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Brain parenchyma sonography and 123I-FP-CIT SPECT in Parkinson's disease and essential tremor.

Identifieur interne : 001F52 ( Ncbi/Merge ); précédent : 001F51; suivant : 001F53

Brain parenchyma sonography and 123I-FP-CIT SPECT in Parkinson's disease and essential tremor.

Auteurs : Florian Doepp [Allemagne] ; Michail Plotkin ; Lara Siegel ; Anatol Kivi ; Doreen Gruber ; Elmar Lobsien ; Andreas Kupsch ; Stephan J. Schreiber

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.

RBID : pubmed:18067184

English descriptors

KwdEn :
- Aged, Brain (pathology), Brain (radionuclide imaging), Essential Tremor (pathology), Essential Tremor (radionuclide imaging), Essential Tremor (ultrasonography), Female, Humans, Male, Middle Aged, Parkinson Disease (pathology), Parkinson Disease (radionuclide imaging), Parkinson Disease (ultrasonography), Tomography, Emission-Computed, Single-Photon (methods), Tropanes (metabolism).
MESH :
- chemical , metabolism : Tropanes.
- methods : Tomography, Emission-Computed, Single-Photon.
- pathology : Brain, Essential Tremor, Parkinson Disease.
- radionuclide imaging : Brain, Essential Tremor, Parkinson Disease.
- ultrasonography : Essential Tremor, Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged.

Abstract

We aimed to investigate the accuracy of transcranial brain parenchyma sonography (TCS) for differentiation between idiopathic Parkinson's disease (PD) and essential tremor (ET) in comparison to (123)I-FP-CIT SPECT (FP-CIT SPECT). Seventy-four patients, in whom PD or ET was suspected on the basis of clinical criteria, were analyzed. The echogenicity of the substantia nigra (SN) and the striatal binding of dopamine transporters (DAT) were evaluated by TCS and FP-CIT SPECT, respectively. Three patients were excluded due to an insufficient transtemporal bone window using TCS. Forty-six and 25 patients were clinically classified as PD and ET. SPECT revealed a reduced DAT binding in 42 of all 71 included patients. Thirty-six of the 42 patients with abnormal FP-CIT SPECT findings had a pathological SN hyperechogenicity, whereas TCS findings in the remaining 6 patients were normal. In 27 of 29 patients with normal SPECT findings the SN echogenicity was regular. Referring to FP-CIT SPECT, the sensitivity and specificity of TCS for detection of PD were 86 and 93%; the positive and negative predictive values were 95 and 82%, respectively. Sensitivity and specificity in detection of clinically diagnosed PD patients were 78 and 92% for TCS and 91 and 100% for FP-CIT SPECT, respectively. In patients with pathological FP-CIT SPECT and pathological TCS, the extent of SN hyperechogenicity did not correlate with the degree of reduction in dopamine transporter binding on the side opposite of the more affected limb. TCS allows a reliable differentiation of PD and ET. The TCS SN hyperechogenicity does not correlate with the extent of dopaminergic neuron degeneration.

DOI: 10.1002/mds.21861
PubMed: 18067184

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Le document en format XML

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<author><name sortKey="Doepp, Florian" sort="Doepp, Florian" uniqKey="Doepp F" first="Florian" last="Doepp">Florian Doepp</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University Hospital Charité, Berlin, Germany. florian.doepp@charite.de</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital Charité, Berlin</wicri:regionArea>
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<author><name sortKey="Plotkin, Michail" sort="Plotkin, Michail" uniqKey="Plotkin M" first="Michail" last="Plotkin">Michail Plotkin</name>
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<author><name sortKey="Siegel, Lara" sort="Siegel, Lara" uniqKey="Siegel L" first="Lara" last="Siegel">Lara Siegel</name>
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<author><name sortKey="Kivi, Anatol" sort="Kivi, Anatol" uniqKey="Kivi A" first="Anatol" last="Kivi">Anatol Kivi</name>
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<author><name sortKey="Gruber, Doreen" sort="Gruber, Doreen" uniqKey="Gruber D" first="Doreen" last="Gruber">Doreen Gruber</name>
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<author><name sortKey="Lobsien, Elmar" sort="Lobsien, Elmar" uniqKey="Lobsien E" first="Elmar" last="Lobsien">Elmar Lobsien</name>
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<author><name sortKey="Kupsch, Andreas" sort="Kupsch, Andreas" uniqKey="Kupsch A" first="Andreas" last="Kupsch">Andreas Kupsch</name>
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<author><name sortKey="Schreiber, Stephan J" sort="Schreiber, Stephan J" uniqKey="Schreiber S" first="Stephan J" last="Schreiber">Stephan J. Schreiber</name>
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<term>Essential Tremor (pathology)</term>
<term>Essential Tremor (radionuclide imaging)</term>
<term>Essential Tremor (ultrasonography)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (radionuclide imaging)</term>
<term>Parkinson Disease (ultrasonography)</term>
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<front><div type="abstract" xml:lang="en">We aimed to investigate the accuracy of transcranial brain parenchyma sonography (TCS) for differentiation between idiopathic Parkinson's disease (PD) and essential tremor (ET) in comparison to (123)I-FP-CIT SPECT (FP-CIT SPECT). Seventy-four patients, in whom PD or ET was suspected on the basis of clinical criteria, were analyzed. The echogenicity of the substantia nigra (SN) and the striatal binding of dopamine transporters (DAT) were evaluated by TCS and FP-CIT SPECT, respectively. Three patients were excluded due to an insufficient transtemporal bone window using TCS. Forty-six and 25 patients were clinically classified as PD and ET. SPECT revealed a reduced DAT binding in 42 of all 71 included patients. Thirty-six of the 42 patients with abnormal FP-CIT SPECT findings had a pathological SN hyperechogenicity, whereas TCS findings in the remaining 6 patients were normal. In 27 of 29 patients with normal SPECT findings the SN echogenicity was regular. Referring to FP-CIT SPECT, the sensitivity and specificity of TCS for detection of PD were 86 and 93%; the positive and negative predictive values were 95 and 82%, respectively. Sensitivity and specificity in detection of clinically diagnosed PD patients were 78 and 92% for TCS and 91 and 100% for FP-CIT SPECT, respectively. In patients with pathological FP-CIT SPECT and pathological TCS, the extent of SN hyperechogenicity did not correlate with the degree of reduction in dopamine transporter binding on the side opposite of the more affected limb. TCS allows a reliable differentiation of PD and ET. The TCS SN hyperechogenicity does not correlate with the extent of dopaminergic neuron degeneration.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Brain parenchyma sonography and 123I-FP-CIT SPECT in Parkinson's disease and essential tremor.

Brain parenchyma sonography and 123I-FP-CIT SPECT in Parkinson's disease and essential tremor.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki