Platelet mitochondrial respiratory chain function in Parkinson's disease.
Identifieur interne : 004600 ( PubMed/Checkpoint ); précédent : 004599; suivant : 004601Platelet mitochondrial respiratory chain function in Parkinson's disease.
Auteurs : C I Blake [États-Unis] ; E. Spitz ; M. Leehey ; B J Hoffer ; S J BoysonSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1997.
English descriptors
- KwdEn :
- Adult, Aged, Blood Platelets (enzymology), Citrate (si)-Synthase (blood), Electron Transport (physiology), Electron Transport Complex III (blood), Electron Transport Complex IV (blood), Female, Humans, Male, Middle Aged, Mitochondria (enzymology), NAD(P)H Dehydrogenase (Quinone) (blood), Parkinson Disease (blood), Reference Values.
- MESH :
- chemical , blood : Citrate (si)-Synthase, Electron Transport Complex III, Electron Transport Complex IV, NAD(P)H Dehydrogenase (Quinone).
- blood : Parkinson Disease.
- enzymology : Blood Platelets, Mitochondria.
- physiology : Electron Transport.
- Adult, Aged, Female, Humans, Male, Middle Aged, Reference Values.
Abstract
Reports on mitochondrial respiratory chain (MRC) complex I (CI) dysfunction in the substantia nigra in Parkinson's disease (PD) support the oxidative stress hypothesis in the neuropathogenesis of PD. Studies in peripheral tissue have found variable decreased CI and occasionally other complex activity suggestive of systemic impairment of MRC function in PD; however, MRC activity may be influenced by numerous variables. We conducted spectrophotometric measurements of MRC function in platelet mitochondrial preparations in 13 individuals with PD and 9 age-matched controls (CON) and have identified additional variables that may affect MRC activity. Mean CI, CIII, CIV, and citrate synthase (CS) activities were similar between PD and CON. CIII and CIV, specific and CS-corrected, activities were significantly positively correlated with CI in combined and individual group data, with the exception of CIII CS-corrected and CIV specific activities in CON and PD, respectively. CIII and CS specific activities were negatively correlated with age in CON, but varied randomly in PD. In PD, CIII specific activity was 1.4-fold higher in those with a history of environmental risk factors for PD and CIV specific activity was lower in those with a positive family history of PD [8.34 +/- 0.74 (n = 4) vs. 12.4 +/- 1.1 (SEM) min-1 mg-1; p = 0.046]. Group heterogeneity, variables affecting enzyme activity, and intrinsic properties of cells may thus contribute to conflicting data in studies of MRC function in platelets and other tissues.
DOI: 10.1002/mds.870120103
PubMed: 8990047
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Platelet mitochondrial respiratory chain function in Parkinson's disease.</title><author><name sortKey="Blake, C I" sort="Blake, C I" uniqKey="Blake C" first="C I" last="Blake">C I Blake</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Colorado Health Sciences Center, Denver 80262</wicri:regionArea><wicri:noRegion>Denver 80262</wicri:noRegion></affiliation></author><author><name sortKey="Spitz, E" sort="Spitz, E" uniqKey="Spitz E" first="E" last="Spitz">E. Spitz</name></author><author><name sortKey="Leehey, M" sort="Leehey, M" uniqKey="Leehey M" first="M" last="Leehey">M. Leehey</name></author><author><name sortKey="Hoffer, B J" sort="Hoffer, B J" uniqKey="Hoffer B" first="B J" last="Hoffer">B J Hoffer</name></author><author><name sortKey="Boyson, S J" sort="Boyson, S J" uniqKey="Boyson S" first="S J" last="Boyson">S J Boyson</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1997">1997</date><idno type="RBID">pubmed:8990047</idno><idno type="pmid">8990047</idno><idno type="doi">10.1002/mds.870120103</idno><idno type="wicri:Area/PubMed/Corpus">004739</idno><idno type="wicri:Area/PubMed/Curation">004739</idno><idno type="wicri:Area/PubMed/Checkpoint">004600</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Platelet mitochondrial respiratory chain function in Parkinson's disease.</title><author><name sortKey="Blake, C I" sort="Blake, C I" uniqKey="Blake C" first="C I" last="Blake">C I Blake</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Colorado Health Sciences Center, Denver 80262</wicri:regionArea><wicri:noRegion>Denver 80262</wicri:noRegion></affiliation></author><author><name sortKey="Spitz, E" sort="Spitz, E" uniqKey="Spitz E" first="E" last="Spitz">E. Spitz</name></author><author><name sortKey="Leehey, M" sort="Leehey, M" uniqKey="Leehey M" first="M" last="Leehey">M. Leehey</name></author><author><name sortKey="Hoffer, B J" sort="Hoffer, B J" uniqKey="Hoffer B" first="B J" last="Hoffer">B J Hoffer</name></author><author><name sortKey="Boyson, S J" sort="Boyson, S J" uniqKey="Boyson S" first="S J" last="Boyson">S J Boyson</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1997" type="published">1997</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Blood Platelets (enzymology)</term><term>Citrate (si)-Synthase (blood)</term><term>Electron Transport (physiology)</term><term>Electron Transport Complex III (blood)</term><term>Electron Transport Complex IV (blood)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Mitochondria (enzymology)</term><term>NAD(P)H Dehydrogenase (Quinone) (blood)</term><term>Parkinson Disease (blood)</term><term>Reference Values</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Citrate (si)-Synthase</term><term>Electron Transport Complex III</term><term>Electron Transport Complex IV</term><term>NAD(P)H Dehydrogenase (Quinone)</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Blood Platelets</term><term>Mitochondria</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Electron Transport</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Reference Values</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Reports on mitochondrial respiratory chain (MRC) complex I (CI) dysfunction in the substantia nigra in Parkinson's disease (PD) support the oxidative stress hypothesis in the neuropathogenesis of PD. Studies in peripheral tissue have found variable decreased CI and occasionally other complex activity suggestive of systemic impairment of MRC function in PD; however, MRC activity may be influenced by numerous variables. We conducted spectrophotometric measurements of MRC function in platelet mitochondrial preparations in 13 individuals with PD and 9 age-matched controls (CON) and have identified additional variables that may affect MRC activity. Mean CI, CIII, CIV, and citrate synthase (CS) activities were similar between PD and CON. CIII and CIV, specific and CS-corrected, activities were significantly positively correlated with CI in combined and individual group data, with the exception of CIII CS-corrected and CIV specific activities in CON and PD, respectively. CIII and CS specific activities were negatively correlated with age in CON, but varied randomly in PD. In PD, CIII specific activity was 1.4-fold higher in those with a history of environmental risk factors for PD and CIV specific activity was lower in those with a positive family history of PD [8.34 +/- 0.74 (n = 4) vs. 12.4 +/- 1.1 (SEM) min-1 mg-1; p = 0.046]. Group heterogeneity, variables affecting enzyme activity, and intrinsic properties of cells may thus contribute to conflicting data in studies of MRC function in platelets and other tissues.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">8990047</PMID><DateCreated><Year>1997</Year><Month>04</Month><Day>02</Day></DateCreated><DateCompleted><Year>1997</Year><Month>04</Month><Day>02</Day></DateCompleted><DateRevised><Year>2007</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>12</Volume><Issue>1</Issue><PubDate><Year>1997</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Platelet mitochondrial respiratory chain function in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>3-8</MedlinePgn></Pagination><Abstract><AbstractText>Reports on mitochondrial respiratory chain (MRC) complex I (CI) dysfunction in the substantia nigra in Parkinson's disease (PD) support the oxidative stress hypothesis in the neuropathogenesis of PD. Studies in peripheral tissue have found variable decreased CI and occasionally other complex activity suggestive of systemic impairment of MRC function in PD; however, MRC activity may be influenced by numerous variables. We conducted spectrophotometric measurements of MRC function in platelet mitochondrial preparations in 13 individuals with PD and 9 age-matched controls (CON) and have identified additional variables that may affect MRC activity. Mean CI, CIII, CIV, and citrate synthase (CS) activities were similar between PD and CON. CIII and CIV, specific and CS-corrected, activities were significantly positively correlated with CI in combined and individual group data, with the exception of CIII CS-corrected and CIV specific activities in CON and PD, respectively. CIII and CS specific activities were negatively correlated with age in CON, but varied randomly in PD. In PD, CIII specific activity was 1.4-fold higher in those with a history of environmental risk factors for PD and CIV specific activity was lower in those with a positive family history of PD [8.34 +/- 0.74 (n = 4) vs. 12.4 +/- 1.1 (SEM) min-1 mg-1; p = 0.046]. Group heterogeneity, variables affecting enzyme activity, and intrinsic properties of cells may thus contribute to conflicting data in studies of MRC function in platelets and other tissues.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Blake</LastName><ForeName>C I</ForeName><Initials>CI</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spitz</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Leehey</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Hoffer</LastName><ForeName>B J</ForeName><Initials>BJ</Initials></Author><Author ValidYN="Y"><LastName>Boyson</LastName><ForeName>S J</ForeName><Initials>SJ</Initials></Author></AuthorList><Language>eng</Language><GrantList 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Transport</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014450">Electron Transport Complex III</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003576">Electron Transport Complex IV</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008928">Mitochondria</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000201">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016660">NAD(P)H Dehydrogenase (Quinone)</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000097">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012016">Reference Values</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1997</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1997</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1997</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8990047</ArticleId><ArticleId IdType="doi">10.1002/mds.870120103</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Boyson, S J" sort="Boyson, S J" uniqKey="Boyson S" first="S J" last="Boyson">S J Boyson</name><name sortKey="Hoffer, B J" sort="Hoffer, B J" uniqKey="Hoffer B" first="B J" last="Hoffer">B J Hoffer</name><name sortKey="Leehey, M" sort="Leehey, M" uniqKey="Leehey M" first="M" last="Leehey">M. Leehey</name><name sortKey="Spitz, E" sort="Spitz, E" uniqKey="Spitz E" first="E" last="Spitz">E. Spitz</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Blake, C I" sort="Blake, C I" uniqKey="Blake C" first="C I" last="Blake">C I Blake</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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