MovDisordV3, PubMed, Checkpoint, bibRecord, 000D56

Living on the edge with too many mouths to feed: why dopamine neurons die.

Identifieur interne : 000D56 ( PubMed/Checkpoint ); précédent : 000D55; suivant : 000D57

Living on the edge with too many mouths to feed: why dopamine neurons die.

Auteurs : J Paul Bolam [Royaume-Uni] ; Eleftheria K. Pissadaki

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.

RBID : pubmed:23008164

English descriptors

KwdEn :
- Animals, Axons (physiology), Cell Death, Dopaminergic Neurons (cytology), Dopaminergic Neurons (physiology), Humans, Parkinson Disease (pathology), Parkinson Disease (physiopathology), Substantia Nigra (cytology), Synapses (physiology).
MESH :
- cytology : Dopaminergic Neurons, Substantia Nigra.
- pathology : Parkinson Disease.
- physiology : Axons, Dopaminergic Neurons, Synapses.
- physiopathology : Parkinson Disease.
- Animals, Cell Death, Humans.

Abstract

Although genes, protein aggregates, environmental toxins, and other factors associated with Parkinson's disease (PD) are widely distributed in the nervous system and affect many classes of neurons, a consistent feature of PD is the exceptional and selective vulnerability of dopamine (DA) neurons of the SNc. What is it about these neurons, among all other neurons in the brain, that makes them so susceptible in PD? We hypothesize that a major contributory factor is the unique cellular architecture of SNc DA neuron axons. Their large, complex axonal arbour puts them under such a tight energy budget that it makes them particularly susceptible to factors that contribute to cell death, including unique molecular characteristics associated with SNc DA neurons and nonspecific, nervous-system-wide factors.

DOI: 10.1002/mds.25135
PubMed: 23008164

Affiliations:

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Le document en format XML

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<author><name sortKey="Bolam, J Paul" sort="Bolam, J Paul" uniqKey="Bolam J" first="J Paul" last="Bolam">J Paul Bolam</name>
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<author><name sortKey="Pissadaki, Eleftheria K" sort="Pissadaki, Eleftheria K" uniqKey="Pissadaki E" first="Eleftheria K" last="Pissadaki">Eleftheria K. Pissadaki</name>
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<term>Dopaminergic Neurons (physiology)</term>
<term>Humans</term>
<term>Parkinson Disease (pathology)</term>
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<front><div type="abstract" xml:lang="en">Although genes, protein aggregates, environmental toxins, and other factors associated with Parkinson's disease (PD) are widely distributed in the nervous system and affect many classes of neurons, a consistent feature of PD is the exceptional and selective vulnerability of dopamine (DA) neurons of the SNc. What is it about these neurons, among all other neurons in the brain, that makes them so susceptible in PD? We hypothesize that a major contributory factor is the unique cellular architecture of SNc DA neuron axons. Their large, complex axonal arbour puts them under such a tight energy budget that it makes them particularly susceptible to factors that contribute to cell death, including unique molecular characteristics associated with SNc DA neurons and nonspecific, nervous-system-wide factors.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Living on the edge with too many mouths to feed: why dopamine neurons die.

Living on the edge with too many mouths to feed: why dopamine neurons die.

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English descriptors

Abstract

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