Unilateral injection of botulinum toxin in blepharospasm: Single fiber electromyography and blink reflex study
Identifieur interne : 005560 ( Main/Exploration ); précédent : 005559; suivant : 005561Unilateral injection of botulinum toxin in blepharospasm: Single fiber electromyography and blink reflex study
Auteurs : Girlanda [Italie] ; A. Quartarone [Italie] ; S. Sinicropi [Italie] ; C. Nicolosi [Italie] ; C. Messina [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 1996-01.
English descriptors
- KwdEn :
- Aged, Blepharospasm, Blepharospasm (drug therapy), Blink reflex, Blinking (drug effects), Botulinum Toxins (administration & dosage), Botulinum Toxins (adverse effects), Botulinum toxin, Electromyography (drug effects), Evoked Potentials, Motor (drug effects), Female, Functional Laterality (drug effects), Humans, Injections, Intramuscular, Male, Middle Aged, Neuromuscular Junction (drug effects), Single fiber electromyography, Synaptic Transmission (drug effects).
- MESH :
- chemical , administration & dosage : Botulinum Toxins.
- chemical , adverse effects : Botulinum Toxins.
- drug effects : Blinking, Electromyography, Evoked Potentials, Motor, Functional Laterality, Neuromuscular Junction, Synaptic Transmission.
- drug therapy : Blepharospasm.
- Aged, Female, Humans, Injections, Intramuscular, Male, Middle Aged.
Abstract
We studied six patients affected with blepharospasm (BSP). We injected botulinum toxin (BTX) around only one eye and saline solution around the other. Clinical rating of BSP was performed. Single fiber electromyography (SFEMG), compound motor action potential (cMAP) at the orbicularis oculi muscle by stimulation of the facial nerve, blink reflex, and blink reflex recovery curve were recorded. All clinical and electrophysiological investigations were carried out before, and 1, 2, and 4 weeks after treatment. Evidence of bilateral clinical benefit was provided. Following therapy, facial cMAP decreased bilaterally and SFEMG revealed statistically significant changes on both sides while the excitability curve of blink reflex remained unmodified. The results confirm that BTX affects merely the neuromuscular junctions. The clinical and neurophysiological effects are present on both sides also for unilateral injection probably because of toxin spreading.
Url:
DOI: 10.1002/mds.870110107
Affiliations:
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Nicolosi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Neurologica 2, University of Messina, Messina</wicri:regionArea><wicri:noRegion>Messina</wicri:noRegion></affiliation></author><author><name sortKey="Messina, C" sort="Messina, C" uniqKey="Messina C" first="C." last="Messina">C. Messina</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Neurologica 2, University of Messina, Messina</wicri:regionArea><wicri:noRegion>Messina</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1996-01">1996-01</date><biblScope unit="vol">11</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="27">27</biblScope><biblScope unit="page" to="31">31</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C4D9300535C983DEE47D1B110F5981C173D1C457</idno><idno type="DOI">10.1002/mds.870110107</idno><idno type="ArticleID">MDS870110107</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Blepharospasm</term><term>Blepharospasm (drug therapy)</term><term>Blink reflex</term><term>Blinking (drug effects)</term><term>Botulinum Toxins (administration & dosage)</term><term>Botulinum Toxins (adverse effects)</term><term>Botulinum toxin</term><term>Electromyography (drug effects)</term><term>Evoked Potentials, Motor (drug effects)</term><term>Female</term><term>Functional Laterality (drug effects)</term><term>Humans</term><term>Injections, Intramuscular</term><term>Male</term><term>Middle Aged</term><term>Neuromuscular Junction (drug effects)</term><term>Single fiber electromyography</term><term>Synaptic Transmission (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Botulinum Toxins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Botulinum Toxins</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Blinking</term><term>Electromyography</term><term>Evoked Potentials, Motor</term><term>Functional Laterality</term><term>Neuromuscular Junction</term><term>Synaptic Transmission</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Blepharospasm</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Injections, Intramuscular</term><term>Male</term><term>Middle Aged</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied six patients affected with blepharospasm (BSP). We injected botulinum toxin (BTX) around only one eye and saline solution around the other. Clinical rating of BSP was performed. Single fiber electromyography (SFEMG), compound motor action potential (cMAP) at the orbicularis oculi muscle by stimulation of the facial nerve, blink reflex, and blink reflex recovery curve were recorded. All clinical and electrophysiological investigations were carried out before, and 1, 2, and 4 weeks after treatment. Evidence of bilateral clinical benefit was provided. Following therapy, facial cMAP decreased bilaterally and SFEMG revealed statistically significant changes on both sides while the excitability curve of blink reflex remained unmodified. The results confirm that BTX affects merely the neuromuscular junctions. The clinical and neurophysiological effects are present on both sides also for unilateral injection probably because of toxin spreading.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Girlanda" sort="Girlanda" uniqKey="Girlanda" last="Girlanda">Girlanda</name></noRegion><name sortKey="Messina, C" sort="Messina, C" uniqKey="Messina C" first="C." last="Messina">C. Messina</name><name sortKey="Nicolosi, C" sort="Nicolosi, C" uniqKey="Nicolosi C" first="C." last="Nicolosi">C. Nicolosi</name><name sortKey="Quartarone, A" sort="Quartarone, A" uniqKey="Quartarone A" first="A." last="Quartarone">A. Quartarone</name><name sortKey="Sinicropi, S" sort="Sinicropi, S" uniqKey="Sinicropi S" first="S." last="Sinicropi">S. Sinicropi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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