Platelet mitochondrial respiratory chain function in Parkinson's disease
Identifieur interne : 005286 ( Main/Curation ); précédent : 005285; suivant : 005287Platelet mitochondrial respiratory chain function in Parkinson's disease
Auteurs : C. I. Blake [États-Unis] ; E. Spitz [États-Unis] ; M. Leehey [États-Unis] ; Hoffer [États-Unis] ; S. J. Boyson [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 1997-01.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adult, Aged, Blood Platelets (enzymology), Blood platelets, Citrate (si)-Synthase (blood), Citrate synthase, Complex I, Complex III, Complex IV, Cytochrome c oxidase, Electron Transport (physiology), Electron Transport Complex III (blood), Electron Transport Complex IV (blood), Enzymatic method, Female, Human, Humans, Male, Middle Aged, Mitochondria, Mitochondria (enzymology), NAD(P)H Dehydrogenase (Quinone) (blood), NADH dehydrogenase, Parkinson Disease (blood), Parkinson disease, Parkinson's disease, Pathophysiology, Platelet, Reference Values, Respiratory chain, Spectrophotometry, Ubiquinol‐Cytochrome c reductase, Ubiquinone.
- MESH :
- chemical , blood : Citrate (si)-Synthase, Electron Transport Complex III, Electron Transport Complex IV, NAD(P)H Dehydrogenase (Quinone).
- blood : Parkinson Disease.
- enzymology : Blood Platelets, Mitochondria.
- physiology : Electron Transport.
- Adult, Aged, Female, Humans, Male, Middle Aged, Reference Values.
Abstract
Reports on mitochondrial respiratory chain (MRC) complex I (CI) dysfunction in the substantia nigra in Parkinson's disease (PD) support the oxidative stress hypothesis in the neuropathogenesis of PD. Studies in peripheral tissue have found variable decreased CI and occasionally other complex activity suggestive of systemic impairment of MRC function in PD; however, MRC activity may be influenced by numerous variables. We conducted spectrophotometric measurements of MRC function in platelet mitochondrial preparations in 13 individuals with PD and 9 age‐matched controls (CON) and have identified additional variables that may affect MRC activity. Mean CI, CIII, CIV, and citrate synthase (CS) activities were similar between PD and CON. CIII and CIV, specific and CS‐corrected, activities were significantly positively correlated with CI in combined and individual group data, with the exception of CIII CS‐corrected and CIV specific activities in CON and PD, respectively. CIII and CS specific activities were negatively correlated with age in CON, but varied randomly in PD. In PD, CIII specific activity was 1.4‐fold higher in those with a history of environmental risk factors for PD and CIV specific activity was lower in those with a positive family history of PD [8.34 ± 0.74 (n = 4) vs. 12.4 ± 1.1 (SEM) min−1 mg−1; p = 0.046]. Group heterogeneity, variables affecting enzyme activity, and intrinsic properties of cells may thus contribute to conflicting data in studies of MRC function in platelets and other tissues.
Url:
DOI: 10.1002/mds.870120103
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000A80
- to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :000A80
- to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003909
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :004739
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :004739
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :004600
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :004C44
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :004C44
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :004C44
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :008314
- to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :003307
- to stream PascalFrancis, to step Curation: Pour aller vers cette notice dans l'étape Curation :003517
- to stream PascalFrancis, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003175
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :008530
Links to Exploration step
ISTEX:2D6FF893D8CFDA596A77FB4C3E9B90F7334BCD90Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Platelet mitochondrial respiratory chain function in Parkinson's disease</title>
<author><name sortKey="Blake, C I" sort="Blake, C I" uniqKey="Blake C" first="C. I." last="Blake">C. I. Blake</name>
</author>
<author><name sortKey="Spitz, E" sort="Spitz, E" uniqKey="Spitz E" first="E." last="Spitz">E. Spitz</name>
</author>
<author><name sortKey="Leehey, M" sort="Leehey, M" uniqKey="Leehey M" first="M." last="Leehey">M. Leehey</name>
</author>
<author><name sortKey="Hoffer" sort="Hoffer" uniqKey="Hoffer" last="Hoffer">Hoffer</name>
</author>
<author><name sortKey="Boyson, S J" sort="Boyson, S J" uniqKey="Boyson S" first="S. J." last="Boyson">S. J. Boyson</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:2D6FF893D8CFDA596A77FB4C3E9B90F7334BCD90</idno>
<date when="1997" year="1997">1997</date>
<idno type="doi">10.1002/mds.870120103</idno>
<idno type="url">https://api.istex.fr/document/2D6FF893D8CFDA596A77FB4C3E9B90F7334BCD90/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000A80</idno>
<idno type="wicri:Area/Istex/Curation">000A80</idno>
<idno type="wicri:Area/Istex/Checkpoint">003909</idno>
<idno type="wicri:doubleKey">0885-3185:1997:Blake C:platelet:mitochondrial:respiratory</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:8990047</idno>
<idno type="wicri:Area/PubMed/Corpus">004739</idno>
<idno type="wicri:Area/PubMed/Curation">004739</idno>
<idno type="wicri:Area/PubMed/Checkpoint">004600</idno>
<idno type="wicri:Area/Ncbi/Merge">004C44</idno>
<idno type="wicri:Area/Ncbi/Curation">004C44</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">004C44</idno>
<idno type="wicri:doubleKey">0885-3185:1997:Blake C:platelet:mitochondrial:respiratory</idno>
<idno type="wicri:Area/Main/Merge">008314</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:97-0142915</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">003307</idno>
<idno type="wicri:Area/PascalFrancis/Curation">003517</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">003175</idno>
<idno type="wicri:doubleKey">0885-3185:1997:Blake C:platelet:mitochondrial:respiratory</idno>
<idno type="wicri:Area/Main/Merge">008530</idno>
<idno type="wicri:Area/Main/Curation">005286</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Platelet mitochondrial respiratory chain function in Parkinson's disease</title>
<author><name sortKey="Blake, C I" sort="Blake, C I" uniqKey="Blake C" first="C. I." last="Blake">C. I. Blake</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology, University of Colorado Health Sciences Center, Denver, Colorado</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Spitz, E" sort="Spitz, E" uniqKey="Spitz E" first="E." last="Spitz">E. Spitz</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology, University of Colorado Health Sciences Center, Denver, Colorado</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leehey, M" sort="Leehey, M" uniqKey="Leehey M" first="M." last="Leehey">M. Leehey</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology, University of Colorado Health Sciences Center, Denver, Colorado</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoffer" sort="Hoffer" uniqKey="Hoffer" last="Hoffer">Hoffer</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boyson, S J" sort="Boyson, S J" uniqKey="Boyson S" first="S. J." last="Boyson">S. J. Boyson</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology, University of Colorado Health Sciences Center, Denver, Colorado</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="1997-01">1997-01</date>
<biblScope unit="vol">12</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="3">3</biblScope>
<biblScope unit="page" to="8">8</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">2D6FF893D8CFDA596A77FB4C3E9B90F7334BCD90</idno>
<idno type="DOI">10.1002/mds.870120103</idno>
<idno type="ArticleID">MDS870120103</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Blood Platelets (enzymology)</term>
<term>Blood platelets</term>
<term>Citrate (si)-Synthase (blood)</term>
<term>Citrate synthase</term>
<term>Complex I</term>
<term>Complex III</term>
<term>Complex IV</term>
<term>Cytochrome c oxidase</term>
<term>Electron Transport (physiology)</term>
<term>Electron Transport Complex III (blood)</term>
<term>Electron Transport Complex IV (blood)</term>
<term>Enzymatic method</term>
<term>Female</term>
<term>Human</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mitochondria</term>
<term>Mitochondria (enzymology)</term>
<term>NAD(P)H Dehydrogenase (Quinone) (blood)</term>
<term>NADH dehydrogenase</term>
<term>Parkinson Disease (blood)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Pathophysiology</term>
<term>Platelet</term>
<term>Reference Values</term>
<term>Respiratory chain</term>
<term>Spectrophotometry</term>
<term>Ubiquinol‐Cytochrome c reductase</term>
<term>Ubiquinone</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Citrate (si)-Synthase</term>
<term>Electron Transport Complex III</term>
<term>Electron Transport Complex IV</term>
<term>NAD(P)H Dehydrogenase (Quinone)</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Blood Platelets</term>
<term>Mitochondria</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Electron Transport</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Reference Values</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Chaîne respiratoire</term>
<term>Homme</term>
<term>Mitochondrie</term>
<term>Méthode enzymatique</term>
<term>Parkinson maladie</term>
<term>Physiopathologie</term>
<term>Spectrophotométrie</term>
<term>Thrombocyte</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Reports on mitochondrial respiratory chain (MRC) complex I (CI) dysfunction in the substantia nigra in Parkinson's disease (PD) support the oxidative stress hypothesis in the neuropathogenesis of PD. Studies in peripheral tissue have found variable decreased CI and occasionally other complex activity suggestive of systemic impairment of MRC function in PD; however, MRC activity may be influenced by numerous variables. We conducted spectrophotometric measurements of MRC function in platelet mitochondrial preparations in 13 individuals with PD and 9 age‐matched controls (CON) and have identified additional variables that may affect MRC activity. Mean CI, CIII, CIV, and citrate synthase (CS) activities were similar between PD and CON. CIII and CIV, specific and CS‐corrected, activities were significantly positively correlated with CI in combined and individual group data, with the exception of CIII CS‐corrected and CIV specific activities in CON and PD, respectively. CIII and CS specific activities were negatively correlated with age in CON, but varied randomly in PD. In PD, CIII specific activity was 1.4‐fold higher in those with a history of environmental risk factors for PD and CIV specific activity was lower in those with a positive family history of PD [8.34 ± 0.74 (n = 4) vs. 12.4 ± 1.1 (SEM) min−1 mg−1; p = 0.046]. Group heterogeneity, variables affecting enzyme activity, and intrinsic properties of cells may thus contribute to conflicting data in studies of MRC function in platelets and other tissues.</div>
</front>
</TEI>
<double idat="0885-3185:1997:Blake C:platelet:mitochondrial:respiratory"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Platelet mitochondrial respiratory chain function in Parkinson's disease</title>
<author><name sortKey="Blake, C I" sort="Blake, C I" uniqKey="Blake C" first="C. I." last="Blake">C. I. Blake</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Colorado Health Sciences Center</s1>
<s2>Denver, Colorado</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Psychiatry, University of Colorado Health Sciences Center</s1>
<s2>Denver, Colorado</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Spitz, E" sort="Spitz, E" uniqKey="Spitz E" first="E." last="Spitz">E. Spitz</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Colorado Health Sciences Center</s1>
<s2>Denver, Colorado</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Psychiatry, University of Colorado Health Sciences Center</s1>
<s2>Denver, Colorado</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leehey, M" sort="Leehey, M" uniqKey="Leehey M" first="M." last="Leehey">M. Leehey</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Colorado Health Sciences Center</s1>
<s2>Denver, Colorado</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoffer, B J" sort="Hoffer, B J" uniqKey="Hoffer B" first="B. J." last="Hoffer">B. J. Hoffer</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Psychiatry, University of Colorado Health Sciences Center</s1>
<s2>Denver, Colorado</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Pharmacology, University of Colorado Health Sciences Center</s1>
<s2>Denver, Colorado</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boyson, S J" sort="Boyson, S J" uniqKey="Boyson S" first="S. J." last="Boyson">S. J. Boyson</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Colorado Health Sciences Center</s1>
<s2>Denver, Colorado</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">97-0142915</idno>
<date when="1997">1997</date>
<idno type="stanalyst">PASCAL 97-0142915 INIST</idno>
<idno type="RBID">Pascal:97-0142915</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">003307</idno>
<idno type="wicri:Area/PascalFrancis/Curation">003517</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">003175</idno>
<idno type="wicri:doubleKey">0885-3185:1997:Blake C:platelet:mitochondrial:respiratory</idno>
<idno type="wicri:Area/Main/Merge">008530</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Platelet mitochondrial respiratory chain function in Parkinson's disease</title>
<author><name sortKey="Blake, C I" sort="Blake, C I" uniqKey="Blake C" first="C. I." last="Blake">C. I. Blake</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Colorado Health Sciences Center</s1>
<s2>Denver, Colorado</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Psychiatry, University of Colorado Health Sciences Center</s1>
<s2>Denver, Colorado</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Spitz, E" sort="Spitz, E" uniqKey="Spitz E" first="E." last="Spitz">E. Spitz</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Colorado Health Sciences Center</s1>
<s2>Denver, Colorado</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Psychiatry, University of Colorado Health Sciences Center</s1>
<s2>Denver, Colorado</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leehey, M" sort="Leehey, M" uniqKey="Leehey M" first="M." last="Leehey">M. Leehey</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Colorado Health Sciences Center</s1>
<s2>Denver, Colorado</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoffer, B J" sort="Hoffer, B J" uniqKey="Hoffer B" first="B. J." last="Hoffer">B. J. Hoffer</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Psychiatry, University of Colorado Health Sciences Center</s1>
<s2>Denver, Colorado</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Pharmacology, University of Colorado Health Sciences Center</s1>
<s2>Denver, Colorado</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boyson, S J" sort="Boyson, S J" uniqKey="Boyson S" first="S. J." last="Boyson">S. J. Boyson</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, University of Colorado Health Sciences Center</s1>
<s2>Denver, Colorado</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="1997">1997</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Enzymatic method</term>
<term>Human</term>
<term>Mitochondria</term>
<term>Parkinson disease</term>
<term>Pathophysiology</term>
<term>Platelet</term>
<term>Respiratory chain</term>
<term>Spectrophotometry</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Chaîne respiratoire</term>
<term>Mitochondrie</term>
<term>Thrombocyte</term>
<term>Méthode enzymatique</term>
<term>Spectrophotométrie</term>
<term>Physiopathologie</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
</TEI>
</INIST>
<ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Platelet mitochondrial respiratory chain function in Parkinson's disease</title>
<author><name sortKey="Blake, C I" sort="Blake, C I" uniqKey="Blake C" first="C. I." last="Blake">C. I. Blake</name>
</author>
<author><name sortKey="Spitz, E" sort="Spitz, E" uniqKey="Spitz E" first="E." last="Spitz">E. Spitz</name>
</author>
<author><name sortKey="Leehey, M" sort="Leehey, M" uniqKey="Leehey M" first="M." last="Leehey">M. Leehey</name>
</author>
<author><name sortKey="Hoffer" sort="Hoffer" uniqKey="Hoffer" last="Hoffer">Hoffer</name>
</author>
<author><name sortKey="Boyson, S J" sort="Boyson, S J" uniqKey="Boyson S" first="S. J." last="Boyson">S. J. Boyson</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:2D6FF893D8CFDA596A77FB4C3E9B90F7334BCD90</idno>
<date when="1997" year="1997">1997</date>
<idno type="doi">10.1002/mds.870120103</idno>
<idno type="url">https://api.istex.fr/document/2D6FF893D8CFDA596A77FB4C3E9B90F7334BCD90/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000A80</idno>
<idno type="wicri:Area/Istex/Curation">000A80</idno>
<idno type="wicri:Area/Istex/Checkpoint">003909</idno>
<idno type="wicri:doubleKey">0885-3185:1997:Blake C:platelet:mitochondrial:respiratory</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:8990047</idno>
<idno type="wicri:Area/PubMed/Corpus">004739</idno>
<idno type="wicri:Area/PubMed/Curation">004739</idno>
<idno type="wicri:Area/PubMed/Checkpoint">004600</idno>
<idno type="wicri:Area/Ncbi/Merge">004C44</idno>
<idno type="wicri:Area/Ncbi/Curation">004C44</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">004C44</idno>
<idno type="wicri:doubleKey">0885-3185:1997:Blake C:platelet:mitochondrial:respiratory</idno>
<idno type="wicri:Area/Main/Merge">008314</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Platelet mitochondrial respiratory chain function in Parkinson's disease</title>
<author><name sortKey="Blake, C I" sort="Blake, C I" uniqKey="Blake C" first="C. I." last="Blake">C. I. Blake</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology, University of Colorado Health Sciences Center, Denver, Colorado</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Spitz, E" sort="Spitz, E" uniqKey="Spitz E" first="E." last="Spitz">E. Spitz</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology, University of Colorado Health Sciences Center, Denver, Colorado</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leehey, M" sort="Leehey, M" uniqKey="Leehey M" first="M." last="Leehey">M. Leehey</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology, University of Colorado Health Sciences Center, Denver, Colorado</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoffer" sort="Hoffer" uniqKey="Hoffer" last="Hoffer">Hoffer</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boyson, S J" sort="Boyson, S J" uniqKey="Boyson S" first="S. J." last="Boyson">S. J. Boyson</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology, University of Colorado Health Sciences Center, Denver, Colorado</wicri:regionArea>
<placeName><region type="state">Colorado</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="1997-01">1997-01</date>
<biblScope unit="vol">12</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="3">3</biblScope>
<biblScope unit="page" to="8">8</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">2D6FF893D8CFDA596A77FB4C3E9B90F7334BCD90</idno>
<idno type="DOI">10.1002/mds.870120103</idno>
<idno type="ArticleID">MDS870120103</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Blood Platelets (enzymology)</term>
<term>Blood platelets</term>
<term>Citrate (si)-Synthase (blood)</term>
<term>Citrate synthase</term>
<term>Complex I</term>
<term>Complex III</term>
<term>Complex IV</term>
<term>Cytochrome c oxidase</term>
<term>Electron Transport (physiology)</term>
<term>Electron Transport Complex III (blood)</term>
<term>Electron Transport Complex IV (blood)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mitochondria (enzymology)</term>
<term>NAD(P)H Dehydrogenase (Quinone) (blood)</term>
<term>NADH dehydrogenase</term>
<term>Parkinson Disease (blood)</term>
<term>Parkinson's disease</term>
<term>Reference Values</term>
<term>Ubiquinol‐Cytochrome c reductase</term>
<term>Ubiquinone</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Citrate (si)-Synthase</term>
<term>Electron Transport Complex III</term>
<term>Electron Transport Complex IV</term>
<term>NAD(P)H Dehydrogenase (Quinone)</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Blood Platelets</term>
<term>Mitochondria</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Electron Transport</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Reference Values</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Reports on mitochondrial respiratory chain (MRC) complex I (CI) dysfunction in the substantia nigra in Parkinson's disease (PD) support the oxidative stress hypothesis in the neuropathogenesis of PD. Studies in peripheral tissue have found variable decreased CI and occasionally other complex activity suggestive of systemic impairment of MRC function in PD; however, MRC activity may be influenced by numerous variables. We conducted spectrophotometric measurements of MRC function in platelet mitochondrial preparations in 13 individuals with PD and 9 age‐matched controls (CON) and have identified additional variables that may affect MRC activity. Mean CI, CIII, CIV, and citrate synthase (CS) activities were similar between PD and CON. CIII and CIV, specific and CS‐corrected, activities were significantly positively correlated with CI in combined and individual group data, with the exception of CIII CS‐corrected and CIV specific activities in CON and PD, respectively. CIII and CS specific activities were negatively correlated with age in CON, but varied randomly in PD. In PD, CIII specific activity was 1.4‐fold higher in those with a history of environmental risk factors for PD and CIV specific activity was lower in those with a positive family history of PD [8.34 ± 0.74 (n = 4) vs. 12.4 ± 1.1 (SEM) min−1 mg−1; p = 0.046]. Group heterogeneity, variables affecting enzyme activity, and intrinsic properties of cells may thus contribute to conflicting data in studies of MRC function in platelets and other tissues.</div>
</front>
</TEI>
</ISTEX>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005286 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 005286 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Curation |type= RBID |clé= ISTEX:2D6FF893D8CFDA596A77FB4C3E9B90F7334BCD90 |texte= Platelet mitochondrial respiratory chain function in Parkinson's disease }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |