Brain parenchyma sonography and 123I-FP-CIT SPECT in Parkinson's disease and essential tremor.
Identifieur interne : 001F52 ( Ncbi/Merge ); précédent : 001F51; suivant : 001F53Brain parenchyma sonography and 123I-FP-CIT SPECT in Parkinson's disease and essential tremor.
Auteurs : Florian Doepp [Allemagne] ; Michail Plotkin ; Lara Siegel ; Anatol Kivi ; Doreen Gruber ; Elmar Lobsien ; Andreas Kupsch ; Stephan J. SchreiberSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- Aged, Brain (pathology), Brain (radionuclide imaging), Essential Tremor (pathology), Essential Tremor (radionuclide imaging), Essential Tremor (ultrasonography), Female, Humans, Male, Middle Aged, Parkinson Disease (pathology), Parkinson Disease (radionuclide imaging), Parkinson Disease (ultrasonography), Tomography, Emission-Computed, Single-Photon (methods), Tropanes (metabolism).
- MESH :
- chemical , metabolism : Tropanes.
- methods : Tomography, Emission-Computed, Single-Photon.
- pathology : Brain, Essential Tremor, Parkinson Disease.
- radionuclide imaging : Brain, Essential Tremor, Parkinson Disease.
- ultrasonography : Essential Tremor, Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged.
Abstract
We aimed to investigate the accuracy of transcranial brain parenchyma sonography (TCS) for differentiation between idiopathic Parkinson's disease (PD) and essential tremor (ET) in comparison to (123)I-FP-CIT SPECT (FP-CIT SPECT). Seventy-four patients, in whom PD or ET was suspected on the basis of clinical criteria, were analyzed. The echogenicity of the substantia nigra (SN) and the striatal binding of dopamine transporters (DAT) were evaluated by TCS and FP-CIT SPECT, respectively. Three patients were excluded due to an insufficient transtemporal bone window using TCS. Forty-six and 25 patients were clinically classified as PD and ET. SPECT revealed a reduced DAT binding in 42 of all 71 included patients. Thirty-six of the 42 patients with abnormal FP-CIT SPECT findings had a pathological SN hyperechogenicity, whereas TCS findings in the remaining 6 patients were normal. In 27 of 29 patients with normal SPECT findings the SN echogenicity was regular. Referring to FP-CIT SPECT, the sensitivity and specificity of TCS for detection of PD were 86 and 93%; the positive and negative predictive values were 95 and 82%, respectively. Sensitivity and specificity in detection of clinically diagnosed PD patients were 78 and 92% for TCS and 91 and 100% for FP-CIT SPECT, respectively. In patients with pathological FP-CIT SPECT and pathological TCS, the extent of SN hyperechogenicity did not correlate with the degree of reduction in dopamine transporter binding on the side opposite of the more affected limb. TCS allows a reliable differentiation of PD and ET. The TCS SN hyperechogenicity does not correlate with the extent of dopaminergic neuron degeneration.
DOI: 10.1002/mds.21861
PubMed: 18067184
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002407
- to stream PubMed, to step Curation: 002407
- to stream PubMed, to step Checkpoint: 002403
Links to Exploration step
pubmed:18067184Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Brain parenchyma sonography and 123I-FP-CIT SPECT in Parkinson's disease and essential tremor.</title>
<author><name sortKey="Doepp, Florian" sort="Doepp, Florian" uniqKey="Doepp F" first="Florian" last="Doepp">Florian Doepp</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University Hospital Charité, Berlin, Germany. florian.doepp@charite.de</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital Charité, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Plotkin, Michail" sort="Plotkin, Michail" uniqKey="Plotkin M" first="Michail" last="Plotkin">Michail Plotkin</name>
</author>
<author><name sortKey="Siegel, Lara" sort="Siegel, Lara" uniqKey="Siegel L" first="Lara" last="Siegel">Lara Siegel</name>
</author>
<author><name sortKey="Kivi, Anatol" sort="Kivi, Anatol" uniqKey="Kivi A" first="Anatol" last="Kivi">Anatol Kivi</name>
</author>
<author><name sortKey="Gruber, Doreen" sort="Gruber, Doreen" uniqKey="Gruber D" first="Doreen" last="Gruber">Doreen Gruber</name>
</author>
<author><name sortKey="Lobsien, Elmar" sort="Lobsien, Elmar" uniqKey="Lobsien E" first="Elmar" last="Lobsien">Elmar Lobsien</name>
</author>
<author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name>
</author>
<author><name sortKey="Schreiber, Stephan J" sort="Schreiber, Stephan J" uniqKey="Schreiber S" first="Stephan J" last="Schreiber">Stephan J. Schreiber</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2008">2008</date>
<idno type="doi">10.1002/mds.21861</idno>
<idno type="RBID">pubmed:18067184</idno>
<idno type="pmid">18067184</idno>
<idno type="wicri:Area/PubMed/Corpus">002407</idno>
<idno type="wicri:Area/PubMed/Curation">002407</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002403</idno>
<idno type="wicri:Area/Ncbi/Merge">001F52</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Brain parenchyma sonography and 123I-FP-CIT SPECT in Parkinson's disease and essential tremor.</title>
<author><name sortKey="Doepp, Florian" sort="Doepp, Florian" uniqKey="Doepp F" first="Florian" last="Doepp">Florian Doepp</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University Hospital Charité, Berlin, Germany. florian.doepp@charite.de</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital Charité, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Plotkin, Michail" sort="Plotkin, Michail" uniqKey="Plotkin M" first="Michail" last="Plotkin">Michail Plotkin</name>
</author>
<author><name sortKey="Siegel, Lara" sort="Siegel, Lara" uniqKey="Siegel L" first="Lara" last="Siegel">Lara Siegel</name>
</author>
<author><name sortKey="Kivi, Anatol" sort="Kivi, Anatol" uniqKey="Kivi A" first="Anatol" last="Kivi">Anatol Kivi</name>
</author>
<author><name sortKey="Gruber, Doreen" sort="Gruber, Doreen" uniqKey="Gruber D" first="Doreen" last="Gruber">Doreen Gruber</name>
</author>
<author><name sortKey="Lobsien, Elmar" sort="Lobsien, Elmar" uniqKey="Lobsien E" first="Elmar" last="Lobsien">Elmar Lobsien</name>
</author>
<author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name>
</author>
<author><name sortKey="Schreiber, Stephan J" sort="Schreiber, Stephan J" uniqKey="Schreiber S" first="Stephan J" last="Schreiber">Stephan J. Schreiber</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2008" type="published">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Brain (pathology)</term>
<term>Brain (radionuclide imaging)</term>
<term>Essential Tremor (pathology)</term>
<term>Essential Tremor (radionuclide imaging)</term>
<term>Essential Tremor (ultrasonography)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (radionuclide imaging)</term>
<term>Parkinson Disease (ultrasonography)</term>
<term>Tomography, Emission-Computed, Single-Photon (methods)</term>
<term>Tropanes (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Tropanes</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Tomography, Emission-Computed, Single-Photon</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
<term>Essential Tremor</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Brain</term>
<term>Essential Tremor</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="ultrasonography" xml:lang="en"><term>Essential Tremor</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We aimed to investigate the accuracy of transcranial brain parenchyma sonography (TCS) for differentiation between idiopathic Parkinson's disease (PD) and essential tremor (ET) in comparison to (123)I-FP-CIT SPECT (FP-CIT SPECT). Seventy-four patients, in whom PD or ET was suspected on the basis of clinical criteria, were analyzed. The echogenicity of the substantia nigra (SN) and the striatal binding of dopamine transporters (DAT) were evaluated by TCS and FP-CIT SPECT, respectively. Three patients were excluded due to an insufficient transtemporal bone window using TCS. Forty-six and 25 patients were clinically classified as PD and ET. SPECT revealed a reduced DAT binding in 42 of all 71 included patients. Thirty-six of the 42 patients with abnormal FP-CIT SPECT findings had a pathological SN hyperechogenicity, whereas TCS findings in the remaining 6 patients were normal. In 27 of 29 patients with normal SPECT findings the SN echogenicity was regular. Referring to FP-CIT SPECT, the sensitivity and specificity of TCS for detection of PD were 86 and 93%; the positive and negative predictive values were 95 and 82%, respectively. Sensitivity and specificity in detection of clinically diagnosed PD patients were 78 and 92% for TCS and 91 and 100% for FP-CIT SPECT, respectively. In patients with pathological FP-CIT SPECT and pathological TCS, the extent of SN hyperechogenicity did not correlate with the degree of reduction in dopamine transporter binding on the side opposite of the more affected limb. TCS allows a reliable differentiation of PD and ET. The TCS SN hyperechogenicity does not correlate with the extent of dopaminergic neuron degeneration.</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">18067184</PMID>
<DateCreated><Year>2008</Year>
<Month>03</Month>
<Day>04</Day>
</DateCreated>
<DateCompleted><Year>2008</Year>
<Month>05</Month>
<Day>08</Day>
</DateCompleted>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>23</Volume>
<Issue>3</Issue>
<PubDate><Year>2008</Year>
<Month>Feb</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>Brain parenchyma sonography and 123I-FP-CIT SPECT in Parkinson's disease and essential tremor.</ArticleTitle>
<Pagination><MedlinePgn>405-10</MedlinePgn>
</Pagination>
<Abstract><AbstractText>We aimed to investigate the accuracy of transcranial brain parenchyma sonography (TCS) for differentiation between idiopathic Parkinson's disease (PD) and essential tremor (ET) in comparison to (123)I-FP-CIT SPECT (FP-CIT SPECT). Seventy-four patients, in whom PD or ET was suspected on the basis of clinical criteria, were analyzed. The echogenicity of the substantia nigra (SN) and the striatal binding of dopamine transporters (DAT) were evaluated by TCS and FP-CIT SPECT, respectively. Three patients were excluded due to an insufficient transtemporal bone window using TCS. Forty-six and 25 patients were clinically classified as PD and ET. SPECT revealed a reduced DAT binding in 42 of all 71 included patients. Thirty-six of the 42 patients with abnormal FP-CIT SPECT findings had a pathological SN hyperechogenicity, whereas TCS findings in the remaining 6 patients were normal. In 27 of 29 patients with normal SPECT findings the SN echogenicity was regular. Referring to FP-CIT SPECT, the sensitivity and specificity of TCS for detection of PD were 86 and 93%; the positive and negative predictive values were 95 and 82%, respectively. Sensitivity and specificity in detection of clinically diagnosed PD patients were 78 and 92% for TCS and 91 and 100% for FP-CIT SPECT, respectively. In patients with pathological FP-CIT SPECT and pathological TCS, the extent of SN hyperechogenicity did not correlate with the degree of reduction in dopamine transporter binding on the side opposite of the more affected limb. TCS allows a reliable differentiation of PD and ET. The TCS SN hyperechogenicity does not correlate with the extent of dopaminergic neuron degeneration.</AbstractText>
<CopyrightInformation>2007 Movement Disorder Society</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Doepp</LastName>
<ForeName>Florian</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, University Hospital Charité, Berlin, Germany. florian.doepp@charite.de</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Plotkin</LastName>
<ForeName>Michail</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Siegel</LastName>
<ForeName>Lara</ForeName>
<Initials>L</Initials>
</Author>
<Author ValidYN="Y"><LastName>Kivi</LastName>
<ForeName>Anatol</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Gruber</LastName>
<ForeName>Doreen</ForeName>
<Initials>D</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lobsien</LastName>
<ForeName>Elmar</ForeName>
<Initials>E</Initials>
</Author>
<Author ValidYN="Y"><LastName>Kupsch</LastName>
<ForeName>Andreas</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Schreiber</LastName>
<ForeName>Stephan J</ForeName>
<Initials>SJ</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Mov Disord</MedlineTA>
<NlmUniqueID>8610688</NlmUniqueID>
<ISSNLinking>0885-3185</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014326">Tropanes</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>155797-99-2</RegistryNumber>
<NameOfSubstance UI="C087552">2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="Y" UI="D001921">Brain</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000531">radionuclide imaging</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="Y" UI="D020329">Essential Tremor</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000531">radionuclide imaging</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000736">ultrasonography</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="Y" UI="D010300">Parkinson Disease</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000531">radionuclide imaging</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000736">ultrasonography</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D015899">Tomography, Emission-Computed, Single-Photon</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000379">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D014326">Tropanes</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year>
<Month>12</Month>
<Day>11</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2008</Year>
<Month>5</Month>
<Day>9</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2007</Year>
<Month>12</Month>
<Day>11</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="doi">10.1002/mds.21861</ArticleId>
<ArticleId IdType="pubmed">18067184</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>Berlin</li>
</region>
<settlement><li>Berlin</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Gruber, Doreen" sort="Gruber, Doreen" uniqKey="Gruber D" first="Doreen" last="Gruber">Doreen Gruber</name>
<name sortKey="Kivi, Anatol" sort="Kivi, Anatol" uniqKey="Kivi A" first="Anatol" last="Kivi">Anatol Kivi</name>
<name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name>
<name sortKey="Lobsien, Elmar" sort="Lobsien, Elmar" uniqKey="Lobsien E" first="Elmar" last="Lobsien">Elmar Lobsien</name>
<name sortKey="Plotkin, Michail" sort="Plotkin, Michail" uniqKey="Plotkin M" first="Michail" last="Plotkin">Michail Plotkin</name>
<name sortKey="Schreiber, Stephan J" sort="Schreiber, Stephan J" uniqKey="Schreiber S" first="Stephan J" last="Schreiber">Stephan J. Schreiber</name>
<name sortKey="Siegel, Lara" sort="Siegel, Lara" uniqKey="Siegel L" first="Lara" last="Siegel">Lara Siegel</name>
</noCountry>
<country name="Allemagne"><region name="Berlin"><name sortKey="Doepp, Florian" sort="Doepp, Florian" uniqKey="Doepp F" first="Florian" last="Doepp">Florian Doepp</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001F52 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 001F52 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Ncbi |étape= Merge |type= RBID |clé= pubmed:18067184 |texte= Brain parenchyma sonography and 123I-FP-CIT SPECT in Parkinson's disease and essential tremor. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:18067184" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a MovDisordV3
![]() | This area was generated with Dilib version V0.6.23. | ![]() |