Deep brain stimulation of the subthalamic nucleus improves sense of well-being in Parkinson’s disease
Identifieur interne : 003593 ( Ncbi/Checkpoint ); précédent : 003592; suivant : 003594Deep brain stimulation of the subthalamic nucleus improves sense of well-being in Parkinson’s disease
Auteurs : Louise M. Mcdonald [Royaume-Uni] ; Donna Page [Royaume-Uni] ; Leonora Wilkinson [Royaume-Uni, États-Unis] ; Marjan Jahanshahi [Royaume-Uni]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2012.
English descriptors
- KwdEn :
- Affect (physiology), Aged, Analysis of Variance, Deep Brain Stimulation (methods), Disability Evaluation, Fatigue (etiology), Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Pain Measurement, Parkinson Disease (complications), Parkinson Disease (therapy), Sensation Disorders (etiology), Sensation Disorders (therapy), Subthalamic Nucleus (physiology).
- MESH :
- complications : Parkinson Disease.
- etiology : Fatigue, Sensation Disorders.
- methods : Deep Brain Stimulation.
- physiology : Affect, Subthalamic Nucleus.
- therapy : Parkinson Disease, Sensation Disorders.
- Aged, Analysis of Variance, Disability Evaluation, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Pain Measurement.
Abstract
Deep brain stimulation of the subthalamic nucleus is an effective treatment for the motor symptoms of Parkinson’s disease. Although a range of psychiatric and behavioural problems have been documented following deep brain stimulation, the short-term effects of subthalamic nucleus stimulation on patients’ mood have only been investigated in a few studies. Our aim was to compare self-reported mood in Parkinson’s patients with deep brain stimulation of the subthalamic nucleus ON versus OFF. Twenty-three Parkinson’s patients with bilateral deep brain stimulation of the subthalamic nucleus and 11 unoperated Parkinson’s patients completed a mood visual analogue scale twice. Operated patients were tested with deep brain stimulation of the subthalamic nucleus both ON and OFF. All were assessed on medication. The operated Parkinson’s group reported feeling significantly better coordinated, stronger and more contented with deep brain stimulation ON compared to OFF. Fourteen of the 16 mood scales changed in a positive direction when deep brain stimulation of the subthalamic nucleus was ON. When changes in motor scores were taken into account, the operated patients still reported feeling better-coordinated, but also less gregarious with stimulation ON. Unoperated Parkinson’s patients showed no differences on any of these measures between their two ratings. Short-term changes in deep brain stimulation of the subthalamic nucleus have a small and mostly positive effect on mood, which may be partly related to improvements in motor symptoms. The implications for day-to-day management of patients with deep brain stimulation of the subthalamic nucleus are discussed.
Url:
DOI: 10.1002/mds.24035
PubMed: 22411848
PubMed Central: 3306058
Affiliations:
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Mcdonald</name><affiliation wicri:level="1"><nlm:aff id="A1">Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Box 146, 33 Queen Square, London WC1N 3BG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Box 146, 33 Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation></author><author><name sortKey="Page, Donna" sort="Page, Donna" uniqKey="Page D" first="Donna" last="Page">Donna Page</name><affiliation wicri:level="1"><nlm:aff id="A1">Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Box 146, 33 Queen Square, London WC1N 3BG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Box 146, 33 Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation></author><author><name sortKey="Wilkinson, Leonora" sort="Wilkinson, Leonora" uniqKey="Wilkinson L" first="Leonora" last="Wilkinson">Leonora Wilkinson</name><affiliation wicri:level="1"><nlm:aff id="A1">Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Box 146, 33 Queen Square, London WC1N 3BG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Box 146, 33 Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Behavioral Neurology Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892-1430, US</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Behavioral Neurology Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892-1430</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Jahanshahi, Marjan" sort="Jahanshahi, Marjan" uniqKey="Jahanshahi M" first="Marjan" last="Jahanshahi">Marjan Jahanshahi</name><affiliation wicri:level="1"><nlm:aff id="A1">Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Box 146, 33 Queen Square, London WC1N 3BG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Box 146, 33 Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Affect (physiology)</term><term>Aged</term><term>Analysis of Variance</term><term>Deep Brain Stimulation (methods)</term><term>Disability Evaluation</term><term>Fatigue (etiology)</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Pain Measurement</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (therapy)</term><term>Sensation Disorders (etiology)</term><term>Sensation Disorders (therapy)</term><term>Subthalamic Nucleus (physiology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Fatigue</term><term>Sensation Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Affect</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term><term>Sensation Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Disability Evaluation</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Pain Measurement</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Deep brain stimulation of the subthalamic nucleus is an effective treatment for the motor symptoms of Parkinson’s disease. Although a range of psychiatric and behavioural problems have been documented following deep brain stimulation, the short-term effects of subthalamic nucleus stimulation on patients’ mood have only been investigated in a few studies. Our aim was to compare self-reported mood in Parkinson’s patients with deep brain stimulation of the subthalamic nucleus ON versus OFF. Twenty-three Parkinson’s patients with bilateral deep brain stimulation of the subthalamic nucleus and 11 unoperated Parkinson’s patients completed a mood visual analogue scale twice. Operated patients were tested with deep brain stimulation of the subthalamic nucleus both ON and OFF. All were assessed on medication. The operated Parkinson’s group reported feeling significantly better coordinated, stronger and more contented with deep brain stimulation ON compared to OFF. Fourteen of the 16 mood scales changed in a positive direction when deep brain stimulation of the subthalamic nucleus was ON. When changes in motor scores were taken into account, the operated patients still reported feeling better-coordinated, but also less gregarious with stimulation ON. Unoperated Parkinson’s patients showed no differences on any of these measures between their two ratings. Short-term changes in deep brain stimulation of the subthalamic nucleus have a small and mostly positive effect on mood, which may be partly related to improvements in motor symptoms. The implications for day-to-day management of patients with deep brain stimulation of the subthalamic nucleus are discussed.</p></div></front></TEI><affiliations><list><country><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Mcdonald, Louise M" sort="Mcdonald, Louise M" uniqKey="Mcdonald L" first="Louise M." last="Mcdonald">Louise M. Mcdonald</name></noRegion><name sortKey="Jahanshahi, Marjan" sort="Jahanshahi, Marjan" uniqKey="Jahanshahi M" first="Marjan" last="Jahanshahi">Marjan Jahanshahi</name><name sortKey="Page, Donna" sort="Page, Donna" uniqKey="Page D" first="Donna" last="Page">Donna Page</name><name sortKey="Wilkinson, Leonora" sort="Wilkinson, Leonora" uniqKey="Wilkinson L" first="Leonora" last="Wilkinson">Leonora Wilkinson</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Wilkinson, Leonora" sort="Wilkinson, Leonora" uniqKey="Wilkinson L" first="Leonora" last="Wilkinson">Leonora Wilkinson</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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