Novel observations with FDOPA‐PET imaging after early nigrostriatal damage
Identifieur interne : 004737 ( Main/Exploration ); précédent : 004736; suivant : 004738Novel observations with FDOPA‐PET imaging after early nigrostriatal damage
Auteurs : R. E. Yee [États-Unis] ; I. Irwin [États-Unis] ; C. Milonas [Suède] ; D. B. Stout [États-Unis] ; S-C. Huang [États-Unis] ; K. Shoghi-Jadid [États-Unis] ; N. Satyamurthy [États-Unis] ; L. E. Delanney [États-Unis] ; D. M. Togasaki [États-Unis] ; K. F. Farahani [États-Unis] ; K. Delfani [États-Unis] ; A. M. Janson [Suède] ; M. E. Phelps [États-Unis] ; J. W. Langston [États-Unis] ; J. R. Barrio [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2001-09.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Singe.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, 6‐[F18]fluoro‐L‐DOPA, Animal, Animal model, Animals, Asymptomatic, Clinical stage, Corpus Striatum (metabolism), Corpus Striatum (pathology), Dihydroxyphenylalanine (analogs & derivatives), Dihydroxyphenylalanine (diagnostic use), Disease Models, Animal, Dopamine (deficiency), Dopaminergic neuron, Evolution, Female, Fluorine Radioisotopes (diagnostic use), Fluorodopa(18F), Kinetics, Locus niger, Male, Monkey, Neural Pathways, Neurotoxins, Parkinson disease, Parkinson's disease, Parkinsonian Disorders (chemically induced), Parkinsonian Disorders (metabolism), Parkinsonian Disorders (pathology), Parkinsonian Disorders (radionuclide imaging), Positron emission tomography, Saimiri, Stereology, Substantia Nigra (metabolism), Substantia Nigra (pathology), Tomography, Emission-Computed, optical fractionator, positron emission tomography, squirrel monkeys, stereology.
- MESH :
- chemical , analogs & derivatives : Dihydroxyphenylalanine.
- chemical , deficiency : Dopamine.
- chemical , diagnostic use : Dihydroxyphenylalanine, Fluorine Radioisotopes.
- chemical : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Neurotoxins.
- chemically induced : Parkinsonian Disorders.
- metabolism : Corpus Striatum, Parkinsonian Disorders, Substantia Nigra.
- pathology : Corpus Striatum, Parkinsonian Disorders, Substantia Nigra.
- radionuclide imaging : Parkinsonian Disorders.
- Animals, Disease Models, Animal, Female, Male, Neural Pathways, Saimiri, Tomography, Emission-Computed.
Abstract
Striatal 6‐[18F]fluoro‐L‐DOPA (FDOPA) kinetic rate constants were measured by positron emission tomography (PET) in 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐treated squirrel monkeys. After scanning, stereological counts of dopaminergic neurons were done in substantia nigra, and dopamine (DA) and metabolite concentrations were determined in the caudate, putamen, and substantia nigra. Graded doses of MPTP produced animals with mild to moderate reductions (10–35%) in dopaminergic neurons, where the percent of cell loss was proportional to the amount of MPTP given. Striatal DA and metabolite concentrations were relatively unchanged in animals given 1.0 and 1.5 mg/kg of MPTP, but were significantly reduced after 2.0 mg/kg of MPTP. All animals injected with a single dose of MPTP showed no overt signs of parkinsonism. In contrast, DA and metabolite concentrations in the substantia nigra were significantly reduced for all MPTP‐treated animals. Reduction of dopaminergic indices in the substantia nigra did not parallel reductions in the striatum, indicating differential sensitivity of the nigrostriatal pathway to the neurotoxic effects of MPTP. The percent change in FDOPA uptake (Ki) and decarboyxlation (k3) after MPTP showed significant positive correlations to striatal DA levels, but not to the number of dopaminergic neurons. This suggests that FDOPA is a good index of striatal DA levels. © 2001 Movement Disorder Society.
Url:
DOI: 10.1002/mds.1168
Affiliations:
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E." last="Yee">R. E. Yee</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Irwin, I" sort="Irwin, I" uniqKey="Irwin I" first="I." last="Irwin">I. Irwin</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Parkinson's Institute, Sunnyvale, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Milonas, C" sort="Milonas, C" uniqKey="Milonas C" first="C." last="Milonas">C. Milonas</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neuroscience, Karolinska Institute, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Stout, D B" sort="Stout, D B" uniqKey="Stout D" first="D. B." last="Stout">D. B. Stout</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Huang, S" sort="Huang, S" uniqKey="Huang S" first="S-C." last="Huang">S-C. Huang</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomathematics, UCLA School of Medicine, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Shoghi Adid, K" sort="Shoghi Adid, K" uniqKey="Shoghi Adid K" first="K." last="Shoghi-Jadid">K. Shoghi-Jadid</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomathematics, UCLA School of Medicine, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Satyamurthy, N" sort="Satyamurthy, N" uniqKey="Satyamurthy N" first="N." last="Satyamurthy">N. Satyamurthy</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Delanney, L E" sort="Delanney, L E" uniqKey="Delanney L" first="L. E." last="Delanney">L. E. Delanney</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Parkinson's Institute, Sunnyvale, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Togasaki, D M" sort="Togasaki, D M" uniqKey="Togasaki D" first="D. M." last="Togasaki">D. M. Togasaki</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Parkinson's Institute, Sunnyvale, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Farahani, K F" sort="Farahani, K F" uniqKey="Farahani K" first="K. F." last="Farahani">K. F. Farahani</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiological Sciences, UCLA School of Medicine, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Delfani, K" sort="Delfani, K" uniqKey="Delfani K" first="K." last="Delfani">K. Delfani</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Janson, A M" sort="Janson, A M" uniqKey="Janson A" first="A. M." last="Janson">A. M. Janson</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neuroscience, Karolinska Institute, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Phelps, M E" sort="Phelps, M E" uniqKey="Phelps M" first="M. E." last="Phelps">M. E. Phelps</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Langston, J W" sort="Langston, J W" uniqKey="Langston J" first="J. W." last="Langston">J. W. Langston</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Parkinson's Institute, Sunnyvale, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Barrio, J R" sort="Barrio, J R" uniqKey="Barrio J" first="J. R." last="Barrio">J. R. Barrio</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2001-09">2001-09</date><biblScope unit="vol">16</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="838">838</biblScope><biblScope unit="page" to="848">848</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">30BF6B3FD3C05C2EEA0624BCFD1583FA06C06E27</idno><idno type="DOI">10.1002/mds.1168</idno><idno type="ArticleID">MDS1168</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term><term>6‐[F18]fluoro‐L‐DOPA</term><term>Animal</term><term>Animal model</term><term>Animals</term><term>Asymptomatic</term><term>Clinical stage</term><term>Corpus Striatum (metabolism)</term><term>Corpus Striatum (pathology)</term><term>Dihydroxyphenylalanine (analogs & derivatives)</term><term>Dihydroxyphenylalanine (diagnostic use)</term><term>Disease Models, Animal</term><term>Dopamine (deficiency)</term><term>Dopaminergic neuron</term><term>Evolution</term><term>Female</term><term>Fluorine Radioisotopes (diagnostic use)</term><term>Fluorodopa(18F)</term><term>Kinetics</term><term>Locus niger</term><term>Male</term><term>Monkey</term><term>Neural Pathways</term><term>Neurotoxins</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Parkinsonian Disorders (chemically induced)</term><term>Parkinsonian Disorders (metabolism)</term><term>Parkinsonian Disorders (pathology)</term><term>Parkinsonian Disorders (radionuclide imaging)</term><term>Positron emission tomography</term><term>Saimiri</term><term>Stereology</term><term>Substantia Nigra (metabolism)</term><term>Substantia Nigra (pathology)</term><term>Tomography, Emission-Computed</term><term>optical fractionator</term><term>positron emission tomography</term><term>squirrel monkeys</term><term>stereology</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Dihydroxyphenylalanine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Dihydroxyphenylalanine</term><term>Fluorine Radioisotopes</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term><term>Neurotoxins</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term><term>Parkinsonian Disorders</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Corpus Striatum</term><term>Parkinsonian Disorders</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Male</term><term>Neural Pathways</term><term>Saimiri</term><term>Tomography, Emission-Computed</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Animal</term><term>Asymptomatique</term><term>Cinétique</term><term>Evolution</term><term>Fluorodopa(18F)</term><term>Locus niger</term><term>Modèle animal</term><term>Neurone dopaminergique</term><term>Parkinson maladie</term><term>Singe</term><term>Stade clinique</term><term>Stéréologie</term><term>Tomographie émission positon</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Singe</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Striatal 6‐[18F]fluoro‐L‐DOPA (FDOPA) kinetic rate constants were measured by positron emission tomography (PET) in 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐treated squirrel monkeys. After scanning, stereological counts of dopaminergic neurons were done in substantia nigra, and dopamine (DA) and metabolite concentrations were determined in the caudate, putamen, and substantia nigra. Graded doses of MPTP produced animals with mild to moderate reductions (10–35%) in dopaminergic neurons, where the percent of cell loss was proportional to the amount of MPTP given. Striatal DA and metabolite concentrations were relatively unchanged in animals given 1.0 and 1.5 mg/kg of MPTP, but were significantly reduced after 2.0 mg/kg of MPTP. All animals injected with a single dose of MPTP showed no overt signs of parkinsonism. In contrast, DA and metabolite concentrations in the substantia nigra were significantly reduced for all MPTP‐treated animals. Reduction of dopaminergic indices in the substantia nigra did not parallel reductions in the striatum, indicating differential sensitivity of the nigrostriatal pathway to the neurotoxic effects of MPTP. The percent change in FDOPA uptake (Ki) and decarboyxlation (k3) after MPTP showed significant positive correlations to striatal DA levels, but not to the number of dopaminergic neurons. This suggests that FDOPA is a good index of striatal DA levels. © 2001 Movement Disorder Society.</div></front></TEI><affiliations><list><country><li>Suède</li><li>États-Unis</li></country><region><li>Californie</li><li>Svealand</li></region><settlement><li>Stockholm</li></settlement></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Yee, R E" sort="Yee, R E" uniqKey="Yee R" first="R. E." last="Yee">R. E. Yee</name></region><name sortKey="Barrio, J R" sort="Barrio, J R" uniqKey="Barrio J" first="J. R." last="Barrio">J. R. Barrio</name><name sortKey="Delanney, L E" sort="Delanney, L E" uniqKey="Delanney L" first="L. E." last="Delanney">L. E. Delanney</name><name sortKey="Delfani, K" sort="Delfani, K" uniqKey="Delfani K" first="K." last="Delfani">K. Delfani</name><name sortKey="Farahani, K F" sort="Farahani, K F" uniqKey="Farahani K" first="K. F." last="Farahani">K. F. Farahani</name><name sortKey="Huang, S" sort="Huang, S" uniqKey="Huang S" first="S-C." last="Huang">S-C. Huang</name><name sortKey="Huang, S" sort="Huang, S" uniqKey="Huang S" first="S-C." last="Huang">S-C. Huang</name><name sortKey="Irwin, I" sort="Irwin, I" uniqKey="Irwin I" first="I." last="Irwin">I. Irwin</name><name sortKey="Langston, J W" sort="Langston, J W" uniqKey="Langston J" first="J. W." last="Langston">J. W. Langston</name><name sortKey="Phelps, M E" sort="Phelps, M E" uniqKey="Phelps M" first="M. E." last="Phelps">M. E. Phelps</name><name sortKey="Satyamurthy, N" sort="Satyamurthy, N" uniqKey="Satyamurthy N" first="N." last="Satyamurthy">N. Satyamurthy</name><name sortKey="Shoghi Adid, K" sort="Shoghi Adid, K" uniqKey="Shoghi Adid K" first="K." last="Shoghi-Jadid">K. Shoghi-Jadid</name><name sortKey="Stout, D B" sort="Stout, D B" uniqKey="Stout D" first="D. B." last="Stout">D. B. Stout</name><name sortKey="Togasaki, D M" sort="Togasaki, D M" uniqKey="Togasaki D" first="D. M." last="Togasaki">D. M. Togasaki</name></country><country name="Suède"><region name="Svealand"><name sortKey="Milonas, C" sort="Milonas, C" uniqKey="Milonas C" first="C." last="Milonas">C. Milonas</name></region><name sortKey="Janson, A M" sort="Janson, A M" uniqKey="Janson A" first="A. M." last="Janson">A. M. Janson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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