Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease
Identifieur interne : 004154 ( Main/Merge ); précédent : 004153; suivant : 004155Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease
Auteurs : Kerrie L. Schoffer [Australie] ; Robert D. Henderson [Australie] ; Karen O'Maley [Australie] ; John D. O'Sullivan [Australie]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
There is limited evidence for the treatment of orthostatic hypotension in idiopathic Parkinson's disease. The objective of this study was to determine the efficacy of three treatments (nonpharmacological therapy, fludrocortisone, and domperidone). Phase I assessed the compliance, safety, and efficacy of nonpharmacological measures. Phase II was a double-blind randomized controlled crossover trial of the two medications. Primary outcome measures consisted of the orthostatic domain of the Composite Autonomic Symptom Scale (COMPASS-OD), a clinical global impression of change (CGI), and postural blood pressure testing via bedside sphygmomanometry (Phase I) or tilt table testing (Phase II). For the 17 patients studied, nonpharmacological therapy did not significantly alter any outcome measure. Both medications improved the CGI and COMPASS-OD scores. There was a trend towards reduced blood pressure drop on tilt table testing, with domperidone having a greater effect.
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 001573
- to stream PascalFrancis, to step Curation: 001748
- to stream PascalFrancis, to step Checkpoint: 001564
Links to Exploration step
Pascal:07-0448787Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease</title>
<author><name sortKey="Schoffer, Kerrie L" sort="Schoffer, Kerrie L" uniqKey="Schoffer K" first="Kerrie L." last="Schoffer">Kerrie L. Schoffer</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Royal Brisbane and Women's Hospital</s1>
<s2>Brisbane, Queensland</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane, Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Henderson, Robert D" sort="Henderson, Robert D" uniqKey="Henderson R" first="Robert D." last="Henderson">Robert D. Henderson</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Royal Brisbane and Women's Hospital</s1>
<s2>Brisbane, Queensland</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane, Queensland</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medicine, University of Queensland</s1>
<s2>Brisbane, Queensland</s2>
<s3>AUS</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane, Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="O Maley, Karen" sort="O Maley, Karen" uniqKey="O Maley K" first="Karen" last="O'Maley">Karen O'Maley</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Royal Brisbane and Women's Hospital</s1>
<s2>Brisbane, Queensland</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane, Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D." last="O'Sullivan">John D. O'Sullivan</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Royal Brisbane and Women's Hospital</s1>
<s2>Brisbane, Queensland</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane, Queensland</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medicine, University of Queensland</s1>
<s2>Brisbane, Queensland</s2>
<s3>AUS</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane, Queensland</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">07-0448787</idno>
<date when="2007">2007</date>
<idno type="stanalyst">PASCAL 07-0448787 INIST</idno>
<idno type="RBID">Pascal:07-0448787</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001573</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001748</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001564</idno>
<idno type="wicri:doubleKey">0885-3185:2007:Schoffer K:nonpharmacological:treatment:fludrocortisone</idno>
<idno type="wicri:Area/Main/Merge">004154</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease</title>
<author><name sortKey="Schoffer, Kerrie L" sort="Schoffer, Kerrie L" uniqKey="Schoffer K" first="Kerrie L." last="Schoffer">Kerrie L. Schoffer</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Royal Brisbane and Women's Hospital</s1>
<s2>Brisbane, Queensland</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane, Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Henderson, Robert D" sort="Henderson, Robert D" uniqKey="Henderson R" first="Robert D." last="Henderson">Robert D. Henderson</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Royal Brisbane and Women's Hospital</s1>
<s2>Brisbane, Queensland</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane, Queensland</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medicine, University of Queensland</s1>
<s2>Brisbane, Queensland</s2>
<s3>AUS</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane, Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="O Maley, Karen" sort="O Maley, Karen" uniqKey="O Maley K" first="Karen" last="O'Maley">Karen O'Maley</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Royal Brisbane and Women's Hospital</s1>
<s2>Brisbane, Queensland</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane, Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D." last="O'Sullivan">John D. O'Sullivan</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Royal Brisbane and Women's Hospital</s1>
<s2>Brisbane, Queensland</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane, Queensland</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medicine, University of Queensland</s1>
<s2>Brisbane, Queensland</s2>
<s3>AUS</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane, Queensland</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Domperidone</term>
<term>Fludrocortisone</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Postural hypotension</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Hypotension artérielle orthostatique</term>
<term>Parkinson maladie</term>
<term>Traitement</term>
<term>Fludrocortisone</term>
<term>Dompéridone</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">There is limited evidence for the treatment of orthostatic hypotension in idiopathic Parkinson's disease. The objective of this study was to determine the efficacy of three treatments (nonpharmacological therapy, fludrocortisone, and domperidone). Phase I assessed the compliance, safety, and efficacy of nonpharmacological measures. Phase II was a double-blind randomized controlled crossover trial of the two medications. Primary outcome measures consisted of the orthostatic domain of the Composite Autonomic Symptom Scale (COMPASS-OD), a clinical global impression of change (CGI), and postural blood pressure testing via bedside sphygmomanometry (Phase I) or tilt table testing (Phase II). For the 17 patients studied, nonpharmacological therapy did not significantly alter any outcome measure. Both medications improved the CGI and COMPASS-OD scores. There was a trend towards reduced blood pressure drop on tilt table testing, with domperidone having a greater effect.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
</country>
</list>
<tree><country name="Australie"><noRegion><name sortKey="Schoffer, Kerrie L" sort="Schoffer, Kerrie L" uniqKey="Schoffer K" first="Kerrie L." last="Schoffer">Kerrie L. Schoffer</name>
</noRegion>
<name sortKey="Henderson, Robert D" sort="Henderson, Robert D" uniqKey="Henderson R" first="Robert D." last="Henderson">Robert D. Henderson</name>
<name sortKey="Henderson, Robert D" sort="Henderson, Robert D" uniqKey="Henderson R" first="Robert D." last="Henderson">Robert D. Henderson</name>
<name sortKey="O Maley, Karen" sort="O Maley, Karen" uniqKey="O Maley K" first="Karen" last="O'Maley">Karen O'Maley</name>
<name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D." last="O'Sullivan">John D. O'Sullivan</name>
<name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D." last="O'Sullivan">John D. O'Sullivan</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004154 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 004154 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Merge |type= RBID |clé= Pascal:07-0448787 |texte= Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |