher M" uniqKey="Kipps C" first="Christopher M" last="Kipps">Christopher M. Kipps</name></author><author><name sortKey="Xuereb, John H" sort="Xuereb, John H" uniqKey="Xuereb J" first="John H" last="Xuereb">John H. Xuereb</name></author><author><name sortKey="Bak, Thomas H" sort="Bak, Thomas H" uniqKey="Bak T" first="Thomas H" last="Bak">Thomas H. Bak</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Alzheimer Disease (complications)</term><term>Alzheimer Disease (diagnosis)</term><term>Alzheimer Disease (pathology)</term><term>Aphasia (etiology)</term><term>Aphasia (pathology)</term><term>Apraxias (etiology)</term><term>Apraxias (pathology)</term><term>Autopsy</term><term>Brain (pathology)</term><term>Cognition Disorders (etiology)</term><term>Cognition Disorders (pathology)</term><term>Diagnosis, Differential</term><term>Disease Progression</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Memory Disorders (etiology)</term><term>Memory Disorders (pathology)</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Predictive Value of Tests</term><term>Syndrome</term><term>Tauopathies (complications)</term><term>Tauopathies (diagnosis)</term><term>Tauopathies (pathology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Alzheimer Disease</term><term>Tauopathies</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Alzheimer Disease</term><term>Tauopathies</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Aphasia</term><term>Apraxias</term><term>Cognition Disorders</term><term>Memory Disorders</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Alzheimer Disease</term><term>Aphasia</term><term>Apraxias</term><term>Brain</term><term>Cognition Disorders</term><term>Memory Disorders</term><term>Tauopathies</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Autopsy</term><term>Diagnosis, Differential</term><term>Disease Progression</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Predictive Value of Tests</term><term>Syndrome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Corticobasal syndrome (CBS) has been associated with a heterogeneous spectrum of pathologies with an increasing number of reports of Alzheimer's type pathology. There is, however, no means of predicting pathology of CBS in vivo at present. We compared the clinical features of patients presenting with CBS who have either pathologic changes of classic corticobasal degeneration (CBD) or Alzheimer's disease (AD) at post-mortem to identify predictors of the specific pathological processes in life. Twelve patients with CBS were followed prospectively; six had AD and six had classic CBD neuropathology. After review of the presenting clinical features, we identified nine potential predictor variables, compared their frequency in the two groups, and performed a discriminant function analysis. Initial episodic memory complaints and poor performance on the combined orientation-memory subtest of the Addenbrooke's Cognitive Examination (ACE) reliably predicted AD pathology while varying combinations of early frontal-lobe type behavioral symptoms, nonfluent language disturbance, orobuccal apraxia, and utilization behavior predicted CBD pathology ante-mortem. CBS is frequently associated with Alzheimer's disease pathology. Early episodic memory impairment versus early behavioral symptomatology appears to best predict AD or CBD pathology in life.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">19533751</PMID><DateCreated><Year>2009</Year><Month>09</Month><Day>01</Day></DateCreated><DateCompleted><Year>2010</Year><Month>01</Month><Day>15</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>11</Issue><PubDate><Year>2009</Year><Month>Aug</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. 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After review of the presenting clinical features, we identified nine potential predictor variables, compared their frequency in the two groups, and performed a discriminant function analysis. Initial episodic memory complaints and poor performance on the combined orientation-memory subtest of the Addenbrooke's Cognitive Examination (ACE) reliably predicted AD pathology while varying combinations of early frontal-lobe type behavioral symptoms, nonfluent language disturbance, orobuccal apraxia, and utilization behavior predicted CBD pathology ante-mortem. CBS is frequently associated with Alzheimer's disease pathology. 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Bak</name><name sortKey="Hodges, John R" sort="Hodges, John R" uniqKey="Hodges J" first="John R" last="Hodges">John R. Hodges</name><name sortKey="Kipps, Christopher M" sort="Kipps, Christopher M" uniqKey="Kipps C" first="Christopher M" last="Kipps">Christopher M. Kipps</name><name sortKey="Xuereb, John H" sort="Xuereb, John H" uniqKey="Xuereb J" first="John H" last="Xuereb">John H. Xuereb</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Shelley, Bhaskara P" sort="Shelley, Bhaskara P" uniqKey="Shelley B" first="Bhaskara P" last="Shelley">Bhaskara P. Shelley</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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