MovDisordV3, PascalFrancis, Corpus, bibRecord, 000D91

Is the Pathology of Corticobasal Syndrome Predictable in Life?

Identifieur interne : 000D91 ( PascalFrancis/Corpus ); précédent : 000D90; suivant : 000D92

Is the Pathology of Corticobasal Syndrome Predictable in Life?

Auteurs : Bhaskara P. Shelley ; John R. Hodges ; Christopher M. Kipps ; John H. Xuereb ; Thomas H. Bak

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:09-0386507

Descripteurs français

Pascal (Inist)
- Dégénérescence, Démence d'Alzheimer, Aphasie, Pathologie du système nerveux, Anatomopathologie, Comportement.

English descriptors

KwdEn :
- Alzheimer disease, Anatomic pathology, Aphasia, Behavior, Degeneration, Nervous system diseases.

Abstract

Corticobasal syndrome (CBS) has been associated with a heterogeneous spectrum of pathologies with an increasing number of reports of Alzheimer's type pathology. There is, however, no means of predicting pathology of CBS in vivo at present. We compared the clinical features of patients presenting with CBS who have either pathologic changes of classic corticobasal degeneration (CBD) or Alzheimer's disease (AD) at post-mortem to identify predictors of the specific pathological processes in life. Twelve patients with CBS were followed prospectively; six had AD and six had classic CBD neuropathology. After review of the presenting clinical features, we identified nine potential predictor variables, compared their frequency in the two groups, and performed a discriminant function analysis. Initial episodic memory complaints and poor performance on the combined orientation-memory subtest of the Addenbrooke's Cognitive Examination (ACE) reliably predicted AD pathology while varying combinations of early frontal-lobe type behavioral symptoms, nonfluent language disturbance, orobuccal apraxia, and utilization behavior predicted CBD pathology ante-mortem. CBS is frequently associated with Alzheimer's disease pathology. Early episodic memory impairment versus early behavioral symptomatology appears to best predict AD or CBD pathology in life.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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C01	`01`		`ENG`	@0 Corticobasal syndrome (CBS) has been associated with a heterogeneous spectrum of pathologies with an increasing number of reports of Alzheimer's type pathology. There is, however, no means of predicting pathology of CBS in vivo at present. We compared the clinical features of patients presenting with CBS who have either pathologic changes of classic corticobasal degeneration (CBD) or Alzheimer's disease (AD) at post-mortem to identify predictors of the specific pathological processes in life. Twelve patients with CBS were followed prospectively; six had AD and six had classic CBD neuropathology. After review of the presenting clinical features, we identified nine potential predictor variables, compared their frequency in the two groups, and performed a discriminant function analysis. Initial episodic memory complaints and poor performance on the combined orientation-memory subtest of the Addenbrooke's Cognitive Examination (ACE) reliably predicted AD pathology while varying combinations of early frontal-lobe type behavioral symptoms, nonfluent language disturbance, orobuccal apraxia, and utilization behavior predicted CBD pathology ante-mortem. CBS is frequently associated with Alzheimer's disease pathology. Early episodic memory impairment versus early behavioral symptomatology appears to best predict AD or CBD pathology in life.
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C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Maladie dégénérative @5 38`
C07	`02`	`X`	`ENG`	`@0 Degenerative disease @5 38`
C07	`02`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 38`
C07	`03`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 39`
C07	`03`	`X`	`ENG`	`@0 Central nervous system disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 39`
C07	`04`	`X`	`FRE`	`@0 Trouble de la communication @5 41`
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Format Inist (serveur)

NO :	PASCAL 09-0386507 INIST
ET :	Is the Pathology of Corticobasal Syndrome Predictable in Life?
AU :	SHELLEY (Bhaskara P.); HODGES (John R.); KIPPS (Christopher M.); XUEREB (John H.); BAK (Thomas H.)
AF :	Department of Clinical Neurosciences, University of Cambridge, Addenbrooke's Hospital/Cambridge/Royaume-Uni (1 aut., 2 aut., 3 aut.); Prince of Wales Medical Research Institute, Barker Street/Randwick, New South Wales/Australie (2 aut.); Department of Pathology (Molecular Histopathology Division), University of Cambridge, Addenbrooke's Hospital/Cambridge/Royaume-Uni (4 aut.); Human Cognitive Neuroscience, University of Edinhurgh/Edinburgh/Royaume-Uni (5 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 11; Pp. 1593-1599; Bibl. 42 ref.
LA :	Anglais
EA :	Corticobasal syndrome (CBS) has been associated with a heterogeneous spectrum of pathologies with an increasing number of reports of Alzheimer's type pathology. There is, however, no means of predicting pathology of CBS in vivo at present. We compared the clinical features of patients presenting with CBS who have either pathologic changes of classic corticobasal degeneration (CBD) or Alzheimer's disease (AD) at post-mortem to identify predictors of the specific pathological processes in life. Twelve patients with CBS were followed prospectively; six had AD and six had classic CBD neuropathology. After review of the presenting clinical features, we identified nine potential predictor variables, compared their frequency in the two groups, and performed a discriminant function analysis. Initial episodic memory complaints and poor performance on the combined orientation-memory subtest of the Addenbrooke's Cognitive Examination (ACE) reliably predicted AD pathology while varying combinations of early frontal-lobe type behavioral symptoms, nonfluent language disturbance, orobuccal apraxia, and utilization behavior predicted CBD pathology ante-mortem. CBS is frequently associated with Alzheimer's disease pathology. Early episodic memory impairment versus early behavioral symptomatology appears to best predict AD or CBD pathology in life.
CC :	002B17; 002B17D
FD :	Dégénérescence; Démence d'Alzheimer; Aphasie; Pathologie du système nerveux; Anatomopathologie; Comportement
FG :	Pathologie de l'encéphale; Maladie dégénérative; Pathologie du système nerveux central; Trouble de la communication; Trouble du langage; Trouble neurologique
ED :	Degeneration; Alzheimer disease; Aphasia; Nervous system diseases; Anatomic pathology; Behavior
EG :	Cerebral disorder; Degenerative disease; Central nervous system disease; Communication disorder; Language disorder; Neurological disorder
SD :	Degeneración; Demencia Alzheimer; Afasia; Sistema nervioso patología; Anatomía patológica; Conducta
LO :	INIST-20953.354000171892190050
ID :	09-0386507

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Pascal:09-0386507

Le document en format XML

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<front><div type="abstract" xml:lang="en">Corticobasal syndrome (CBS) has been associated with a heterogeneous spectrum of pathologies with an increasing number of reports of Alzheimer's type pathology. There is, however, no means of predicting pathology of CBS in vivo at present. We compared the clinical features of patients presenting with CBS who have either pathologic changes of classic corticobasal degeneration (CBD) or Alzheimer's disease (AD) at post-mortem to identify predictors of the specific pathological processes in life. Twelve patients with CBS were followed prospectively; six had AD and six had classic CBD neuropathology. After review of the presenting clinical features, we identified nine potential predictor variables, compared their frequency in the two groups, and performed a discriminant function analysis. Initial episodic memory complaints and poor performance on the combined orientation-memory subtest of the Addenbrooke's Cognitive Examination (ACE) reliably predicted AD pathology while varying combinations of early frontal-lobe type behavioral symptoms, nonfluent language disturbance, orobuccal apraxia, and utilization behavior predicted CBD pathology ante-mortem. CBS is frequently associated with Alzheimer's disease pathology. Early episodic memory impairment versus early behavioral symptomatology appears to best predict AD or CBD pathology in life.</div>
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</fC03>
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<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Conducta</s0>
<s5>10</s5>
</fC03>
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<s5>37</s5>
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<s5>37</s5>
</fC07>
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<s5>37</s5>
</fC07>
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<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Trouble de la communication</s0>
<s5>41</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Communication disorder</s0>
<s5>41</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Trastorno comunicación</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Trouble du langage</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Language disorder</s0>
<s5>42</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Trastorno lenguaje</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Trouble neurologique</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Neurological disorder</s0>
<s5>43</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Trastorno neurológico</s0>
<s5>43</s5>
</fC07>
<fN21><s1>278</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
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<server><NO>PASCAL 09-0386507 INIST</NO>
<ET>Is the Pathology of Corticobasal Syndrome Predictable in Life?</ET>
<AU>SHELLEY (Bhaskara P.); HODGES (John R.); KIPPS (Christopher M.); XUEREB (John H.); BAK (Thomas H.)</AU>
<AF>Department of Clinical Neurosciences, University of Cambridge, Addenbrooke's Hospital/Cambridge/Royaume-Uni (1 aut., 2 aut., 3 aut.); Prince of Wales Medical Research Institute, Barker Street/Randwick, New South Wales/Australie (2 aut.); Department of Pathology (Molecular Histopathology Division), University of Cambridge, Addenbrooke's Hospital/Cambridge/Royaume-Uni (4 aut.); Human Cognitive Neuroscience, University of Edinhurgh/Edinburgh/Royaume-Uni (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 11; Pp. 1593-1599; Bibl. 42 ref.</SO>
<LA>Anglais</LA>
<EA>Corticobasal syndrome (CBS) has been associated with a heterogeneous spectrum of pathologies with an increasing number of reports of Alzheimer's type pathology. There is, however, no means of predicting pathology of CBS in vivo at present. We compared the clinical features of patients presenting with CBS who have either pathologic changes of classic corticobasal degeneration (CBD) or Alzheimer's disease (AD) at post-mortem to identify predictors of the specific pathological processes in life. Twelve patients with CBS were followed prospectively; six had AD and six had classic CBD neuropathology. After review of the presenting clinical features, we identified nine potential predictor variables, compared their frequency in the two groups, and performed a discriminant function analysis. Initial episodic memory complaints and poor performance on the combined orientation-memory subtest of the Addenbrooke's Cognitive Examination (ACE) reliably predicted AD pathology while varying combinations of early frontal-lobe type behavioral symptoms, nonfluent language disturbance, orobuccal apraxia, and utilization behavior predicted CBD pathology ante-mortem. CBS is frequently associated with Alzheimer's disease pathology. Early episodic memory impairment versus early behavioral symptomatology appears to best predict AD or CBD pathology in life.</EA>
<CC>002B17; 002B17D</CC>
<FD>Dégénérescence; Démence d'Alzheimer; Aphasie; Pathologie du   système nerveux; Anatomopathologie; Comportement</FD>
<FG>Pathologie de l'encéphale; Maladie dégénérative; Pathologie du   système nerveux central; Trouble de la communication; Trouble du langage; Trouble neurologique</FG>
<ED>Degeneration; Alzheimer disease; Aphasia; Nervous system diseases; Anatomic pathology; Behavior</ED>
<EG>Cerebral disorder; Degenerative disease; Central nervous system disease; Communication disorder; Language disorder; Neurological disorder</EG>
<SD>Degeneración; Demencia Alzheimer; Afasia; Sistema nervioso patología; Anatomía patológica; Conducta</SD>
<LO>INIST-20953.354000171892190050</LO>
<ID>09-0386507</ID>
</server>
</inist>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Is the Pathology of Corticobasal Syndrome Predictable in Life?

Is the Pathology of Corticobasal Syndrome Predictable in Life?

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