Novel observations with FDOPA-PET imaging after early nigrostriatal damage
Identifieur interne : 002936 ( PascalFrancis/Corpus ); précédent : 002935; suivant : 002937Novel observations with FDOPA-PET imaging after early nigrostriatal damage
Auteurs : R. E. Yee ; I. Irwin ; C. Milonas ; D. B. Stout ; S-C. Huang ; K. Shoghi-Jadid ; N. Satyamurthy ; L. E. Delanney ; D. M. Togasaki ; K. F. Farahani ; K. Delfani ; A. M. Janson ; M. E. Phelps ; J. W. Langston ; J. R. BarrioSource :
- Movement disorders [ 0885-3185 ] ; 2001.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Striatal 6-[18F]fluoro-L-DOPA (FDOPA) kinetic rate constants were measured by positron emission tomography (PET) in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated squirrel monkeys. After scanning, stereological counts of dopaminergic neurons were done in substantia nigra, and dopamine (DA) and metabolite concentrations were determined in the caudate, putamen, and substantia nigra. Graded doses of MPTP produced animals with mild to moderate reductions (10-35%) in dopaminergic neurons, where the percent of cell loss was proportional to the amount of MPTP given. Striatal DA and metabolite concentrations were relatively unchanged in animals given 1.0 and 1.5 mg/kg of MPTP, but were significantly reduced after 2.0 mg/kg of MPTP. All animals injected with a single dose of MPTP showed no overt signs of parkinsonism. In contrast, DA and metabolite concentrations in the substantia nigra were significantly reduced for all MPTP-treated animals. Reduction of dopaminergic indices in the substantia nigra did not parallel reductions in the striatum, indicating differential sensitivity of the nigrostriatal pathway to the neurotoxic effects of MPTP. The percent change in FDOPA uptake (Ki) and decarboyxlation (k3) after MPTP showed significant positive correlations to striatal DA levels, but not to the number of dopaminergic neurons. This suggests that FDOPA is a good index of striatal DA levels.
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NO : | PASCAL 02-0049765 INIST |
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ET : | Novel observations with FDOPA-PET imaging after early nigrostriatal damage |
AU : | YEE (R. E.); IRWIN (I.); MILONAS (C.); STOUT (D. B.); HUANG (S-C.); SHOGHI-JADID (K.); SATYAMURTHY (N.); DELANNEY (L. E.); TOGASAKI (D. M.); FARAHANI (K. F.); DELFANI (K.); JANSON (A. M.); PHELPS (M. E.); LANGSTON (J. W.); BARRIO (J. R.) |
AF : | Department of Molecular and Medical Pharmacology, UCLA School of Medicine/Los Angeles, California/Etats-Unis (1 aut., 4 aut., 5 aut., 7 aut., 13 aut., 15 aut.); The Parkinson's Institute/Sunnyvale, California/Etats-Unis (2 aut., 8 aut., 9 aut., 14 aut.); Department of Neuroscience, Karolinska Institute/Stockholm, Sweden/Etats-Unis (3 aut., 11 aut., 12 aut.); Department of Biomathematics, UCLA School of Medicine/Los Angeles, California/Etats-Unis (5 aut., 6 aut.); Department of Radiological Sciences, UCLA School of Medicine/Los Angeles, California/Etats-Unis (10 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2001; Vol. 16; No. 5; Pp. 838-848; Bibl. 60 ref. |
LA : | Anglais |
EA : | Striatal 6-[18F]fluoro-L-DOPA (FDOPA) kinetic rate constants were measured by positron emission tomography (PET) in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated squirrel monkeys. After scanning, stereological counts of dopaminergic neurons were done in substantia nigra, and dopamine (DA) and metabolite concentrations were determined in the caudate, putamen, and substantia nigra. Graded doses of MPTP produced animals with mild to moderate reductions (10-35%) in dopaminergic neurons, where the percent of cell loss was proportional to the amount of MPTP given. Striatal DA and metabolite concentrations were relatively unchanged in animals given 1.0 and 1.5 mg/kg of MPTP, but were significantly reduced after 2.0 mg/kg of MPTP. All animals injected with a single dose of MPTP showed no overt signs of parkinsonism. In contrast, DA and metabolite concentrations in the substantia nigra were significantly reduced for all MPTP-treated animals. Reduction of dopaminergic indices in the substantia nigra did not parallel reductions in the striatum, indicating differential sensitivity of the nigrostriatal pathway to the neurotoxic effects of MPTP. The percent change in FDOPA uptake (Ki) and decarboyxlation (k3) after MPTP showed significant positive correlations to striatal DA levels, but not to the number of dopaminergic neurons. This suggests that FDOPA is a good index of striatal DA levels. |
CC : | 002B17G |
FD : | Parkinson maladie; Stade clinique; Asymptomatique; Tomographie émission positon; Fluorodopa(18F); Locus niger; Stéréologie; Neurone dopaminergique; Modèle animal; Evolution; Cinétique; Singe; Animal |
FG : | Primates; Mammalia; Vertebrata; Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Exploration radioisotopique |
ED : | Parkinson disease; Clinical stage; Asymptomatic; Positron emission tomography; Fluorodopa(18F); Locus niger; Stereology; Dopaminergic neuron; Animal model; Evolution; Kinetics; Monkey; Animal |
EG : | Primates; Mammalia; Vertebrata; Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Radionuclide study |
SD : | Parkinson enfermedad; Estadio clínico; Asintomático; Tomografía emisión positrones; Fluorodopa(18F); Locus níger; Estereología; Neurona dopaminérgica; Modelo animal; Evolución; Cinética; Mono; Animal |
LO : | INIST-20953.354000099256460060 |
ID : | 02-0049765 |
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Pascal:02-0049765Le document en format XML
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<term>Animal model</term>
<term>Asymptomatic</term>
<term>Clinical stage</term>
<term>Dopaminergic neuron</term>
<term>Evolution</term>
<term>Fluorodopa(18F)</term>
<term>Kinetics</term>
<term>Locus niger</term>
<term>Monkey</term>
<term>Parkinson disease</term>
<term>Positron emission tomography</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Stade clinique</term>
<term>Asymptomatique</term>
<term>Tomographie émission positon</term>
<term>Fluorodopa(18F)</term>
<term>Locus niger</term>
<term>Stéréologie</term>
<term>Neurone dopaminergique</term>
<term>Modèle animal</term>
<term>Evolution</term>
<term>Cinétique</term>
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<front><div type="abstract" xml:lang="en">Striatal 6-[<sup>18</sup>
F]fluoro-L-DOPA (FDOPA) kinetic rate constants were measured by positron emission tomography (PET) in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated squirrel monkeys. After scanning, stereological counts of dopaminergic neurons were done in substantia nigra, and dopamine (DA) and metabolite concentrations were determined in the caudate, putamen, and substantia nigra. Graded doses of MPTP produced animals with mild to moderate reductions (10-35%) in dopaminergic neurons, where the percent of cell loss was proportional to the amount of MPTP given. Striatal DA and metabolite concentrations were relatively unchanged in animals given 1.0 and 1.5 mg/kg of MPTP, but were significantly reduced after 2.0 mg/kg of MPTP. All animals injected with a single dose of MPTP showed no overt signs of parkinsonism. In contrast, DA and metabolite concentrations in the substantia nigra were significantly reduced for all MPTP-treated animals. Reduction of dopaminergic indices in the substantia nigra did not parallel reductions in the striatum, indicating differential sensitivity of the nigrostriatal pathway to the neurotoxic effects of MPTP. The percent change in FDOPA uptake (Ki) and decarboyxlation (k<sub>3</sub>
) after MPTP showed significant positive correlations to striatal DA levels, but not to the number of dopaminergic neurons. This suggests that FDOPA is a good index of striatal DA levels.</div>
</front>
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<fA08 i1="01" i2="1" l="ENG"><s1>Novel observations with FDOPA-PET imaging after early nigrostriatal damage</s1>
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<fA11 i1="01" i2="1"><s1>YEE (R. E.)</s1>
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<fA11 i1="15" i2="1"><s1>BARRIO (J. R.)</s1>
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<fA14 i1="01"><s1>Department of Molecular and Medical Pharmacology, UCLA School of Medicine</s1>
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<fA14 i1="03"><s1>Department of Neuroscience, Karolinska Institute</s1>
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<sZ>3 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
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<fA14 i1="04"><s1>Department of Biomathematics, UCLA School of Medicine</s1>
<s2>Los Angeles, California</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
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<fA14 i1="05"><s1>Department of Radiological Sciences, UCLA School of Medicine</s1>
<s2>Los Angeles, California</s2>
<s3>USA</s3>
<sZ>10 aut.</sZ>
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<fC01 i1="01" l="ENG"><s0>Striatal 6-[<sup>18</sup>
F]fluoro-L-DOPA (FDOPA) kinetic rate constants were measured by positron emission tomography (PET) in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated squirrel monkeys. After scanning, stereological counts of dopaminergic neurons were done in substantia nigra, and dopamine (DA) and metabolite concentrations were determined in the caudate, putamen, and substantia nigra. Graded doses of MPTP produced animals with mild to moderate reductions (10-35%) in dopaminergic neurons, where the percent of cell loss was proportional to the amount of MPTP given. Striatal DA and metabolite concentrations were relatively unchanged in animals given 1.0 and 1.5 mg/kg of MPTP, but were significantly reduced after 2.0 mg/kg of MPTP. All animals injected with a single dose of MPTP showed no overt signs of parkinsonism. In contrast, DA and metabolite concentrations in the substantia nigra were significantly reduced for all MPTP-treated animals. Reduction of dopaminergic indices in the substantia nigra did not parallel reductions in the striatum, indicating differential sensitivity of the nigrostriatal pathway to the neurotoxic effects of MPTP. The percent change in FDOPA uptake (Ki) and decarboyxlation (k<sub>3</sub>
) after MPTP showed significant positive correlations to striatal DA levels, but not to the number of dopaminergic neurons. This suggests that FDOPA is a good index of striatal DA levels.</s0>
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<s2>FR</s2>
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<server><NO>PASCAL 02-0049765 INIST</NO>
<ET>Novel observations with FDOPA-PET imaging after early nigrostriatal damage</ET>
<AU>YEE (R. E.); IRWIN (I.); MILONAS (C.); STOUT (D. B.); HUANG (S-C.); SHOGHI-JADID (K.); SATYAMURTHY (N.); DELANNEY (L. E.); TOGASAKI (D. M.); FARAHANI (K. F.); DELFANI (K.); JANSON (A. M.); PHELPS (M. E.); LANGSTON (J. W.); BARRIO (J. R.)</AU>
<AF>Department of Molecular and Medical Pharmacology, UCLA School of Medicine/Los Angeles, California/Etats-Unis (1 aut., 4 aut., 5 aut., 7 aut., 13 aut., 15 aut.); The Parkinson's Institute/Sunnyvale, California/Etats-Unis (2 aut., 8 aut., 9 aut., 14 aut.); Department of Neuroscience, Karolinska Institute/Stockholm, Sweden/Etats-Unis (3 aut., 11 aut., 12 aut.); Department of Biomathematics, UCLA School of Medicine/Los Angeles, California/Etats-Unis (5 aut., 6 aut.); Department of Radiological Sciences, UCLA School of Medicine/Los Angeles, California/Etats-Unis (10 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2001; Vol. 16; No. 5; Pp. 838-848; Bibl. 60 ref.</SO>
<LA>Anglais</LA>
<EA>Striatal 6-[<sup>18</sup>
F]fluoro-L-DOPA (FDOPA) kinetic rate constants were measured by positron emission tomography (PET) in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated squirrel monkeys. After scanning, stereological counts of dopaminergic neurons were done in substantia nigra, and dopamine (DA) and metabolite concentrations were determined in the caudate, putamen, and substantia nigra. Graded doses of MPTP produced animals with mild to moderate reductions (10-35%) in dopaminergic neurons, where the percent of cell loss was proportional to the amount of MPTP given. Striatal DA and metabolite concentrations were relatively unchanged in animals given 1.0 and 1.5 mg/kg of MPTP, but were significantly reduced after 2.0 mg/kg of MPTP. All animals injected with a single dose of MPTP showed no overt signs of parkinsonism. In contrast, DA and metabolite concentrations in the substantia nigra were significantly reduced for all MPTP-treated animals. Reduction of dopaminergic indices in the substantia nigra did not parallel reductions in the striatum, indicating differential sensitivity of the nigrostriatal pathway to the neurotoxic effects of MPTP. The percent change in FDOPA uptake (Ki) and decarboyxlation (k<sub>3</sub>
) after MPTP showed significant positive correlations to striatal DA levels, but not to the number of dopaminergic neurons. This suggests that FDOPA is a good index of striatal DA levels.</EA>
<CC>002B17G</CC>
<FD>Parkinson maladie; Stade clinique; Asymptomatique; Tomographie émission positon; Fluorodopa(18F); Locus niger; Stéréologie; Neurone dopaminergique; Modèle animal; Evolution; Cinétique; Singe; Animal</FD>
<FG>Primates; Mammalia; Vertebrata; Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Exploration radioisotopique</FG>
<ED>Parkinson disease; Clinical stage; Asymptomatic; Positron emission tomography; Fluorodopa(18F); Locus niger; Stereology; Dopaminergic neuron; Animal model; Evolution; Kinetics; Monkey; Animal</ED>
<EG>Primates; Mammalia; Vertebrata; Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Radionuclide study</EG>
<SD>Parkinson enfermedad; Estadio clínico; Asintomático; Tomografía emisión positrones; Fluorodopa(18F); Locus níger; Estereología; Neurona dopaminérgica; Modelo animal; Evolución; Cinética; Mono; Animal</SD>
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