Brain parenchyma sonography and 123I‐FP‐CIT SPECT in Parkinson's disease and essential tremor
Identifieur interne : 002968 ( Main/Exploration ); précédent : 002967; suivant : 002969Brain parenchyma sonography and 123I‐FP‐CIT SPECT in Parkinson's disease and essential tremor
Auteurs : Florian Doepp [Allemagne] ; Michail Plotkin [Allemagne] ; Lara Siegel [Allemagne] ; Anatol Kivi [Allemagne] ; Doreen Gruber [Allemagne] ; Elmar Lobsien [Allemagne] ; Andreas Kupsch [Allemagne] ; Stephan J. Schreiber [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-02-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Brain (pathology), Brain (radionuclide imaging), Encephalon, Essential Tremor (pathology), Essential Tremor (radionuclide imaging), Essential Tremor (ultrasonography), FP‐CIT SPECT, Female, Humans, Male, Middle Aged, Nervous system diseases, Parkinson Disease (pathology), Parkinson Disease (radionuclide imaging), Parkinson Disease (ultrasonography), Parkinson disease, Parkinson's disease, Photon, SN hyperechogenicity, Single photon emission tomography, Sonography, Tomography, Emission-Computed, Single-Photon (methods), Tremor, Tropanes (metabolism), essential tremor, transcranial sonography.
- MESH :
- chemical , metabolism : Tropanes.
- methods : Tomography, Emission-Computed, Single-Photon.
- pathology : Brain, Essential Tremor, Parkinson Disease.
- radionuclide imaging : Brain, Essential Tremor, Parkinson Disease.
- ultrasonography : Essential Tremor, Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged.
Abstract
We aimed to investigate the accuracy of transcranial brain parenchyma sonography (TCS) for differentiation between idiopathic Parkinson's disease (PD) and essential tremor (ET) in comparison to 123I‐FP‐CIT SPECT (FP‐CIT SPECT). Seventy‐four patients, in whom PD or ET was suspected on the basis of clinical criteria, were analyzed. The echogenicity of the substantia nigra (SN) and the striatal binding of dopamine transporters (DAT) were evaluated by TCS and FP‐CIT SPECT, respectively. Three patients were excluded due to an insufficient transtemporal bone window using TCS. Forty‐six and 25 patients were clinically classified as PD and ET. SPECT revealed a reduced DAT binding in 42 of all 71 included patients. Thirty‐six of the 42 patients with abnormal FP‐CIT SPECT findings had a pathological SN hyperechogenicity, whereas TCS findings in the remaining 6 patients were normal. In 27 of 29 patients with normal SPECT findings the SN echogenicity was regular. Referring to FP‐CIT SPECT, the sensitivity and specificity of TCS for detection of PD were 86 and 93%; the positive and negative predictive values were 95 and 82%, respectively. Sensitivity and specificity in detection of clinically diagnosed PD patients were 78 and 92% for TCS and 91 and 100% for FP‐CIT SPECT, respectively. In patients with pathological FP‐CIT SPECT and pathological TCS, the extent of SN hyperechogenicity did not correlate with the degree of reduction in dopamine transporter binding on the side opposite of the more affected limb. TCS allows a reliable differentiation of PD and ET. The TCS SN hyperechogenicity does not correlate with the extent of dopaminergic neuron degeneration. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21861
Affiliations:
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Le document en format XML
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<term>Brain (pathology)</term>
<term>Brain (radionuclide imaging)</term>
<term>Encephalon</term>
<term>Essential Tremor (pathology)</term>
<term>Essential Tremor (radionuclide imaging)</term>
<term>Essential Tremor (ultrasonography)</term>
<term>FP‐CIT SPECT</term>
<term>Female</term>
<term>Humans</term>
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<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (radionuclide imaging)</term>
<term>Parkinson Disease (ultrasonography)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Photon</term>
<term>SN hyperechogenicity</term>
<term>Single photon emission tomography</term>
<term>Sonography</term>
<term>Tomography, Emission-Computed, Single-Photon (methods)</term>
<term>Tremor</term>
<term>Tropanes (metabolism)</term>
<term>essential tremor</term>
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<term>Parkinson Disease</term>
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<front><div type="abstract" xml:lang="fr">We aimed to investigate the accuracy of transcranial brain parenchyma sonography (TCS) for differentiation between idiopathic Parkinson's disease (PD) and essential tremor (ET) in comparison to 123I‐FP‐CIT SPECT (FP‐CIT SPECT). Seventy‐four patients, in whom PD or ET was suspected on the basis of clinical criteria, were analyzed. The echogenicity of the substantia nigra (SN) and the striatal binding of dopamine transporters (DAT) were evaluated by TCS and FP‐CIT SPECT, respectively. Three patients were excluded due to an insufficient transtemporal bone window using TCS. Forty‐six and 25 patients were clinically classified as PD and ET. SPECT revealed a reduced DAT binding in 42 of all 71 included patients. Thirty‐six of the 42 patients with abnormal FP‐CIT SPECT findings had a pathological SN hyperechogenicity, whereas TCS findings in the remaining 6 patients were normal. In 27 of 29 patients with normal SPECT findings the SN echogenicity was regular. Referring to FP‐CIT SPECT, the sensitivity and specificity of TCS for detection of PD were 86 and 93%; the positive and negative predictive values were 95 and 82%, respectively. Sensitivity and specificity in detection of clinically diagnosed PD patients were 78 and 92% for TCS and 91 and 100% for FP‐CIT SPECT, respectively. In patients with pathological FP‐CIT SPECT and pathological TCS, the extent of SN hyperechogenicity did not correlate with the degree of reduction in dopamine transporter binding on the side opposite of the more affected limb. TCS allows a reliable differentiation of PD and ET. The TCS SN hyperechogenicity does not correlate with the extent of dopaminergic neuron degeneration. © 2007 Movement Disorder Society</div>
</front>
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<name sortKey="Gruber, Doreen" sort="Gruber, Doreen" uniqKey="Gruber D" first="Doreen" last="Gruber">Doreen Gruber</name>
<name sortKey="Kivi, Anatol" sort="Kivi, Anatol" uniqKey="Kivi A" first="Anatol" last="Kivi">Anatol Kivi</name>
<name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name>
<name sortKey="Lobsien, Elmar" sort="Lobsien, Elmar" uniqKey="Lobsien E" first="Elmar" last="Lobsien">Elmar Lobsien</name>
<name sortKey="Plotkin, Michail" sort="Plotkin, Michail" uniqKey="Plotkin M" first="Michail" last="Plotkin">Michail Plotkin</name>
<name sortKey="Schreiber, Stephan J" sort="Schreiber, Stephan J" uniqKey="Schreiber S" first="Stephan J." last="Schreiber">Stephan J. Schreiber</name>
<name sortKey="Siegel, Lara" sort="Siegel, Lara" uniqKey="Siegel L" first="Lara" last="Siegel">Lara Siegel</name>
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