Cell type‐specific neuronal loss in the putamen of patients with multiple system atrophy
Identifieur interne : 002F66 ( Main/Exploration ); précédent : 002F65; suivant : 002F67Cell type‐specific neuronal loss in the putamen of patients with multiple system atrophy
Auteurs : Kenta Sato [Japon] ; Ryuji Kaji [Japon] ; Sadayuki Matsumoto [Japon] ; Satoshi Goto [Japon]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-04-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aged, Calcineurin (analysis), Cell death, Choline O-Acetyltransferase (analysis), Choline O-acetyltransferase, Female, Human, Humans, Immunoenzyme Techniques, Middle Aged, Multiple System Atrophy (pathology), Multiple system atrophy, Nerve Degeneration (pathology), Nervous system diseases, Neuron, Neurons (pathology), Parkinsonian Disorders (pathology), Putamen, Putamen (pathology), choline acetyltransferase, medium spiny neurons, multiple system atrophy, neurodegeneration, striatum.
- MESH :
- chemical , analysis : Calcineurin, Choline O-Acetyltransferase.
- pathology : Multiple System Atrophy, Nerve Degeneration, Neurons, Parkinsonian Disorders, Putamen.
- Aged, Female, Humans, Immunoenzyme Techniques, Middle Aged.
Abstract
Using antibodies to calcineurin (CaN) and choline acetyltransferase (ChAT), we performed topographical and cellular immunohistochemical analysis on the posterior putamen of autopsied patients with multiple system atrophy with predominant parkinsonism (MSA‐P). We document that in these patients, medium spiny neurons positive for CaN were severely depleted in the dorsolateral portion of the posterior putamen where ChAT‐positive neurons are normally distributed. Our findings indicate that in patients with MSA‐P, striatal neurons manifest a cell type‐specific vulnerability to neurodegeneration. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21385
Affiliations:
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Le document en format XML
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<term>Female</term>
<term>Human</term>
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<term>Multiple System Atrophy (pathology)</term>
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<term>Neurons (pathology)</term>
<term>Parkinsonian Disorders (pathology)</term>
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<term>Putamen (pathology)</term>
<term>choline acetyltransferase</term>
<term>medium spiny neurons</term>
<term>multiple system atrophy</term>
<term>neurodegeneration</term>
<term>striatum</term>
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<term>Choline O-Acetyltransferase</term>
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<term>Middle Aged</term>
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<term>Neurone</term>
<term>Putamen</term>
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<front><div type="abstract" xml:lang="en">Using antibodies to calcineurin (CaN) and choline acetyltransferase (ChAT), we performed topographical and cellular immunohistochemical analysis on the posterior putamen of autopsied patients with multiple system atrophy with predominant parkinsonism (MSA‐P). We document that in these patients, medium spiny neurons positive for CaN were severely depleted in the dorsolateral portion of the posterior putamen where ChAT‐positive neurons are normally distributed. Our findings indicate that in patients with MSA‐P, striatal neurons manifest a cell type‐specific vulnerability to neurodegeneration. © 2007 Movement Disorder Society</div>
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