Influence of cholinergic system on myoclonus in myoclonic epilepsies
Identifieur interne : 006008 ( Main/Exploration ); précédent : 006007; suivant : 006009Influence of cholinergic system on myoclonus in myoclonic epilepsies
Auteurs : Rektor [Tchécoslovaquie] ; Milada Švejdová [France] ; Carmen Silva-Barrat [Tchécoslovaquie] ; Christian Menini [France]Source :
- Movement Disorders [ 0885-3185 ] ; 1992.
English descriptors
- KwdEn :
- Adolescent, Adult, Atropine, Atropine (diagnostic use), Cerebral Cortex (drug effects), Cerebral Cortex (physiopathology), Cholinergic Fibers (drug effects), Cholinergic Fibers (physiology), Cholinergic system, Dose-Response Relationship, Drug, Electroencephalography (drug effects), Electromyography (drug effects), Epilepsies, Myoclonic (physiopathology), Female, Humans, Male, Middle Aged, Myoclonic epilepsies, Myoclonus, Physostigmine, Physostigmine (diagnostic use), Receptors, Cholinergic (drug effects), Receptors, Cholinergic (physiology), Single-Blind Method.
- MESH :
- chemical , diagnostic use : Atropine, Physostigmine.
- drug effects : Cerebral Cortex, Cholinergic Fibers, Electroencephalography, Electromyography, Receptors, Cholinergic.
- physiology : Cholinergic Fibers, Receptors, Cholinergic.
- physiopathology : Cerebral Cortex, Epilepsies, Myoclonic.
- Adolescent, Adult, Dose-Response Relationship, Drug, Female, Humans, Male, Middle Aged, Single-Blind Method.
Abstract
The effect of two drugs upon multifocal myoclonic jerks was evaluated. The drugs influence the central cholinergic system in opposite ways. Eight patients with progressive and nonprogressive myoclonic epilepsy were tested. The single blind test was used. The number of myoclonic jerks after intravenous physostigmine (mean dose 0.02 mg/kg) and that after atropine (0.04 mg/kg) was compared to number of myoclonic jerks in the drug‐free periods and with placebo. Placebo was without an effect. Physostigmine slightly increased the number of jerks. Atropine decreased the number significantly. In most patients the results were not striking. It is suggested that the cholinergic system may participate in the physiopathology of the studied myoclonic in a rather indirect, perhaps modulating way.
Url:
DOI: 10.1002/mds.870070306
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1992">1992</date><biblScope unit="vol">7</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="224">224</biblScope><biblScope unit="page" to="227">227</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">BC64EC5D09D283F16F193AB707057FD7D27C3CAC</idno><idno type="DOI">10.1002/mds.870070306</idno><idno type="ArticleID">MDS870070306</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Atropine</term><term>Atropine (diagnostic use)</term><term>Cerebral Cortex (drug effects)</term><term>Cerebral Cortex (physiopathology)</term><term>Cholinergic Fibers (drug effects)</term><term>Cholinergic Fibers (physiology)</term><term>Cholinergic system</term><term>Dose-Response Relationship, Drug</term><term>Electroencephalography (drug effects)</term><term>Electromyography (drug effects)</term><term>Epilepsies, Myoclonic (physiopathology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Myoclonic epilepsies</term><term>Myoclonus</term><term>Physostigmine</term><term>Physostigmine (diagnostic use)</term><term>Receptors, Cholinergic (drug effects)</term><term>Receptors, Cholinergic (physiology)</term><term>Single-Blind Method</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Atropine</term><term>Physostigmine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cerebral Cortex</term><term>Cholinergic Fibers</term><term>Electroencephalography</term><term>Electromyography</term><term>Receptors, Cholinergic</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cholinergic Fibers</term><term>Receptors, Cholinergic</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebral Cortex</term><term>Epilepsies, Myoclonic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Dose-Response Relationship, Drug</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Single-Blind Method</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effect of two drugs upon multifocal myoclonic jerks was evaluated. The drugs influence the central cholinergic system in opposite ways. Eight patients with progressive and nonprogressive myoclonic epilepsy were tested. The single blind test was used. The number of myoclonic jerks after intravenous physostigmine (mean dose 0.02 mg/kg) and that after atropine (0.04 mg/kg) was compared to number of myoclonic jerks in the drug‐free periods and with placebo. Placebo was without an effect. Physostigmine slightly increased the number of jerks. Atropine decreased the number significantly. In most patients the results were not striking. It is suggested that the cholinergic system may participate in the physiopathology of the studied myoclonic in a rather indirect, perhaps modulating way.</div></front></TEI><affiliations><list><country><li>France</li><li>Tchécoslovaquie</li></country><region><li>Moravie</li></region><settlement><li>Brno</li></settlement></list><tree><country name="Tchécoslovaquie"><region name="Moravie"><name sortKey="Rektor" sort="Rektor" uniqKey="Rektor" last="Rektor">Rektor</name></region><name sortKey="Silva Arrat, Carmen" sort="Silva Arrat, Carmen" uniqKey="Silva Arrat C" first="Carmen" last="Silva-Barrat">Carmen Silva-Barrat</name></country><country name="France"><noRegion><name sortKey="Svejdova, Milada" sort="Svejdova, Milada" uniqKey="Svejdova M" first="Milada" last="Švejdová">Milada Švejdová</name></noRegion><name sortKey="Menini, Christian" sort="Menini, Christian" uniqKey="Menini C" first="Christian" last="Menini">Christian Menini</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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