Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease
Identifieur interne : 002D15 ( Main/Exploration ); précédent : 002D14; suivant : 002D16Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease
Auteurs : Kerrie L. Schoffer [Australie] ; Robert D. Henderson [Australie] ; Karen O'Maley [Australie] ; John D. O'Sullivan [Australie]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-08-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Anti-Inflammatory Agents (therapeutic use), Blood Pressure (drug effects), Blood Pressure (physiology), Cross-Over Studies, Domperidone, Domperidone (therapeutic use), Dopamine Antagonists (therapeutic use), Double-Blind Method, Female, Fludrocortisone, Fludrocortisone (therapeutic use), Humans, Hypotension, Orthostatic (diagnosis), Hypotension, Orthostatic (etiology), Hypotension, Orthostatic (therapy), Male, Middle Aged, Nervous system diseases, Parkinson Disease (complications), Parkinson Disease (therapy), Parkinson disease, Parkinson's disease, Patient Compliance, Postural hypotension, Retrospective Studies, Severity of Illness Index, Sphygmomanometers, Tilt-Table Test (methods), Treatment, domperidone, fludrocortisone, nonpharmacological therapy, orthostatic hypotension.
- MESH :
- chemical , therapeutic use : Anti-Inflammatory Agents, Domperidone, Dopamine Antagonists, Fludrocortisone.
- complications : Parkinson Disease.
- diagnosis : Hypotension, Orthostatic.
- drug effects : Blood Pressure.
- etiology : Hypotension, Orthostatic.
- methods : Tilt-Table Test.
- physiology : Blood Pressure.
- therapy : Hypotension, Orthostatic, Parkinson Disease.
- Aged, Aged, 80 and over, Cross-Over Studies, Double-Blind Method, Female, Humans, Male, Middle Aged, Patient Compliance, Retrospective Studies, Severity of Illness Index, Sphygmomanometers.
Abstract
There is limited evidence for the treatment of orthostatic hypotension in idiopathic Parkinson's disease. The objective of this study was to determine the efficacy of three treatments (nonpharmacological therapy, fludrocortisone, and domperidone). Phase I assessed the compliance, safety, and efficacy of nonpharmacological measures. Phase II was a double‐blind randomized controlled crossover trial of the two medications. Primary outcome measures consisted of the orthostatic domain of the Composite Autonomic Symptom Scale (COMPASS‐OD), a clinical global impression of change (CGI), and postural blood pressure testing via bedside sphygmomanometry (Phase I) or tilt table testing (Phase II). For the 17 patients studied, nonpharmacological therapy did not significantly alter any outcome measure. Both medications improved the CGI and COMPASS‐OD scores. There was a trend towards reduced blood pressure drop on tilt table testing, with domperidone having a greater effect. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21428
Affiliations:
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Le document en format XML
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The objective of this study was to determine the efficacy of three treatments (nonpharmacological therapy, fludrocortisone, and domperidone). Phase I assessed the compliance, safety, and efficacy of nonpharmacological measures. Phase II was a double‐blind randomized controlled crossover trial of the two medications. Primary outcome measures consisted of the orthostatic domain of the Composite Autonomic Symptom Scale (COMPASS‐OD), a clinical global impression of change (CGI), and postural blood pressure testing via bedside sphygmomanometry (Phase I) or tilt table testing (Phase II). For the 17 patients studied, nonpharmacological therapy did not significantly alter any outcome measure. Both medications improved the CGI and COMPASS‐OD scores. There was a trend towards reduced blood pressure drop on tilt table testing, with domperidone having a greater effect. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Schoffer, Kerrie L" sort="Schoffer, Kerrie L" uniqKey="Schoffer K" first="Kerrie L." last="Schoffer">Kerrie L. Schoffer</name></noRegion><name sortKey="Henderson, Robert D" sort="Henderson, Robert D" uniqKey="Henderson R" first="Robert D." last="Henderson">Robert D. Henderson</name><name sortKey="Henderson, Robert D" sort="Henderson, Robert D" uniqKey="Henderson R" first="Robert D." last="Henderson">Robert D. Henderson</name><name sortKey="O Maley, Karen" sort="O Maley, Karen" uniqKey="O Maley K" first="Karen" last="O'Maley">Karen O'Maley</name><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D." last="O'Sullivan">John D. O'Sullivan</name><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D." last="O'Sullivan">John D. O'Sullivan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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