MovDisordV3, Main, Merge, bibRecord, 007633

Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apolipoprotein E gene polymorphisms in Parkinson's disease

Identifieur interne : 007633 ( Main/Merge ); précédent : 007632; suivant : 007634

Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apolipoprotein E gene polymorphisms in Parkinson's disease

Auteurs : D. M. Maraganore [États-Unis] ; M. J. Farrer [États-Unis] ; J. A. Hardy [États-Unis] ; S. K. Mcdonnell [États-Unis] ; D. J. Schaid [États-Unis] ; W. A. Rocca [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2000.

RBID : Pascal:00-0394759

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Débrisoquine, Hydroxylase, Acyltransferases, Apolipoprotéine E, Polymorphisme, Exploration, Homme, Génétique.
Wicri :
- topic : Homme, Génétique.

English descriptors

KwdEn :
- Acyltransferases, Apolipoprotein E, Debrisoquine, Exploration, Genetics, Human, Hydroxylase, Parkinson disease, Polymorphism.

Abstract

We investigated the association of Parkinson's disease (PD) with two genes encoding liver-detoxifying enzymes, debrisoquine 4-hydroxylase (CYP2D6) and N-acetyltransferase 2 (NAT2), and with one gene related to Alzheimer's disease, apolipoprotein E (APOE). In a sample of 139 unrelated PD cases and 113 control subjects, the NAT2 M3 allele was associated with PD (odds ratio = 7.9; 95% confidence interval = 1.7-36.3). Case-control analyses for CYP2D6, APOE, and NAT2 M1 or M2 did not show a significant association. However, the age at onset of PD was significantly earlier in cases with the APOE ∈2/∈3 genotype than in cases with the ∈3/∈3 genotype.

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Pascal:00-0394759

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acyltransferases</term>
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<term>Debrisoquine</term>
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<term>Genetics</term>
<term>Human</term>
<term>Hydroxylase</term>
<term>Parkinson disease</term>
<term>Polymorphism</term>
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<term>Débrisoquine</term>
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<term>Polymorphisme</term>
<term>Exploration</term>
<term>Homme</term>
<term>Génétique</term>
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<front><div type="abstract" xml:lang="en">We investigated the association of Parkinson's disease (PD) with two genes encoding liver-detoxifying enzymes, debrisoquine 4-hydroxylase (CYP2D6) and N-acetyltransferase 2 (NAT2), and with one gene related to Alzheimer's disease, apolipoprotein E (APOE). In a sample of 139 unrelated PD cases and 113 control subjects, the NAT2 M3 allele was associated with PD (odds ratio = 7.9; 95% confidence interval = 1.7-36.3). Case-control analyses for CYP2D6, APOE, and NAT2 M1 or M2 did not show a significant association. However, the age at onset of PD was significantly earlier in cases with the APOE ∈2/∈3 genotype than in cases with the ∈3/∈3 genotype.</div>
</front>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apolipoprotein E gene polymorphisms in Parkinson's disease

Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apolipoprotein E gene polymorphisms in Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri