MovDisordV3, PascalFrancis, Corpus, bibRecord, 000E64

A Follow-Up Study on 6-[18F]Fluoro-L-dopa Uptake in Early Parkinson's Disease Shows Nonlinear Progression in the Putamen

Identifieur interne : 000E64 ( PascalFrancis/Corpus ); précédent : 000E63; suivant : 000E65

A Follow-Up Study on 6-[18F]Fluoro-L-dopa Uptake in Early Parkinson's Disease Shows Nonlinear Progression in the Putamen

Auteurs : Anna Brück ; Sargo Aalto ; Elina Rauhala ; Jörgen Bergman ; Reijo Marttila ; Juha O. Rinne

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:09-0257362

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Etude longitudinale, Lévodopa, Captation, Non linéarité, Putamen, Tomoscintigraphie, Tomographie par émission de positons.

English descriptors

KwdEn :
- Emission tomography, Follow up study, Levodopa, Nervous system diseases, Nonlinearity, Parkinson disease, Positron emission tomography, Putamen, Uptake.

Abstract

Sixteen subjects with de novo Parkinson s disease (PD) underwent three 6-[18F]fluoro-L-dopa (Fdopa positron emission tomography (PET) scans during a follow-up time of 5 years (mean ± SD 5.5 ± 0.4 years) to study the progression of striatal dopaminergic hypofunction. Throughout the study, the smallest Fdopa uptake values were found in the dorso-caudal part of the putamen contralateral to the side with dominant motor symptoms. The rate of decline in Fdopa uptake in the contralateral putamen was faster in the beginning of the disease and slowed down as the disease progressed. The annual decline in Fdopa influx constant (Ki, unit × 10^-3 min^-1) was on average 0.5 during the first 2 years and 0.2 during the subsequent 3 years (P = 0.002) in the contralateral putamen. In caudate, the rate of decline in Fdopa values was slower than in the putamen and did not change significantly during the follow-up time, annual decline in the contralateral caudate being 0.1 between baseline and 2 years and 0.3 between 2 and 5 years (P = 0.4). These results suggest that progression of putaminal dopaminergic hypofuncion in PD follows a nonlinear pattern at least in the contralateral side being faster in the beginning of the disease.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03		`1`		`@0 Mov. disord.`
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A08	`01`	`1`	`ENG`	`@1 A Follow-Up Study on 6-[¹⁸F]Fluoro-L-dopa Uptake in Early Parkinson's Disease Shows Nonlinear Progression in the Putamen`
A11	`01`	`1`		`@1 BRÜCK (Anna)`
A11	`02`	`1`		`@1 AALTO (Sargo)`
A11	`03`	`1`		`@1 RAUHALA (Elina)`
A11	`04`	`1`		`@1 BERGMAN (Jörgen)`
A11	`05`	`1`		`@1 MARTTILA (Reijo)`
A11	`06`	`1`		`@1 RINNE (Juha O.)`
A14	`01`			`@1 Turku PET Centre, University of Turku @2 Turku @3 FIN @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 6 aut.`
A14	`02`			`@1 Department of Psychology, Abo Akademi University @2 Turku @3 FIN @Z 2 aut.`
A14	`03`			`@1 Department of Neurology, Turku University Hospital @2 Turku @3 FIN @Z 5 aut.`
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A21				`@1 2009`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000188271060080`
A44				`@0 0000 @1 © 2009 INIST-CNRS. All rights reserved.`
A45				`@0 25 ref.`
A47	`01`	`1`		`@0 09-0257362`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
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C01	`01`		`ENG`	@0 Sixteen subjects with de novo Parkinson s disease (PD) underwent three 6-[18F]fluoro-L-dopa (Fdopa positron emission tomography (PET) scans during a follow-up time of 5 years (mean ± SD 5.5 ± 0.4 years) to study the progression of striatal dopaminergic hypofunction. Throughout the study, the smallest Fdopa uptake values were found in the dorso-caudal part of the putamen contralateral to the side with dominant motor symptoms. The rate of decline in Fdopa uptake in the contralateral putamen was faster in the beginning of the disease and slowed down as the disease progressed. The annual decline in Fdopa influx constant (Ki, unit × 10^-3 min^-1) was on average 0.5 during the first 2 years and 0.2 during the subsequent 3 years (P = 0.002) in the contralateral putamen. In caudate, the rate of decline in Fdopa values was slower than in the putamen and did not change significantly during the follow-up time, annual decline in the contralateral caudate being 0.1 between baseline and 2 years and 0.3 between 2 and 5 years (P = 0.4). These results suggest that progression of putaminal dopaminergic hypofuncion in PD follows a nonlinear pattern at least in the contralateral side being faster in the beginning of the disease.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 01`
C03	`01`	`X`	`ENG`	`@0 Parkinson disease @2 NM @5 01`
C03	`01`	`X`	`SPA`	`@0 Parkinson enfermedad @2 NM @5 01`
C03	`02`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 02`
C03	`02`	`X`	`ENG`	`@0 Nervous system diseases @5 02`
C03	`02`	`X`	`SPA`	`@0 Sistema nervioso patología @5 02`
C03	`03`	`X`	`FRE`	`@0 Etude longitudinale @5 09`
C03	`03`	`X`	`ENG`	`@0 Follow up study @5 09`
C03	`03`	`X`	`SPA`	`@0 Estudio longitudinal @5 09`
C03	`04`	`X`	`FRE`	`@0 Lévodopa @2 NK @2 FR @5 10`
C03	`04`	`X`	`ENG`	`@0 Levodopa @2 NK @2 FR @5 10`
C03	`04`	`X`	`SPA`	`@0 Levodopa @2 NK @2 FR @5 10`
C03	`05`	`X`	`FRE`	`@0 Captation @5 11`
C03	`05`	`X`	`ENG`	`@0 Uptake @5 11`
C03	`05`	`X`	`SPA`	`@0 Captación @5 11`
C03	`06`	`X`	`FRE`	`@0 Non linéarité @5 12`
C03	`06`	`X`	`ENG`	`@0 Nonlinearity @5 12`
C03	`06`	`X`	`SPA`	`@0 No linealidad @5 12`
C03	`07`	`X`	`FRE`	`@0 Putamen @5 13`
C03	`07`	`X`	`ENG`	`@0 Putamen @5 13`
C03	`07`	`X`	`SPA`	`@0 Putamen @5 13`
C03	`08`	`X`	`FRE`	`@0 Tomoscintigraphie @5 14`
C03	`08`	`X`	`ENG`	`@0 Emission tomography @5 14`
C03	`08`	`X`	`SPA`	`@0 Tomocentelleografía @5 14`
C03	`09`	`X`	`FRE`	`@0 Tomographie par émission de positons @5 15`
C03	`09`	`X`	`ENG`	`@0 Positron emission tomography @5 15`
C03	`09`	`X`	`SPA`	`@0 Tomografía emisión positrones @5 15`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 38`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
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C07	`04`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 40`
C07	`04`	`X`	`ENG`	`@0 Central nervous system disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 40`
N21				`@1 187`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 09-0257362 INIST
ET :	A Follow-Up Study on 6-[¹⁸F]Fluoro-L-dopa Uptake in Early Parkinson's Disease Shows Nonlinear Progression in the Putamen
AU :	BRÜCK (Anna); AALTO (Sargo); RAUHALA (Elina); BERGMAN (Jörgen); MARTTILA (Reijo); RINNE (Juha O.)
AF :	Turku PET Centre, University of Turku/Turku/Finlande (1 aut., 2 aut., 3 aut., 4 aut., 6 aut.); Department of Psychology, Abo Akademi University/Turku/Finlande (2 aut.); Department of Neurology, Turku University Hospital/Turku/Finlande (5 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 7; Pp. 1009-1015; Bibl. 25 ref.
LA :	Anglais
EA :	Sixteen subjects with de novo Parkinson s disease (PD) underwent three 6-[18F]fluoro-L-dopa (Fdopa positron emission tomography (PET) scans during a follow-up time of 5 years (mean ± SD 5.5 ± 0.4 years) to study the progression of striatal dopaminergic hypofunction. Throughout the study, the smallest Fdopa uptake values were found in the dorso-caudal part of the putamen contralateral to the side with dominant motor symptoms. The rate of decline in Fdopa uptake in the contralateral putamen was faster in the beginning of the disease and slowed down as the disease progressed. The annual decline in Fdopa influx constant (Ki, unit × 10^-3 min^-1) was on average 0.5 during the first 2 years and 0.2 during the subsequent 3 years (P = 0.002) in the contralateral putamen. In caudate, the rate of decline in Fdopa values was slower than in the putamen and did not change significantly during the follow-up time, annual decline in the contralateral caudate being 0.1 between baseline and 2 years and 0.3 between 2 and 5 years (P = 0.4). These results suggest that progression of putaminal dopaminergic hypofuncion in PD follows a nonlinear pattern at least in the contralateral side being faster in the beginning of the disease.
CC :	002B17; 002B17G
FD :	Maladie de Parkinson; Pathologie du système nerveux; Etude longitudinale; Lévodopa; Captation; Non linéarité; Putamen; Tomoscintigraphie; Tomographie par émission de positons
FG :	Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central
ED :	Parkinson disease; Nervous system diseases; Follow up study; Levodopa; Uptake; Nonlinearity; Putamen; Emission tomography; Positron emission tomography
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Parkinson enfermedad; Sistema nervioso patología; Estudio longitudinal; Levodopa; Captación; No linealidad; Putamen; Tomocentelleografía; Tomografía emisión positrones
LO :	INIST-20953.354000188271060080
ID :	09-0257362

Links to Exploration step

Pascal:09-0257362

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">A Follow-Up Study on 6-[<sup>18</sup>
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<author><name sortKey="Bruck, Anna" sort="Bruck, Anna" uniqKey="Bruck A" first="Anna" last="Brück">Anna Brück</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Emission tomography</term>
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</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
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<front><div type="abstract" xml:lang="en">Sixteen subjects with de novo Parkinson s disease (PD) underwent three 6-[18F]fluoro-L-dopa (Fdopa positron emission tomography (PET) scans during a follow-up time of 5 years (mean ± SD 5.5 ± 0.4 years) to study the progression of striatal dopaminergic hypofunction. Throughout the study, the smallest Fdopa uptake values were found in the dorso-caudal part of the putamen contralateral to the side with dominant motor symptoms. The rate of decline in Fdopa uptake in the contralateral putamen was faster in the beginning of the disease and slowed down as the disease progressed. The annual decline in Fdopa influx constant (Ki, unit × 10<sup>-3</sup>
 min<sup>-1</sup>
) was on average 0.5 during the first 2 years and 0.2 during the subsequent 3 years (P = 0.002) in the contralateral putamen. In caudate, the rate of decline in Fdopa values was slower than in the putamen and did not change significantly during the follow-up time, annual decline in the contralateral caudate being 0.1 between baseline and 2 years and 0.3 between 2 and 5 years (P = 0.4). These results suggest that progression of putaminal dopaminergic hypofuncion in PD follows a nonlinear pattern at least in the contralateral side being faster in the beginning of the disease.</div>
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 min<sup>-1</sup>
) was on average 0.5 during the first 2 years and 0.2 during the subsequent 3 years (P = 0.002) in the contralateral putamen. In caudate, the rate of decline in Fdopa values was slower than in the putamen and did not change significantly during the follow-up time, annual decline in the contralateral caudate being 0.1 between baseline and 2 years and 0.3 between 2 and 5 years (P = 0.4). These results suggest that progression of putaminal dopaminergic hypofuncion in PD follows a nonlinear pattern at least in the contralateral side being faster in the beginning of the disease.</s0>
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</fC02>
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<s2>FR</s2>
<s5>10</s5>
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<s2>FR</s2>
<s5>10</s5>
</fC03>
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<s2>FR</s2>
<s5>10</s5>
</fC03>
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</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Putamen</s0>
<s5>13</s5>
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<s5>13</s5>
</fC03>
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<fC03 i1="08" i2="X" l="ENG"><s0>Emission tomography</s0>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Tomocentelleografía</s0>
<s5>14</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Tomographie par émission de positons</s0>
<s5>15</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Positron emission tomography</s0>
<s5>15</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Tomografía emisión positrones</s0>
<s5>15</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
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<s5>38</s5>
</fC07>
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<s5>38</s5>
</fC07>
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<s5>38</s5>
</fC07>
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<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
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<server><NO>PASCAL 09-0257362 INIST</NO>
<ET>A Follow-Up Study on 6-[<sup>18</sup>
F]Fluoro-L-dopa Uptake in Early Parkinson's Disease Shows Nonlinear Progression in the Putamen</ET>
<AU>BRÜCK (Anna); AALTO (Sargo); RAUHALA (Elina); BERGMAN (Jörgen); MARTTILA (Reijo); RINNE (Juha O.)</AU>
<AF>Turku PET Centre, University of Turku/Turku/Finlande (1 aut., 2 aut., 3 aut., 4 aut., 6 aut.); Department of Psychology, Abo Akademi University/Turku/Finlande (2 aut.); Department of Neurology, Turku University Hospital/Turku/Finlande (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 7; Pp. 1009-1015; Bibl. 25 ref.</SO>
<LA>Anglais</LA>
<EA>Sixteen subjects with de novo Parkinson s disease (PD) underwent three 6-[18F]fluoro-L-dopa (Fdopa positron emission tomography (PET) scans during a follow-up time of 5 years (mean ± SD 5.5 ± 0.4 years) to study the progression of striatal dopaminergic hypofunction. Throughout the study, the smallest Fdopa uptake values were found in the dorso-caudal part of the putamen contralateral to the side with dominant motor symptoms. The rate of decline in Fdopa uptake in the contralateral putamen was faster in the beginning of the disease and slowed down as the disease progressed. The annual decline in Fdopa influx constant (Ki, unit × 10<sup>-3</sup>
 min<sup>-1</sup>
) was on average 0.5 during the first 2 years and 0.2 during the subsequent 3 years (P = 0.002) in the contralateral putamen. In caudate, the rate of decline in Fdopa values was slower than in the putamen and did not change significantly during the follow-up time, annual decline in the contralateral caudate being 0.1 between baseline and 2 years and 0.3 between 2 and 5 years (P = 0.4). These results suggest that progression of putaminal dopaminergic hypofuncion in PD follows a nonlinear pattern at least in the contralateral side being faster in the beginning of the disease.</EA>
<CC>002B17; 002B17G</CC>
<FD>Maladie de Parkinson; Pathologie du   système nerveux; Etude longitudinale; Lévodopa; Captation; Non linéarité; Putamen; Tomoscintigraphie; Tomographie par émission de positons</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central</FG>
<ED>Parkinson disease; Nervous system diseases; Follow up study; Levodopa; Uptake; Nonlinearity; Putamen; Emission tomography; Positron emission tomography</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Parkinson enfermedad; Sistema nervioso patología; Estudio longitudinal; Levodopa; Captación; No linealidad; Putamen; Tomocentelleografía; Tomografía emisión positrones</SD>
<LO>INIST-20953.354000188271060080</LO>
<ID>09-0257362</ID>
</server>
</inist>
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	Movement Disorders (revue)
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Movement Disorders (revue)

A Follow-Up Study on 6-[18F]Fluoro-L-dopa Uptake in Early Parkinson's Disease Shows Nonlinear Progression in the Putamen

A Follow-Up Study on 6-[18F]Fluoro-L-dopa Uptake in Early Parkinson's Disease Shows Nonlinear Progression in the Putamen

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