Microstructural White Matter Changes in Primary Torsion Dystonia
Identifieur interne : 000441 ( Pmc/Checkpoint ); précédent : 000440; suivant : 000442Microstructural White Matter Changes in Primary Torsion Dystonia
Auteurs : Maren Carbon [États-Unis] ; Peter B. Kingsley [États-Unis] ; Chengke Tang [États-Unis] ; Susan Bressman [États-Unis] ; David Eidelberg [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2008.
Abstract
Primary torsion dystonia (PTD) has been conceptualized as a disorder of the basal ganglia. However, recent data suggest a widespread pathology involving motor control pathways. In this report, we explored whether PTD is associated with abnormal anatomical connectivity within motor control pathways. We used diffusion tensor magnetic resonance imaging (DT-MRI) to assess the microstructure of white matter. We found that fractional anisotropy, a measure of axonal integrity and coherence, was significantly reduced in PTD patients in the pontine brainstem in the vicinity of the left superior cerebellar peduncle and bilaterally in the white matter of the sensorimotor region. Our data thus support the possibility of a disturbance in cerebello-thalamo-cortical pathways as a cause of the clinical manifestations of PTD.
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DOI: 10.1002/mds.21806
PubMed: 17999428
PubMed Central: 4456010
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Kingsley</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Radiology, North Shore University Hospital, Manhasset, New York</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Radiology, North Shore University Hospital, Manhasset</wicri:cityArea></affiliation></author><author><name sortKey="Tang, Chengke" sort="Tang, Chengke" uniqKey="Tang C" first="Chengke" last="Tang">Chengke Tang</name><affiliation wicri:level="2"><nlm:aff id="A1">Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset</wicri:cityArea></affiliation></author><author><name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name><affiliation wicri:level="2"><nlm:aff id="A4">Department of Neurology, Beth Israel Medical Center, New York, New York</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Neurology, Beth Israel Medical Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name><affiliation wicri:level="2"><nlm:aff id="A1">Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Departments of Neurology and Medicine, New York University School of Medicine, New York, New York</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Departments of Neurology and Medicine, New York University School of Medicine, New York</wicri:cityArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Primary torsion dystonia (PTD) has been conceptualized as a disorder of the basal ganglia. However, recent data suggest a widespread pathology involving motor control pathways. In this report, we explored whether PTD is associated with abnormal anatomical connectivity within motor control pathways. We used diffusion tensor magnetic resonance imaging (DT-MRI) to assess the microstructure of white matter. We found that fractional anisotropy, a measure of axonal integrity and coherence, was significantly reduced in PTD patients in the pontine brainstem in the vicinity of the left superior cerebellar peduncle and bilaterally in the white matter of the sensorimotor region. Our data thus support the possibility of a disturbance in cerebello-thalamo-cortical pathways as a cause of the clinical manifestations of PTD.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id><journal-id journal-id-type="pubmed-jr-id">5937</journal-id><journal-id journal-id-type="nlm-ta">Mov Disord</journal-id><journal-id journal-id-type="iso-abbrev">Mov. Disord.</journal-id><journal-title-group><journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title></journal-title-group><issn pub-type="ppub">0885-3185</issn><issn pub-type="epub">1531-8257</issn></journal-meta><article-meta><article-id pub-id-type="pmid">17999428</article-id><article-id pub-id-type="pmc">4456010</article-id><article-id pub-id-type="doi">10.1002/mds.21806</article-id><article-id pub-id-type="manuscript">NIHMS57765</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Microstructural White Matter Changes in Primary Torsion Dystonia</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Carbon</surname><given-names>Maren</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Kingsley</surname><given-names>Peter B.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Tang</surname><given-names>Chengke</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Bressman</surname><given-names>Susan</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Eidelberg</surname><given-names>David</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York</aff><aff id="A2"><label>2</label>Departments of Neurology and Medicine, New York University School of Medicine, New York, New York</aff><aff id="A3"><label>3</label>Department of Radiology, North Shore University Hospital, Manhasset, New York</aff><aff id="A4"><label>4</label>Department of Neurology, Beth Israel Medical Center, New York, New York</aff><author-notes><corresp id="FN1"><label>*</label>Correspondence to: Dr. Carbon, Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, 350 Community Drive, Manhasset, New York 11030. <email>mcarbon@nshs.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>29</day><month>5</month><year>2015</year></pub-date><pub-date pub-type="ppub"><day>30</day><month>1</month><year>2008</year></pub-date><pub-date pub-type="pmc-release"><day>04</day><month>6</month><year>2015</year></pub-date><volume>23</volume><issue>2</issue><fpage>234</fpage><lpage>239</lpage><pmc-comment>elocation-id from pubmed: 10.1002/mds.21806</pmc-comment>
<permissions><copyright-statement>© 2007 Movement Disorder Society</copyright-statement><copyright-year>2007</copyright-year></permissions><abstract><p id="P1">Primary torsion dystonia (PTD) has been conceptualized as a disorder of the basal ganglia. However, recent data suggest a widespread pathology involving motor control pathways. In this report, we explored whether PTD is associated with abnormal anatomical connectivity within motor control pathways. We used diffusion tensor magnetic resonance imaging (DT-MRI) to assess the microstructure of white matter. We found that fractional anisotropy, a measure of axonal integrity and coherence, was significantly reduced in PTD patients in the pontine brainstem in the vicinity of the left superior cerebellar peduncle and bilaterally in the white matter of the sensorimotor region. Our data thus support the possibility of a disturbance in cerebello-thalamo-cortical pathways as a cause of the clinical manifestations of PTD.</p></abstract><kwd-group><kwd>diffusion tensor MRI</kwd><kwd>primary dystonia</kwd><kwd>motor control</kwd><kwd>cerebellum</kwd><kwd>brainstem</kwd><kwd>basal ganglia</kwd><kwd>torsinA</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Carbon, Maren" sort="Carbon, Maren" uniqKey="Carbon M" first="Maren" last="Carbon">Maren Carbon</name></region><name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name><name sortKey="Carbon, Maren" sort="Carbon, Maren" uniqKey="Carbon M" first="Maren" last="Carbon">Maren Carbon</name><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name><name sortKey="Kingsley, Peter B" sort="Kingsley, Peter B" uniqKey="Kingsley P" first="Peter B." last="Kingsley">Peter B. Kingsley</name><name sortKey="Tang, Chengke" sort="Tang, Chengke" uniqKey="Tang C" first="Chengke" last="Tang">Chengke Tang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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