Living on the Edge With Too Many Mouths to Feed: Why Dopamine Neurons Die
Identifieur interne : 001071 ( Main/Exploration ); précédent : 001070; suivant : 001072Living on the Edge With Too Many Mouths to Feed: Why Dopamine Neurons Die
Auteurs : J. Paul Bolam [Royaume-Uni] ; Eleftheria K. Pissadaki [Royaume-Uni, Grèce]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- MESH :
- cytology : Dopaminergic Neurons, Substantia Nigra.
- pathology : Parkinson Disease.
- physiology : Axons, Dopaminergic Neurons, Synapses.
- physiopathology : Parkinson Disease.
- Animals, Cell Death, Humans.
Abstract
Although genes, protein aggregates, environmental toxins, and other factors associated with Parkinson's disease (PD) are widely distributed in the nervous system and affect many classes of neurons, a consistent feature of PD is the exceptional and selective vulnerability of dopamine (DA) neurons of the SNc. What is it about these neurons, among all other neurons in the brain, that makes them so susceptible in PD? We hypothesize that a major contributory factor is the unique cellular architecture of SNc DA neuron axons. Their large, complex axonal arbour puts them under such a tight energy budget that it makes them particularly susceptible to factors that contribute to cell death, including unique molecular characteristics associated with SNc DA neurons and nonspecific, nervous-system-wide factors.
Url:
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000050
- to stream PascalFrancis, to step Curation: 002C64
- to stream PascalFrancis, to step Checkpoint: 000144
- to stream Main, to step Merge: 001123
- to stream Pmc, to step Corpus: 000461
- to stream Pmc, to step Curation: 000461
- to stream Pmc, to step Checkpoint: 000180
- to stream PubMed, to step Corpus: 000C38
- to stream PubMed, to step Curation: 000C38
- to stream PubMed, to step Checkpoint: 000D56
- to stream Ncbi, to step Merge: 003824
- to stream Ncbi, to step Curation: 003824
- to stream Ncbi, to step Checkpoint: 003824
- to stream Main, to step Merge: 000D48
- to stream Main, to step Curation: 001071
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Living on the Edge With Too Many Mouths to Feed: Why Dopamine Neurons Die</title>
<author><name sortKey="Bolam, J Paul" sort="Bolam, J Paul" uniqKey="Bolam J" first="J. Paul" last="Bolam">J. Paul Bolam</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, and Oxford Parkinson's Disease Centre, University of Oxford</s1>
<s2>Oxford</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Pissadaki, Eleftheria K" sort="Pissadaki, Eleftheria K" uniqKey="Pissadaki E" first="Eleftheria K." last="Pissadaki">Eleftheria K. Pissadaki</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, and Oxford Parkinson's Disease Centre, University of Oxford</s1>
<s2>Oxford</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Basic Sciences, Faculty of Medicine, University of Crete</s1>
<s2>Heraklion</s2>
<s3>GRC</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Grèce</country>
<wicri:noRegion>Heraklion</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">12-0423957</idno>
<date when="2012">2012</date>
<idno type="stanalyst">PASCAL 12-0423957 INIST</idno>
<idno type="RBID">Pascal:12-0423957</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000050</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002C64</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000144</idno>
<idno type="wicri:doubleKey">0885-3185:2012:Bolam J:living:on:the</idno>
<idno type="wicri:Area/Main/Merge">001123</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504389</idno>
<idno type="RBID">PMC:3504389</idno>
<idno type="wicri:Area/Pmc/Corpus">000461</idno>
<idno type="wicri:Area/Pmc/Curation">000461</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000180</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000C38</idno>
<idno type="wicri:Area/PubMed/Curation">000C38</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000D56</idno>
<idno type="wicri:Area/Ncbi/Merge">003824</idno>
<idno type="wicri:Area/Ncbi/Curation">003824</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003824</idno>
<idno type="wicri:doubleKey">0885-3185:2012:Bolam J:living:on:the</idno>
<idno type="wicri:Area/Main/Merge">000D48</idno>
<idno type="wicri:Area/Main/Curation">001071</idno>
<idno type="wicri:Area/Main/Exploration">001071</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Living on the Edge With Too Many Mouths to Feed: Why Dopamine Neurons Die</title>
<author><name sortKey="Bolam, J Paul" sort="Bolam, J Paul" uniqKey="Bolam J" first="J. Paul" last="Bolam">J. Paul Bolam</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, and Oxford Parkinson's Disease Centre, University of Oxford</s1>
<s2>Oxford</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Pissadaki, Eleftheria K" sort="Pissadaki, Eleftheria K" uniqKey="Pissadaki E" first="Eleftheria K." last="Pissadaki">Eleftheria K. Pissadaki</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, and Oxford Parkinson's Disease Centre, University of Oxford</s1>
<s2>Oxford</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Basic Sciences, Faculty of Medicine, University of Crete</s1>
<s2>Heraklion</s2>
<s3>GRC</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Grèce</country>
<wicri:noRegion>Heraklion</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Axons (physiology)</term>
<term>Cell Death</term>
<term>Dopamine</term>
<term>Dopaminergic Neurons (cytology)</term>
<term>Dopaminergic Neurons (physiology)</term>
<term>Humans</term>
<term>Nervous system diseases</term>
<term>Neuron</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Substantia Nigra (cytology)</term>
<term>Synapses (physiology)</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Dopaminergic Neurons</term>
<term>Substantia Nigra</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Axons</term>
<term>Dopaminergic Neurons</term>
<term>Synapses</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Death</term>
<term>Humans</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Pathologie du système nerveux</term>
<term>Dopamine</term>
<term>Neurone</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Although genes, protein aggregates, environmental toxins, and other factors associated with Parkinson's disease (PD) are widely distributed in the nervous system and affect many classes of neurons, a consistent feature of PD is the exceptional and selective vulnerability of dopamine (DA) neurons of the SNc. What is it about these neurons, among all other neurons in the brain, that makes them so susceptible in PD? We hypothesize that a major contributory factor is the unique cellular architecture of SNc DA neuron axons. Their large, complex axonal arbour puts them under such a tight energy budget that it makes them particularly susceptible to factors that contribute to cell death, including unique molecular characteristics associated with SNc DA neurons and nonspecific, nervous-system-wide factors.</div>
</front>
</TEI>
<affiliations><list><country><li>Grèce</li>
<li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Oxfordshire</li>
</region>
<settlement><li>Oxford</li>
</settlement>
<orgName><li>Université d'Oxford</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Bolam, J Paul" sort="Bolam, J Paul" uniqKey="Bolam J" first="J. Paul" last="Bolam">J. Paul Bolam</name>
</region>
<name sortKey="Pissadaki, Eleftheria K" sort="Pissadaki, Eleftheria K" uniqKey="Pissadaki E" first="Eleftheria K." last="Pissadaki">Eleftheria K. Pissadaki</name>
</country>
<country name="Grèce"><noRegion><name sortKey="Pissadaki, Eleftheria K" sort="Pissadaki, Eleftheria K" uniqKey="Pissadaki E" first="Eleftheria K." last="Pissadaki">Eleftheria K. Pissadaki</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001071 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001071 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Exploration |type= RBID |clé= Pascal:12-0423957 |texte= Living on the Edge With Too Many Mouths to Feed: Why Dopamine Neurons Die }}
This area was generated with Dilib version V0.6.23. |