Deep Brain Stimulation of the Subthalamic Nucleus Improves Sense of Well-Being in Parkinson's Disease
Identifieur interne : 001153 ( Main/Curation ); précédent : 001152; suivant : 001154Deep Brain Stimulation of the Subthalamic Nucleus Improves Sense of Well-Being in Parkinson's Disease
Auteurs : Louise M. Mcdonald [Royaume-Uni] ; Donna Page [Royaume-Uni] ; Leonora Wilkinson [Royaume-Uni, États-Unis] ; Marjan Jahanshahi [Royaume-Uni]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Affect (physiology), Aged, Analysis of Variance, Deep Brain Stimulation (methods), Deep brain stimulation, Disability Evaluation, Fatigue (etiology), Female, Follow-Up Studies, Humans, Male, Middle Aged, Mood, Nervous system diseases, Neuropsychological Tests, Pain Measurement, Parkinson Disease (complications), Parkinson Disease (therapy), Parkinson disease, Sensation Disorders (etiology), Sensation Disorders (therapy), Subthalamic Nucleus (physiology), Subthalamic nucleus, Well being.
- MESH :
- complications : Parkinson Disease.
- etiology : Fatigue, Sensation Disorders.
- methods : Deep Brain Stimulation.
- physiology : Affect, Subthalamic Nucleus.
- therapy : Parkinson Disease, Sensation Disorders.
- Aged, Analysis of Variance, Disability Evaluation, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Pain Measurement.
Abstract
Deep brain stimulation of the subthalamic nucleus is an effective treatment for the motor symptoms of Parkinson's disease. Although a range of psychiatric and behavioral problems have been documented following deep brain stimulation, the short-term effects of subthalamic nucleus stimulation on patients' mood have only been investigated in a few studies. Our aim was to compare self-reported mood in Parkinson's patients with deep brain stimulation of the subthalamic nucleus ON versus OFF. Twenty-three Parkinson's patients with bilateral deep brain stimulation of the subthalamic nucleus and 11 unoperated Parkinson's patients completed a mood visual analogue scale twice. Operated patients were tested with deep brain stimulation of the subthalamic nucleus both ON and OFF. All were assessed on medication. The operated Parkinson's group reported feeling significantly better coordinated, stronger, and more contented with deep brain stimulation ON compared to OFF. Fourteen of the 16 mood scales changed in a positive direction when deep brain stimulation of the subthalamic nucleus was ON. When changes in motor scores were taken into account, the operated patients still reported feeling better-coordinated, but also less gregarious with stimulation ON. Unoperated Parkinson's patients showed no differences on any of these measures between their 2 ratings. Short-term changes in deep brain stimulation of the subthalamic nucleus have a small and mostly positive effect on mood, which may be partly related to improvements in motor symptoms. The implications for day-to-day management of patients with deep brain stimulation of the subthalamic nucleus are discussed.
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sortKey="Jahanshahi, Marjan" sort="Jahanshahi, Marjan" uniqKey="Jahanshahi M" first="Marjan" last="Jahanshahi">Marjan Jahanshahi</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Affect (physiology)</term><term>Aged</term><term>Analysis of Variance</term><term>Deep Brain Stimulation (methods)</term><term>Deep brain stimulation</term><term>Disability Evaluation</term><term>Fatigue (etiology)</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Mood</term><term>Nervous system diseases</term><term>Neuropsychological Tests</term><term>Pain Measurement</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (therapy)</term><term>Parkinson disease</term><term>Sensation Disorders (etiology)</term><term>Sensation Disorders (therapy)</term><term>Subthalamic Nucleus (physiology)</term><term>Subthalamic nucleus</term><term>Well being</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Fatigue</term><term>Sensation Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Affect</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term><term>Sensation Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Disability Evaluation</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Pain Measurement</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Noyau sousthalamique</term><term>Bien-être</term><term>Humeur</term><term>Stimulation cérébrale profonde</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation of the subthalamic nucleus is an effective treatment for the motor symptoms of Parkinson's disease. Although a range of psychiatric and behavioral problems have been documented following deep brain stimulation, the short-term effects of subthalamic nucleus stimulation on patients' mood have only been investigated in a few studies. Our aim was to compare self-reported mood in Parkinson's patients with deep brain stimulation of the subthalamic nucleus ON versus OFF. Twenty-three Parkinson's patients with bilateral deep brain stimulation of the subthalamic nucleus and 11 unoperated Parkinson's patients completed a mood visual analogue scale twice. Operated patients were tested with deep brain stimulation of the subthalamic nucleus both ON and OFF. All were assessed on medication. The operated Parkinson's group reported feeling significantly better coordinated, stronger, and more contented with deep brain stimulation ON compared to OFF. Fourteen of the 16 mood scales changed in a positive direction when deep brain stimulation of the subthalamic nucleus was ON. When changes in motor scores were taken into account, the operated patients still reported feeling better-coordinated, but also less gregarious with stimulation ON. Unoperated Parkinson's patients showed no differences on any of these measures between their 2 ratings. Short-term changes in deep brain stimulation of the subthalamic nucleus have a small and mostly positive effect on mood, which may be partly related to improvements in motor symptoms. The implications for day-to-day management of patients with deep brain stimulation of the subthalamic nucleus are discussed.</div></front></TEI><double idat="0885-3185:2012:Mcdonald L:deep:brain:stimulation"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Deep Brain Stimulation of the Subthalamic Nucleus Improves Sense of Well-Being in Parkinson's Disease</title><author><name sortKey="Mcdonald, Louise M" sort="Mcdonald, Louise M" uniqKey="Mcdonald L" first="Louise M." last="Mcdonald">Louise M. Mcdonald</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Page, Donna" sort="Page, Donna" uniqKey="Page D" first="Donna" last="Page">Donna Page</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Wilkinson, Leonora" sort="Wilkinson, Leonora" uniqKey="Wilkinson L" first="Leonora" last="Wilkinson">Leonora Wilkinson</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Behavioral Neurology Unit, National Institute of Neurological Disorders and Stroke</s1><s2>Bethesda, MD</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Jahanshahi, Marjan" sort="Jahanshahi, Marjan" uniqKey="Jahanshahi M" first="Marjan" last="Jahanshahi">Marjan Jahanshahi</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0198672</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0198672 INIST</idno><idno type="RBID">Pascal:12-0198672</idno><idno type="wicri:Area/PascalFrancis/Corpus">000227</idno><idno type="wicri:Area/PascalFrancis/Curation">002A87</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000226</idno><idno type="wicri:doubleKey">0885-3185:2012:Mcdonald L:deep:brain:stimulation</idno><idno type="wicri:Area/Main/Merge">001205</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Deep Brain Stimulation of the Subthalamic Nucleus Improves Sense of Well-Being in Parkinson's Disease</title><author><name sortKey="Mcdonald, Louise M" sort="Mcdonald, Louise M" uniqKey="Mcdonald L" first="Louise M." last="Mcdonald">Louise M. Mcdonald</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Page, Donna" sort="Page, Donna" uniqKey="Page D" first="Donna" last="Page">Donna Page</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Wilkinson, Leonora" sort="Wilkinson, Leonora" uniqKey="Wilkinson L" first="Leonora" last="Wilkinson">Leonora Wilkinson</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Behavioral Neurology Unit, National Institute of Neurological Disorders and Stroke</s1><s2>Bethesda, MD</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Jahanshahi, Marjan" sort="Jahanshahi, Marjan" uniqKey="Jahanshahi M" first="Marjan" last="Jahanshahi">Marjan Jahanshahi</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Deep brain stimulation</term><term>Mood</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Subthalamic nucleus</term><term>Well being</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Noyau sousthalamique</term><term>Bien-être</term><term>Humeur</term><term>Stimulation cérébrale profonde</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation of the subthalamic nucleus is an effective treatment for the motor symptoms of Parkinson's disease. Although a range of psychiatric and behavioral problems have been documented following deep brain stimulation, the short-term effects of subthalamic nucleus stimulation on patients' mood have only been investigated in a few studies. Our aim was to compare self-reported mood in Parkinson's patients with deep brain stimulation of the subthalamic nucleus ON versus OFF. Twenty-three Parkinson's patients with bilateral deep brain stimulation of the subthalamic nucleus and 11 unoperated Parkinson's patients completed a mood visual analogue scale twice. Operated patients were tested with deep brain stimulation of the subthalamic nucleus both ON and OFF. All were assessed on medication. The operated Parkinson's group reported feeling significantly better coordinated, stronger, and more contented with deep brain stimulation ON compared to OFF. Fourteen of the 16 mood scales changed in a positive direction when deep brain stimulation of the subthalamic nucleus was ON. When changes in motor scores were taken into account, the operated patients still reported feeling better-coordinated, but also less gregarious with stimulation ON. Unoperated Parkinson's patients showed no differences on any of these measures between their 2 ratings. Short-term changes in deep brain stimulation of the subthalamic nucleus have a small and mostly positive effect on mood, which may be partly related to improvements in motor symptoms. The implications for day-to-day management of patients with deep brain stimulation of the subthalamic nucleus are discussed.</div></front></TEI></INIST><PMC><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Deep brain stimulation of the subthalamic nucleus improves sense of well-being in Parkinson’s disease</title><author><name sortKey="Mcdonald, Louise M" sort="Mcdonald, Louise M" uniqKey="Mcdonald L" first="Louise M." last="Mcdonald">Louise M. Mcdonald</name><affiliation wicri:level="1"><nlm:aff id="A1">Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Box 146, 33 Queen Square, London WC1N 3BG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Box 146, 33 Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation></author><author><name sortKey="Page, Donna" sort="Page, Donna" uniqKey="Page D" first="Donna" last="Page">Donna Page</name><affiliation wicri:level="1"><nlm:aff id="A1">Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Box 146, 33 Queen Square, London WC1N 3BG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Box 146, 33 Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation></author><author><name sortKey="Wilkinson, Leonora" sort="Wilkinson, Leonora" uniqKey="Wilkinson L" first="Leonora" last="Wilkinson">Leonora Wilkinson</name><affiliation wicri:level="1"><nlm:aff id="A1">Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Box 146, 33 Queen Square, London WC1N 3BG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Box 146, 33 Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Behavioral Neurology Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892-1430, US</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Behavioral Neurology Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892-1430</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Jahanshahi, Marjan" sort="Jahanshahi, Marjan" uniqKey="Jahanshahi M" first="Marjan" last="Jahanshahi">Marjan Jahanshahi</name><affiliation wicri:level="1"><nlm:aff id="A1">Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Box 146, 33 Queen Square, London WC1N 3BG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Box 146, 33 Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22411848</idno><idno type="pmc">3306058</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306058</idno><idno type="RBID">PMC:3306058</idno><idno type="doi">10.1002/mds.24035</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000259</idno><idno type="wicri:Area/Pmc/Curation">000259</idno><idno type="wicri:Area/Pmc/Checkpoint">000192</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000E37</idno><idno type="wicri:Area/PubMed/Curation">000E37</idno><idno type="wicri:Area/PubMed/Checkpoint">000E65</idno><idno type="wicri:Area/Ncbi/Merge">003593</idno><idno type="wicri:Area/Ncbi/Curation">003593</idno><idno type="wicri:Area/Ncbi/Checkpoint">003593</idno><idno type="wicri:doubleKey">0885-3185:2012:Mcdonald L:deep:brain:stimulation</idno><idno type="wicri:Area/Main/Merge">000E55</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Deep brain stimulation of the subthalamic nucleus improves sense of well-being in Parkinson’s disease</title><author><name sortKey="Mcdonald, Louise M" sort="Mcdonald, Louise M" uniqKey="Mcdonald L" first="Louise M." last="Mcdonald">Louise M. Mcdonald</name><affiliation wicri:level="1"><nlm:aff id="A1">Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Box 146, 33 Queen Square, London WC1N 3BG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Box 146, 33 Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation></author><author><name sortKey="Page, Donna" sort="Page, Donna" uniqKey="Page D" first="Donna" last="Page">Donna Page</name><affiliation wicri:level="1"><nlm:aff id="A1">Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Box 146, 33 Queen Square, London WC1N 3BG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Box 146, 33 Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation></author><author><name sortKey="Wilkinson, Leonora" sort="Wilkinson, Leonora" uniqKey="Wilkinson L" first="Leonora" last="Wilkinson">Leonora Wilkinson</name><affiliation wicri:level="1"><nlm:aff id="A1">Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Box 146, 33 Queen Square, London WC1N 3BG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Box 146, 33 Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Behavioral Neurology Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892-1430, US</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Behavioral Neurology Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892-1430</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Jahanshahi, Marjan" sort="Jahanshahi, Marjan" uniqKey="Jahanshahi M" first="Marjan" last="Jahanshahi">Marjan Jahanshahi</name><affiliation wicri:level="1"><nlm:aff id="A1">Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Box 146, 33 Queen Square, London WC1N 3BG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Box 146, 33 Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Affect (physiology)</term><term>Aged</term><term>Analysis of Variance</term><term>Deep Brain Stimulation (methods)</term><term>Disability Evaluation</term><term>Fatigue (etiology)</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Pain Measurement</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (therapy)</term><term>Sensation Disorders (etiology)</term><term>Sensation Disorders (therapy)</term><term>Subthalamic Nucleus (physiology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Fatigue</term><term>Sensation Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Affect</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term><term>Sensation Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Disability Evaluation</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Pain Measurement</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Deep brain stimulation of the subthalamic nucleus is an effective treatment for the motor symptoms of Parkinson’s disease. Although a range of psychiatric and behavioural problems have been documented following deep brain stimulation, the short-term effects of subthalamic nucleus stimulation on patients’ mood have only been investigated in a few studies. Our aim was to compare self-reported mood in Parkinson’s patients with deep brain stimulation of the subthalamic nucleus ON versus OFF. Twenty-three Parkinson’s patients with bilateral deep brain stimulation of the subthalamic nucleus and 11 unoperated Parkinson’s patients completed a mood visual analogue scale twice. Operated patients were tested with deep brain stimulation of the subthalamic nucleus both ON and OFF. All were assessed on medication. The operated Parkinson’s group reported feeling significantly better coordinated, stronger and more contented with deep brain stimulation ON compared to OFF. Fourteen of the 16 mood scales changed in a positive direction when deep brain stimulation of the subthalamic nucleus was ON. When changes in motor scores were taken into account, the operated patients still reported feeling better-coordinated, but also less gregarious with stimulation ON. Unoperated Parkinson’s patients showed no differences on any of these measures between their two ratings. Short-term changes in deep brain stimulation of the subthalamic nucleus have a small and mostly positive effect on mood, which may be partly related to improvements in motor symptoms. The implications for day-to-day management of patients with deep brain stimulation of the subthalamic nucleus are discussed.</p></div></front></TEI></PMC></double></record>Pour manipuler ce document sous Unix (Dilib)
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