Unilateral injection of botulinum toxin in blepharospasm: single fiber electromyography and blink reflex study.
Identifieur interne : 004B39 ( Ncbi/Checkpoint ); précédent : 004B38; suivant : 004B40Unilateral injection of botulinum toxin in blepharospasm: single fiber electromyography and blink reflex study.
Auteurs : P. Girlanda [Italie] ; A. Quartarone ; S. Sinicropi ; C. Nicolosi ; C. MessinaSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1996.
English descriptors
- KwdEn :
- Aged, Blepharospasm (drug therapy), Blinking (drug effects), Botulinum Toxins (administration & dosage), Botulinum Toxins (adverse effects), Electromyography (drug effects), Evoked Potentials, Motor (drug effects), Female, Functional Laterality (drug effects), Humans, Injections, Intramuscular, Male, Middle Aged, Neuromuscular Junction (drug effects), Synaptic Transmission (drug effects).
- MESH :
- chemical , administration & dosage : Botulinum Toxins.
- chemical , adverse effects : Botulinum Toxins.
- drug effects : Blinking, Electromyography, Evoked Potentials, Motor, Functional Laterality, Neuromuscular Junction, Synaptic Transmission.
- drug therapy : Blepharospasm.
- Aged, Female, Humans, Injections, Intramuscular, Male, Middle Aged.
Abstract
We studied six patients affected with blepharospasm (BSP). We injected botulinum toxin (BTX) around only one eye and saline solution around the other. Clinical rating of BSP was performed. Single fiber electromyography (SFEMG), compound motor action potential (cMAP) at the orbicularis oculi muscle by stimulation of the facial nerve, blink reflex, and blink reflex recovery curve were recorded. All clinical and electrophysiological investigations were carried out before, and 1, 2, and 4 weeks after treatment. Evidence of bilateral clinical benefit was provided. Following therapy, facial cMAP decreased bilaterally and SFEMG revealed statistically significant changes on both sides while the excitability curve of blink reflex remained unmodified. The results confirm that BTX affects merely the neuromuscular junctions. The clinical and neurophysiological effects are present on both sides also for unilateral injection probably because of toxin spreading.
DOI: 10.1002/mds.870110107
PubMed: 8771064
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Unilateral injection of botulinum toxin in blepharospasm: single fiber electromyography and blink reflex study.</title><author><name sortKey="Girlanda, P" sort="Girlanda, P" uniqKey="Girlanda P" first="P" last="Girlanda">P. Girlanda</name><affiliation wicri:level="1"><nlm:affiliation>Clinica Neurologica 2, University of Messina, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Neurologica 2, University of Messina</wicri:regionArea><wicri:noRegion>University of Messina</wicri:noRegion></affiliation></author><author><name sortKey="Quartarone, A" sort="Quartarone, A" uniqKey="Quartarone A" first="A" last="Quartarone">A. Quartarone</name></author><author><name sortKey="Sinicropi, S" sort="Sinicropi, S" uniqKey="Sinicropi S" first="S" last="Sinicropi">S. Sinicropi</name></author><author><name sortKey="Nicolosi, C" sort="Nicolosi, C" uniqKey="Nicolosi C" first="C" last="Nicolosi">C. Nicolosi</name></author><author><name sortKey="Messina, C" sort="Messina, C" uniqKey="Messina C" first="C" last="Messina">C. Messina</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1996">1996</date><idno type="RBID">pubmed:8771064</idno><idno type="pmid">8771064</idno><idno type="doi">10.1002/mds.870110107</idno><idno type="wicri:Area/PubMed/Corpus">004890</idno><idno type="wicri:Area/PubMed/Curation">004890</idno><idno type="wicri:Area/PubMed/Checkpoint">004744</idno><idno type="wicri:Area/Ncbi/Merge">004B39</idno><idno type="wicri:Area/Ncbi/Curation">004B39</idno><idno type="wicri:Area/Ncbi/Checkpoint">004B39</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Unilateral injection of botulinum toxin in blepharospasm: single fiber electromyography and blink reflex study.</title><author><name sortKey="Girlanda, P" sort="Girlanda, P" uniqKey="Girlanda P" first="P" last="Girlanda">P. Girlanda</name><affiliation wicri:level="1"><nlm:affiliation>Clinica Neurologica 2, University of Messina, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Neurologica 2, University of Messina</wicri:regionArea><wicri:noRegion>University of Messina</wicri:noRegion></affiliation></author><author><name sortKey="Quartarone, A" sort="Quartarone, A" uniqKey="Quartarone A" first="A" last="Quartarone">A. Quartarone</name></author><author><name sortKey="Sinicropi, S" sort="Sinicropi, S" uniqKey="Sinicropi S" first="S" last="Sinicropi">S. Sinicropi</name></author><author><name sortKey="Nicolosi, C" sort="Nicolosi, C" uniqKey="Nicolosi C" first="C" last="Nicolosi">C. Nicolosi</name></author><author><name sortKey="Messina, C" sort="Messina, C" uniqKey="Messina C" first="C" last="Messina">C. Messina</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1996" type="published">1996</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Blepharospasm (drug therapy)</term><term>Blinking (drug effects)</term><term>Botulinum Toxins (administration & dosage)</term><term>Botulinum Toxins (adverse effects)</term><term>Electromyography (drug effects)</term><term>Evoked Potentials, Motor (drug effects)</term><term>Female</term><term>Functional Laterality (drug effects)</term><term>Humans</term><term>Injections, Intramuscular</term><term>Male</term><term>Middle Aged</term><term>Neuromuscular Junction (drug effects)</term><term>Synaptic Transmission (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Botulinum Toxins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Botulinum Toxins</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Blinking</term><term>Electromyography</term><term>Evoked Potentials, Motor</term><term>Functional Laterality</term><term>Neuromuscular Junction</term><term>Synaptic Transmission</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Blepharospasm</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Injections, Intramuscular</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied six patients affected with blepharospasm (BSP). We injected botulinum toxin (BTX) around only one eye and saline solution around the other. Clinical rating of BSP was performed. Single fiber electromyography (SFEMG), compound motor action potential (cMAP) at the orbicularis oculi muscle by stimulation of the facial nerve, blink reflex, and blink reflex recovery curve were recorded. All clinical and electrophysiological investigations were carried out before, and 1, 2, and 4 weeks after treatment. Evidence of bilateral clinical benefit was provided. Following therapy, facial cMAP decreased bilaterally and SFEMG revealed statistically significant changes on both sides while the excitability curve of blink reflex remained unmodified. The results confirm that BTX affects merely the neuromuscular junctions. The clinical and neurophysiological effects are present on both sides also for unilateral injection probably because of toxin spreading.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Messina, C" sort="Messina, C" uniqKey="Messina C" first="C" last="Messina">C. Messina</name><name sortKey="Nicolosi, C" sort="Nicolosi, C" uniqKey="Nicolosi C" first="C" last="Nicolosi">C. Nicolosi</name><name sortKey="Quartarone, A" sort="Quartarone, A" uniqKey="Quartarone A" first="A" last="Quartarone">A. Quartarone</name><name sortKey="Sinicropi, S" sort="Sinicropi, S" uniqKey="Sinicropi S" first="S" last="Sinicropi">S. Sinicropi</name></noCountry><country name="Italie"><noRegion><name sortKey="Girlanda, P" sort="Girlanda, P" uniqKey="Girlanda P" first="P" last="Girlanda">P. Girlanda</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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