Brain parenchyma sonography detects preclinical parkinsonism
Identifieur interne : 003D91 ( Main/Exploration ); précédent : 003D90; suivant : 003D92Brain parenchyma sonography detects preclinical parkinsonism
Auteurs : Uwe Walter [Allemagne] ; Christine Klein [Allemagne] ; Ruediger Hilker [Allemagne] ; Reiner Benecke [Allemagne] ; Peter P. Pramstaller [Italie] ; Dirk Dressler [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2004-12.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Alleles, Asymptomatic, Brain (pathology), Encephalon, Female, Fluorodeoxyglucose F18 (diagnostic use), Humans, Male, Middle Aged, Nervous system diseases, PARK2, Parkinson Disease (genetics), Parkinson Disease (pathology), Parkinson Disease (ultrasonography), Parkinson's disease, Parkinsonism, Point Mutation (genetics), Positron-Emission Tomography, Radiopharmaceuticals (diagnostic use), Sonography, Substantia Nigra (metabolism), Substantia Nigra (ultrasonography), Ubiquitin-Protein Ligases (genetics), brain parenchyma sonography, parkin, substantia nigra, substantia nigra hyperechogenicity.
- MESH :
- chemical , diagnostic use : Fluorodeoxyglucose F18, Radiopharmaceuticals.
- genetics : Parkinson Disease, Point Mutation, Ubiquitin-Protein Ligases.
- metabolism : Substantia Nigra.
- pathology : Brain, Parkinson Disease.
- ultrasonography : Parkinson Disease, Substantia Nigra.
- Adult, Aged, Aged, 80 and over, Alleles, Female, Humans, Male, Middle Aged, Positron-Emission Tomography.
Abstract
Substantia nigra (SN) hyperechogenicity on brain parenchyma sonography (BPS) is highly characteristic for idiopathic PD. We studied 7 symptomatic and 7 asymptomatic parkin mutation carriers (PMC) from a large kindred with adult‐onset parkinsonism. BPS revealed larger SN echogenic sizes in PMC with parkin mutations on both alleles (homozygous, compound‐heterozygous), compared to PMC with only one mutated allele (Mann–Whitney U test, P = 0.007). In symptomatic PMC, larger SN echogenic size was correlated with younger age at onset of the disease (Spearman rank correlation, Rho = −0.937, P = 0.002) but not with age, disease duration, or disease severity. BPS demonstrated SN hyperechogenicity, in concordance with abnormal nigrostriatal 18F‐dopa positron emission tomography (PET), in all symptomatic and 3 asymptomatic PMC. In 2 asymptomatic PMC, PET and BPS were normal. However, in another 2 asymptomatic PET‐normal PMC, SN hyperechogenicity could be detected. Data suggest SN hyperechogenicity as an early marker to detect preclinical parkinsonism. © 2004 Movement Disorder Society
Url:
DOI: 10.1002/mds.20232
Affiliations:
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Le document en format XML
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<term>Brain (pathology)</term>
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<front><div type="abstract" xml:lang="en">Substantia nigra (SN) hyperechogenicity on brain parenchyma sonography (BPS) is highly characteristic for idiopathic PD. We studied 7 symptomatic and 7 asymptomatic parkin mutation carriers (PMC) from a large kindred with adult‐onset parkinsonism. BPS revealed larger SN echogenic sizes in PMC with parkin mutations on both alleles (homozygous, compound‐heterozygous), compared to PMC with only one mutated allele (Mann–Whitney U test, P = 0.007). In symptomatic PMC, larger SN echogenic size was correlated with younger age at onset of the disease (Spearman rank correlation, Rho = −0.937, P = 0.002) but not with age, disease duration, or disease severity. BPS demonstrated SN hyperechogenicity, in concordance with abnormal nigrostriatal 18F‐dopa positron emission tomography (PET), in all symptomatic and 3 asymptomatic PMC. In 2 asymptomatic PMC, PET and BPS were normal. However, in another 2 asymptomatic PET‐normal PMC, SN hyperechogenicity could be detected. Data suggest SN hyperechogenicity as an early marker to detect preclinical parkinsonism. © 2004 Movement Disorder Society</div>
</front>
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