Influence of cholinergic system on myoclonus in myoclonic epilepsies.
Identifieur interne : 004D40 ( PubMed/Checkpoint ); précédent : 004D39; suivant : 004D41Influence of cholinergic system on myoclonus in myoclonic epilepsies.
Auteurs : I. Rektor [Tchécoslovaquie] ; M. Svejdová ; C. Silva-Barrat ; C. MeniniSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1992.
English descriptors
- KwdEn :
- Adolescent, Adult, Atropine (diagnostic use), Cerebral Cortex (drug effects), Cerebral Cortex (physiopathology), Cholinergic Fibers (drug effects), Cholinergic Fibers (physiology), Dose-Response Relationship, Drug, Electroencephalography (drug effects), Electromyography (drug effects), Epilepsies, Myoclonic (physiopathology), Female, Humans, Male, Middle Aged, Physostigmine (diagnostic use), Receptors, Cholinergic (drug effects), Receptors, Cholinergic (physiology), Single-Blind Method.
- MESH :
- chemical , diagnostic use : Atropine, Physostigmine.
- drug effects : Cerebral Cortex, Cholinergic Fibers, Electroencephalography, Electromyography, Receptors, Cholinergic.
- physiology : Cholinergic Fibers, Receptors, Cholinergic.
- physiopathology : Cerebral Cortex, Epilepsies, Myoclonic.
- Adolescent, Adult, Dose-Response Relationship, Drug, Female, Humans, Male, Middle Aged, Single-Blind Method.
Abstract
The effect of two drugs upon multifocal myoclonic jerks was evaluated. The drugs influence the central cholinergic system in opposite ways. Eight patients with progressive and nonprogressive myoclonic epilepsy were tested. The single blind test was used. The number of myoclonic jerks after intravenous physostigmine (mean dose 0.02 mg/kg) and that after atropine (0.04 mg/kg) was compared to number of myoclonic jerks in the drug-free periods and with placebo. Placebo was without an effect. Physostigmine slightly increased the number of jerks. Atropine decreased the number significantly. In most patients the results were not striking. It is suggested that the cholinergic system may participate in the physiopathology of the studied myoclonus in a rather indirect, perhaps modulating way.
DOI: 10.1002/mds.870070306
PubMed: 1620139
Affiliations:
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Rektor</name><affiliation wicri:level="3"><nlm:affiliation>Clinic of Neurology, Masaryk University, Brno, Czechoslovakia.</nlm:affiliation><country xml:lang="fr">Tchécoslovaquie</country><wicri:regionArea>Clinic of Neurology, Masaryk University, Brno</wicri:regionArea><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation></author><author><name sortKey="Svejdova, M" sort="Svejdova, M" uniqKey="Svejdova M" first="M" last="Svejdová">M. Svejdová</name></author><author><name sortKey="Silva Barrat, C" sort="Silva Barrat, C" uniqKey="Silva Barrat C" first="C" last="Silva-Barrat">C. Silva-Barrat</name></author><author><name sortKey="Menini, C" sort="Menini, C" uniqKey="Menini C" first="C" last="Menini">C. Menini</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Atropine (diagnostic use)</term><term>Cerebral Cortex (drug effects)</term><term>Cerebral Cortex (physiopathology)</term><term>Cholinergic Fibers (drug effects)</term><term>Cholinergic Fibers (physiology)</term><term>Dose-Response Relationship, Drug</term><term>Electroencephalography (drug effects)</term><term>Electromyography (drug effects)</term><term>Epilepsies, Myoclonic (physiopathology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Physostigmine (diagnostic use)</term><term>Receptors, Cholinergic (drug effects)</term><term>Receptors, Cholinergic (physiology)</term><term>Single-Blind Method</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Atropine</term><term>Physostigmine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cerebral Cortex</term><term>Cholinergic Fibers</term><term>Electroencephalography</term><term>Electromyography</term><term>Receptors, Cholinergic</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cholinergic Fibers</term><term>Receptors, Cholinergic</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebral Cortex</term><term>Epilepsies, Myoclonic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Dose-Response Relationship, Drug</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Single-Blind Method</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effect of two drugs upon multifocal myoclonic jerks was evaluated. The drugs influence the central cholinergic system in opposite ways. Eight patients with progressive and nonprogressive myoclonic epilepsy were tested. The single blind test was used. The number of myoclonic jerks after intravenous physostigmine (mean dose 0.02 mg/kg) and that after atropine (0.04 mg/kg) was compared to number of myoclonic jerks in the drug-free periods and with placebo. Placebo was without an effect. Physostigmine slightly increased the number of jerks. Atropine decreased the number significantly. In most patients the results were not striking. It is suggested that the cholinergic system may participate in the physiopathology of the studied myoclonus in a rather indirect, perhaps modulating way.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">1620139</PMID><DateCreated><Year>1992</Year><Month>08</Month><Day>04</Day></DateCreated><DateCompleted><Year>1992</Year><Month>08</Month><Day>04</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>7</Volume><Issue>3</Issue><PubDate><Year>1992</Year></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Influence of cholinergic system on myoclonus in myoclonic epilepsies.</ArticleTitle><Pagination><MedlinePgn>224-7</MedlinePgn></Pagination><Abstract><AbstractText>The effect of two drugs upon multifocal myoclonic jerks was evaluated. The drugs influence the central cholinergic system in opposite ways. Eight patients with progressive and nonprogressive myoclonic epilepsy were tested. The single blind test was used. The number of myoclonic jerks after intravenous physostigmine (mean dose 0.02 mg/kg) and that after atropine (0.04 mg/kg) was compared to number of myoclonic jerks in the drug-free periods and with placebo. Placebo was without an effect. Physostigmine slightly increased the number of jerks. Atropine decreased the number significantly. In most patients the results were not striking. It is suggested that the cholinergic system may participate in the physiopathology of the studied myoclonus in a rather indirect, perhaps modulating way.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rektor</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Clinic of Neurology, Masaryk University, Brno, Czechoslovakia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Svejdová</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Silva-Barrat</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Menini</LastName><ForeName>C</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D018848">Controlled Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>UNITED STATES</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011950">Receptors, Cholinergic</NameOfSubstance></Chemical><Chemical><RegistryNumber>7C0697DR9I</RegistryNumber><NameOfSubstance UI="D001285">Atropine</NameOfSubstance></Chemical><Chemical><RegistryNumber>9U1VM840SP</RegistryNumber><NameOfSubstance UI="D010830">Physostigmine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000293">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001285">Atropine</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000176">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002540">Cerebral Cortex</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002799">Cholinergic Fibers</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004305">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004569">Electroencephalography</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000187">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004576">Electromyography</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004831">Epilepsies, Myoclonic</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010830">Physostigmine</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000176">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011950">Receptors, Cholinergic</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016037">Single-Blind Method</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1992</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1992</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1992</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">1620139</ArticleId><ArticleId IdType="doi">10.1002/mds.870070306</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Tchécoslovaquie</li></country><region><li>Moravie</li></region><settlement><li>Brno</li></settlement></list><tree><noCountry><name sortKey="Menini, C" sort="Menini, C" uniqKey="Menini C" first="C" last="Menini">C. Menini</name><name sortKey="Silva Barrat, C" sort="Silva Barrat, C" uniqKey="Silva Barrat C" first="C" last="Silva-Barrat">C. Silva-Barrat</name><name sortKey="Svejdova, M" sort="Svejdova, M" uniqKey="Svejdova M" first="M" last="Svejdová">M. Svejdová</name></noCountry><country name="Tchécoslovaquie"><region name="Moravie"><name sortKey="Rektor, I" sort="Rektor, I" uniqKey="Rektor I" first="I" last="Rektor">I. Rektor</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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