MovDisordV3, Main, Merge, bibRecord, 004154

Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease

Identifieur interne : 004154 ( Main/Merge ); précédent : 004153; suivant : 004155

Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease

Auteurs : Kerrie L. Schoffer [Australie] ; Robert D. Henderson [Australie] ; Karen O'Maley [Australie] ; John D. O'Sullivan [Australie]

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0448787

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Hypotension artérielle orthostatique, Parkinson maladie, Traitement, Fludrocortisone, Dompéridone.

English descriptors

KwdEn :
- Domperidone, Fludrocortisone, Nervous system diseases, Parkinson disease, Postural hypotension, Treatment.

Abstract

There is limited evidence for the treatment of orthostatic hypotension in idiopathic Parkinson's disease. The objective of this study was to determine the efficacy of three treatments (nonpharmacological therapy, fludrocortisone, and domperidone). Phase I assessed the compliance, safety, and efficacy of nonpharmacological measures. Phase II was a double-blind randomized controlled crossover trial of the two medications. Primary outcome measures consisted of the orthostatic domain of the Composite Autonomic Symptom Scale (COMPASS-OD), a clinical global impression of change (CGI), and postural blood pressure testing via bedside sphygmomanometry (Phase I) or tilt table testing (Phase II). For the 17 patients studied, nonpharmacological therapy did not significantly alter any outcome measure. Both medications improved the CGI and COMPASS-OD scores. There was a trend towards reduced blood pressure drop on tilt table testing, with domperidone having a greater effect.

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Pascal:07-0448787

Le document en format XML

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<front><div type="abstract" xml:lang="en">There is limited evidence for the treatment of orthostatic hypotension in idiopathic Parkinson's disease. The objective of this study was to determine the efficacy of three treatments (nonpharmacological therapy, fludrocortisone, and domperidone). Phase I assessed the compliance, safety, and efficacy of nonpharmacological measures. Phase II was a double-blind randomized controlled crossover trial of the two medications. Primary outcome measures consisted of the orthostatic domain of the Composite Autonomic Symptom Scale (COMPASS-OD), a clinical global impression of change (CGI), and postural blood pressure testing via bedside sphygmomanometry (Phase I) or tilt table testing (Phase II). For the 17 patients studied, nonpharmacological therapy did not significantly alter any outcome measure. Both medications improved the CGI and COMPASS-OD scores. There was a trend towards reduced blood pressure drop on tilt table testing, with domperidone having a greater effect.</div>
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<name sortKey="Henderson, Robert D" sort="Henderson, Robert D" uniqKey="Henderson R" first="Robert D." last="Henderson">Robert D. Henderson</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease

Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri