Living on the edge with too many mouths to feed: Why dopamine neurons die
Identifieur interne : 003824 ( Ncbi/Checkpoint ); précédent : 003823; suivant : 003825Living on the edge with too many mouths to feed: Why dopamine neurons die
Auteurs : J Paul Bolam [Royaume-Uni] ; Eleftheria K. Pissadaki [Royaume-Uni, Grèce]Source :
- Movement Disorders [ 0885-3185 ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- cytology : Dopaminergic Neurons, Substantia Nigra.
- pathology : Parkinson Disease.
- physiology : Axons, Dopaminergic Neurons, Synapses.
- physiopathology : Parkinson Disease.
- Animals, Cell Death, Humans.
Abstract
Although genes, protein aggregates, environmental toxins, and other factors associated with Parkinson’s disease (PD) are widely distributed in the nervous system and affect many classes of neurons, a consistent feature of PD is the exceptional and selective vulnerability of dopamine (DA) neurons of the SNc. What is it about these neurons, among all other neurons in the brain, that makes them so susceptible in PD? We hypothesize that a major contributory factor is the unique cellular architecture of SNc DA neuron axons. Their large, complex axonal arbour puts them under such a tight energy budget that it makes them particularly susceptible to factors that contribute to cell death, including unique molecular characteristics associated with SNc DA neurons and nonspecific, nervous-system–wide factors. © 2012 Movement Disorder Society
Url:
DOI: 10.1002/mds.25135
PubMed: 23008164
PubMed Central: 3504389
Affiliations:
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Pissadaki</name><affiliation wicri:level="4"><nlm:aff id="au1"><institution>Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, and Oxford Parkinson’s Disease Centre,</institution><addr-line>University of Oxford, Oxford, UK</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Basic Sciences, Faculty of Medicine,</institution><addr-line>University of Crete, Heraklion, Greece</addr-line></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>University of Crete, Heraklion</wicri:regionArea><wicri:noRegion>Heraklion</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23008164</idno><idno type="pmc">3504389</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504389</idno><idno type="RBID">PMC:3504389</idno><idno type="doi">10.1002/mds.25135</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000461</idno><idno type="wicri:Area/Pmc/Curation">000461</idno><idno type="wicri:Area/Pmc/Checkpoint">000180</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000C38</idno><idno type="wicri:Area/PubMed/Curation">000C38</idno><idno type="wicri:Area/PubMed/Checkpoint">000D56</idno><idno type="wicri:Area/Ncbi/Merge">003824</idno><idno type="wicri:Area/Ncbi/Curation">003824</idno><idno type="wicri:Area/Ncbi/Checkpoint">003824</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Living on the edge with too many mouths to feed: Why dopamine neurons die</title><author><name sortKey="Bolam, J Paul" sort="Bolam, J Paul" uniqKey="Bolam J" first="J Paul" last="Bolam">J Paul Bolam</name><affiliation wicri:level="4"><nlm:aff id="au1"><institution>Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, and Oxford Parkinson’s Disease Centre,</institution><addr-line>University of Oxford, Oxford, UK</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Pissadaki, Eleftheria K" sort="Pissadaki, Eleftheria K" uniqKey="Pissadaki E" first="Eleftheria K" last="Pissadaki">Eleftheria K. Pissadaki</name><affiliation wicri:level="4"><nlm:aff id="au1"><institution>Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, and Oxford Parkinson’s Disease Centre,</institution><addr-line>University of Oxford, Oxford, UK</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Basic Sciences, Faculty of Medicine,</institution><addr-line>University of Crete, Heraklion, Greece</addr-line></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>University of Crete, Heraklion</wicri:regionArea><wicri:noRegion>Heraklion</wicri:noRegion></affiliation></author></analytic><series><title level="j">Movement Disorders</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Axons (physiology)</term><term>Cell Death</term><term>Dopaminergic Neurons (cytology)</term><term>Dopaminergic Neurons (physiology)</term><term>Humans</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Substantia Nigra (cytology)</term><term>Synapses (physiology)</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Dopaminergic Neurons</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Axons</term><term>Dopaminergic Neurons</term><term>Synapses</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Death</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Although genes, protein aggregates, environmental toxins, and other factors associated with Parkinson’s disease (PD) are widely distributed in the nervous system and affect many classes of neurons, a consistent feature of PD is the exceptional and selective vulnerability of dopamine (DA) neurons of the SNc. What is it about these neurons, among all other neurons in the brain, that makes them so susceptible in PD? We hypothesize that a major contributory factor is the unique cellular architecture of SNc DA neuron axons. Their large, complex axonal arbour puts them under such a tight energy budget that it makes them particularly susceptible to factors that contribute to cell death, including unique molecular characteristics associated with SNc DA neurons and nonspecific, nervous-system–wide factors. © 2012 Movement Disorder Society</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Martin, I" uniqKey="Martin I">I Martin</name></author><author><name sortKey="Dawson, Vl" uniqKey="Dawson V">VL Dawson</name></author><author><name sortKey="Dawson, Tm" uniqKey="Dawson T">TM Dawson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schapira, Ah" uniqKey="Schapira A">AH Schapira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sulzer, D" uniqKey="Sulzer D">D Sulzer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gasser, T" uniqKey="Gasser T">T 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A">A Björklund</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosenblad, C" uniqKey="Rosenblad C">C Rosenblad</name></author><author><name sortKey="Kirik, D" uniqKey="Kirik D">D Kirik</name></author><author><name sortKey="Devaux, B" uniqKey="Devaux B">B Devaux</name></author><author><name sortKey="Moffat, B" uniqKey="Moffat B">B Moffat</name></author><author><name sortKey="Phillips, Hs" uniqKey="Phillips H">HS Phillips</name></author><author><name sortKey="Bjorklund, A" uniqKey="Bjorklund A">A Björklund</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Welberg, L" uniqKey="Welberg L">L Welberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kincaid, Ae" uniqKey="Kincaid A">AE Kincaid</name></author><author><name sortKey="Zheng, T" uniqKey="Zheng T">T Zheng</name></author><author><name sortKey="Wilson, Cj" uniqKey="Wilson C">CJ Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lacey, Cj" uniqKey="Lacey C">CJ Lacey</name></author><author><name sortKey="Boyes, J" uniqKey="Boyes J">J Boyes</name></author><author><name sortKey="Gerlach, O" uniqKey="Gerlach O">O Gerlach</name></author><author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name></author><author><name sortKey="Magill, Pj" uniqKey="Magill P">PJ Magill</name></author><author><name sortKey="Bolam, Jp" uniqKey="Bolam J">JP Bolam</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Grèce</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Oxfordshire</li></region><settlement><li>Oxford</li></settlement><orgName><li>Université d'Oxford</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Bolam, J Paul" sort="Bolam, J Paul" uniqKey="Bolam J" first="J Paul" last="Bolam">J Paul Bolam</name></region><name sortKey="Pissadaki, Eleftheria K" sort="Pissadaki, Eleftheria K" uniqKey="Pissadaki E" first="Eleftheria K" last="Pissadaki">Eleftheria K. Pissadaki</name></country><country name="Grèce"><noRegion><name sortKey="Pissadaki, Eleftheria K" sort="Pissadaki, Eleftheria K" uniqKey="Pissadaki E" first="Eleftheria K" last="Pissadaki">Eleftheria K. Pissadaki</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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