MovDisordV3, Main, Exploration, bibRecord, 004B13

Case‐control study of debrisoquine 4‐hydroxylase, n‐acetyltransferase 2, and apolipoprotein e gene polymorphisms in Parkinson's disease

Identifieur interne : 004B13 ( Main/Exploration ); précédent : 004B12; suivant : 004B14

Case‐control study of debrisoquine 4‐hydroxylase, n‐acetyltransferase 2, and apolipoprotein e gene polymorphisms in Parkinson's disease

Auteurs : Demetrius M. Maraganore [États-Unis] ; Matthew J. Farrer [États-Unis] ; John A. Hardy [États-Unis] ; Shannon K. Mcdonnell [États-Unis] ; Daniel J. Schaid [États-Unis] ; Walter A. Rocca [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2000-07.

RBID : ISTEX:0125CBD0DA113E6A3A9E3CA687A682FC82C44D28

Descripteurs français

Pascal (Inist)
- Acyltransferases, Apolipoprotéine E, Débrisoquine, Exploration, Génétique, Homme, Hydroxylase, Parkinson maladie, Polymorphisme.
Wicri :
- topic : Génétique, Homme.

English descriptors

KwdEn :
- APOE, Acyltransferases, Adult, Aged, Aged, 80 and over, Alleles, Apolipoprotein E, Apolipoproteins E (genetics), Arylamine N-Acetyltransferase (blood), Arylamine N-Acetyltransferase (genetics), CYP2D6, Case-Control Studies, Case‐control study, Cytochrome P-450 CYP2D6 (blood), Cytochrome P-450 CYP2D6 (genetics), Debrisoquine, Exploration, Female, Genetics, Genotype, Human, Humans, Hydroxylase, Male, Middle Aged, NAT2, Parkinson Disease (diagnosis), Parkinson Disease (enzymology), Parkinson Disease (genetics), Parkinson disease, Parkinson's disease, Polymorphism, Polymorphism, Genetic (genetics), Susceptibility genes.
MESH :
- chemical , blood : Arylamine N-Acetyltransferase, Cytochrome P-450 CYP2D6.
- chemical , genetics : Apolipoproteins E, Arylamine N-Acetyltransferase, Cytochrome P-450 CYP2D6.
- diagnosis : Parkinson Disease.
- enzymology : Parkinson Disease.
- genetics : Parkinson Disease, Polymorphism, Genetic.
- Adult, Aged, Aged, 80 and over, Alleles, Case-Control Studies, Female, Genotype, Humans, Male, Middle Aged.

Abstract

We investigated the association of Parkinson's disease (PD) with two genes encoding liver‐detoxifying enzymes, debrisoquine 4‐hydroxylase (CYP2D6) and N‐acetyltransferase 2 (NAT2), and with one gene related to Alzheimer's disease, apolipoprotein E (APOE). In a sample of 139 unrelated PD cases and 113 control subjects, the NAT2 M3 allele was associated with PD (odds ratio = 7.9; 95% confidence interval = 1.7–36.3). Case‐control analyses for CYP2D6, APOE, and NAT2 M1 or M2 did not show a significant association. However, the age at onset of PD was significantly earlier in cases with the APOE ϵ2/ϵ3 genotype than in cases with the ϵ3/ϵ3 genotype.

Url:

https://api.istex.fr/document/0125CBD0DA113E6A3A9E3CA687A682FC82C44D28/fulltext/pdf

DOI: 10.1002/1531-8257(200007)15:4<714::AID-MDS1018>3.0.CO;2-3

Affiliations:

Le document en format XML

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<term>Acyltransferases</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Alleles</term>
<term>Apolipoprotein E</term>
<term>Apolipoproteins E (genetics)</term>
<term>Arylamine N-Acetyltransferase (blood)</term>
<term>Arylamine N-Acetyltransferase (genetics)</term>
<term>CYP2D6</term>
<term>Case-Control Studies</term>
<term>Case‐control study</term>
<term>Cytochrome P-450 CYP2D6 (blood)</term>
<term>Cytochrome P-450 CYP2D6 (genetics)</term>
<term>Debrisoquine</term>
<term>Exploration</term>
<term>Female</term>
<term>Genetics</term>
<term>Genotype</term>
<term>Human</term>
<term>Humans</term>
<term>Hydroxylase</term>
<term>Male</term>
<term>Middle Aged</term>
<term>NAT2</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (enzymology)</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Polymorphism</term>
<term>Polymorphism, Genetic (genetics)</term>
<term>Susceptibility genes</term>
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<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Arylamine N-Acetyltransferase</term>
<term>Cytochrome P-450 CYP2D6</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Apolipoproteins E</term>
<term>Arylamine N-Acetyltransferase</term>
<term>Cytochrome P-450 CYP2D6</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term>
<term>Polymorphism, Genetic</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Alleles</term>
<term>Case-Control Studies</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Acyltransferases</term>
<term>Apolipoprotéine E</term>
<term>Débrisoquine</term>
<term>Exploration</term>
<term>Génétique</term>
<term>Homme</term>
<term>Hydroxylase</term>
<term>Parkinson maladie</term>
<term>Polymorphisme</term>
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<front><div type="abstract" xml:lang="en">We investigated the association of Parkinson's disease (PD) with two genes encoding liver‐detoxifying enzymes, debrisoquine 4‐hydroxylase (CYP2D6) and N‐acetyltransferase 2 (NAT2), and with one gene related to Alzheimer's disease, apolipoprotein E (APOE). In a sample of 139 unrelated PD cases and 113 control subjects, the NAT2 M3 allele was associated with PD (odds ratio = 7.9; 95% confidence interval = 1.7–36.3). Case‐control analyses for CYP2D6, APOE, and NAT2 M1 or M2 did not show a significant association. However, the age at onset of PD was significantly earlier in cases with the APOE ϵ2/ϵ3 genotype than in cases with the ϵ3/ϵ3 genotype.</div>
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Movement Disorders (revue)

Case‐control study of debrisoquine 4‐hydroxylase, n‐acetyltransferase 2, and apolipoprotein e gene polymorphisms in Parkinson's disease

Case‐control study of debrisoquine 4‐hydroxylase, n‐acetyltransferase 2, and apolipoprotein e gene polymorphisms in Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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	Movement Disorders (revue)
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