MovDisordV3, PascalFrancis, Checkpoint, bibRecord, 002223

Brain parenchyma sonography detects preclinical Parkinsonism

Identifieur interne : 002223 ( PascalFrancis/Checkpoint ); précédent : 002222; suivant : 002224

Brain parenchyma sonography detects preclinical Parkinsonism

Auteurs : Uwe Walter [Allemagne] ; Christine Klein [Allemagne] ; Ruediger Hilker [Allemagne] ; Reiner Benecke [Allemagne] ; Peter P. Pramstaller [Italie] ; Dirk Dressier [Allemagne]

Source :

Movement disorders [ 0885-3185 ] ; 2004.

RBID : Pascal:05-0069717

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Encéphale, Exploration ultrason, Parkinsonisme, Asymptomatique.

English descriptors

KwdEn :
- Asymptomatic, Encephalon, Nervous system diseases, Parkinsonism, Sonography.

Abstract

Substantia nigra (SN) hyperechogenicity on brain parenchyma sonography (BPS) is highly characteristic for idiopathic PD. We studied 7 symptomatic and 7 asymptomatic parkin mutation carriers (PMC) from a large kindred with adult-onset parkinsonism. BPS revealed larger SN echogenic sizes in PMC with parkin mutations on both alleles (homozygous, compound-heterozygous), compared to PMC with only one mutated allele (Mann-Whitney U test, P = 0.007). In symptomatic PMC, larger SN echogenic size was correlated with younger age at onset of the disease (Spearman rank correlation, Rho = -0.937, P = 0.002) but not with age, disease duration, or disease severity. BPS demonstrated SN hyperechogenicity, in concordance with abnormal nigrostriatal ¹⁸F-dopa positron emission tomography (PET), in all symptomatic and 3 asymptomatic PMC. In 2 asymptomatic PMC, PET and BPS were normal. However, in another 2 asymptomatic PET-normal PMC, SN hyperechogenicity could be detected. Data suggest SN hyperechogenicity as an early marker to detect preclinical parkinsonism.

Affiliations:

Allemagne, Italie

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Substantia nigra (SN) hyperechogenicity on brain parenchyma sonography (BPS) is highly characteristic for idiopathic PD. We studied 7 symptomatic and 7 asymptomatic parkin mutation carriers (PMC) from a large kindred with adult-onset parkinsonism. BPS revealed larger SN echogenic sizes in PMC with parkin mutations on both alleles (homozygous, compound-heterozygous), compared to PMC with only one mutated allele (Mann-Whitney U test, P = 0.007). In symptomatic PMC, larger SN echogenic size was correlated with younger age at onset of the disease (Spearman rank correlation, Rho = -0.937, P = 0.002) but not with age, disease duration, or disease severity. BPS demonstrated SN hyperechogenicity, in concordance with abnormal nigrostriatal <sup>18</sup>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Brain parenchyma sonography detects preclinical Parkinsonism

Brain parenchyma sonography detects preclinical Parkinsonism

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Descripteurs français

English descriptors

Abstract

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