Microstructural white matter changes in primary torsion dystonia
Identifieur interne : 002768 ( Main/Exploration ); précédent : 002767; suivant : 002769Microstructural white matter changes in primary torsion dystonia
Auteurs : Maren Carbon [États-Unis] ; Peter B. Kingsley [États-Unis] ; Chengke Tang [États-Unis] ; Susan Bressman [États-Unis] ; David Eidelberg [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-01-30.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adolescent, Adult, Basal ganglion, Brain Mapping, Cerebellum, Cerebral Cortex (pathology), Diffusion tensor, Dystonia, Dystonia Musculorum Deformans (pathology), Dystonia Musculorum Deformans (physiopathology), Female, Humans, Magnetic Resonance Imaging, Male, Motor control, Nervous system diseases, Neuroglia (pathology), Nuclear magnetic resonance imaging, Torsion, White matter, basal ganglia, brainstem, cerebellum, diffusion tensor MRI, motor control, primary dystonia, torsinA.
- MESH :
- pathology : Cerebral Cortex, Dystonia Musculorum Deformans, Neuroglia.
- physiopathology : Dystonia Musculorum Deformans.
- Adolescent, Adult, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male.
Abstract
Primary torsion dystonia (PTD) has been conceptualized as a disorder of the basal ganglia. However, recent data suggest a widespread pathology involving motor control pathways. In this report, we explored whether PTD is associated with abnormal anatomical connectivity within motor control pathways. We used diffusion tensor magnetic resonance imaging (DT‐MRI) to assess the microstructure of white matter. We found that fractional anisotropy, a measure of axonal integrity and coherence, was significantly reduced in PTD patients in the pontine brainstem in the vicinity of the left superior cerebellar peduncle and bilaterally in the white matter of the sensorimotor region. Our data thus support the possibility of a disturbance in cerebello‐thalamo‐cortical pathways as a cause of the clinical manifestations of PTD. © 2007 Movement Disorder Society
Url:
- https://api.istex.fr/document/DF1E333175E5129BD88A13823413C8CF7E414827/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456010
DOI: 10.1002/mds.21806
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001F46
- to stream Istex, to step Curation: 001F46
- to stream Istex, to step Checkpoint: 001324
- to stream Pmc, to step Corpus: 000199
- to stream Pmc, to step Curation: 000199
- to stream Pmc, to step Checkpoint: 000441
- to stream PubMed, to step Corpus: 002443
- to stream PubMed, to step Curation: 002443
- to stream PubMed, to step Checkpoint: 002219
- to stream Ncbi, to step Merge: 001F16
- to stream Ncbi, to step Curation: 001F16
- to stream Ncbi, to step Checkpoint: 001F16
- to stream Main, to step Merge: 003346
- to stream PascalFrancis, to step Corpus: 001386
- to stream PascalFrancis, to step Curation: 001933
- to stream PascalFrancis, to step Checkpoint: 001194
- to stream Main, to step Merge: 003802
- to stream Main, to step Curation: 002768
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Microstructural white matter changes in primary torsion dystonia</title><author><name sortKey="Carbon, Maren" sort="Carbon, Maren" uniqKey="Carbon M" first="Maren" last="Carbon">Maren Carbon</name></author><author><name sortKey="Kingsley, Peter B" sort="Kingsley, Peter B" uniqKey="Kingsley P" first="Peter B." last="Kingsley">Peter B. Kingsley</name></author><author><name sortKey="Tang, Chengke" sort="Tang, Chengke" uniqKey="Tang C" first="Chengke" last="Tang">Chengke Tang</name></author><author><name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name></author><author><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:DF1E333175E5129BD88A13823413C8CF7E414827</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1002/mds.21806</idno><idno type="url">https://api.istex.fr/document/DF1E333175E5129BD88A13823413C8CF7E414827/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001F46</idno><idno type="wicri:Area/Istex/Curation">001F46</idno><idno type="wicri:Area/Istex/Checkpoint">001324</idno><idno type="wicri:doubleKey">0885-3185:2008:Carbon M:microstructural:white:matter</idno><idno type="wicri:source">PMC</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456010</idno><idno type="RBID">PMC:4456010</idno><idno type="wicri:Area/Pmc/Corpus">000199</idno><idno type="wicri:Area/Pmc/Curation">000199</idno><idno type="wicri:Area/Pmc/Checkpoint">000441</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002443</idno><idno type="wicri:Area/PubMed/Curation">002443</idno><idno type="wicri:Area/PubMed/Checkpoint">002219</idno><idno type="wicri:Area/Ncbi/Merge">001F16</idno><idno type="wicri:Area/Ncbi/Curation">001F16</idno><idno type="wicri:Area/Ncbi/Checkpoint">001F16</idno><idno type="wicri:doubleKey">0885-3185:2008:Carbon M:microstructural:white:matter</idno><idno type="wicri:Area/Main/Merge">003346</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:08-0133666</idno><idno type="wicri:Area/PascalFrancis/Corpus">001386</idno><idno type="wicri:Area/PascalFrancis/Curation">001933</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001194</idno><idno type="wicri:doubleKey">0885-3185:2008:Carbon M:microstructural:white:matter</idno><idno type="wicri:Area/Main/Merge">003802</idno><idno type="wicri:Area/Main/Curation">002768</idno><idno type="wicri:Area/Main/Exploration">002768</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Microstructural white matter changes in primary torsion dystonia</title><author><name sortKey="Carbon, Maren" sort="Carbon, Maren" uniqKey="Carbon M" first="Maren" last="Carbon">Maren Carbon</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore‐Long Island Jewish Health System, Manhasset</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Departments of Neurology and Medicine, New York University School of Medicine, New York</wicri:cityArea></affiliation></author><author><name sortKey="Kingsley, Peter B" sort="Kingsley, Peter B" uniqKey="Kingsley P" first="Peter B." last="Kingsley">Peter B. Kingsley</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Radiology, North Shore University Hospital, Manhasset</wicri:cityArea></affiliation></author><author><name sortKey="Tang, Chengke" sort="Tang, Chengke" uniqKey="Tang C" first="Chengke" last="Tang">Chengke Tang</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore‐Long Island Jewish Health System, Manhasset</wicri:cityArea></affiliation></author><author><name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Neurology, Beth Israel Medical Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore‐Long Island Jewish Health System, Manhasset</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Departments of Neurology and Medicine, New York University School of Medicine, New York</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-01-30">2008-01-30</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="234">234</biblScope><biblScope unit="page" to="239">239</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">DF1E333175E5129BD88A13823413C8CF7E414827</idno><idno type="DOI">10.1002/mds.21806</idno><idno type="ArticleID">MDS21806</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Basal ganglion</term><term>Brain Mapping</term><term>Cerebellum</term><term>Cerebral Cortex (pathology)</term><term>Diffusion tensor</term><term>Dystonia</term><term>Dystonia Musculorum Deformans (pathology)</term><term>Dystonia Musculorum Deformans (physiopathology)</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Motor control</term><term>Nervous system diseases</term><term>Neuroglia (pathology)</term><term>Nuclear magnetic resonance imaging</term><term>Torsion</term><term>White matter</term><term>basal ganglia</term><term>brainstem</term><term>cerebellum</term><term>diffusion tensor MRI</term><term>motor control</term><term>primary dystonia</term><term>torsinA</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cerebral Cortex</term><term>Dystonia Musculorum Deformans</term><term>Neuroglia</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dystonia Musculorum Deformans</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cervelet</term><term>Contrôle moteur</term><term>Dystonie</term><term>Imagerie RMN</term><term>Noyau gris central</term><term>Pathologie du système nerveux</term><term>Substance blanche</term><term>Tenseur de diffusion</term><term>Torsion</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Primary torsion dystonia (PTD) has been conceptualized as a disorder of the basal ganglia. However, recent data suggest a widespread pathology involving motor control pathways. In this report, we explored whether PTD is associated with abnormal anatomical connectivity within motor control pathways. We used diffusion tensor magnetic resonance imaging (DT‐MRI) to assess the microstructure of white matter. We found that fractional anisotropy, a measure of axonal integrity and coherence, was significantly reduced in PTD patients in the pontine brainstem in the vicinity of the left superior cerebellar peduncle and bilaterally in the white matter of the sensorimotor region. Our data thus support the possibility of a disturbance in cerebello‐thalamo‐cortical pathways as a cause of the clinical manifestations of PTD. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Carbon, Maren" sort="Carbon, Maren" uniqKey="Carbon M" first="Maren" last="Carbon">Maren Carbon</name></region><name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name><name sortKey="Carbon, Maren" sort="Carbon, Maren" uniqKey="Carbon M" first="Maren" last="Carbon">Maren Carbon</name><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name><name sortKey="Kingsley, Peter B" sort="Kingsley, Peter B" uniqKey="Kingsley P" first="Peter B." last="Kingsley">Peter B. Kingsley</name><name sortKey="Tang, Chengke" sort="Tang, Chengke" uniqKey="Tang C" first="Chengke" last="Tang">Chengke Tang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002768 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002768 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:DF1E333175E5129BD88A13823413C8CF7E414827
|texte= Microstructural white matter changes in primary torsion dystonia
}}
| This area was generated with Dilib version V0.6.23. |  |