Cell type-specific neuronal loss in the putamen of patients with multiple system atrophy.
Identifieur interne : 001A71 ( Ncbi/Checkpoint ); précédent : 001A70; suivant : 001A72Cell type-specific neuronal loss in the putamen of patients with multiple system atrophy.
Auteurs : Kenta Sato [Japon] ; Ryuji Kaji ; Sadayuki Matsumoto ; Satoshi GotoSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Calcineurin, Choline O-Acetyltransferase.
- pathology : Multiple System Atrophy, Nerve Degeneration, Neurons, Parkinsonian Disorders, Putamen.
- Aged, Female, Humans, Immunoenzyme Techniques, Middle Aged.
Abstract
Using antibodies to calcineurin (CaN) and choline acetyltransferase (ChAT), we performed topographical and cellular immunohistochemical analysis on the posterior putamen of autopsied patients with multiple system atrophy with predominant parkinsonism (MSA-P). We document that in these patients, medium spiny neurons positive for CaN were severely depleted in the dorsolateral portion of the posterior putamen where ChAT-positive neurons are normally distributed. Our findings indicate that in patients with MSA-P, striatal neurons manifest a cell type-specific vulnerability to neurodegeneration.
DOI: 10.1002/mds.21385
PubMed: 17266045
Affiliations:
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pubmed:17266045Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cell type-specific neuronal loss in the putamen of patients with multiple system atrophy.</title><author><name sortKey="Sato, Kenta" sort="Sato, Kenta" uniqKey="Sato K" first="Kenta" last="Sato">Kenta Sato</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Neuroscience, Institute of Health Biosciences, Graduate School of Medicine, University of Tokushima, Tokushima, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Clinical Neuroscience, Institute of Health Biosciences, Graduate School of Medicine, University of Tokushima, Tokushima</wicri:regionArea><wicri:noRegion>Tokushima</wicri:noRegion></affiliation></author><author><name sortKey="Kaji, Ryuji" sort="Kaji, Ryuji" uniqKey="Kaji R" first="Ryuji" last="Kaji">Ryuji Kaji</name></author><author><name sortKey="Matsumoto, Sadayuki" sort="Matsumoto, Sadayuki" uniqKey="Matsumoto S" first="Sadayuki" last="Matsumoto">Sadayuki Matsumoto</name></author><author><name sortKey="Goto, Satoshi" sort="Goto, Satoshi" uniqKey="Goto S" first="Satoshi" last="Goto">Satoshi Goto</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21385</idno><idno type="RBID">pubmed:17266045</idno><idno type="pmid">17266045</idno><idno type="wicri:Area/PubMed/Corpus">002868</idno><idno type="wicri:Area/PubMed/Curation">002868</idno><idno type="wicri:Area/PubMed/Checkpoint">002923</idno><idno type="wicri:Area/Ncbi/Merge">001A71</idno><idno type="wicri:Area/Ncbi/Curation">001A71</idno><idno type="wicri:Area/Ncbi/Checkpoint">001A71</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cell type-specific neuronal loss in the putamen of patients with multiple system atrophy.</title><author><name sortKey="Sato, Kenta" sort="Sato, Kenta" uniqKey="Sato K" first="Kenta" last="Sato">Kenta Sato</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Neuroscience, Institute of Health Biosciences, Graduate School of Medicine, University of Tokushima, Tokushima, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Clinical Neuroscience, Institute of Health Biosciences, Graduate School of Medicine, University of Tokushima, Tokushima</wicri:regionArea><wicri:noRegion>Tokushima</wicri:noRegion></affiliation></author><author><name sortKey="Kaji, Ryuji" sort="Kaji, Ryuji" uniqKey="Kaji R" first="Ryuji" last="Kaji">Ryuji Kaji</name></author><author><name sortKey="Matsumoto, Sadayuki" sort="Matsumoto, Sadayuki" uniqKey="Matsumoto S" first="Sadayuki" last="Matsumoto">Sadayuki Matsumoto</name></author><author><name sortKey="Goto, Satoshi" sort="Goto, Satoshi" uniqKey="Goto S" first="Satoshi" last="Goto">Satoshi Goto</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Calcineurin (analysis)</term><term>Choline O-Acetyltransferase (analysis)</term><term>Female</term><term>Humans</term><term>Immunoenzyme Techniques</term><term>Middle Aged</term><term>Multiple System Atrophy (pathology)</term><term>Nerve Degeneration (pathology)</term><term>Neurons (pathology)</term><term>Parkinsonian Disorders (pathology)</term><term>Putamen (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Calcineurin</term><term>Choline O-Acetyltransferase</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Multiple System Atrophy</term><term>Nerve Degeneration</term><term>Neurons</term><term>Parkinsonian Disorders</term><term>Putamen</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Immunoenzyme Techniques</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Using antibodies to calcineurin (CaN) and choline acetyltransferase (ChAT), we performed topographical and cellular immunohistochemical analysis on the posterior putamen of autopsied patients with multiple system atrophy with predominant parkinsonism (MSA-P). We document that in these patients, medium spiny neurons positive for CaN were severely depleted in the dorsolateral portion of the posterior putamen where ChAT-positive neurons are normally distributed. Our findings indicate that in patients with MSA-P, striatal neurons manifest a cell type-specific vulnerability to neurodegeneration.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Goto, Satoshi" sort="Goto, Satoshi" uniqKey="Goto S" first="Satoshi" last="Goto">Satoshi Goto</name><name sortKey="Kaji, Ryuji" sort="Kaji, Ryuji" uniqKey="Kaji R" first="Ryuji" last="Kaji">Ryuji Kaji</name><name sortKey="Matsumoto, Sadayuki" sort="Matsumoto, Sadayuki" uniqKey="Matsumoto S" first="Sadayuki" last="Matsumoto">Sadayuki Matsumoto</name></noCountry><country name="Japon"><noRegion><name sortKey="Sato, Kenta" sort="Sato, Kenta" uniqKey="Sato K" first="Kenta" last="Sato">Kenta Sato</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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