Influence of cholinergic system on myoclonus in myoclonic epilepsies.
Identifieur interne : 001456 ( Ncbi/Curation ); précédent : 001455; suivant : 001457Influence of cholinergic system on myoclonus in myoclonic epilepsies.
Auteurs : I. Rektor [Tchécoslovaquie] ; M. Svejdová ; C. Silva-Barrat ; C. MeniniSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1992.
English descriptors
- KwdEn :
- Adolescent, Adult, Atropine (diagnostic use), Cerebral Cortex (drug effects), Cerebral Cortex (physiopathology), Cholinergic Fibers (drug effects), Cholinergic Fibers (physiology), Dose-Response Relationship, Drug, Electroencephalography (drug effects), Electromyography (drug effects), Epilepsies, Myoclonic (physiopathology), Female, Humans, Male, Middle Aged, Physostigmine (diagnostic use), Receptors, Cholinergic (drug effects), Receptors, Cholinergic (physiology), Single-Blind Method.
- MESH :
- chemical , diagnostic use : Atropine, Physostigmine.
- drug effects : Cerebral Cortex, Cholinergic Fibers, Electroencephalography, Electromyography, Receptors, Cholinergic.
- physiology : Cholinergic Fibers, Receptors, Cholinergic.
- physiopathology : Cerebral Cortex, Epilepsies, Myoclonic.
- Adolescent, Adult, Dose-Response Relationship, Drug, Female, Humans, Male, Middle Aged, Single-Blind Method.
Abstract
The effect of two drugs upon multifocal myoclonic jerks was evaluated. The drugs influence the central cholinergic system in opposite ways. Eight patients with progressive and nonprogressive myoclonic epilepsy were tested. The single blind test was used. The number of myoclonic jerks after intravenous physostigmine (mean dose 0.02 mg/kg) and that after atropine (0.04 mg/kg) was compared to number of myoclonic jerks in the drug-free periods and with placebo. Placebo was without an effect. Physostigmine slightly increased the number of jerks. Atropine decreased the number significantly. In most patients the results were not striking. It is suggested that the cholinergic system may participate in the physiopathology of the studied myoclonus in a rather indirect, perhaps modulating way.
DOI: 10.1002/mds.870070306
PubMed: 1620139
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Menini</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1992">1992</date><idno type="RBID">pubmed:1620139</idno><idno type="pmid">1620139</idno><idno type="doi">10.1002/mds.870070306</idno><idno type="wicri:Area/PubMed/Corpus">004D34</idno><idno type="wicri:Area/PubMed/Curation">004D34</idno><idno type="wicri:Area/PubMed/Checkpoint">004D40</idno><idno type="wicri:Area/Ncbi/Merge">001456</idno><idno type="wicri:Area/Ncbi/Curation">001456</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Influence of cholinergic system on myoclonus in myoclonic epilepsies.</title><author><name sortKey="Rektor, I" sort="Rektor, I" uniqKey="Rektor I" first="I" last="Rektor">I. Rektor</name><affiliation wicri:level="3"><nlm:affiliation>Clinic of Neurology, Masaryk University, Brno, Czechoslovakia.</nlm:affiliation><country xml:lang="fr">Tchécoslovaquie</country><wicri:regionArea>Clinic of Neurology, Masaryk University, Brno</wicri:regionArea><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation></author><author><name sortKey="Svejdova, M" sort="Svejdova, M" uniqKey="Svejdova M" first="M" last="Svejdová">M. Svejdová</name></author><author><name sortKey="Silva Barrat, C" sort="Silva Barrat, C" uniqKey="Silva Barrat C" first="C" last="Silva-Barrat">C. Silva-Barrat</name></author><author><name sortKey="Menini, C" sort="Menini, C" uniqKey="Menini C" first="C" last="Menini">C. Menini</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Atropine (diagnostic use)</term><term>Cerebral Cortex (drug effects)</term><term>Cerebral Cortex (physiopathology)</term><term>Cholinergic Fibers (drug effects)</term><term>Cholinergic Fibers (physiology)</term><term>Dose-Response Relationship, Drug</term><term>Electroencephalography (drug effects)</term><term>Electromyography (drug effects)</term><term>Epilepsies, Myoclonic (physiopathology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Physostigmine (diagnostic use)</term><term>Receptors, Cholinergic (drug effects)</term><term>Receptors, Cholinergic (physiology)</term><term>Single-Blind Method</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Atropine</term><term>Physostigmine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cerebral Cortex</term><term>Cholinergic Fibers</term><term>Electroencephalography</term><term>Electromyography</term><term>Receptors, Cholinergic</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cholinergic Fibers</term><term>Receptors, Cholinergic</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebral Cortex</term><term>Epilepsies, Myoclonic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Dose-Response Relationship, Drug</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Single-Blind Method</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effect of two drugs upon multifocal myoclonic jerks was evaluated. The drugs influence the central cholinergic system in opposite ways. Eight patients with progressive and nonprogressive myoclonic epilepsy were tested. The single blind test was used. The number of myoclonic jerks after intravenous physostigmine (mean dose 0.02 mg/kg) and that after atropine (0.04 mg/kg) was compared to number of myoclonic jerks in the drug-free periods and with placebo. Placebo was without an effect. Physostigmine slightly increased the number of jerks. Atropine decreased the number significantly. In most patients the results were not striking. It is suggested that the cholinergic system may participate in the physiopathology of the studied myoclonus in a rather indirect, perhaps modulating way.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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