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Microstructural white matter changes in primary torsion dystonia.

Identifieur interne : 002219 ( PubMed/Checkpoint ); précédent : 002218; suivant : 002220

Microstructural white matter changes in primary torsion dystonia.

Auteurs : Maren Carbon [États-Unis] ; Peter B. Kingsley ; Chengke Tang ; Susan Bressman ; David Eidelberg

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.

RBID : pubmed:17999428

English descriptors

KwdEn :
- Adolescent, Adult, Brain Mapping, Cerebral Cortex (pathology), Dystonia Musculorum Deformans (pathology), Dystonia Musculorum Deformans (physiopathology), Female, Humans, Magnetic Resonance Imaging, Male, Neuroglia (pathology).
MESH :
- pathology : Cerebral Cortex, Dystonia Musculorum Deformans, Neuroglia.
- physiopathology : Dystonia Musculorum Deformans.
- Adolescent, Adult, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male.

Abstract

Primary torsion dystonia (PTD) has been conceptualized as a disorder of the basal ganglia. However, recent data suggest a widespread pathology involving motor control pathways. In this report, we explored whether PTD is associated with abnormal anatomical connectivity within motor control pathways. We used diffusion tensor magnetic resonance imaging (DT-MRI) to assess the microstructure of white matter. We found that fractional anisotropy, a measure of axonal integrity and coherence, was significantly reduced in PTD patients in the pontine brainstem in the vicinity of the left superior cerebellar peduncle and bilaterally in the white matter of the sensorimotor region. Our data thus support the possibility of a disturbance in cerebello-thalamo-cortical pathways as a cause of the clinical manifestations of PTD.

DOI: 10.1002/mds.21806
PubMed: 17999428

Affiliations:

États-Unis

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pubmed:17999428

Le document en format XML

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<author><name sortKey="Carbon, Maren" sort="Carbon, Maren" uniqKey="Carbon M" first="Maren" last="Carbon">Maren Carbon</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York 11030, USA. mcarbon@nshs.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York 11030</wicri:regionArea>
<wicri:noRegion>New York 11030</wicri:noRegion>
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<author><name sortKey="Kingsley, Peter B" sort="Kingsley, Peter B" uniqKey="Kingsley P" first="Peter B" last="Kingsley">Peter B. Kingsley</name>
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<author><name sortKey="Tang, Chengke" sort="Tang, Chengke" uniqKey="Tang C" first="Chengke" last="Tang">Chengke Tang</name>
</author>
<author><name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name>
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<author><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name>
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<term>Adult</term>
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<front><div type="abstract" xml:lang="en">Primary torsion dystonia (PTD) has been conceptualized as a disorder of the basal ganglia. However, recent data suggest a widespread pathology involving motor control pathways. In this report, we explored whether PTD is associated with abnormal anatomical connectivity within motor control pathways. We used diffusion tensor magnetic resonance imaging (DT-MRI) to assess the microstructure of white matter. We found that fractional anisotropy, a measure of axonal integrity and coherence, was significantly reduced in PTD patients in the pontine brainstem in the vicinity of the left superior cerebellar peduncle and bilaterally in the white matter of the sensorimotor region. Our data thus support the possibility of a disturbance in cerebello-thalamo-cortical pathways as a cause of the clinical manifestations of PTD.</div>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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<ArticleTitle>Microstructural white matter changes in primary torsion dystonia.</ArticleTitle>
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<Abstract><AbstractText>Primary torsion dystonia (PTD) has been conceptualized as a disorder of the basal ganglia. However, recent data suggest a widespread pathology involving motor control pathways. In this report, we explored whether PTD is associated with abnormal anatomical connectivity within motor control pathways. We used diffusion tensor magnetic resonance imaging (DT-MRI) to assess the microstructure of white matter. We found that fractional anisotropy, a measure of axonal integrity and coherence, was significantly reduced in PTD patients in the pontine brainstem in the vicinity of the left superior cerebellar peduncle and bilaterally in the white matter of the sensorimotor region. Our data thus support the possibility of a disturbance in cerebello-thalamo-cortical pathways as a cause of the clinical manifestations of PTD.</AbstractText>
<CopyrightInformation>2007 Movement Disorder Society</CopyrightInformation>
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<name sortKey="Kingsley, Peter B" sort="Kingsley, Peter B" uniqKey="Kingsley P" first="Peter B" last="Kingsley">Peter B. Kingsley</name>
<name sortKey="Tang, Chengke" sort="Tang, Chengke" uniqKey="Tang C" first="Chengke" last="Tang">Chengke Tang</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Microstructural white matter changes in primary torsion dystonia.

Microstructural white matter changes in primary torsion dystonia.

Source :

English descriptors

Abstract

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