MovDisordV3, Main, Merge, bibRecord, 003103

A Follow-Up Study on 6-[18F]Fluoro-L-dopa Uptake in Early Parkinson's Disease Shows Nonlinear Progression in the Putamen

Identifieur interne : 003103 ( Main/Merge ); précédent : 003102; suivant : 003104

A Follow-Up Study on 6-[18F]Fluoro-L-dopa Uptake in Early Parkinson's Disease Shows Nonlinear Progression in the Putamen

Auteurs : Anna Brück [Finlande] ; Sargo Aalto [Finlande] ; Elina Rauhala [Finlande] ; Jörgen Bergman [Finlande] ; Reijo Marttila [Finlande] ; Juha O. Rinne [Finlande]

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:09-0257362

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Etude longitudinale, Lévodopa, Captation, Non linéarité, Putamen, Tomoscintigraphie, Tomographie par émission de positons.

English descriptors

KwdEn :
- Emission tomography, Follow up study, Levodopa, Nervous system diseases, Nonlinearity, Parkinson disease, Positron emission tomography, Putamen, Uptake.

Abstract

Sixteen subjects with de novo Parkinson s disease (PD) underwent three 6-[18F]fluoro-L-dopa (Fdopa positron emission tomography (PET) scans during a follow-up time of 5 years (mean ± SD 5.5 ± 0.4 years) to study the progression of striatal dopaminergic hypofunction. Throughout the study, the smallest Fdopa uptake values were found in the dorso-caudal part of the putamen contralateral to the side with dominant motor symptoms. The rate of decline in Fdopa uptake in the contralateral putamen was faster in the beginning of the disease and slowed down as the disease progressed. The annual decline in Fdopa influx constant (Ki, unit × 10^-3 min^-1) was on average 0.5 during the first 2 years and 0.2 during the subsequent 3 years (P = 0.002) in the contralateral putamen. In caudate, the rate of decline in Fdopa values was slower than in the putamen and did not change significantly during the follow-up time, annual decline in the contralateral caudate being 0.1 between baseline and 2 years and 0.3 between 2 and 5 years (P = 0.4). These results suggest that progression of putaminal dopaminergic hypofuncion in PD follows a nonlinear pattern at least in the contralateral side being faster in the beginning of the disease.

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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Emission tomography</term>
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<term>Nervous system diseases</term>
<term>Nonlinearity</term>
<term>Parkinson disease</term>
<term>Positron emission tomography</term>
<term>Putamen</term>
<term>Uptake</term>
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<term>Pathologie du   système nerveux</term>
<term>Etude longitudinale</term>
<term>Lévodopa</term>
<term>Captation</term>
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<front><div type="abstract" xml:lang="en">Sixteen subjects with de novo Parkinson s disease (PD) underwent three 6-[18F]fluoro-L-dopa (Fdopa positron emission tomography (PET) scans during a follow-up time of 5 years (mean ± SD 5.5 ± 0.4 years) to study the progression of striatal dopaminergic hypofunction. Throughout the study, the smallest Fdopa uptake values were found in the dorso-caudal part of the putamen contralateral to the side with dominant motor symptoms. The rate of decline in Fdopa uptake in the contralateral putamen was faster in the beginning of the disease and slowed down as the disease progressed. The annual decline in Fdopa influx constant (Ki, unit × 10<sup>-3</sup>
 min<sup>-1</sup>
) was on average 0.5 during the first 2 years and 0.2 during the subsequent 3 years (P = 0.002) in the contralateral putamen. In caudate, the rate of decline in Fdopa values was slower than in the putamen and did not change significantly during the follow-up time, annual decline in the contralateral caudate being 0.1 between baseline and 2 years and 0.3 between 2 and 5 years (P = 0.4). These results suggest that progression of putaminal dopaminergic hypofuncion in PD follows a nonlinear pattern at least in the contralateral side being faster in the beginning of the disease.</div>
</front>
</TEI>
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<name sortKey="Aalto, Sargo" sort="Aalto, Sargo" uniqKey="Aalto S" first="Sargo" last="Aalto">Sargo Aalto</name>
<name sortKey="Aalto, Sargo" sort="Aalto, Sargo" uniqKey="Aalto S" first="Sargo" last="Aalto">Sargo Aalto</name>
<name sortKey="Bergman, Jorgen" sort="Bergman, Jorgen" uniqKey="Bergman J" first="Jörgen" last="Bergman">Jörgen Bergman</name>
<name sortKey="Marttila, Reijo" sort="Marttila, Reijo" uniqKey="Marttila R" first="Reijo" last="Marttila">Reijo Marttila</name>
<name sortKey="Rauhala, Elina" sort="Rauhala, Elina" uniqKey="Rauhala E" first="Elina" last="Rauhala">Elina Rauhala</name>
<name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. Rinne</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

A Follow-Up Study on 6-[18F]Fluoro-L-dopa Uptake in Early Parkinson's Disease Shows Nonlinear Progression in the Putamen

A Follow-Up Study on 6-[18F]Fluoro-L-dopa Uptake in Early Parkinson's Disease Shows Nonlinear Progression in the Putamen

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri