A follow‐up study on 6‐[18F]fluoro‐L‐dopa uptake in early Parkinson's disease shows nonlinear progression in the putamen
Identifieur interne : 002481 ( Main/Exploration ); précédent : 002480; suivant : 002482A follow‐up study on 6‐[18F]fluoro‐L‐dopa uptake in early Parkinson's disease shows nonlinear progression in the putamen
Auteurs : Anna Brück [Finlande] ; Sargo Aalto [Finlande] ; Elina Rauhala [Finlande] ; Jörgen Bergman [Finlande] ; Reijo Marttila [Finlande] ; Juha O. Rinne [Finlande]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-05-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- 6‐[18F]fluoro‐L‐dopa, Aged, Brain Mapping, Disease Progression, Emission tomography, Female, Fluorodeoxyglucose F18 (diagnostic use), Follow up study, Functional Laterality, Humans, Levodopa, Levodopa (metabolism), Longitudinal Studies, Male, Middle Aged, Nervous system diseases, Nonlinear Dynamics, Nonlinearity, PET, Parkinson Disease (metabolism), Parkinson Disease (pathology), Parkinson Disease (radionuclide imaging), Parkinson disease, Parkinson's disease, Positron emission tomography, Positron-Emission Tomography (methods), Postmortem Changes, Putamen, Putamen (radionuclide imaging), Time Factors, Uptake, progression.
- MESH :
- chemical , diagnostic use : Fluorodeoxyglucose F18.
- chemical , metabolism : Levodopa.
- metabolism : Parkinson Disease.
- methods : Positron-Emission Tomography.
- pathology : Parkinson Disease.
- radionuclide imaging : Parkinson Disease, Putamen.
- Aged, Brain Mapping, Disease Progression, Female, Functional Laterality, Humans, Longitudinal Studies, Male, Middle Aged, Nonlinear Dynamics, Postmortem Changes, Time Factors.
Abstract
Sixteen subjects with de novo Parkinson's disease (PD) underwent three 6‐[18F]fluoro‐L‐dopa (Fdopa) positron emission tomography (PET) scans during a follow‐up time of 5 years (mean ± SD 5.5 ± 0.4 years) to study the progression of striatal dopaminergic hypofunction. Throughout the study, the smallest Fdopa uptake values were found in the dorso‐caudal part of the putamen contralateral to the side with dominant motor symptoms. The rate of decline in Fdopa uptake in the contralateral putamen was faster in the beginning of the disease and slowed down as the disease progressed. The annual decline in Fdopa influx constant (Ki, unit × 10−3 min−1) was on average 0.5 during the first 2 years and 0.2 during the subsequent 3 years (P = 0.002) in the contralateral putamen. In caudate, the rate of decline in Fdopa values was slower than in the putamen and did not change significantly during the follow‐up time, annual decline in the contralateral caudate being 0.1 between baseline and 2 years and 0.3 between 2 and 5 years (P = 0.4). These results suggest that progression of putaminal dopaminergic hypofuncion in PD follows a nonlinear pattern at least in the contralateral side being faster in the beginning of the disease. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22484
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-05-15">2009-05-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1009">1009</biblScope><biblScope unit="page" to="1015">1015</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">12548E91311719D3CCC6D5C8F6C6C3FA73C373D5</idno><idno type="DOI">10.1002/mds.22484</idno><idno type="ArticleID">MDS22484</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>6‐[18F]fluoro‐L‐dopa</term><term>Aged</term><term>Brain Mapping</term><term>Disease Progression</term><term>Emission tomography</term><term>Female</term><term>Fluorodeoxyglucose F18 (diagnostic use)</term><term>Follow up study</term><term>Functional Laterality</term><term>Humans</term><term>Levodopa</term><term>Levodopa (metabolism)</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Nonlinear Dynamics</term><term>Nonlinearity</term><term>PET</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (radionuclide imaging)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Positron emission tomography</term><term>Positron-Emission Tomography (methods)</term><term>Postmortem Changes</term><term>Putamen</term><term>Putamen (radionuclide imaging)</term><term>Time Factors</term><term>Uptake</term><term>progression</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Fluorodeoxyglucose F18</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Positron-Emission Tomography</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Parkinson Disease</term><term>Putamen</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Disease Progression</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Nonlinear Dynamics</term><term>Postmortem Changes</term><term>Time Factors</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Captation</term><term>Etude longitudinale</term><term>Lévodopa</term><term>Maladie de Parkinson</term><term>Non linéarité</term><term>Pathologie du système nerveux</term><term>Putamen</term><term>Tomographie par émission de positons</term><term>Tomoscintigraphie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sixteen subjects with de novo Parkinson's disease (PD) underwent three 6‐[18F]fluoro‐L‐dopa (Fdopa) positron emission tomography (PET) scans during a follow‐up time of 5 years (mean ± SD 5.5 ± 0.4 years) to study the progression of striatal dopaminergic hypofunction. Throughout the study, the smallest Fdopa uptake values were found in the dorso‐caudal part of the putamen contralateral to the side with dominant motor symptoms. The rate of decline in Fdopa uptake in the contralateral putamen was faster in the beginning of the disease and slowed down as the disease progressed. The annual decline in Fdopa influx constant (Ki, unit × 10−3 min−1) was on average 0.5 during the first 2 years and 0.2 during the subsequent 3 years (P = 0.002) in the contralateral putamen. In caudate, the rate of decline in Fdopa values was slower than in the putamen and did not change significantly during the follow‐up time, annual decline in the contralateral caudate being 0.1 between baseline and 2 years and 0.3 between 2 and 5 years (P = 0.4). These results suggest that progression of putaminal dopaminergic hypofuncion in PD follows a nonlinear pattern at least in the contralateral side being faster in the beginning of the disease. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Finlande</li></country><region><li>Finlande occidentale</li></region><settlement><li>Turku</li></settlement><orgName><li>Université de Turku</li></orgName></list><tree><country name="Finlande"><region name="Finlande occidentale"><name sortKey="Bruck, Anna" sort="Bruck, Anna" uniqKey="Bruck A" first="Anna" last="Brück">Anna Brück</name></region><name sortKey="Aalto, Sargo" sort="Aalto, Sargo" uniqKey="Aalto S" first="Sargo" last="Aalto">Sargo Aalto</name><name sortKey="Aalto, Sargo" sort="Aalto, Sargo" uniqKey="Aalto S" first="Sargo" last="Aalto">Sargo Aalto</name><name sortKey="Bergman, Jorgen" sort="Bergman, Jorgen" uniqKey="Bergman J" first="Jörgen" last="Bergman">Jörgen Bergman</name><name sortKey="Marttila, Reijo" sort="Marttila, Reijo" uniqKey="Marttila R" first="Reijo" last="Marttila">Reijo Marttila</name><name sortKey="Rauhala, Elina" sort="Rauhala, Elina" uniqKey="Rauhala E" first="Elina" last="Rauhala">Elina Rauhala</name><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. Rinne</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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