Novel observations with FDOPA-PET imaging after early nigrostriatal damage.
Identifieur interne : 006988 ( Main/Merge ); précédent : 006987; suivant : 006989Novel observations with FDOPA-PET imaging after early nigrostriatal damage.
Auteurs : R E Yee [États-Unis] ; I. Irwin ; C. Milonas ; D B Stout ; S C Huang ; K. Shoghi-Jadid ; N. Satyamurthy ; L E Delanney ; D M Togasaki ; K F Farahani ; K. Delfani ; A M Janson ; M E Phelps ; J W Langston ; J R BarrioSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2001.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Corpus Striatum (metabolism), Corpus Striatum (pathology), Dihydroxyphenylalanine (analogs & derivatives), Dihydroxyphenylalanine (diagnostic use), Disease Models, Animal, Dopamine (deficiency), Female, Fluorine Radioisotopes (diagnostic use), Male, Neural Pathways, Neurotoxins, Parkinsonian Disorders (chemically induced), Parkinsonian Disorders (metabolism), Parkinsonian Disorders (pathology), Parkinsonian Disorders (radionuclide imaging), Saimiri, Substantia Nigra (metabolism), Substantia Nigra (pathology), Tomography, Emission-Computed.
- MESH :
- chemical , analogs & derivatives : Dihydroxyphenylalanine.
- chemical , deficiency : Dopamine.
- chemical , diagnostic use : Dihydroxyphenylalanine, Fluorine Radioisotopes.
- chemical : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Neurotoxins.
- chemically induced : Parkinsonian Disorders.
- metabolism : Corpus Striatum, Parkinsonian Disorders, Substantia Nigra.
- pathology : Corpus Striatum, Parkinsonian Disorders, Substantia Nigra.
- radionuclide imaging : Parkinsonian Disorders.
- Animals, Disease Models, Animal, Female, Male, Neural Pathways, Saimiri, Tomography, Emission-Computed.
Abstract
Striatal 6-[18F]fluoro-L-DOPA (FDOPA) kinetic rate constants were measured by positron emission tomography (PET) in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated squirrel monkeys. After scanning, stereological counts of dopaminergic neurons were done in substantia nigra, and dopamine (DA) and metabolite concentrations were determined in the caudate, putamen, and substantia nigra. Graded doses of MPTP produced animals with mild to moderate reductions (10-35%) in dopaminergic neurons, where the percent of cell loss was proportional to the amount of MPTP given. Striatal DA and metabolite concentrations were relatively unchanged in animals given 1.0 and 1.5 mg/kg of MPTP, but were significantly reduced after 2.0 mg/kg of MPTP. All animals injected with a single dose of MPTP showed no overt signs of parkinsonism. In contrast, DA and metabolite concentrations in the substantia nigra were significantly reduced for all MPTP-treated animals. Reduction of dopaminergic indices in the substantia nigra did not parallel reductions in the striatum, indicating differential sensitivity of the nigrostriatal pathway to the neurotoxic effects of MPTP. The percent change in FDOPA uptake (Ki) and decarboyxlation (k3) after MPTP showed significant positive correlations to striatal DA levels, but not to the number of dopaminergic neurons. This suggests that FDOPA is a good index of striatal DA levels.
PubMed: 11746613
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pubmed:11746613Le document en format XML
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Milonas</name></author><author><name sortKey="Stout, D B" sort="Stout, D B" uniqKey="Stout D" first="D B" last="Stout">D B Stout</name></author><author><name sortKey="Huang, S C" sort="Huang, S C" uniqKey="Huang S" first="S C" last="Huang">S C Huang</name></author><author><name sortKey="Shoghi Jadid, K" sort="Shoghi Jadid, K" uniqKey="Shoghi Jadid K" first="K" last="Shoghi-Jadid">K. Shoghi-Jadid</name></author><author><name sortKey="Satyamurthy, N" sort="Satyamurthy, N" uniqKey="Satyamurthy N" first="N" last="Satyamurthy">N. Satyamurthy</name></author><author><name sortKey="Delanney, L E" sort="Delanney, L E" uniqKey="Delanney L" first="L E" last="Delanney">L E Delanney</name></author><author><name sortKey="Togasaki, D M" sort="Togasaki, D M" uniqKey="Togasaki D" first="D M" last="Togasaki">D M Togasaki</name></author><author><name sortKey="Farahani, K F" sort="Farahani, K F" uniqKey="Farahani K" first="K F" last="Farahani">K F Farahani</name></author><author><name sortKey="Delfani, K" sort="Delfani, K" uniqKey="Delfani K" first="K" last="Delfani">K. 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Irwin</name></author><author><name sortKey="Milonas, C" sort="Milonas, C" uniqKey="Milonas C" first="C" last="Milonas">C. Milonas</name></author><author><name sortKey="Stout, D B" sort="Stout, D B" uniqKey="Stout D" first="D B" last="Stout">D B Stout</name></author><author><name sortKey="Huang, S C" sort="Huang, S C" uniqKey="Huang S" first="S C" last="Huang">S C Huang</name></author><author><name sortKey="Shoghi Jadid, K" sort="Shoghi Jadid, K" uniqKey="Shoghi Jadid K" first="K" last="Shoghi-Jadid">K. Shoghi-Jadid</name></author><author><name sortKey="Satyamurthy, N" sort="Satyamurthy, N" uniqKey="Satyamurthy N" first="N" last="Satyamurthy">N. Satyamurthy</name></author><author><name sortKey="Delanney, L E" sort="Delanney, L E" uniqKey="Delanney L" first="L E" last="Delanney">L E Delanney</name></author><author><name sortKey="Togasaki, D M" sort="Togasaki, D M" uniqKey="Togasaki D" first="D M" last="Togasaki">D M Togasaki</name></author><author><name sortKey="Farahani, K F" sort="Farahani, K F" uniqKey="Farahani K" first="K F" last="Farahani">K F Farahani</name></author><author><name sortKey="Delfani, K" sort="Delfani, K" uniqKey="Delfani K" first="K" last="Delfani">K. Delfani</name></author><author><name sortKey="Janson, A M" sort="Janson, A M" uniqKey="Janson A" first="A M" last="Janson">A M Janson</name></author><author><name sortKey="Phelps, M E" sort="Phelps, M E" uniqKey="Phelps M" first="M E" last="Phelps">M E Phelps</name></author><author><name sortKey="Langston, J W" sort="Langston, J W" uniqKey="Langston J" first="J W" last="Langston">J W Langston</name></author><author><name sortKey="Barrio, J R" sort="Barrio, J R" uniqKey="Barrio J" first="J R" last="Barrio">J R Barrio</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term><term>Animals</term><term>Corpus Striatum (metabolism)</term><term>Corpus Striatum (pathology)</term><term>Dihydroxyphenylalanine (analogs & derivatives)</term><term>Dihydroxyphenylalanine (diagnostic use)</term><term>Disease Models, Animal</term><term>Dopamine (deficiency)</term><term>Female</term><term>Fluorine Radioisotopes (diagnostic use)</term><term>Male</term><term>Neural Pathways</term><term>Neurotoxins</term><term>Parkinsonian Disorders (chemically induced)</term><term>Parkinsonian Disorders (metabolism)</term><term>Parkinsonian Disorders (pathology)</term><term>Parkinsonian Disorders (radionuclide imaging)</term><term>Saimiri</term><term>Substantia Nigra (metabolism)</term><term>Substantia Nigra (pathology)</term><term>Tomography, Emission-Computed</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Dihydroxyphenylalanine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Dihydroxyphenylalanine</term><term>Fluorine Radioisotopes</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term><term>Neurotoxins</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term><term>Parkinsonian Disorders</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Corpus Striatum</term><term>Parkinsonian Disorders</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Male</term><term>Neural Pathways</term><term>Saimiri</term><term>Tomography, Emission-Computed</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Striatal 6-[18F]fluoro-L-DOPA (FDOPA) kinetic rate constants were measured by positron emission tomography (PET) in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated squirrel monkeys. After scanning, stereological counts of dopaminergic neurons were done in substantia nigra, and dopamine (DA) and metabolite concentrations were determined in the caudate, putamen, and substantia nigra. Graded doses of MPTP produced animals with mild to moderate reductions (10-35%) in dopaminergic neurons, where the percent of cell loss was proportional to the amount of MPTP given. Striatal DA and metabolite concentrations were relatively unchanged in animals given 1.0 and 1.5 mg/kg of MPTP, but were significantly reduced after 2.0 mg/kg of MPTP. All animals injected with a single dose of MPTP showed no overt signs of parkinsonism. In contrast, DA and metabolite concentrations in the substantia nigra were significantly reduced for all MPTP-treated animals. Reduction of dopaminergic indices in the substantia nigra did not parallel reductions in the striatum, indicating differential sensitivity of the nigrostriatal pathway to the neurotoxic effects of MPTP. The percent change in FDOPA uptake (Ki) and decarboyxlation (k3) after MPTP showed significant positive correlations to striatal DA levels, but not to the number of dopaminergic neurons. This suggests that FDOPA is a good index of striatal DA levels.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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