Novel observations with FDOPA‐PET imaging after early nigrostriatal damage
Identifieur interne : 004737 ( Main/Exploration ); précédent : 004736; suivant : 004738Novel observations with FDOPA‐PET imaging after early nigrostriatal damage
Auteurs : R. E. Yee [États-Unis] ; I. Irwin [États-Unis] ; C. Milonas [Suède] ; D. B. Stout [États-Unis] ; S-C. Huang [États-Unis] ; K. Shoghi-Jadid [États-Unis] ; N. Satyamurthy [États-Unis] ; L. E. Delanney [États-Unis] ; D. M. Togasaki [États-Unis] ; K. F. Farahani [États-Unis] ; K. Delfani [États-Unis] ; A. M. Janson [Suède] ; M. E. Phelps [États-Unis] ; J. W. Langston [États-Unis] ; J. R. Barrio [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2001-09.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Singe.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, 6‐[F18]fluoro‐L‐DOPA, Animal, Animal model, Animals, Asymptomatic, Clinical stage, Corpus Striatum (metabolism), Corpus Striatum (pathology), Dihydroxyphenylalanine (analogs & derivatives), Dihydroxyphenylalanine (diagnostic use), Disease Models, Animal, Dopamine (deficiency), Dopaminergic neuron, Evolution, Female, Fluorine Radioisotopes (diagnostic use), Fluorodopa(18F), Kinetics, Locus niger, Male, Monkey, Neural Pathways, Neurotoxins, Parkinson disease, Parkinson's disease, Parkinsonian Disorders (chemically induced), Parkinsonian Disorders (metabolism), Parkinsonian Disorders (pathology), Parkinsonian Disorders (radionuclide imaging), Positron emission tomography, Saimiri, Stereology, Substantia Nigra (metabolism), Substantia Nigra (pathology), Tomography, Emission-Computed, optical fractionator, positron emission tomography, squirrel monkeys, stereology.
- MESH :
- chemical , analogs & derivatives : Dihydroxyphenylalanine.
- chemical , deficiency : Dopamine.
- chemical , diagnostic use : Dihydroxyphenylalanine, Fluorine Radioisotopes.
- chemical : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Neurotoxins.
- chemically induced : Parkinsonian Disorders.
- metabolism : Corpus Striatum, Parkinsonian Disorders, Substantia Nigra.
- pathology : Corpus Striatum, Parkinsonian Disorders, Substantia Nigra.
- radionuclide imaging : Parkinsonian Disorders.
- Animals, Disease Models, Animal, Female, Male, Neural Pathways, Saimiri, Tomography, Emission-Computed.
Abstract
Striatal 6‐[18F]fluoro‐L‐DOPA (FDOPA) kinetic rate constants were measured by positron emission tomography (PET) in 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐treated squirrel monkeys. After scanning, stereological counts of dopaminergic neurons were done in substantia nigra, and dopamine (DA) and metabolite concentrations were determined in the caudate, putamen, and substantia nigra. Graded doses of MPTP produced animals with mild to moderate reductions (10–35%) in dopaminergic neurons, where the percent of cell loss was proportional to the amount of MPTP given. Striatal DA and metabolite concentrations were relatively unchanged in animals given 1.0 and 1.5 mg/kg of MPTP, but were significantly reduced after 2.0 mg/kg of MPTP. All animals injected with a single dose of MPTP showed no overt signs of parkinsonism. In contrast, DA and metabolite concentrations in the substantia nigra were significantly reduced for all MPTP‐treated animals. Reduction of dopaminergic indices in the substantia nigra did not parallel reductions in the striatum, indicating differential sensitivity of the nigrostriatal pathway to the neurotoxic effects of MPTP. The percent change in FDOPA uptake (Ki) and decarboyxlation (k3) after MPTP showed significant positive correlations to striatal DA levels, but not to the number of dopaminergic neurons. This suggests that FDOPA is a good index of striatal DA levels. © 2001 Movement Disorder Society.
Url:
DOI: 10.1002/mds.1168
Affiliations:
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Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term>
<term>6‐[F18]fluoro‐L‐DOPA</term>
<term>Animal</term>
<term>Animal model</term>
<term>Animals</term>
<term>Asymptomatic</term>
<term>Clinical stage</term>
<term>Corpus Striatum (metabolism)</term>
<term>Corpus Striatum (pathology)</term>
<term>Dihydroxyphenylalanine (analogs & derivatives)</term>
<term>Dihydroxyphenylalanine (diagnostic use)</term>
<term>Disease Models, Animal</term>
<term>Dopamine (deficiency)</term>
<term>Dopaminergic neuron</term>
<term>Evolution</term>
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<term>Fluorine Radioisotopes (diagnostic use)</term>
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<term>Parkinsonian Disorders (chemically induced)</term>
<term>Parkinsonian Disorders (metabolism)</term>
<term>Parkinsonian Disorders (pathology)</term>
<term>Parkinsonian Disorders (radionuclide imaging)</term>
<term>Positron emission tomography</term>
<term>Saimiri</term>
<term>Stereology</term>
<term>Substantia Nigra (metabolism)</term>
<term>Substantia Nigra (pathology)</term>
<term>Tomography, Emission-Computed</term>
<term>optical fractionator</term>
<term>positron emission tomography</term>
<term>squirrel monkeys</term>
<term>stereology</term>
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<front><div type="abstract" xml:lang="en">Striatal 6‐[18F]fluoro‐L‐DOPA (FDOPA) kinetic rate constants were measured by positron emission tomography (PET) in 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐treated squirrel monkeys. After scanning, stereological counts of dopaminergic neurons were done in substantia nigra, and dopamine (DA) and metabolite concentrations were determined in the caudate, putamen, and substantia nigra. Graded doses of MPTP produced animals with mild to moderate reductions (10–35%) in dopaminergic neurons, where the percent of cell loss was proportional to the amount of MPTP given. Striatal DA and metabolite concentrations were relatively unchanged in animals given 1.0 and 1.5 mg/kg of MPTP, but were significantly reduced after 2.0 mg/kg of MPTP. All animals injected with a single dose of MPTP showed no overt signs of parkinsonism. In contrast, DA and metabolite concentrations in the substantia nigra were significantly reduced for all MPTP‐treated animals. Reduction of dopaminergic indices in the substantia nigra did not parallel reductions in the striatum, indicating differential sensitivity of the nigrostriatal pathway to the neurotoxic effects of MPTP. The percent change in FDOPA uptake (Ki) and decarboyxlation (k3) after MPTP showed significant positive correlations to striatal DA levels, but not to the number of dopaminergic neurons. This suggests that FDOPA is a good index of striatal DA levels. © 2001 Movement Disorder Society.</div>
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