Brain parenchyma sonography detects preclinical parkinsonism.
Identifieur interne : 001045 ( Ncbi/Curation ); précédent : 001044; suivant : 001046Brain parenchyma sonography detects preclinical parkinsonism.
Auteurs : Uwe Walter [Allemagne] ; Christine Klein ; Ruediger Hilker ; Reiner Benecke ; Peter P. Pramstaller ; Dirk DresslerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2004.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Alleles, Brain (pathology), Female, Fluorodeoxyglucose F18 (diagnostic use), Humans, Male, Middle Aged, Parkinson Disease (genetics), Parkinson Disease (pathology), Parkinson Disease (ultrasonography), Point Mutation (genetics), Positron-Emission Tomography, Radiopharmaceuticals (diagnostic use), Substantia Nigra (metabolism), Substantia Nigra (ultrasonography), Ubiquitin-Protein Ligases (genetics).
- MESH :
- chemical , diagnostic use : Fluorodeoxyglucose F18, Radiopharmaceuticals.
- genetics : Parkinson Disease, Point Mutation, Ubiquitin-Protein Ligases.
- metabolism : Substantia Nigra.
- pathology : Brain, Parkinson Disease.
- ultrasonography : Parkinson Disease, Substantia Nigra.
- Adult, Aged, Aged, 80 and over, Alleles, Female, Humans, Male, Middle Aged, Positron-Emission Tomography.
Abstract
Substantia nigra (SN) hyperechogenicity on brain parenchyma sonography (BPS) is highly characteristic for idiopathic PD. We studied 7 symptomatic and 7 asymptomatic parkin mutation carriers (PMC) from a large kindred with adult-onset parkinsonism. BPS revealed larger SN echogenic sizes in PMC with parkin mutations on both alleles (homozygous, compound-heterozygous), compared to PMC with only one mutated allele (Mann-Whitney U test, P = 0.007). In symptomatic PMC, larger SN echogenic size was correlated with younger age at onset of the disease (Spearman rank correlation, Rho = -0.937, P = 0.002) but not with age, disease duration, or disease severity. BPS demonstrated SN hyperechogenicity, in concordance with abnormal nigrostriatal (18)F-dopa positron emission tomography (PET), in all symptomatic and 3 asymptomatic PMC. In 2 asymptomatic PMC, PET and BPS were normal. However, in another 2 asymptomatic PET-normal PMC, SN hyperechogenicity could be detected. Data suggest SN hyperechogenicity as an early marker to detect preclinical parkinsonism.
DOI: 10.1002/mds.20232
PubMed: 15390070
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Brain parenchyma sonography detects preclinical parkinsonism.</title><author><name sortKey="Walter, Uwe" sort="Walter, Uwe" uniqKey="Walter U" first="Uwe" last="Walter">Uwe Walter</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of Rostock, Rostock, Germany. uwe.walter@med.uni-rostock.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Rostock, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name></author><author><name sortKey="Hilker, Ruediger" sort="Hilker, Ruediger" uniqKey="Hilker R" first="Ruediger" last="Hilker">Ruediger Hilker</name></author><author><name sortKey="Benecke, Reiner" sort="Benecke, Reiner" uniqKey="Benecke R" first="Reiner" last="Benecke">Reiner Benecke</name></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P" last="Pramstaller">Peter P. Pramstaller</name></author><author><name sortKey="Dressler, Dirk" sort="Dressler, Dirk" uniqKey="Dressler D" first="Dirk" last="Dressler">Dirk Dressler</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15390070</idno><idno type="pmid">15390070</idno><idno type="doi">10.1002/mds.20232</idno><idno type="wicri:Area/PubMed/Corpus">003243</idno><idno type="wicri:Area/PubMed/Curation">003243</idno><idno type="wicri:Area/PubMed/Checkpoint">003539</idno><idno type="wicri:Area/Ncbi/Merge">001045</idno><idno type="wicri:Area/Ncbi/Curation">001045</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Brain parenchyma sonography detects preclinical parkinsonism.</title><author><name sortKey="Walter, Uwe" sort="Walter, Uwe" uniqKey="Walter U" first="Uwe" last="Walter">Uwe Walter</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of Rostock, Rostock, Germany. uwe.walter@med.uni-rostock.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Rostock, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name></author><author><name sortKey="Hilker, Ruediger" sort="Hilker, Ruediger" uniqKey="Hilker R" first="Ruediger" last="Hilker">Ruediger Hilker</name></author><author><name sortKey="Benecke, Reiner" sort="Benecke, Reiner" uniqKey="Benecke R" first="Reiner" last="Benecke">Reiner Benecke</name></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P" last="Pramstaller">Peter P. Pramstaller</name></author><author><name sortKey="Dressler, Dirk" sort="Dressler, Dirk" uniqKey="Dressler D" first="Dirk" last="Dressler">Dirk Dressler</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Alleles</term><term>Brain (pathology)</term><term>Female</term><term>Fluorodeoxyglucose F18 (diagnostic use)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (ultrasonography)</term><term>Point Mutation (genetics)</term><term>Positron-Emission Tomography</term><term>Radiopharmaceuticals (diagnostic use)</term><term>Substantia Nigra (metabolism)</term><term>Substantia Nigra (ultrasonography)</term><term>Ubiquitin-Protein Ligases (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Fluorodeoxyglucose F18</term><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term><term>Point Mutation</term><term>Ubiquitin-Protein Ligases</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="ultrasonography" xml:lang="en"><term>Parkinson Disease</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Alleles</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Positron-Emission Tomography</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Substantia nigra (SN) hyperechogenicity on brain parenchyma sonography (BPS) is highly characteristic for idiopathic PD. We studied 7 symptomatic and 7 asymptomatic parkin mutation carriers (PMC) from a large kindred with adult-onset parkinsonism. BPS revealed larger SN echogenic sizes in PMC with parkin mutations on both alleles (homozygous, compound-heterozygous), compared to PMC with only one mutated allele (Mann-Whitney U test, P = 0.007). In symptomatic PMC, larger SN echogenic size was correlated with younger age at onset of the disease (Spearman rank correlation, Rho = -0.937, P = 0.002) but not with age, disease duration, or disease severity. BPS demonstrated SN hyperechogenicity, in concordance with abnormal nigrostriatal (18)F-dopa positron emission tomography (PET), in all symptomatic and 3 asymptomatic PMC. In 2 asymptomatic PMC, PET and BPS were normal. However, in another 2 asymptomatic PET-normal PMC, SN hyperechogenicity could be detected. Data suggest SN hyperechogenicity as an early marker to detect preclinical parkinsonism.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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