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Platelet mitochondrial respiratory chain function in Parkinson's disease

Identifieur interne : 005286 ( Main/Exploration ); précédent : 005285; suivant : 005287

Platelet mitochondrial respiratory chain function in Parkinson's disease

Auteurs : C. I. Blake [États-Unis] ; E. Spitz [États-Unis] ; M. Leehey [États-Unis] ; Hoffer [États-Unis] ; S. J. Boyson [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 1997-01.

RBID : ISTEX:2D6FF893D8CFDA596A77FB4C3E9B90F7334BCD90

Descripteurs français

Pascal (Inist)
- Chaîne respiratoire, Homme, Mitochondrie, Méthode enzymatique, Parkinson maladie, Physiopathologie, Spectrophotométrie, Thrombocyte.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Adult, Aged, Blood Platelets (enzymology), Blood platelets, Citrate (si)-Synthase (blood), Citrate synthase, Complex I, Complex III, Complex IV, Cytochrome c oxidase, Electron Transport (physiology), Electron Transport Complex III (blood), Electron Transport Complex IV (blood), Enzymatic method, Female, Human, Humans, Male, Middle Aged, Mitochondria, Mitochondria (enzymology), NAD(P)H Dehydrogenase (Quinone) (blood), NADH dehydrogenase, Parkinson Disease (blood), Parkinson disease, Parkinson's disease, Pathophysiology, Platelet, Reference Values, Respiratory chain, Spectrophotometry, Ubiquinol‐Cytochrome c reductase, Ubiquinone.
MESH :
- chemical , blood : Citrate (si)-Synthase, Electron Transport Complex III, Electron Transport Complex IV, NAD(P)H Dehydrogenase (Quinone).
- blood : Parkinson Disease.
- enzymology : Blood Platelets, Mitochondria.
- physiology : Electron Transport.
- Adult, Aged, Female, Humans, Male, Middle Aged, Reference Values.

Abstract

Reports on mitochondrial respiratory chain (MRC) complex I (CI) dysfunction in the substantia nigra in Parkinson's disease (PD) support the oxidative stress hypothesis in the neuropathogenesis of PD. Studies in peripheral tissue have found variable decreased CI and occasionally other complex activity suggestive of systemic impairment of MRC function in PD; however, MRC activity may be influenced by numerous variables. We conducted spectrophotometric measurements of MRC function in platelet mitochondrial preparations in 13 individuals with PD and 9 age‐matched controls (CON) and have identified additional variables that may affect MRC activity. Mean CI, CIII, CIV, and citrate synthase (CS) activities were similar between PD and CON. CIII and CIV, specific and CS‐corrected, activities were significantly positively correlated with CI in combined and individual group data, with the exception of CIII CS‐corrected and CIV specific activities in CON and PD, respectively. CIII and CS specific activities were negatively correlated with age in CON, but varied randomly in PD. In PD, CIII specific activity was 1.4‐fold higher in those with a history of environmental risk factors for PD and CIV specific activity was lower in those with a positive family history of PD [8.34 ± 0.74 (n = 4) vs. 12.4 ± 1.1 (SEM) min−1 mg−1; p = 0.046]. Group heterogeneity, variables affecting enzyme activity, and intrinsic properties of cells may thus contribute to conflicting data in studies of MRC function in platelets and other tissues.

Url:

https://api.istex.fr/document/2D6FF893D8CFDA596A77FB4C3E9B90F7334BCD90/fulltext/pdf

DOI: 10.1002/mds.870120103

Affiliations:

Le document en format XML

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<term>Citrate (si)-Synthase (blood)</term>
<term>Citrate synthase</term>
<term>Complex I</term>
<term>Complex III</term>
<term>Complex IV</term>
<term>Cytochrome c oxidase</term>
<term>Electron Transport (physiology)</term>
<term>Electron Transport Complex III (blood)</term>
<term>Electron Transport Complex IV (blood)</term>
<term>Enzymatic method</term>
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<term>Mitochondria (enzymology)</term>
<term>NAD(P)H Dehydrogenase (Quinone) (blood)</term>
<term>NADH dehydrogenase</term>
<term>Parkinson Disease (blood)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Pathophysiology</term>
<term>Platelet</term>
<term>Reference Values</term>
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<front><div type="abstract" xml:lang="en">Reports on mitochondrial respiratory chain (MRC) complex I (CI) dysfunction in the substantia nigra in Parkinson's disease (PD) support the oxidative stress hypothesis in the neuropathogenesis of PD. Studies in peripheral tissue have found variable decreased CI and occasionally other complex activity suggestive of systemic impairment of MRC function in PD; however, MRC activity may be influenced by numerous variables. We conducted spectrophotometric measurements of MRC function in platelet mitochondrial preparations in 13 individuals with PD and 9 age‐matched controls (CON) and have identified additional variables that may affect MRC activity. Mean CI, CIII, CIV, and citrate synthase (CS) activities were similar between PD and CON. CIII and CIV, specific and CS‐corrected, activities were significantly positively correlated with CI in combined and individual group data, with the exception of CIII CS‐corrected and CIV specific activities in CON and PD, respectively. CIII and CS specific activities were negatively correlated with age in CON, but varied randomly in PD. In PD, CIII specific activity was 1.4‐fold higher in those with a history of environmental risk factors for PD and CIV specific activity was lower in those with a positive family history of PD [8.34 ± 0.74 (n = 4) vs. 12.4 ± 1.1 (SEM) min−1 mg−1; p = 0.046]. Group heterogeneity, variables affecting enzyme activity, and intrinsic properties of cells may thus contribute to conflicting data in studies of MRC function in platelets and other tissues.</div>
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Movement Disorders (revue)

Platelet mitochondrial respiratory chain function in Parkinson's disease

Platelet mitochondrial respiratory chain function in Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.