Brain parenchyma sonography and 123I‐FP‐CIT SPECT in Parkinson's disease and essential tremor
Identifieur interne : 002968 ( Main/Curation ); précédent : 002967; suivant : 002969Brain parenchyma sonography and 123I‐FP‐CIT SPECT in Parkinson's disease and essential tremor
Auteurs : Florian Doepp [Allemagne] ; Michail Plotkin [Allemagne] ; Lara Siegel [Allemagne] ; Anatol Kivi [Allemagne] ; Doreen Gruber [Allemagne] ; Elmar Lobsien [Allemagne] ; Andreas Kupsch [Allemagne] ; Stephan J. Schreiber [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-02-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Brain (pathology), Brain (radionuclide imaging), Encephalon, Essential Tremor (pathology), Essential Tremor (radionuclide imaging), Essential Tremor (ultrasonography), FP‐CIT SPECT, Female, Humans, Male, Middle Aged, Nervous system diseases, Parkinson Disease (pathology), Parkinson Disease (radionuclide imaging), Parkinson Disease (ultrasonography), Parkinson disease, Parkinson's disease, Photon, SN hyperechogenicity, Single photon emission tomography, Sonography, Tomography, Emission-Computed, Single-Photon (methods), Tremor, Tropanes (metabolism), essential tremor, transcranial sonography.
- MESH :
- chemical , metabolism : Tropanes.
- methods : Tomography, Emission-Computed, Single-Photon.
- pathology : Brain, Essential Tremor, Parkinson Disease.
- radionuclide imaging : Brain, Essential Tremor, Parkinson Disease.
- ultrasonography : Essential Tremor, Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged.
Abstract
We aimed to investigate the accuracy of transcranial brain parenchyma sonography (TCS) for differentiation between idiopathic Parkinson's disease (PD) and essential tremor (ET) in comparison to 123I‐FP‐CIT SPECT (FP‐CIT SPECT). Seventy‐four patients, in whom PD or ET was suspected on the basis of clinical criteria, were analyzed. The echogenicity of the substantia nigra (SN) and the striatal binding of dopamine transporters (DAT) were evaluated by TCS and FP‐CIT SPECT, respectively. Three patients were excluded due to an insufficient transtemporal bone window using TCS. Forty‐six and 25 patients were clinically classified as PD and ET. SPECT revealed a reduced DAT binding in 42 of all 71 included patients. Thirty‐six of the 42 patients with abnormal FP‐CIT SPECT findings had a pathological SN hyperechogenicity, whereas TCS findings in the remaining 6 patients were normal. In 27 of 29 patients with normal SPECT findings the SN echogenicity was regular. Referring to FP‐CIT SPECT, the sensitivity and specificity of TCS for detection of PD were 86 and 93%; the positive and negative predictive values were 95 and 82%, respectively. Sensitivity and specificity in detection of clinically diagnosed PD patients were 78 and 92% for TCS and 91 and 100% for FP‐CIT SPECT, respectively. In patients with pathological FP‐CIT SPECT and pathological TCS, the extent of SN hyperechogenicity did not correlate with the degree of reduction in dopamine transporter binding on the side opposite of the more affected limb. TCS allows a reliable differentiation of PD and ET. The TCS SN hyperechogenicity does not correlate with the extent of dopaminergic neuron degeneration. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21861
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Schreiber</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital Charité, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-02-15">2008-02-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="405">405</biblScope><biblScope unit="page" to="410">410</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">961DFF908550AF3B708A55BFBC17D2876E98B812</idno><idno type="DOI">10.1002/mds.21861</idno><idno type="ArticleID">MDS21861</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Brain (pathology)</term><term>Brain (radionuclide imaging)</term><term>Encephalon</term><term>Essential Tremor (pathology)</term><term>Essential Tremor (radionuclide imaging)</term><term>Essential Tremor (ultrasonography)</term><term>FP‐CIT SPECT</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (radionuclide imaging)</term><term>Parkinson Disease (ultrasonography)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Photon</term><term>SN hyperechogenicity</term><term>Single photon emission tomography</term><term>Sonography</term><term>Tomography, Emission-Computed, Single-Photon (methods)</term><term>Tremor</term><term>Tropanes (metabolism)</term><term>essential tremor</term><term>transcranial sonography</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Tropanes</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Essential Tremor</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Brain</term><term>Essential Tremor</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="ultrasonography" xml:lang="en"><term>Essential Tremor</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Encéphale</term><term>Exploration ultrason</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Photon</term><term>Tomoscintigraphie émission monophotonique</term><term>Tremblement</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="fr">We aimed to investigate the accuracy of transcranial brain parenchyma sonography (TCS) for differentiation between idiopathic Parkinson's disease (PD) and essential tremor (ET) in comparison to 123I‐FP‐CIT SPECT (FP‐CIT SPECT). Seventy‐four patients, in whom PD or ET was suspected on the basis of clinical criteria, were analyzed. The echogenicity of the substantia nigra (SN) and the striatal binding of dopamine transporters (DAT) were evaluated by TCS and FP‐CIT SPECT, respectively. Three patients were excluded due to an insufficient transtemporal bone window using TCS. Forty‐six and 25 patients were clinically classified as PD and ET. SPECT revealed a reduced DAT binding in 42 of all 71 included patients. Thirty‐six of the 42 patients with abnormal FP‐CIT SPECT findings had a pathological SN hyperechogenicity, whereas TCS findings in the remaining 6 patients were normal. In 27 of 29 patients with normal SPECT findings the SN echogenicity was regular. Referring to FP‐CIT SPECT, the sensitivity and specificity of TCS for detection of PD were 86 and 93%; the positive and negative predictive values were 95 and 82%, respectively. Sensitivity and specificity in detection of clinically diagnosed PD patients were 78 and 92% for TCS and 91 and 100% for FP‐CIT SPECT, respectively. In patients with pathological FP‐CIT SPECT and pathological TCS, the extent of SN hyperechogenicity did not correlate with the degree of reduction in dopamine transporter binding on the side opposite of the more affected limb. TCS allows a reliable differentiation of PD and ET. The TCS SN hyperechogenicity does not correlate with the extent of dopaminergic neuron degeneration. © 2007 Movement Disorder Society</div></front></TEI><double idat="0885-3185:2008:Doepp F:brain:parenchyma:sonography"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Brain Parenchyma Sonography and <sup>123</sup>I-FP-CIT SPECT in Parkinson's Disease and Essential Tremor</title><author><name sortKey="Doepp, Florian" sort="Doepp, Florian" uniqKey="Doepp F" first="Florian" last="Doepp">Florian Doepp</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Charité</s1><s2>Berlin</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Plotkin, Michail" sort="Plotkin, Michail" uniqKey="Plotkin M" first="Michail" last="Plotkin">Michail Plotkin</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Radiology, Nuclear Medicine and Radiation Oncology, University Hospital Charité</s1><s2>Berlin</s2><s3>DEU</s3><sZ>2 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Siegel, Lara" sort="Siegel, Lara" uniqKey="Siegel L" first="Lara" last="Siegel">Lara Siegel</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Charité</s1><s2>Berlin</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Kivi, Anatol" sort="Kivi, Anatol" uniqKey="Kivi A" first="Anatol" last="Kivi">Anatol Kivi</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Charité</s1><s2>Berlin</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Gruber, Doreen" sort="Gruber, Doreen" uniqKey="Gruber D" first="Doreen" last="Gruber">Doreen Gruber</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Charité</s1><s2>Berlin</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Lobsien, Elmar" sort="Lobsien, Elmar" uniqKey="Lobsien E" first="Elmar" last="Lobsien">Elmar Lobsien</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Charité</s1><s2>Berlin</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Charité</s1><s2>Berlin</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Schreiber, Stephan J" sort="Schreiber, Stephan J" uniqKey="Schreiber S" first="Stephan J." last="Schreiber">Stephan J. Schreiber</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Charité</s1><s2>Berlin</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">08-0169571</idno><date when="2008">2008</date><idno type="stanalyst">PASCAL 08-0169571 INIST</idno><idno type="RBID">Pascal:08-0169571</idno><idno type="wicri:Area/PascalFrancis/Corpus">001333</idno><idno type="wicri:Area/PascalFrancis/Curation">001986</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001341</idno><idno type="wicri:doubleKey">0885-3185:2008:Doepp F:brain:parenchyma:sonography</idno><idno type="wicri:Area/Main/Merge">003949</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Brain Parenchyma Sonography and <sup>123</sup>I-FP-CIT SPECT in Parkinson's Disease and Essential Tremor</title><author><name sortKey="Doepp, Florian" sort="Doepp, Florian" uniqKey="Doepp F" first="Florian" last="Doepp">Florian Doepp</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Charité</s1><s2>Berlin</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Plotkin, Michail" sort="Plotkin, Michail" uniqKey="Plotkin M" first="Michail" last="Plotkin">Michail Plotkin</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Radiology, Nuclear Medicine and Radiation Oncology, University Hospital Charité</s1><s2>Berlin</s2><s3>DEU</s3><sZ>2 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Siegel, Lara" sort="Siegel, Lara" uniqKey="Siegel L" first="Lara" last="Siegel">Lara Siegel</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Charité</s1><s2>Berlin</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Kivi, Anatol" sort="Kivi, Anatol" uniqKey="Kivi A" first="Anatol" last="Kivi">Anatol Kivi</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Charité</s1><s2>Berlin</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Gruber, Doreen" sort="Gruber, Doreen" uniqKey="Gruber D" first="Doreen" last="Gruber">Doreen Gruber</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Charité</s1><s2>Berlin</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Lobsien, Elmar" sort="Lobsien, Elmar" uniqKey="Lobsien E" first="Elmar" last="Lobsien">Elmar Lobsien</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Charité</s1><s2>Berlin</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Charité</s1><s2>Berlin</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Schreiber, Stephan J" sort="Schreiber, Stephan J" uniqKey="Schreiber S" first="Stephan J." last="Schreiber">Stephan J. Schreiber</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, University Hospital Charité</s1><s2>Berlin</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Encephalon</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Photon</term><term>Single photon emission tomography</term><term>Sonography</term><term>Tremor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Tremblement</term><term>Pathologie du système nerveux</term><term>Encéphale</term><term>Exploration ultrason</term><term>Tomoscintigraphie émission monophotonique</term><term>Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We aimed to investigate the accuracy of transcranial brain parenchyma sonography (TCS) for differentiation between idiopathic Parkinson's disease (PD) and essential tremor (ET) in comparison to <sup>123</sup>I-FP-CIT SPECT (FP-CIT SPECT). Seventy-four patients, in whom PD or ET was suspected on the basis of clinical criteria, were analyzed. The echogenicity of the substantia nigra (SN) and the striatal binding of dopamine transporters (DAT) were evaluated by TCS and FP-CIT SPECT, respectively. Three patients were excluded due to an insufficient transtemporal bone window using TCS. Forty-six and 25 patients were clinically classified as PD and ET. SPECT revealed a reduced DAT binding in 42 of all 71 included patients. Thirty-six of the 42 patients with abnormal FP-CIT SPECT findings had a pathological SN hyperechogenicity, whereas TCS findings in the remaining 6 patients were normal. In 27 of 29 patients with normal SPECT findings the SN echogenicity was regular. Referring to FP-CIT SPECT, the sensitivity and specificity of TCS for detection of PD were 86 and 93%; the positive and negative predictive values were 95 and 82%, respectively. Sensitivity and specificity in detection of clinically diagnosed PD patients were 78 and 92% for TCS and 91 and 100% for FP-CIT SPECT, respectively. In patients with pathological FP-CIT SPECT and pathological TCS, the extent of SN hyperechogenicity did not correlate with the degree of reduction in dopamine transporter binding on the side opposite of the more affected limb. TCS allows a reliable differentiation of PD and ET. The TCS SN hyperechogenicity does not correlate with the extent of dopaminergic neuron degeneration.</div></front></TEI></INIST><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Brain parenchyma sonography and 123I‐FP‐CIT SPECT in Parkinson's disease and essential tremor</title><author><name sortKey="Doepp, Florian" sort="Doepp, Florian" uniqKey="Doepp F" first="Florian" last="Doepp">Florian Doepp</name></author><author><name sortKey="Plotkin, Michail" sort="Plotkin, Michail" uniqKey="Plotkin M" first="Michail" last="Plotkin">Michail Plotkin</name></author><author><name sortKey="Siegel, Lara" sort="Siegel, Lara" uniqKey="Siegel L" first="Lara" last="Siegel">Lara Siegel</name></author><author><name sortKey="Kivi, Anatol" sort="Kivi, Anatol" uniqKey="Kivi A" first="Anatol" last="Kivi">Anatol Kivi</name></author><author><name sortKey="Gruber, Doreen" sort="Gruber, Doreen" uniqKey="Gruber D" first="Doreen" last="Gruber">Doreen Gruber</name></author><author><name sortKey="Lobsien, Elmar" sort="Lobsien, Elmar" uniqKey="Lobsien E" first="Elmar" last="Lobsien">Elmar Lobsien</name></author><author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name></author><author><name sortKey="Schreiber, Stephan J" sort="Schreiber, Stephan J" uniqKey="Schreiber S" first="Stephan J." last="Schreiber">Stephan J. Schreiber</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:961DFF908550AF3B708A55BFBC17D2876E98B812</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1002/mds.21861</idno><idno type="url">https://api.istex.fr/document/961DFF908550AF3B708A55BFBC17D2876E98B812/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000F41</idno><idno type="wicri:Area/Istex/Curation">000F41</idno><idno type="wicri:Area/Istex/Checkpoint">001525</idno><idno type="wicri:doubleKey">0885-3185:2008:Doepp F:brain:parenchyma:sonography</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:18067184</idno><idno type="wicri:Area/PubMed/Corpus">002407</idno><idno type="wicri:Area/PubMed/Curation">002407</idno><idno type="wicri:Area/PubMed/Checkpoint">002403</idno><idno type="wicri:Area/Ncbi/Merge">001F52</idno><idno type="wicri:Area/Ncbi/Curation">001F52</idno><idno type="wicri:Area/Ncbi/Checkpoint">001F52</idno><idno type="wicri:Area/Main/Merge">003547</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Brain parenchyma sonography and 123I‐FP‐CIT SPECT in Parkinson's disease and essential tremor</title><author><name sortKey="Doepp, Florian" sort="Doepp, Florian" uniqKey="Doepp F" first="Florian" last="Doepp">Florian Doepp</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital Charité, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Plotkin, Michail" sort="Plotkin, Michail" uniqKey="Plotkin M" first="Michail" last="Plotkin">Michail Plotkin</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Radiology, Nuclear Medicine and Radiation Oncology, University Hospital Charité, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Siegel, Lara" sort="Siegel, Lara" uniqKey="Siegel L" first="Lara" last="Siegel">Lara Siegel</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital Charité, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Kivi, Anatol" sort="Kivi, Anatol" uniqKey="Kivi A" first="Anatol" last="Kivi">Anatol Kivi</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital Charité, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Gruber, Doreen" sort="Gruber, Doreen" uniqKey="Gruber D" first="Doreen" last="Gruber">Doreen Gruber</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital Charité, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Lobsien, Elmar" sort="Lobsien, Elmar" uniqKey="Lobsien E" first="Elmar" last="Lobsien">Elmar Lobsien</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital Charité, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital Charité, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Schreiber, Stephan J" sort="Schreiber, Stephan J" uniqKey="Schreiber S" first="Stephan J." last="Schreiber">Stephan J. Schreiber</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital Charité, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-02-15">2008-02-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="405">405</biblScope><biblScope unit="page" to="410">410</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">961DFF908550AF3B708A55BFBC17D2876E98B812</idno><idno type="DOI">10.1002/mds.21861</idno><idno type="ArticleID">MDS21861</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Brain (pathology)</term><term>Brain (radionuclide imaging)</term><term>Essential Tremor (pathology)</term><term>Essential Tremor (radionuclide imaging)</term><term>Essential Tremor (ultrasonography)</term><term>FP‐CIT SPECT</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (radionuclide imaging)</term><term>Parkinson Disease (ultrasonography)</term><term>Parkinson's disease</term><term>SN hyperechogenicity</term><term>Tomography, Emission-Computed, Single-Photon (methods)</term><term>Tropanes (metabolism)</term><term>essential tremor</term><term>transcranial sonography</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Tropanes</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Essential Tremor</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Brain</term><term>Essential Tremor</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="ultrasonography" xml:lang="en"><term>Essential Tremor</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="fr">We aimed to investigate the accuracy of transcranial brain parenchyma sonography (TCS) for differentiation between idiopathic Parkinson's disease (PD) and essential tremor (ET) in comparison to 123I‐FP‐CIT SPECT (FP‐CIT SPECT). Seventy‐four patients, in whom PD or ET was suspected on the basis of clinical criteria, were analyzed. The echogenicity of the substantia nigra (SN) and the striatal binding of dopamine transporters (DAT) were evaluated by TCS and FP‐CIT SPECT, respectively. Three patients were excluded due to an insufficient transtemporal bone window using TCS. Forty‐six and 25 patients were clinically classified as PD and ET. SPECT revealed a reduced DAT binding in 42 of all 71 included patients. Thirty‐six of the 42 patients with abnormal FP‐CIT SPECT findings had a pathological SN hyperechogenicity, whereas TCS findings in the remaining 6 patients were normal. In 27 of 29 patients with normal SPECT findings the SN echogenicity was regular. Referring to FP‐CIT SPECT, the sensitivity and specificity of TCS for detection of PD were 86 and 93%; the positive and negative predictive values were 95 and 82%, respectively. Sensitivity and specificity in detection of clinically diagnosed PD patients were 78 and 92% for TCS and 91 and 100% for FP‐CIT SPECT, respectively. In patients with pathological FP‐CIT SPECT and pathological TCS, the extent of SN hyperechogenicity did not correlate with the degree of reduction in dopamine transporter binding on the side opposite of the more affected limb. TCS allows a reliable differentiation of PD and ET. The TCS SN hyperechogenicity does not correlate with the extent of dopaminergic neuron degeneration. © 2007 Movement Disorder Society</div></front></TEI></ISTEX></double></record>Pour manipuler ce document sous Unix (Dilib)
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