Movement Disorders (revue)

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Cell type‐specific neuronal loss in the putamen of patients with multiple system atrophy

Identifieur interne : 003092 ( Istex/Corpus ); précédent : 003091; suivant : 003093

Cell type‐specific neuronal loss in the putamen of patients with multiple system atrophy

Auteurs : Kenta Sato ; Ryuji Kaji ; Sadayuki Matsumoto ; Satoshi Goto

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RBID : ISTEX:82D7E5D647067812CD396FB00B3790D3EAA69E24

English descriptors

Abstract

Using antibodies to calcineurin (CaN) and choline acetyltransferase (ChAT), we performed topographical and cellular immunohistochemical analysis on the posterior putamen of autopsied patients with multiple system atrophy with predominant parkinsonism (MSA‐P). We document that in these patients, medium spiny neurons positive for CaN were severely depleted in the dorsolateral portion of the posterior putamen where ChAT‐positive neurons are normally distributed. Our findings indicate that in patients with MSA‐P, striatal neurons manifest a cell type‐specific vulnerability to neurodegeneration. © 2007 Movement Disorder Society

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DOI: 10.1002/mds.21385

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ISTEX:82D7E5D647067812CD396FB00B3790D3EAA69E24

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<dateIssued encoding="w3cdtf">2007-04-15</dateIssued>
<dateCaptured encoding="w3cdtf">2006-10-30</dateCaptured>
<dateValid encoding="w3cdtf">2006-12-04</dateValid>
<copyrightDate encoding="w3cdtf">2007</copyrightDate>
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<abstract lang="en">Using antibodies to calcineurin (CaN) and choline acetyltransferase (ChAT), we performed topographical and cellular immunohistochemical analysis on the posterior putamen of autopsied patients with multiple system atrophy with predominant parkinsonism (MSA‐P). We document that in these patients, medium spiny neurons positive for CaN were severely depleted in the dorsolateral portion of the posterior putamen where ChAT‐positive neurons are normally distributed. Our findings indicate that in patients with MSA‐P, striatal neurons manifest a cell type‐specific vulnerability to neurodegeneration. © 2007 Movement Disorder Society</abstract>
<note type="funding">Grant on Stress Control 21st Century Center of Excellence Program (COE)</note>
<subject lang="en">
<genre>Keywords</genre>
<topic>multiple system atrophy</topic>
<topic>striatum</topic>
<topic>neurodegeneration</topic>
<topic>choline acetyltransferase</topic>
<topic>medium spiny neurons</topic>
</subject>
<relatedItem type="host">
<titleInfo>
<title>Movement Disorders</title>
</titleInfo>
<titleInfo type="abbreviated">
<title>Mov. Disord.</title>
</titleInfo>
<subject>
<genre>article category</genre>
<topic>Brief Report</topic>
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<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
<identifier type="PublisherID">MDS</identifier>
<part>
<date>2007</date>
<detail type="volume">
<caption>vol.</caption>
<number>22</number>
</detail>
<detail type="issue">
<caption>no.</caption>
<number>5</number>
</detail>
<extent unit="pages">
<start>738</start>
<end>742</end>
<total>4</total>
</extent>
</part>
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<identifier type="DOI">10.1002/mds.21385</identifier>
<identifier type="ArticleID">MDS21385</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 Movement Disorder Society</accessCondition>
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<recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin>
<recordContentSource>WILEY</recordContentSource>
</recordInfo>
</mods>
</metadata>
<serie></serie>
</istex>
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