MovDisordV3, Main, Exploration, bibRecordById, Pascal:12-0198672

Deep Brain Stimulation of the Subthalamic Nucleus Improves Sense of Well-Being in Parkinson's Disease

Identifieur interne : 001153 ( Main/Exploration ); précédent : 001152; suivant : 001154

Deep Brain Stimulation of the Subthalamic Nucleus Improves Sense of Well-Being in Parkinson's Disease

Auteurs : Louise M. Mcdonald [Royaume-Uni] ; Donna Page [Royaume-Uni] ; Leonora Wilkinson [Royaume-Uni, États-Unis] ; Marjan Jahanshahi [Royaume-Uni]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0198672

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Noyau sousthalamique, Bien-être, Humeur, Stimulation cérébrale profonde.

English descriptors

KwdEn :
- Affect (physiology), Aged, Analysis of Variance, Deep Brain Stimulation (methods), Deep brain stimulation, Disability Evaluation, Fatigue (etiology), Female, Follow-Up Studies, Humans, Male, Middle Aged, Mood, Nervous system diseases, Neuropsychological Tests, Pain Measurement, Parkinson Disease (complications), Parkinson Disease (therapy), Parkinson disease, Sensation Disorders (etiology), Sensation Disorders (therapy), Subthalamic Nucleus (physiology), Subthalamic nucleus, Well being.
MESH :
- complications : Parkinson Disease.
- etiology : Fatigue, Sensation Disorders.
- methods : Deep Brain Stimulation.
- physiology : Affect, Subthalamic Nucleus.
- therapy : Parkinson Disease, Sensation Disorders.
- Aged, Analysis of Variance, Disability Evaluation, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Pain Measurement.

Abstract

Deep brain stimulation of the subthalamic nucleus is an effective treatment for the motor symptoms of Parkinson's disease. Although a range of psychiatric and behavioral problems have been documented following deep brain stimulation, the short-term effects of subthalamic nucleus stimulation on patients' mood have only been investigated in a few studies. Our aim was to compare self-reported mood in Parkinson's patients with deep brain stimulation of the subthalamic nucleus ON versus OFF. Twenty-three Parkinson's patients with bilateral deep brain stimulation of the subthalamic nucleus and 11 unoperated Parkinson's patients completed a mood visual analogue scale twice. Operated patients were tested with deep brain stimulation of the subthalamic nucleus both ON and OFF. All were assessed on medication. The operated Parkinson's group reported feeling significantly better coordinated, stronger, and more contented with deep brain stimulation ON compared to OFF. Fourteen of the 16 mood scales changed in a positive direction when deep brain stimulation of the subthalamic nucleus was ON. When changes in motor scores were taken into account, the operated patients still reported feeling better-coordinated, but also less gregarious with stimulation ON. Unoperated Parkinson's patients showed no differences on any of these measures between their 2 ratings. Short-term changes in deep brain stimulation of the subthalamic nucleus have a small and mostly positive effect on mood, which may be partly related to improvements in motor symptoms. The implications for day-to-day management of patients with deep brain stimulation of the subthalamic nucleus are discussed.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306058

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Deep brain stimulation of the subthalamic nucleus is an effective treatment for the motor symptoms of Parkinson's disease. Although a range of psychiatric and behavioral problems have been documented following deep brain stimulation, the short-term effects of subthalamic nucleus stimulation on patients' mood have only been investigated in a few studies. Our aim was to compare self-reported mood in Parkinson's patients with deep brain stimulation of the subthalamic nucleus ON versus OFF. Twenty-three Parkinson's patients with bilateral deep brain stimulation of the subthalamic nucleus and 11 unoperated Parkinson's patients completed a mood visual analogue scale twice. Operated patients were tested with deep brain stimulation of the subthalamic nucleus both ON and OFF. All were assessed on medication. The operated Parkinson's group reported feeling significantly better coordinated, stronger, and more contented with deep brain stimulation ON compared to OFF. Fourteen of the 16 mood scales changed in a positive direction when deep brain stimulation of the subthalamic nucleus was ON. When changes in motor scores were taken into account, the operated patients still reported feeling better-coordinated, but also less gregarious with stimulation ON. Unoperated Parkinson's patients showed no differences on any of these measures between their 2 ratings. Short-term changes in deep brain stimulation of the subthalamic nucleus have a small and mostly positive effect on mood, which may be partly related to improvements in motor symptoms. The implications for day-to-day management of patients with deep brain stimulation of the subthalamic nucleus are discussed.</div>
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Movement Disorders (revue)

Deep Brain Stimulation of the Subthalamic Nucleus Improves Sense of Well-Being in Parkinson's Disease

Deep Brain Stimulation of the Subthalamic Nucleus Improves Sense of Well-Being in Parkinson's Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.