Two-year follow-up of subthalamic deep brain stimulation in Parkinson's disease
Identifieur interne : 005E31 ( Main/Merge ); précédent : 005E30; suivant : 005E32Two-year follow-up of subthalamic deep brain stimulation in Parkinson's disease
Auteurs : Jan Herzog [Allemagne] ; Jens Volkmann [Allemagne] ; Paul Krack [Allemagne] ; Florian Kopper [Allemagne] ; Monika Potter [Allemagne] ; Delia Lorenz [Allemagne] ; Meike Steinbach [Allemagne] ; Stefan Klebe [Allemagne] ; Wolfgang Hamel [Allemagne] ; Bettina Schrader [Allemagne] ; Dieter Weinert [Allemagne] ; Dieter Müller [Allemagne] ; Hubertus M. Mehdorn [Allemagne] ; Günther Deuschl [Allemagne]Source :
- Movement disorders [ 0885-3185 ] ; 2003.
Descripteurs français
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Abstract
We studied 48 patients after bilateral subthalamic nucleus deep brain stimulation (STN-DBS) who were evaluated 6 months after the surgical procedure using the Unified Parkinson's Disease Rating Scale (UPDRS) in a standardized levodopa test. Additional follow-up was available in 32 patients after 12 months and in 20 patients after 24 months. At 6 months follow-up, STN-DBS reduced the UPDRS motor score by 50.9% compared to baseline. This improvement remained constant at 12 months with 57.5% and at 24 months with 57.3%. Relevant side effects after STN-DBS included intraoperative subdural hematoma without neurological sequelae (n = 1), minor intracerebral bleeding with slight transient hemiparesis (n = 1), dislocation of impulse generator (n = 2), transient perioperative confusional symptoms (n = 7), psychotic symptoms (n = 2), depression (n = 5), hypomanic behaviour (n = 2), and transient manic psychosis (n = 1). One patient died because of heart failure during the first postoperative year. The current series demonstrates efficacy and safety of STN-DBS beyond the first year after surgical procedure. Complications of STN-DBS comprise a wide range of psychiatric adverse events which, however, were temporary.
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Two-year follow-up of subthalamic deep brain stimulation in Parkinson's disease</title>
<author><name sortKey="Herzog, Jan" sort="Herzog, Jan" uniqKey="Herzog J" first="Jan" last="Herzog">Jan Herzog</name>
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<author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name>
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<author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name>
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<author><name sortKey="Kopper, Florian" sort="Kopper, Florian" uniqKey="Kopper F" first="Florian" last="Kopper">Florian Kopper</name>
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<author><name sortKey="Potter, Monika" sort="Potter, Monika" uniqKey="Potter M" first="Monika" last="Potter">Monika Potter</name>
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<author><name sortKey="Lorenz, Delia" sort="Lorenz, Delia" uniqKey="Lorenz D" first="Delia" last="Lorenz">Delia Lorenz</name>
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<author><name sortKey="Steinbach, Meike" sort="Steinbach, Meike" uniqKey="Steinbach M" first="Meike" last="Steinbach">Meike Steinbach</name>
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<author><name sortKey="Klebe, Stefan" sort="Klebe, Stefan" uniqKey="Klebe S" first="Stefan" last="Klebe">Stefan Klebe</name>
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<author><name sortKey="Hamel, Wolfgang" sort="Hamel, Wolfgang" uniqKey="Hamel W" first="Wolfgang" last="Hamel">Wolfgang Hamel</name>
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<author><name sortKey="Schrader, Bettina" sort="Schrader, Bettina" uniqKey="Schrader B" first="Bettina" last="Schrader">Bettina Schrader</name>
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<author><name sortKey="Weinert, Dieter" sort="Weinert, Dieter" uniqKey="Weinert D" first="Dieter" last="Weinert">Dieter Weinert</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurosurgery, Christian-Albrechts Universität Kiel</s1>
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<author><name sortKey="Muller, Dieter" sort="Muller, Dieter" uniqKey="Muller D" first="Dieter" last="Müller">Dieter Müller</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Neurosurgery, University of Hamburg</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mehdorn, Hubertus M" sort="Mehdorn, Hubertus M" uniqKey="Mehdorn H" first="Hubertus M." last="Mehdorn">Hubertus M. Mehdorn</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurosurgery, Christian-Albrechts Universität Kiel</s1>
<s2>Kiel</s2>
<s3>DEU</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Schleswig-Holstein</region>
<settlement type="city">Kiel</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Christian-Albrechts Universität Kiel</s1>
<s2>Kiel</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Schleswig-Holstein</region>
<settlement type="city">Kiel</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2003">2003</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bilateral</term>
<term>Evolution</term>
<term>Follow up study</term>
<term>Human</term>
<term>Instrumental stimulation</term>
<term>Parkinson disease</term>
<term>Subthalamic nucleus</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Stimulation instrumentale</term>
<term>Noyau sousthalamique</term>
<term>Bilatéral</term>
<term>Etude longitudinale</term>
<term>Traitement</term>
<term>Evolution</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We studied 48 patients after bilateral subthalamic nucleus deep brain stimulation (STN-DBS) who were evaluated 6 months after the surgical procedure using the Unified Parkinson's Disease Rating Scale (UPDRS) in a standardized levodopa test. Additional follow-up was available in 32 patients after 12 months and in 20 patients after 24 months. At 6 months follow-up, STN-DBS reduced the UPDRS motor score by 50.9% compared to baseline. This improvement remained constant at 12 months with 57.5% and at 24 months with 57.3%. Relevant side effects after STN-DBS included intraoperative subdural hematoma without neurological sequelae (n = 1), minor intracerebral bleeding with slight transient hemiparesis (n = 1), dislocation of impulse generator (n = 2), transient perioperative confusional symptoms (n = 7), psychotic symptoms (n = 2), depression (n = 5), hypomanic behaviour (n = 2), and transient manic psychosis (n = 1). One patient died because of heart failure during the first postoperative year. The current series demonstrates efficacy and safety of STN-DBS beyond the first year after surgical procedure. Complications of STN-DBS comprise a wide range of psychiatric adverse events which, however, were temporary.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>Hambourg</li>
<li>Schleswig-Holstein</li>
</region>
<settlement><li>Hambourg</li>
<li>Kiel</li>
</settlement>
</list>
<tree><country name="Allemagne"><region name="Schleswig-Holstein"><name sortKey="Herzog, Jan" sort="Herzog, Jan" uniqKey="Herzog J" first="Jan" last="Herzog">Jan Herzog</name>
</region>
<name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name>
<name sortKey="Hamel, Wolfgang" sort="Hamel, Wolfgang" uniqKey="Hamel W" first="Wolfgang" last="Hamel">Wolfgang Hamel</name>
<name sortKey="Klebe, Stefan" sort="Klebe, Stefan" uniqKey="Klebe S" first="Stefan" last="Klebe">Stefan Klebe</name>
<name sortKey="Kopper, Florian" sort="Kopper, Florian" uniqKey="Kopper F" first="Florian" last="Kopper">Florian Kopper</name>
<name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name>
<name sortKey="Lorenz, Delia" sort="Lorenz, Delia" uniqKey="Lorenz D" first="Delia" last="Lorenz">Delia Lorenz</name>
<name sortKey="Mehdorn, Hubertus M" sort="Mehdorn, Hubertus M" uniqKey="Mehdorn H" first="Hubertus M." last="Mehdorn">Hubertus M. Mehdorn</name>
<name sortKey="Muller, Dieter" sort="Muller, Dieter" uniqKey="Muller D" first="Dieter" last="Müller">Dieter Müller</name>
<name sortKey="Potter, Monika" sort="Potter, Monika" uniqKey="Potter M" first="Monika" last="Potter">Monika Potter</name>
<name sortKey="Schrader, Bettina" sort="Schrader, Bettina" uniqKey="Schrader B" first="Bettina" last="Schrader">Bettina Schrader</name>
<name sortKey="Steinbach, Meike" sort="Steinbach, Meike" uniqKey="Steinbach M" first="Meike" last="Steinbach">Meike Steinbach</name>
<name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name>
<name sortKey="Weinert, Dieter" sort="Weinert, Dieter" uniqKey="Weinert D" first="Dieter" last="Weinert">Dieter Weinert</name>
</country>
</tree>
</affiliations>
</record>
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