MovDisordV3, PascalFrancis, Corpus, bibRecord, 001573

Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease

Identifieur interne : 001573 ( PascalFrancis/Corpus ); précédent : 001572; suivant : 001574

Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease

Auteurs : Kerrie L. Schoffer ; Robert D. Henderson ; Karen O'Maley ; John D. O'Sullivan

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0448787

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Hypotension artérielle orthostatique, Parkinson maladie, Traitement, Fludrocortisone, Dompéridone.

English descriptors

KwdEn :
- Domperidone, Fludrocortisone, Nervous system diseases, Parkinson disease, Postural hypotension, Treatment.

Abstract

There is limited evidence for the treatment of orthostatic hypotension in idiopathic Parkinson's disease. The objective of this study was to determine the efficacy of three treatments (nonpharmacological therapy, fludrocortisone, and domperidone). Phase I assessed the compliance, safety, and efficacy of nonpharmacological measures. Phase II was a double-blind randomized controlled crossover trial of the two medications. Primary outcome measures consisted of the orthostatic domain of the Composite Autonomic Symptom Scale (COMPASS-OD), a clinical global impression of change (CGI), and postural blood pressure testing via bedside sphygmomanometry (Phase I) or tilt table testing (Phase II). For the 17 patients studied, nonpharmacological therapy did not significantly alter any outcome measure. Both medications improved the CGI and COMPASS-OD scores. There was a trend towards reduced blood pressure drop on tilt table testing, with domperidone having a greater effect.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`01`	`1`		`@1 SCHOFFER (Kerrie L.)`
A11	`02`	`1`		`@1 HENDERSON (Robert D.)`
A11	`03`	`1`		`@1 O'MALEY (Karen)`
A11	`04`	`1`		`@1 O'SULLIVAN (John D.)`
A14	`01`			`@1 Department of Neurology, Royal Brisbane and Women's Hospital @2 Brisbane, Queensland @3 AUS @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut.`
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A44				`@0 0000 @1 © 2007 INIST-CNRS. All rights reserved.`
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C01	`01`		`ENG`	@0 There is limited evidence for the treatment of orthostatic hypotension in idiopathic Parkinson's disease. The objective of this study was to determine the efficacy of three treatments (nonpharmacological therapy, fludrocortisone, and domperidone). Phase I assessed the compliance, safety, and efficacy of nonpharmacological measures. Phase II was a double-blind randomized controlled crossover trial of the two medications. Primary outcome measures consisted of the orthostatic domain of the Composite Autonomic Symptom Scale (COMPASS-OD), a clinical global impression of change (CGI), and postural blood pressure testing via bedside sphygmomanometry (Phase I) or tilt table testing (Phase II). For the 17 patients studied, nonpharmacological therapy did not significantly alter any outcome measure. Both medications improved the CGI and COMPASS-OD scores. There was a trend towards reduced blood pressure drop on tilt table testing, with domperidone having a greater effect.
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C07	`02`	`X`	`FRE`	`@0 Système nerveux autonome pathologie @5 38`
C07	`02`	`X`	`ENG`	`@0 Diseases of the autonomic nervous system @5 38`
C07	`02`	`X`	`SPA`	`@0 Sistema nervioso autónomo patología @5 38`
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Format Inist (serveur)

NO :	PASCAL 07-0448787 INIST
ET :	Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease
AU :	SCHOFFER (Kerrie L.); HENDERSON (Robert D.); O'MALEY (Karen); O'SULLIVAN (John D.)
AF :	Department of Neurology, Royal Brisbane and Women's Hospital/Brisbane, Queensland/Australie (1 aut., 2 aut., 3 aut., 4 aut.); Department of Medicine, University of Queensland/Brisbane, Queensland/Australie (2 aut., 4 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 11; Pp. 1543-1549; Bibl. 33 ref.
LA :	Anglais
EA :	There is limited evidence for the treatment of orthostatic hypotension in idiopathic Parkinson's disease. The objective of this study was to determine the efficacy of three treatments (nonpharmacological therapy, fludrocortisone, and domperidone). Phase I assessed the compliance, safety, and efficacy of nonpharmacological measures. Phase II was a double-blind randomized controlled crossover trial of the two medications. Primary outcome measures consisted of the orthostatic domain of the Composite Autonomic Symptom Scale (COMPASS-OD), a clinical global impression of change (CGI), and postural blood pressure testing via bedside sphygmomanometry (Phase I) or tilt table testing (Phase II). For the 17 patients studied, nonpharmacological therapy did not significantly alter any outcome measure. Both medications improved the CGI and COMPASS-OD scores. There was a trend towards reduced blood pressure drop on tilt table testing, with domperidone having a greater effect.
CC :	002B17; 002B17G; 002B17A03
FD :	Système nerveux pathologie; Hypotension artérielle orthostatique; Parkinson maladie; Traitement; Fludrocortisone; Dompéridone
FG :	Appareil circulatoire pathologie; Système nerveux autonome pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie
ED :	Nervous system diseases; Postural hypotension; Parkinson disease; Treatment; Fludrocortisone; Domperidone
EG :	Cardiovascular disease; Diseases of the autonomic nervous system; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Sistema nervioso patología; Hipotensión arterial ortostática; Parkinson enfermedad; Tratamiento; Fludrocortisona; Domperidona
LO :	INIST-20953.354000149744800040
ID :	07-0448787

Links to Exploration step

Pascal:07-0448787

Le document en format XML

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<front><div type="abstract" xml:lang="en">There is limited evidence for the treatment of orthostatic hypotension in idiopathic Parkinson's disease. The objective of this study was to determine the efficacy of three treatments (nonpharmacological therapy, fludrocortisone, and domperidone). Phase I assessed the compliance, safety, and efficacy of nonpharmacological measures. Phase II was a double-blind randomized controlled crossover trial of the two medications. Primary outcome measures consisted of the orthostatic domain of the Composite Autonomic Symptom Scale (COMPASS-OD), a clinical global impression of change (CGI), and postural blood pressure testing via bedside sphygmomanometry (Phase I) or tilt table testing (Phase II). For the 17 patients studied, nonpharmacological therapy did not significantly alter any outcome measure. Both medications improved the CGI and COMPASS-OD scores. There was a trend towards reduced blood pressure drop on tilt table testing, with domperidone having a greater effect.</div>
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</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cardiovascular disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Aparato circulatorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux autonome pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Diseases of the autonomic nervous system</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervioso autónomo patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>42</s5>
</fC07>
<fN21><s1>295</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
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<server><NO>PASCAL 07-0448787 INIST</NO>
<ET>Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease</ET>
<AU>SCHOFFER (Kerrie L.); HENDERSON (Robert D.); O'MALEY (Karen); O'SULLIVAN (John D.)</AU>
<AF>Department of Neurology, Royal Brisbane and Women's Hospital/Brisbane, Queensland/Australie (1 aut., 2 aut., 3 aut., 4 aut.); Department of Medicine, University of Queensland/Brisbane, Queensland/Australie (2 aut., 4 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 11; Pp. 1543-1549; Bibl. 33 ref.</SO>
<LA>Anglais</LA>
<EA>There is limited evidence for the treatment of orthostatic hypotension in idiopathic Parkinson's disease. The objective of this study was to determine the efficacy of three treatments (nonpharmacological therapy, fludrocortisone, and domperidone). Phase I assessed the compliance, safety, and efficacy of nonpharmacological measures. Phase II was a double-blind randomized controlled crossover trial of the two medications. Primary outcome measures consisted of the orthostatic domain of the Composite Autonomic Symptom Scale (COMPASS-OD), a clinical global impression of change (CGI), and postural blood pressure testing via bedside sphygmomanometry (Phase I) or tilt table testing (Phase II). For the 17 patients studied, nonpharmacological therapy did not significantly alter any outcome measure. Both medications improved the CGI and COMPASS-OD scores. There was a trend towards reduced blood pressure drop on tilt table testing, with domperidone having a greater effect.</EA>
<CC>002B17; 002B17G; 002B17A03</CC>
<FD>Système nerveux pathologie; Hypotension artérielle orthostatique; Parkinson maladie; Traitement; Fludrocortisone; Dompéridone</FD>
<FG>Appareil circulatoire pathologie; Système nerveux autonome pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie</FG>
<ED>Nervous system diseases; Postural hypotension; Parkinson disease; Treatment; Fludrocortisone; Domperidone</ED>
<EG>Cardiovascular disease; Diseases of the autonomic nervous system; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Sistema nervioso patología; Hipotensión arterial ortostática; Parkinson enfermedad; Tratamiento; Fludrocortisona; Domperidona</SD>
<LO>INIST-20953.354000149744800040</LO>
<ID>07-0448787</ID>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease

Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease

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