Two‐year follow‐up of subthalamic deep brain stimulation in Parkinson's disease
Identifieur interne : 003F03 ( Main/Exploration ); précédent : 003F02; suivant : 003F04Two‐year follow‐up of subthalamic deep brain stimulation in Parkinson's disease
Auteurs : Jan Herzog [Allemagne] ; Jens Volkmann [Allemagne] ; Paul Krack [Allemagne, France] ; Florian Kopper [Allemagne] ; Monika Pötter [Allemagne] ; Delia Lorenz [Allemagne] ; Meike Steinbach [Allemagne] ; Stefan Klebe [Allemagne] ; Wolfgang Hamel [Allemagne] ; Bettina Schrader [Allemagne] ; Dieter Weinert [Allemagne] ; Dieter Müller [Allemagne] ; Hubertus M. Mehdorn [Allemagne] ; Günther Deuschl [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-11.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Bilateral, Electric Stimulation (instrumentation), Evolution, Female, Follow up study, Follow-Up Studies, Human, Humans, Instrumental stimulation, Male, Middle Aged, Parkinson Disease (diagnosis), Parkinson Disease (therapy), Parkinson disease, Severity of Illness Index, Subthalamic Nucleus (physiology), Subthalamic nucleus, Treatment, deep brain stimulation, subthalamic nucleus.
- MESH :
- diagnosis : Parkinson Disease.
- instrumentation : Electric Stimulation.
- physiology : Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Female, Follow-Up Studies, Humans, Male, Middle Aged, Severity of Illness Index.
Abstract
We studied 48 patients after bilateral subthalamic nucleus deep brain stimulation (STN‐DBS) who were evaluated 6 months after the surgical procedure using the Unified Parkinson's Disease Rating Scale (UPDRS) in a standardized levodopa test. Additional follow‐up was available in 32 patients after 12 months and in 20 patients after 24 months. At 6 months follow‐up, STN‐DBS reduced the UPDRS motor score by 50.9% compared to baseline. This improvement remained constant at 12 months with 57.5% and at 24 months with 57.3%. Relevant side effects after STN‐DBS included intraoperative subdural hematoma without neurological sequelae (n = 1), minor intracerebral bleeding with slight transient hemiparesis (n = 1), dislocation of impulse generator (n = 2), transient perioperative confusional symptoms (n = 7), psychotic symptoms (n = 2), depression (n = 5), hypomanic behaviour (n = 2), and transient manic psychosis (n = 1). One patient died because of heart failure during the first postoperative year. The current series demonstrates efficacy and safety of STN‐DBS beyond the first year after surgical procedure. Complications of STN‐DBS comprise a wide range of psychiatric adverse events which, however, were temporary. © 2003 Movement Disorder Society
Url:
DOI: 10.1002/mds.10518
Affiliations:
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<author><name sortKey="Hamel, Wolfgang" sort="Hamel, Wolfgang" uniqKey="Hamel W" first="Wolfgang" last="Hamel">Wolfgang Hamel</name>
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<term>Follow up study</term>
<term>Follow-Up Studies</term>
<term>Human</term>
<term>Humans</term>
<term>Instrumental stimulation</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (therapy)</term>
<term>Parkinson disease</term>
<term>Severity of Illness Index</term>
<term>Subthalamic Nucleus (physiology)</term>
<term>Subthalamic nucleus</term>
<term>Treatment</term>
<term>deep brain stimulation</term>
<term>subthalamic nucleus</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Subthalamic Nucleus</term>
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<front><div type="abstract" xml:lang="en">We studied 48 patients after bilateral subthalamic nucleus deep brain stimulation (STN‐DBS) who were evaluated 6 months after the surgical procedure using the Unified Parkinson's Disease Rating Scale (UPDRS) in a standardized levodopa test. Additional follow‐up was available in 32 patients after 12 months and in 20 patients after 24 months. At 6 months follow‐up, STN‐DBS reduced the UPDRS motor score by 50.9% compared to baseline. This improvement remained constant at 12 months with 57.5% and at 24 months with 57.3%. Relevant side effects after STN‐DBS included intraoperative subdural hematoma without neurological sequelae (n = 1), minor intracerebral bleeding with slight transient hemiparesis (n = 1), dislocation of impulse generator (n = 2), transient perioperative confusional symptoms (n = 7), psychotic symptoms (n = 2), depression (n = 5), hypomanic behaviour (n = 2), and transient manic psychosis (n = 1). One patient died because of heart failure during the first postoperative year. The current series demonstrates efficacy and safety of STN‐DBS beyond the first year after surgical procedure. Complications of STN‐DBS comprise a wide range of psychiatric adverse events which, however, were temporary. © 2003 Movement Disorder Society</div>
</front>
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